Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5T0_LEIMA

TriTrypDb:

LmjF.32.0060 , LMJLV39_320005600 , LMJSD75_320005600

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.475
CLV_NRD_NRD_1	108	110	PF00675	0.571
CLV_NRD_NRD_1	128	130	PF00675	0.434
CLV_NRD_NRD_1	135	137	PF00675	0.617
CLV_NRD_NRD_1	216	218	PF00675	0.471
CLV_NRD_NRD_1	268	270	PF00675	0.594
CLV_NRD_NRD_1	319	321	PF00675	0.545
CLV_PCSK_KEX2_1	108	110	PF00082	0.568
CLV_PCSK_KEX2_1	128	130	PF00082	0.455
CLV_PCSK_KEX2_1	135	137	PF00082	0.615
CLV_PCSK_KEX2_1	216	218	PF00082	0.405
CLV_PCSK_KEX2_1	267	269	PF00082	0.572
CLV_PCSK_KEX2_1	280	282	PF00082	0.564
CLV_PCSK_KEX2_1	319	321	PF00082	0.545
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.564
CLV_PCSK_PC7_1	315	321	PF00082	0.475
CLV_PCSK_SKI1_1	129	133	PF00082	0.538
CLV_PCSK_SKI1_1	187	191	PF00082	0.521
CLV_PCSK_SKI1_1	193	197	PF00082	0.462
CLV_PCSK_SKI1_1	315	319	PF00082	0.529
DEG_SPOP_SBC_1	288	292	PF00917	0.465
DOC_CDC14_PxL_1	224	232	PF14671	0.633
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.578
DOC_MAPK_gen_1	108	114	PF00069	0.646
DOC_MAPK_gen_1	128	134	PF00069	0.305
DOC_MAPK_gen_1	256	264	PF00069	0.652
DOC_PP4_FxxP_1	368	371	PF00568	0.564
DOC_USP7_MATH_1	26	30	PF00917	0.677
DOC_USP7_MATH_1	288	292	PF00917	0.647
DOC_USP7_MATH_1	69	73	PF00917	0.615
DOC_WW_Pin1_4	21	26	PF00397	0.642
DOC_WW_Pin1_4	33	38	PF00397	0.557
DOC_WW_Pin1_4	39	44	PF00397	0.581
DOC_WW_Pin1_4	57	62	PF00397	0.673
LIG_14-3-3_CanoR_1	324	333	PF00244	0.578
LIG_Actin_WH2_2	202	218	PF00022	0.508
LIG_Clathr_ClatBox_1	88	92	PF01394	0.532
LIG_FHA_1	161	167	PF00498	0.442
LIG_FHA_1	218	224	PF00498	0.583
LIG_FHA_1	25	31	PF00498	0.655
LIG_FHA_1	291	297	PF00498	0.548
LIG_FHA_2	169	175	PF00498	0.385
LIG_FHA_2	231	237	PF00498	0.627
LIG_FHA_2	329	335	PF00498	0.479
LIG_FHA_2	370	376	PF00498	0.468
LIG_LIR_Apic_2	259	263	PF02991	0.679
LIG_LIR_Apic_2	375	380	PF02991	0.762
LIG_LIR_Gen_1	167	177	PF02991	0.421
LIG_LIR_Nem_3	167	173	PF02991	0.436
LIG_LIR_Nem_3	210	215	PF02991	0.458
LIG_LIR_Nem_3	259	264	PF02991	0.637
LIG_MYND_1	5	9	PF01753	0.603
LIG_SH2_CRK	191	195	PF00017	0.530
LIG_SH2_NCK_1	191	195	PF00017	0.585
LIG_SH2_NCK_1	333	337	PF00017	0.549
LIG_SH2_PTP2	261	264	PF00017	0.679
LIG_SH2_SRC	261	264	PF00017	0.679
LIG_SH2_STAP1	102	106	PF00017	0.670
LIG_SH2_STAP1	306	310	PF00017	0.529
LIG_SH2_STAT5	102	105	PF00017	0.582
LIG_SH2_STAT5	116	119	PF00017	0.337
LIG_SH2_STAT5	261	264	PF00017	0.640
LIG_SH3_3	222	228	PF00018	0.515
LIG_SH3_3	31	37	PF00018	0.630
LIG_SH3_3	55	61	PF00018	0.629
LIG_SH3_3	92	98	PF00018	0.559
LIG_SUMO_SIM_par_1	85	92	PF11976	0.586
LIG_TRAF2_1	9	12	PF00917	0.556
LIG_TRFH_1	94	98	PF08558	0.553
LIG_WRC_WIRS_1	20	25	PF05994	0.686
MOD_CK1_1	159	165	PF00069	0.498
MOD_CK1_1	19	25	PF00069	0.663
MOD_CK1_1	290	296	PF00069	0.580
MOD_CK1_1	337	343	PF00069	0.594
MOD_CK1_1	359	365	PF00069	0.592
MOD_CK1_1	42	48	PF00069	0.703
MOD_CK1_1	53	59	PF00069	0.640
MOD_CK2_1	161	167	PF00069	0.393
MOD_CK2_1	168	174	PF00069	0.364
MOD_CK2_1	230	236	PF00069	0.673
MOD_CK2_1	328	334	PF00069	0.477
MOD_CK2_1	337	343	PF00069	0.479
MOD_GlcNHglycan	141	144	PF01048	0.714
MOD_GlcNHglycan	217	220	PF01048	0.610
MOD_GlcNHglycan	277	280	PF01048	0.632
MOD_GlcNHglycan	358	361	PF01048	0.604
MOD_GSK3_1	156	163	PF00069	0.497
MOD_GSK3_1	288	295	PF00069	0.644
MOD_GSK3_1	352	359	PF00069	0.638
MOD_GSK3_1	49	56	PF00069	0.642
MOD_GSK3_1	64	71	PF00069	0.529
MOD_N-GLC_1	159	164	PF02516	0.455
MOD_N-GLC_1	62	67	PF02516	0.610
MOD_N-GLC_2	46	48	PF02516	0.614
MOD_NEK2_1	101	106	PF00069	0.550
MOD_NEK2_1	161	166	PF00069	0.513
MOD_NEK2_1	215	220	PF00069	0.586
MOD_NEK2_1	230	235	PF00069	0.522
MOD_NEK2_1	44	49	PF00069	0.606
MOD_NEK2_1	62	67	PF00069	0.730
MOD_PIKK_1	325	331	PF00454	0.502
MOD_PIKK_1	7	13	PF00454	0.574
MOD_PKA_2	215	221	PF00069	0.608
MOD_PKA_2	230	236	PF00069	0.573
MOD_Plk_1	166	172	PF00069	0.515
MOD_Plk_1	207	213	PF00069	0.340
MOD_Plk_1	238	244	PF00069	0.509
MOD_Plk_1	53	59	PF00069	0.713
MOD_Plk_1	63	69	PF00069	0.735
MOD_Plk_1	84	90	PF00069	0.531
MOD_Plk_4	161	167	PF00069	0.448
MOD_Plk_4	26	32	PF00069	0.692
MOD_Plk_4	328	334	PF00069	0.517
MOD_Plk_4	69	75	PF00069	0.644
MOD_Plk_4	84	90	PF00069	0.612
MOD_ProDKin_1	21	27	PF00069	0.643
MOD_ProDKin_1	33	39	PF00069	0.558
MOD_ProDKin_1	57	63	PF00069	0.669
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.539
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.674
TRG_ENDOCYTIC_2	212	215	PF00928	0.516
TRG_ENDOCYTIC_2	261	264	PF00928	0.609
TRG_ER_diArg_1	128	130	PF00400	0.615
TRG_ER_diArg_1	134	136	PF00400	0.654
TRG_ER_diArg_1	215	217	PF00400	0.499
TRG_ER_diArg_1	267	269	PF00400	0.591
TRG_ER_diArg_1	318	320	PF00400	0.549
TRG_ER_diArg_1	78	81	PF00400	0.511
TRG_NLS_Bipartite_1	267	284	PF00514	0.624
TRG_NLS_MonoCore_2	279	284	PF00514	0.568
TRG_NLS_MonoExtC_3	279	285	PF00514	0.599
TRG_NLS_MonoExtN_4	277	284	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P875	Leptomonas seymouri	60%	100%
A0A0S4JFY4	Bodo saltans	31%	100%
A0A1X0P6X1	Trypanosomatidae	35%	87%
A0A3R7M1V0	Trypanosoma rangeli	31%	83%
A0A3S7X519	Leishmania donovani	92%	86%
A4HJY6	Leishmania braziliensis	77%	100%
A4I7G9	Leishmania infantum	91%	100%
C9ZZZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	83%
E9B2C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DTD7	Trypanosoma cruzi	30%	82%