Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5S7_LEIMA

TriTrypDb:

LmjF.32.0090 , LMJLV39_320005900 , LMJSD75_320005900

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	9
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q5S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.520
CLV_NRD_NRD_1	22	24	PF00675	0.682
CLV_NRD_NRD_1	274	276	PF00675	0.411
CLV_NRD_NRD_1	88	90	PF00675	0.432
CLV_NRD_NRD_1	94	96	PF00675	0.433
CLV_PCSK_FUR_1	272	276	PF00082	0.437
CLV_PCSK_FUR_1	85	89	PF00082	0.436
CLV_PCSK_KEX2_1	169	171	PF00082	0.520
CLV_PCSK_KEX2_1	272	274	PF00082	0.407
CLV_PCSK_KEX2_1	87	89	PF00082	0.435
CLV_PCSK_KEX2_1	94	96	PF00082	0.436
CLV_PCSK_SKI1_1	207	211	PF00082	0.429
CLV_PCSK_SKI1_1	28	32	PF00082	0.597
CLV_PCSK_SKI1_1	95	99	PF00082	0.434
DEG_APCC_KENBOX_2	30	34	PF00400	0.479
DEG_MDM2_SWIB_1	276	284	PF02201	0.650
DOC_ANK_TNKS_1	254	261	PF00023	0.677
DOC_CYCLIN_RxL_1	89	101	PF00134	0.709
DOC_MAPK_gen_1	108	116	PF00069	0.573
DOC_MAPK_gen_1	169	176	PF00069	0.668
DOC_MAPK_gen_1	85	93	PF00069	0.654
DOC_PP1_RVXF_1	87	94	PF00149	0.565
DOC_PP4_FxxP_1	209	212	PF00568	0.656
DOC_SPAK_OSR1_1	170	174	PF12202	0.645
DOC_USP7_MATH_1	126	130	PF00917	0.760
DOC_USP7_MATH_1	71	75	PF00917	0.480
DOC_WW_Pin1_4	130	135	PF00397	0.728
LIG_14-3-3_CanoR_1	180	186	PF00244	0.638
LIG_14-3-3_CanoR_1	88	94	PF00244	0.680
LIG_BRCT_BRCA1_1	213	217	PF00533	0.691
LIG_Clathr_ClatBox_1	124	128	PF01394	0.591
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.629
LIG_DLG_GKlike_1	89	97	PF00625	0.567
LIG_EH_1	34	38	PF12763	0.436
LIG_FHA_1	119	125	PF00498	0.680
LIG_FHA_1	144	150	PF00498	0.772
LIG_FHA_1	225	231	PF00498	0.669
LIG_FHA_1	5	11	PF00498	0.521
LIG_FHA_2	10	16	PF00498	0.456
LIG_LIR_Apic_2	208	212	PF02991	0.657
LIG_LIR_Gen_1	121	130	PF02991	0.666
LIG_LIR_Gen_1	168	178	PF02991	0.676
LIG_LIR_Gen_1	74	83	PF02991	0.562
LIG_LIR_Nem_3	121	125	PF02991	0.693
LIG_LIR_Nem_3	49	55	PF02991	0.422
LIG_LIR_Nem_3	74	78	PF02991	0.559
LIG_NRBOX	280	286	PF00104	0.518
LIG_Pex14_2	276	280	PF04695	0.661
LIG_SH2_CRK	218	222	PF00017	0.603
LIG_SH2_SRC	55	58	PF00017	0.404
LIG_SH2_STAT5	55	58	PF00017	0.328
LIG_SH3_3	112	118	PF00018	0.579
LIG_SH3_3	131	137	PF00018	0.606
LIG_SH3_3	263	269	PF00018	0.657
LIG_SH3_3	294	300	PF00018	0.629
LIG_SUMO_SIM_par_1	123	129	PF11976	0.704
LIG_SUMO_SIM_par_1	243	249	PF11976	0.575
LIG_TYR_ITIM	216	221	PF00017	0.564
LIG_UBA3_1	25	31	PF00899	0.462
LIG_WRC_WIRS_1	119	124	PF05994	0.550
LIG_WRC_WIRS_1	72	77	PF05994	0.454
LIG_WW_2	117	120	PF00397	0.657
MOD_CK1_1	143	149	PF00069	0.734
MOD_CK1_1	182	188	PF00069	0.701
MOD_CK1_1	4	10	PF00069	0.521
MOD_CK2_1	253	259	PF00069	0.650
MOD_CK2_1	264	270	PF00069	0.528
MOD_CMANNOS	261	264	PF00535	0.410
MOD_GlcNHglycan	128	131	PF01048	0.573
MOD_GlcNHglycan	142	145	PF01048	0.555
MOD_GlcNHglycan	175	179	PF01048	0.435
MOD_GlcNHglycan	58	61	PF01048	0.356
MOD_GSK3_1	126	133	PF00069	0.704
MOD_GSK3_1	143	150	PF00069	0.720
MOD_GSK3_1	154	161	PF00069	0.639
MOD_GSK3_1	174	181	PF00069	0.583
MOD_GSK3_1	249	256	PF00069	0.580
MOD_N-GLC_1	147	152	PF02516	0.513
MOD_N-GLC_1	249	254	PF02516	0.416
MOD_NEK2_1	140	145	PF00069	0.692
MOD_NEK2_1	174	179	PF00069	0.689
MOD_NEK2_1	51	56	PF00069	0.398
MOD_NEK2_1	62	67	PF00069	0.325
MOD_PIKK_1	211	217	PF00454	0.545
MOD_PKA_2	179	185	PF00069	0.625
MOD_PKB_1	87	95	PF00069	0.567
MOD_Plk_1	147	153	PF00069	0.713
MOD_Plk_1	155	161	PF00069	0.638
MOD_Plk_1	249	255	PF00069	0.621
MOD_Plk_4	135	141	PF00069	0.698
MOD_Plk_4	147	153	PF00069	0.771
MOD_Plk_4	46	52	PF00069	0.405
MOD_Plk_4	71	77	PF00069	0.397
MOD_ProDKin_1	130	136	PF00069	0.730
MOD_SUMO_rev_2	17	26	PF00179	0.478
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.517
TRG_ENDOCYTIC_2	218	221	PF00928	0.705
TRG_ENDOCYTIC_2	72	75	PF00928	0.346
TRG_ER_diArg_1	169	171	PF00400	0.676
TRG_ER_diArg_1	230	233	PF00400	0.688
TRG_ER_diArg_1	272	275	PF00400	0.585
TRG_ER_diArg_1	86	89	PF00400	0.633
TRG_ER_diArg_1	93	95	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	196	201	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P876	Leptomonas seymouri	58%	97%
A0A1X0P6T9	Trypanosomatidae	39%	100%
A0A3Q8IF74	Leishmania donovani	90%	100%
A0A422NPR8	Trypanosoma rangeli	40%	100%
A4HJY9	Leishmania braziliensis	73%	100%
A4I7H2	Leishmania infantum	89%	100%
D0A004	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B2C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BWT8	Trypanosoma cruzi	39%	69%