Putative mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

Q4Q5S5_LEIMA

TriTrypDb:

LmjF.32.0110 , LMJLV39_320006100 , LMJSD75_320006100

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q5S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	2
GO:0005215	transporter activity	1	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015101	organic cation transmembrane transporter activity	5	2
GO:0022857	transmembrane transporter activity	2	2
GO:1901682	sulfur compound transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	69	71	PF00082	0.575
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.575
CLV_PCSK_SKI1_1	138	142	PF00082	0.286
CLV_PCSK_SKI1_1	237	241	PF00082	0.268
CLV_PCSK_SKI1_1	253	257	PF00082	0.287
CLV_PCSK_SKI1_1	70	74	PF00082	0.565
DEG_APCC_DBOX_1	252	260	PF00400	0.541
DEG_COP1_1	153	161	PF00400	0.432
DEG_Nend_UBRbox_2	1	3	PF02207	0.270
DOC_AGCK_PIF_2	295	300	PF00069	0.465
DOC_CKS1_1	227	232	PF01111	0.324
DOC_CYCLIN_RxL_1	178	186	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	227	233	PF00134	0.360
DOC_MAPK_gen_1	69	75	PF00069	0.469
DOC_PP1_RVXF_1	281	287	PF00149	0.349
DOC_PP2B_LxvP_1	211	214	PF13499	0.415
DOC_PP2B_LxvP_1	75	78	PF13499	0.448
DOC_USP7_MATH_1	151	155	PF00917	0.432
DOC_USP7_MATH_1	51	55	PF00917	0.324
DOC_USP7_MATH_1	68	72	PF00917	0.358
DOC_USP7_MATH_1	76	80	PF00917	0.417
DOC_WW_Pin1_4	143	148	PF00397	0.476
DOC_WW_Pin1_4	157	162	PF00397	0.489
DOC_WW_Pin1_4	226	231	PF00397	0.324
DOC_WW_Pin1_4	90	95	PF00397	0.466
LIG_14-3-3_CanoR_1	278	287	PF00244	0.508
LIG_14-3-3_CanoR_1	70	76	PF00244	0.476
LIG_BRCT_BRCA1_1	211	215	PF00533	0.371
LIG_BRCT_BRCA1_1	291	295	PF00533	0.324
LIG_CtBP_PxDLS_1	117	121	PF00389	0.541
LIG_eIF4E_1	254	260	PF01652	0.515
LIG_FHA_1	132	138	PF00498	0.511
LIG_FHA_1	144	150	PF00498	0.467
LIG_FHA_1	226	232	PF00498	0.324
LIG_FHA_1	280	286	PF00498	0.411
LIG_FHA_1	91	97	PF00498	0.438
LIG_FHA_2	227	233	PF00498	0.324
LIG_HCF-1_HBM_1	205	208	PF13415	0.474
LIG_LIR_Gen_1	182	193	PF02991	0.327
LIG_LIR_Gen_1	205	215	PF02991	0.442
LIG_LIR_Gen_1	297	305	PF02991	0.301
LIG_LIR_Gen_1	71	78	PF02991	0.345
LIG_LIR_Nem_3	182	188	PF02991	0.327
LIG_LIR_Nem_3	191	196	PF02991	0.262
LIG_LIR_Nem_3	205	211	PF02991	0.409
LIG_LIR_Nem_3	292	298	PF02991	0.332
LIG_LIR_Nem_3	303	308	PF02991	0.283
LIG_LIR_Nem_3	41	47	PF02991	0.543
LIG_LIR_Nem_3	71	75	PF02991	0.335
LIG_MLH1_MIPbox_1	291	295	PF16413	0.324
LIG_Pex14_2	215	219	PF04695	0.465
LIG_REV1ctd_RIR_1	274	282	PF16727	0.470
LIG_SH2_CRK	208	212	PF00017	0.445
LIG_SH2_CRK	44	48	PF00017	0.324
LIG_SH2_SRC	65	68	PF00017	0.262
LIG_SH2_STAP1	272	276	PF00017	0.571
LIG_SH2_STAT5	254	257	PF00017	0.578
LIG_SH3_2	159	164	PF14604	0.511
LIG_SH3_3	145	151	PF00018	0.526
LIG_SH3_3	155	161	PF00018	0.515
LIG_SH3_3	260	266	PF00018	0.523
LIG_SUMO_SIM_anti_2	228	236	PF11976	0.324
LIG_TRAF2_1	245	248	PF00917	0.554
MOD_CDK_SPxxK_3	157	164	PF00069	0.432
MOD_CK1_1	207	213	PF00069	0.386
MOD_CK1_1	71	77	PF00069	0.388
MOD_CK2_1	188	194	PF00069	0.339
MOD_CK2_1	80	86	PF00069	0.475
MOD_GlcNHglycan	153	156	PF01048	0.368
MOD_GlcNHglycan	165	168	PF01048	0.310
MOD_GlcNHglycan	219	222	PF01048	0.349
MOD_GlcNHglycan	302	305	PF01048	0.515
MOD_GlcNHglycan	47	50	PF01048	0.319
MOD_GlcNHglycan	78	81	PF01048	0.673
MOD_GSK3_1	188	195	PF00069	0.423
MOD_GSK3_1	200	207	PF00069	0.462
MOD_GSK3_1	23	30	PF00069	0.466
MOD_GSK3_1	285	292	PF00069	0.324
MOD_GSK3_1	300	307	PF00069	0.270
MOD_GSK3_1	47	54	PF00069	0.232
MOD_GSK3_1	76	83	PF00069	0.482
MOD_GSK3_1	86	93	PF00069	0.518
MOD_N-GLC_1	138	143	PF02516	0.354
MOD_N-GLC_1	248	253	PF02516	0.190
MOD_NEK2_1	192	197	PF00069	0.294
MOD_NEK2_1	285	290	PF00069	0.349
MOD_NEK2_1	300	305	PF00069	0.287
MOD_NEK2_1	47	52	PF00069	0.442
MOD_NEK2_2	20	25	PF00069	0.324
MOD_NEK2_2	304	309	PF00069	0.311
MOD_PKA_2	151	157	PF00069	0.432
MOD_PKA_2	163	169	PF00069	0.541
MOD_Plk_1	14	20	PF00069	0.324
MOD_Plk_1	204	210	PF00069	0.330
MOD_Plk_1	248	254	PF00069	0.390
MOD_Plk_1	85	91	PF00069	0.469
MOD_Plk_4	132	138	PF00069	0.516
MOD_Plk_4	14	20	PF00069	0.380
MOD_Plk_4	188	194	PF00069	0.423
MOD_Plk_4	289	295	PF00069	0.332
MOD_Plk_4	92	98	PF00069	0.477
MOD_ProDKin_1	143	149	PF00069	0.476
MOD_ProDKin_1	157	163	PF00069	0.489
MOD_ProDKin_1	226	232	PF00069	0.324
MOD_ProDKin_1	90	96	PF00069	0.459
MOD_SUMO_for_1	196	199	PF00179	0.232
TRG_ENDOCYTIC_2	193	196	PF00928	0.270
TRG_ENDOCYTIC_2	208	211	PF00928	0.383
TRG_ENDOCYTIC_2	298	301	PF00928	0.287
TRG_ENDOCYTIC_2	44	47	PF00928	0.324
TRG_NES_CRM1_1	182	194	PF08389	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K5L2	Rattus norvegicus	24%	96%
A0A0N0P7Y4	Leptomonas seymouri	26%	100%
A0A0N0P8W6	Leptomonas seymouri	24%	91%
A0A0N1HX21	Leptomonas seymouri	24%	81%
A0A0N1I0W9	Leptomonas seymouri	71%	100%
A0A0N1I6I9	Leptomonas seymouri	25%	100%
A0A0N1IMA2	Leptomonas seymouri	26%	96%
A0A0S4JM95	Bodo saltans	25%	100%
A0A0S4KJX8	Bodo saltans	26%	89%
A0A1X0NJD2	Trypanosomatidae	24%	100%
A0A1X0P4Q9	Trypanosomatidae	28%	100%
A0A1X0P6V9	Trypanosomatidae	52%	100%
A0A1X0P952	Trypanosomatidae	25%	100%
A0A3Q8IFM5	Leishmania donovani	94%	100%
A0A3R7KLL6	Trypanosoma rangeli	24%	100%
A0A3R7M746	Trypanosoma rangeli	27%	97%
A0A3R7RT89	Trypanosoma rangeli	24%	100%
A0A3S7WXX9	Leishmania donovani	26%	78%
A0A3S7X2U2	Leishmania donovani	24%	100%
A0A422P122	Trypanosoma rangeli	55%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	22%	93%
A2ASZ8	Mus musculus	25%	66%
A2CEQ0	Danio rerio	24%	66%
A4HHT5	Leishmania braziliensis	24%	100%
A4HJZ1	Leishmania braziliensis	85%	100%
A4I0J6	Leishmania infantum	26%	78%
A4I4Z5	Leishmania infantum	24%	100%
A4I7H4	Leishmania infantum	94%	100%
A6QR09	Bos taurus	38%	100%
B2MVX9	Ovis aries	24%	100%
C9ZKK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	91%
D0A075	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AEE0	Leishmania major	24%	100%
E9AFF7	Leishmania major	23%	100%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AWF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	78%
E9B2D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F4HT41	Arabidopsis thaliana	31%	90%
O14281	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O60029	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%
O94344	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P0CAT2	Danio rerio	20%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	99%
P23500	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	97%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P53320	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	85%
Q05AQ3	Xenopus tropicalis	24%	95%
Q08CI8	Danio rerio	25%	100%
Q08DK4	Bos taurus	26%	97%
Q09461	Caenorhabditis elegans	24%	86%
Q0V7M4	Bos taurus	24%	66%
Q10442	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	90%
Q17QI7	Bos taurus	26%	87%
Q27257	Caenorhabditis elegans	26%	100%
Q287T7	Danio rerio	26%	94%
Q499U1	Rattus norvegicus	24%	95%
Q4QB15	Leishmania major	26%	78%
Q4V8K4	Rattus norvegicus	25%	87%
Q4V9P0	Danio rerio	39%	100%
Q505J6	Rattus norvegicus	29%	97%
Q552L9	Dictyostelium discoideum	26%	85%
Q55E45	Dictyostelium discoideum	24%	100%
Q55GE2	Dictyostelium discoideum	24%	100%
Q5EAC0	Bos taurus	24%	100%
Q5PQ27	Xenopus laevis	23%	95%
Q5RD81	Pongo abelii	25%	96%
Q5U680	Mus musculus	37%	100%
Q641C8	Xenopus laevis	39%	100%
Q66H23	Rattus norvegicus	25%	92%
Q6DE75	Xenopus laevis	23%	100%
Q6DHC3	Danio rerio	22%	88%
Q6DJ08	Xenopus tropicalis	25%	100%
Q6GLA2	Xenopus tropicalis	39%	100%
Q6KCM7	Homo sapiens	25%	66%
Q70HW3	Homo sapiens	38%	100%
Q76PC3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	92%
Q7SXW0	Danio rerio	26%	87%
Q7T292	Danio rerio	27%	83%
Q86AV5	Dictyostelium discoideum	27%	100%
Q8K3P6	Rattus norvegicus	25%	66%
Q8R0Z5	Mus musculus	28%	85%
Q91XD8	Mus musculus	24%	95%
Q920G8	Mus musculus	25%	92%
Q94AG6	Arabidopsis thaliana	32%	96%
Q96A46	Homo sapiens	28%	85%
Q96DW6	Homo sapiens	25%	100%
Q9BZJ4	Homo sapiens	26%	87%
Q9CA93	Arabidopsis thaliana	22%	100%
Q9D6M3	Mus musculus	25%	96%
Q9D8K8	Mus musculus	27%	87%
Q9DB41	Mus musculus	29%	97%
Q9FHX2	Arabidopsis thaliana	30%	75%
Q9H1K4	Homo sapiens	30%	99%
Q9H936	Homo sapiens	26%	96%
Q9NYZ2	Homo sapiens	24%	92%
Q9P6N6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9VAY3	Drosophila melanogaster	25%	82%
Q9VBN7	Drosophila melanogaster	39%	100%
Q9VWG0	Drosophila melanogaster	23%	80%
V5BSW1	Trypanosoma cruzi	25%	100%
V5BVW0	Trypanosoma cruzi	27%	100%
V5C243	Trypanosoma cruzi	25%	96%
V5DFJ2	Trypanosoma cruzi	26%	97%