Qa-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Qa-SNARE protein

Gene product:

Qa-SNARE protein

Species:

Leishmania major

UniProt:

Q4Q5S9_LEIMA

TriTrypDb:

LmjF.32.0070 , LMJLV39_320005700 , LMJSD75_320005700

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005794	Golgi apparatus	5	2
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	2
GO:0031201	SNARE complex	3	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q5S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0016192	vesicle-mediated transport	4	12
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.402
CLV_NRD_NRD_1	46	48	PF00675	0.469
CLV_PCSK_KEX2_1	115	117	PF00082	0.396
CLV_PCSK_KEX2_1	45	47	PF00082	0.435
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.435
CLV_PCSK_SKI1_1	107	111	PF00082	0.381
CLV_PCSK_SKI1_1	116	120	PF00082	0.416
CLV_PCSK_SKI1_1	213	217	PF00082	0.330
CLV_PCSK_SKI1_1	63	67	PF00082	0.540
CLV_Separin_Metazoa	210	214	PF03568	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DOC_PIKK_1	36	44	PF02985	0.647
DOC_USP7_MATH_1	48	52	PF00917	0.652
LIG_14-3-3_CanoR_1	116	125	PF00244	0.563
LIG_14-3-3_CanoR_1	99	103	PF00244	0.579
LIG_Actin_WH2_2	95	112	PF00022	0.564
LIG_BIR_III_4	61	65	PF00653	0.685
LIG_BRCT_BRCA1_1	129	133	PF00533	0.628
LIG_FHA_1	15	21	PF00498	0.589
LIG_FHA_1	178	184	PF00498	0.580
LIG_FHA_1	22	28	PF00498	0.528
LIG_FHA_2	118	124	PF00498	0.626
LIG_FHA_2	193	199	PF00498	0.463
LIG_FHA_2	38	44	PF00498	0.577
LIG_FHA_2	80	86	PF00498	0.572
LIG_GBD_Chelix_1	83	91	PF00786	0.357
LIG_LIR_Gen_1	174	183	PF02991	0.540
LIG_LIR_LC3C_4	241	244	PF02991	0.171
LIG_LIR_Nem_3	174	179	PF02991	0.534
LIG_Pex14_2	229	233	PF04695	0.303
LIG_Pex14_2	235	239	PF04695	0.303
LIG_PTB_Apo_2	148	155	PF02174	0.614
LIG_PTB_Phospho_1	148	154	PF10480	0.617
LIG_SH2_STAT3	154	157	PF00017	0.563
LIG_SH2_STAT5	214	217	PF00017	0.442
LIG_SUMO_SIM_par_1	160	166	PF11976	0.595
LIG_TRAF2_1	168	171	PF00917	0.613
LIG_TRAF2_1	40	43	PF00917	0.583
MOD_CK1_1	21	27	PF00069	0.593
MOD_CK2_1	37	43	PF00069	0.576
MOD_CK2_1	79	85	PF00069	0.592
MOD_GlcNHglycan	129	132	PF01048	0.425
MOD_GlcNHglycan	146	149	PF01048	0.377
MOD_GSK3_1	105	112	PF00069	0.560
MOD_GSK3_1	14	21	PF00069	0.614
MOD_GSK3_1	192	199	PF00069	0.460
MOD_GSK3_1	213	220	PF00069	0.538
MOD_GSK3_1	48	55	PF00069	0.580
MOD_GSK3_1	73	80	PF00069	0.610
MOD_N-GLC_1	216	221	PF02516	0.263
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	109	114	PF00069	0.580
MOD_NEK2_1	144	149	PF00069	0.646
MOD_NEK2_1	238	243	PF00069	0.171
MOD_NEK2_1	26	31	PF00069	0.645
MOD_NEK2_1	65	70	PF00069	0.693
MOD_NEK2_1	91	96	PF00069	0.573
MOD_NEK2_1	98	103	PF00069	0.560
MOD_PIKK_1	1	7	PF00454	0.591
MOD_PIKK_1	149	155	PF00454	0.641
MOD_PIKK_1	21	27	PF00454	0.627
MOD_PIKK_1	48	54	PF00454	0.662
MOD_PKA_2	1	7	PF00069	0.611
MOD_PKA_2	73	79	PF00069	0.607
MOD_PKA_2	98	104	PF00069	0.575
MOD_Plk_1	177	183	PF00069	0.565
MOD_Plk_1	21	27	PF00069	0.618
MOD_Plk_2-3	37	43	PF00069	0.578
MOD_Plk_4	238	244	PF00069	0.171
MOD_Plk_4	79	85	PF00069	0.597
MOD_Plk_4	8	14	PF00069	0.639
TRG_ER_diArg_1	87	90	PF00400	0.590
TRG_NLS_MonoExtC_3	44	50	PF00514	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME4	Leptomonas seymouri	85%	82%
A0A0S4JCP0	Bodo saltans	58%	78%
A0A1X0P6P0	Trypanosomatidae	68%	75%
A0A3R7KH07	Trypanosoma rangeli	65%	74%
A0A3S7X532	Leishmania donovani	94%	100%
A4HJY7	Leishmania braziliensis	91%	100%
A4I7H0	Leishmania infantum	94%	100%
C9ZZZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	75%
E9B2C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13644	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	79%
Q01590	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	72%
Q08851	Rattus norvegicus	30%	69%
Q08DB5	Bos taurus	30%	69%
Q13190	Homo sapiens	30%	69%
Q8K1E0	Mus musculus	31%	69%
Q9FFK1	Arabidopsis thaliana	24%	73%
Q9LK09	Arabidopsis thaliana	26%	71%
V5BWT4	Trypanosoma cruzi	66%	74%