Skp1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5S3_LEIMA

TriTrypDb:

LmjF.32.0130 , LMJLV39_320006300 , LMJSD75_320006400

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.351
CLV_NRD_NRD_1	76	78	PF00675	0.579
CLV_PCSK_KEX2_1	162	164	PF00082	0.602
CLV_PCSK_KEX2_1	76	78	PF00082	0.543
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.602
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.543
CLV_PCSK_SKI1_1	187	191	PF00082	0.305
CLV_PCSK_SKI1_1	205	209	PF00082	0.348
CLV_Separin_Metazoa	184	188	PF03568	0.315
CLV_Separin_Metazoa	206	210	PF03568	0.290
DEG_APCC_DBOX_1	121	129	PF00400	0.361
DOC_CDC14_PxL_1	226	234	PF14671	0.544
DOC_CYCLIN_RxL_1	101	111	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.416
DOC_CYCLIN_yCln2_LP_2	85	88	PF00134	0.422
DOC_MAPK_MEF2A_6	12	19	PF00069	0.435
DOC_PP2B_LxvP_1	121	124	PF13499	0.362
DOC_PP2B_LxvP_1	85	88	PF13499	0.422
DOC_USP7_MATH_1	37	41	PF00917	0.475
LIG_14-3-3_CanoR_1	163	169	PF00244	0.561
LIG_FHA_1	188	194	PF00498	0.368
LIG_FHA_2	216	222	PF00498	0.405
LIG_FHA_2	3	9	PF00498	0.574
LIG_LIR_Gen_1	179	186	PF02991	0.319
LIG_LIR_Gen_1	223	232	PF02991	0.402
LIG_LIR_Gen_1	29	37	PF02991	0.332
LIG_LIR_Nem_3	100	106	PF02991	0.409
LIG_LIR_Nem_3	179	183	PF02991	0.318
LIG_LIR_Nem_3	223	229	PF02991	0.374
LIG_LIR_Nem_3	29	35	PF02991	0.340
LIG_NRBOX	59	65	PF00104	0.426
LIG_Pex14_1	132	136	PF04695	0.299
LIG_SH2_CRK	226	230	PF00017	0.463
LIG_SH2_PTP2	32	35	PF00017	0.475
LIG_SH2_STAT5	105	108	PF00017	0.302
LIG_SH2_STAT5	136	139	PF00017	0.445
LIG_SH2_STAT5	18	21	PF00017	0.452
LIG_SH2_STAT5	32	35	PF00017	0.312
LIG_SH3_3	86	92	PF00018	0.395
LIG_TRAF2_1	124	127	PF00917	0.357
LIG_TRAF2_1	218	221	PF00917	0.412
MOD_CK1_1	200	206	PF00069	0.416
MOD_CK2_1	200	206	PF00069	0.402
MOD_CK2_1	215	221	PF00069	0.432
MOD_GlcNHglycan	152	155	PF01048	0.502
MOD_GlcNHglycan	199	202	PF01048	0.534
MOD_GlcNHglycan	28	31	PF01048	0.416
MOD_GlcNHglycan	39	42	PF01048	0.437
MOD_GlcNHglycan	8	12	PF01048	0.586
MOD_GSK3_1	108	115	PF00069	0.360
MOD_GSK3_1	193	200	PF00069	0.455
MOD_GSK3_1	63	70	PF00069	0.424
MOD_NEK2_1	108	113	PF00069	0.379
MOD_NEK2_1	156	161	PF00069	0.446
MOD_NEK2_1	193	198	PF00069	0.319
MOD_NEK2_1	63	68	PF00069	0.328
MOD_PKB_1	24	32	PF00069	0.386
MOD_Plk_4	112	118	PF00069	0.399
MOD_Plk_4	63	69	PF00069	0.359
MOD_SUMO_rev_2	147	153	PF00179	0.536
TRG_DiLeu_BaEn_1	133	138	PF01217	0.294
TRG_DiLeu_BaEn_4	220	226	PF01217	0.404
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.322
TRG_ENDOCYTIC_2	105	108	PF00928	0.302
TRG_ENDOCYTIC_2	226	229	PF00928	0.381
TRG_ENDOCYTIC_2	32	35	PF00928	0.366
TRG_NES_CRM1_1	166	179	PF08389	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P1	Leptomonas seymouri	79%	100%
A0A1X0P7H5	Trypanosomatidae	45%	77%
A0A3S7X513	Leishmania donovani	95%	100%
A0A422P0X4	Trypanosoma rangeli	41%	75%
A4HJZ3	Leishmania braziliensis	86%	100%
A4I7H6	Leishmania infantum	95%	100%
D0A078	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	71%
E9B2D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DTE4	Trypanosoma cruzi	46%	75%