FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q5S6_LEIMA

TriTrypDb:

LmjF.32.0100 , LMJLV39_320006000 , LMJSD75_320006000

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.340
CLV_C14_Caspase3-7	151	155	PF00656	0.368
CLV_NRD_NRD_1	22	24	PF00675	0.416
CLV_NRD_NRD_1	68	70	PF00675	0.340
CLV_PCSK_KEX2_1	22	24	PF00082	0.416
CLV_PCSK_KEX2_1	68	70	PF00082	0.275
CLV_PCSK_SKI1_1	127	131	PF00082	0.340
CLV_PCSK_SKI1_1	23	27	PF00082	0.191
CLV_PCSK_SKI1_1	7	11	PF00082	0.543
CLV_PCSK_SKI1_1	86	90	PF00082	0.365
CLV_PCSK_SKI1_1	97	101	PF00082	0.209
DEG_APCC_DBOX_1	96	104	PF00400	0.340
DOC_CYCLIN_RxL_1	20	31	PF00134	0.340
DOC_CYCLIN_RxL_1	97	106	PF00134	0.318
DOC_MAPK_MEF2A_6	203	211	PF00069	0.395
DOC_MAPK_MEF2A_6	22	29	PF00069	0.336
DOC_MAPK_NFAT4_5	22	30	PF00069	0.340
DOC_PP2B_LxvP_1	163	166	PF13499	0.289
DOC_PP4_FxxP_1	38	41	PF00568	0.340
DOC_PP4_FxxP_1	67	70	PF00568	0.275
DOC_PP4_FxxP_1	9	12	PF00568	0.549
LIG_14-3-3_CanoR_1	143	147	PF00244	0.274
LIG_14-3-3_CanoR_1	22	26	PF00244	0.340
LIG_14-3-3_CanoR_1	223	231	PF00244	0.496
LIG_14-3-3_CanoR_1	86	95	PF00244	0.340
LIG_APCC_ABBAyCdc20_2	22	28	PF00400	0.340
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_EVH1_2	5	9	PF00568	0.550
LIG_FHA_1	143	149	PF00498	0.273
LIG_FHA_1	22	28	PF00498	0.340
LIG_FHA_1	40	46	PF00498	0.173
LIG_FHA_2	173	179	PF00498	0.340
LIG_FHA_2	200	206	PF00498	0.414
LIG_FHA_2	45	51	PF00498	0.323
LIG_FHA_2	53	59	PF00498	0.283
LIG_FHA_2	8	14	PF00498	0.548
LIG_FHA_2	87	93	PF00498	0.275
LIG_LIR_Gen_1	24	34	PF02991	0.318
LIG_LIR_Nem_3	123	128	PF02991	0.471
LIG_LIR_Nem_3	13	18	PF02991	0.666
LIG_LIR_Nem_3	49	54	PF02991	0.427
LIG_LIR_Nem_3	61	67	PF02991	0.274
LIG_REV1ctd_RIR_1	6	11	PF16727	0.546
LIG_SH2_CRK	125	129	PF00017	0.454
LIG_SH2_CRK	215	219	PF00017	0.436
LIG_SH2_PTP2	15	18	PF00017	0.514
LIG_SH2_STAP1	115	119	PF00017	0.154
LIG_SH2_STAP1	83	87	PF00017	0.275
LIG_SH2_STAP1	95	99	PF00017	0.275
LIG_SH2_STAT3	157	160	PF00017	0.340
LIG_SH2_STAT5	115	118	PF00017	0.275
LIG_SH2_STAT5	15	18	PF00017	0.514
LIG_SH2_STAT5	221	224	PF00017	0.520
LIG_SH2_STAT5	37	40	PF00017	0.284
LIG_SH3_3	204	210	PF00018	0.392
LIG_SUMO_SIM_par_1	144	151	PF11976	0.202
LIG_TRAF2_1	175	178	PF00917	0.275
LIG_WW_3	4	8	PF00397	0.562
MOD_CK2_1	172	178	PF00069	0.282
MOD_CK2_1	7	13	PF00069	0.552
MOD_CK2_1	86	92	PF00069	0.474
MOD_GlcNHglycan	149	153	PF01048	0.312
MOD_GSK3_1	109	116	PF00069	0.475
MOD_GSK3_1	217	224	PF00069	0.534
MOD_N-GLC_1	130	135	PF02516	0.340
MOD_NEK2_1	148	153	PF00069	0.305
MOD_NEK2_1	217	222	PF00069	0.463
MOD_NEK2_1	29	34	PF00069	0.275
MOD_PKA_2	142	148	PF00069	0.202
MOD_PKA_2	21	27	PF00069	0.340
MOD_PKA_2	222	228	PF00069	0.534
MOD_Plk_1	109	115	PF00069	0.390
MOD_Plk_1	130	136	PF00069	0.275
MOD_Plk_1	29	35	PF00069	0.275
MOD_Plk_4	130	136	PF00069	0.340
MOD_Plk_4	142	148	PF00069	0.202
MOD_Plk_4	29	35	PF00069	0.275
MOD_Plk_4	39	45	PF00069	0.275
MOD_Plk_4	60	66	PF00069	0.340
MOD_SUMO_for_1	227	230	PF00179	0.521
TRG_DiLeu_BaEn_1	142	147	PF01217	0.340
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.340
TRG_ENDOCYTIC_2	125	128	PF00928	0.335
TRG_ENDOCYTIC_2	15	18	PF00928	0.514
TRG_ENDOCYTIC_2	180	183	PF00928	0.376
TRG_ENDOCYTIC_2	215	218	PF00928	0.364
TRG_ENDOCYTIC_2	64	67	PF00928	0.275
TRG_ER_diArg_1	67	69	PF00400	0.340
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM73	Leptomonas seymouri	55%	100%
A0A3Q8IKJ6	Leishmania donovani	99%	100%
A4HJZ0	Leishmania braziliensis	95%	100%
A4I7H3	Leishmania infantum	99%	100%
E9B2D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O95476	Homo sapiens	29%	95%
Q1RMV9	Bos taurus	29%	95%
Q28HW9	Xenopus tropicalis	29%	95%
Q29I63	Drosophila pseudoobscura pseudoobscura	30%	95%
Q3B7T6	Rattus norvegicus	29%	95%
Q3TP92	Mus musculus	29%	95%
Q5U395	Danio rerio	30%	94%
Q5U3T3	Danio rerio	30%	94%
Q8JIL9	Xenopus laevis	29%	95%
Q9VRG7	Drosophila melanogaster	29%	95%