Armadillo/beta-catenin-like repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 9

Species:

Leishmania major

UniProt:

Q4Q5S2_LEIMA

TriTrypDb:

LmjF.32.0140 , LMJLV39_320006400 , LMJSD75_320006500

Length:

1042

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q5S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5S2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.580
CLV_C14_Caspase3-7	481	485	PF00656	0.375
CLV_C14_Caspase3-7	508	512	PF00656	0.298
CLV_C14_Caspase3-7	894	898	PF00656	0.508
CLV_NRD_NRD_1	1026	1028	PF00675	0.383
CLV_NRD_NRD_1	350	352	PF00675	0.351
CLV_NRD_NRD_1	485	487	PF00675	0.405
CLV_NRD_NRD_1	581	583	PF00675	0.364
CLV_NRD_NRD_1	596	598	PF00675	0.411
CLV_NRD_NRD_1	93	95	PF00675	0.498
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.383
CLV_PCSK_KEX2_1	140	142	PF00082	0.744
CLV_PCSK_KEX2_1	661	663	PF00082	0.623
CLV_PCSK_KEX2_1	93	95	PF00082	0.498
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.744
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.623
CLV_PCSK_PC7_1	89	95	PF00082	0.591
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.451
CLV_PCSK_SKI1_1	106	110	PF00082	0.564
CLV_PCSK_SKI1_1	352	356	PF00082	0.435
CLV_PCSK_SKI1_1	414	418	PF00082	0.340
CLV_PCSK_SKI1_1	578	582	PF00082	0.556
CLV_PCSK_SKI1_1	965	969	PF00082	0.494
CLV_Separin_Metazoa	500	504	PF03568	0.405
DEG_APCC_DBOX_1	193	201	PF00400	0.555
DEG_APCC_DBOX_1	413	421	PF00400	0.341
DEG_APCC_DBOX_1	485	493	PF00400	0.290
DEG_Nend_UBRbox_1	1	4	PF02207	0.436
DEG_SCF_FBW7_1	761	768	PF00400	0.413
DEG_SPOP_SBC_1	551	555	PF00917	0.297
DOC_CDC14_PxL_1	492	500	PF14671	0.290
DOC_CDC14_PxL_1	542	550	PF14671	0.405
DOC_CKS1_1	762	767	PF01111	0.487
DOC_CYCLIN_yCln2_LP_2	730	736	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.470
DOC_MAPK_gen_1	102	113	PF00069	0.567
DOC_MAPK_gen_1	582	589	PF00069	0.355
DOC_MAPK_MEF2A_6	102	111	PF00069	0.488
DOC_MAPK_MEF2A_6	582	591	PF00069	0.349
DOC_MAPK_MEF2A_6	640	649	PF00069	0.354
DOC_MAPK_MEF2A_6	801	808	PF00069	0.468
DOC_MAPK_NFAT4_5	106	114	PF00069	0.473
DOC_PP1_RVXF_1	376	383	PF00149	0.436
DOC_PP1_RVXF_1	990	997	PF00149	0.373
DOC_PP2B_LxvP_1	209	212	PF13499	0.429
DOC_PP2B_LxvP_1	730	733	PF13499	0.480
DOC_PP2B_LxvP_1	734	737	PF13499	0.458
DOC_PP2B_LxvP_1	767	770	PF13499	0.483
DOC_PP4_FxxP_1	326	329	PF00568	0.423
DOC_PP4_FxxP_1	762	765	PF00568	0.518
DOC_PP4_FxxP_1	829	832	PF00568	0.599
DOC_USP7_MATH_1	1028	1032	PF00917	0.455
DOC_USP7_MATH_1	199	203	PF00917	0.508
DOC_USP7_MATH_1	239	243	PF00917	0.494
DOC_USP7_MATH_1	25	29	PF00917	0.525
DOC_USP7_MATH_1	275	279	PF00917	0.503
DOC_USP7_MATH_1	282	286	PF00917	0.507
DOC_USP7_MATH_1	340	344	PF00917	0.521
DOC_USP7_MATH_1	399	403	PF00917	0.364
DOC_USP7_MATH_1	464	468	PF00917	0.393
DOC_USP7_MATH_1	50	54	PF00917	0.475
DOC_USP7_MATH_1	607	611	PF00917	0.653
DOC_USP7_MATH_1	705	709	PF00917	0.431
DOC_USP7_MATH_1	718	722	PF00917	0.519
DOC_USP7_MATH_1	763	767	PF00917	0.615
DOC_USP7_MATH_1	812	816	PF00917	0.557
DOC_USP7_MATH_1	884	888	PF00917	0.363
DOC_USP7_MATH_1	967	971	PF00917	0.404
DOC_USP7_MATH_1	999	1003	PF00917	0.416
DOC_USP7_UBL2_3	102	106	PF12436	0.460
DOC_USP7_UBL2_3	1038	1042	PF12436	0.559
DOC_USP7_UBL2_3	58	62	PF12436	0.572
DOC_USP7_UBL2_3	722	726	PF12436	0.613
DOC_WW_Pin1_4	129	134	PF00397	0.639
DOC_WW_Pin1_4	180	185	PF00397	0.729
DOC_WW_Pin1_4	189	194	PF00397	0.611
DOC_WW_Pin1_4	276	281	PF00397	0.557
DOC_WW_Pin1_4	665	670	PF00397	0.684
DOC_WW_Pin1_4	687	692	PF00397	0.355
DOC_WW_Pin1_4	711	716	PF00397	0.476
DOC_WW_Pin1_4	761	766	PF00397	0.474
DOC_WW_Pin1_4	851	856	PF00397	0.576
DOC_WW_Pin1_4	867	872	PF00397	0.410
LIG_14-3-3_CanoR_1	1019	1025	PF00244	0.502
LIG_14-3-3_CanoR_1	1027	1033	PF00244	0.475
LIG_14-3-3_CanoR_1	662	670	PF00244	0.574
LIG_14-3-3_CanoR_1	782	788	PF00244	0.354
LIG_14-3-3_CanoR_1	944	949	PF00244	0.361
LIG_Actin_WH2_2	400	416	PF00022	0.312
LIG_BIR_III_4	122	126	PF00653	0.648
LIG_BRCT_BRCA1_1	813	817	PF00533	0.414
LIG_eIF4E_1	811	817	PF01652	0.381
LIG_FHA_1	307	313	PF00498	0.354
LIG_FHA_1	332	338	PF00498	0.481
LIG_FHA_1	37	43	PF00498	0.430
LIG_FHA_1	420	426	PF00498	0.367
LIG_FHA_1	456	462	PF00498	0.386
LIG_FHA_1	535	541	PF00498	0.278
LIG_FHA_1	609	615	PF00498	0.475
LIG_FHA_1	681	687	PF00498	0.330
LIG_FHA_1	705	711	PF00498	0.380
LIG_FHA_1	738	744	PF00498	0.637
LIG_FHA_1	762	768	PF00498	0.504
LIG_FHA_1	79	85	PF00498	0.392
LIG_FHA_1	798	804	PF00498	0.324
LIG_FHA_2	386	392	PF00498	0.488
LIG_FHA_2	437	443	PF00498	0.366
LIG_FHA_2	506	512	PF00498	0.349
LIG_FHA_2	687	693	PF00498	0.438
LIG_FHA_2	784	790	PF00498	0.358
LIG_FHA_2	80	86	PF00498	0.549
LIG_LIR_Apic_2	325	329	PF02991	0.432
LIG_LIR_Apic_2	827	832	PF02991	0.630
LIG_LIR_Gen_1	513	523	PF02991	0.348
LIG_LIR_Gen_1	704	712	PF02991	0.462
LIG_LIR_Gen_1	71	79	PF02991	0.491
LIG_LIR_Gen_1	931	941	PF02991	0.359
LIG_LIR_Nem_3	242	246	PF02991	0.490
LIG_LIR_Nem_3	513	518	PF02991	0.348
LIG_LIR_Nem_3	541	545	PF02991	0.290
LIG_LIR_Nem_3	704	709	PF02991	0.460
LIG_LIR_Nem_3	71	77	PF02991	0.490
LIG_LIR_Nem_3	729	734	PF02991	0.491
LIG_LIR_Nem_3	931	937	PF02991	0.374
LIG_LYPXL_yS_3	243	246	PF13949	0.459
LIG_MYND_3	425	429	PF01753	0.459
LIG_NRBOX	204	210	PF00104	0.506
LIG_NRBOX	307	313	PF00104	0.425
LIG_NRBOX	382	388	PF00104	0.345
LIG_NRBOX	497	503	PF00104	0.315
LIG_NRBOX	589	595	PF00104	0.456
LIG_NRBOX	936	942	PF00104	0.335
LIG_PCNA_PIPBox_1	250	259	PF02747	0.467
LIG_PTB_Apo_2	509	516	PF02174	0.323
LIG_PTB_Phospho_1	509	515	PF10480	0.323
LIG_SH2_CRK	542	546	PF00017	0.290
LIG_SH2_CRK	74	78	PF00017	0.432
LIG_SH2_CRK	934	938	PF00017	0.354
LIG_SH2_STAP1	421	425	PF00017	0.378
LIG_SH2_STAP1	752	756	PF00017	0.387
LIG_SH2_STAT3	1003	1006	PF00017	0.465
LIG_SH2_STAT3	226	229	PF00017	0.460
LIG_SH2_STAT3	274	277	PF00017	0.479
LIG_SH2_STAT5	1003	1006	PF00017	0.474
LIG_SH2_STAT5	112	115	PF00017	0.560
LIG_SH2_STAT5	226	229	PF00017	0.469
LIG_SH2_STAT5	421	424	PF00017	0.378
LIG_SH2_STAT5	437	440	PF00017	0.353
LIG_SH2_STAT5	656	659	PF00017	0.539
LIG_SH3_2	599	604	PF14604	0.523
LIG_SH3_3	130	136	PF00018	0.673
LIG_SH3_3	166	172	PF00018	0.714
LIG_SH3_3	257	263	PF00018	0.425
LIG_SH3_3	596	602	PF00018	0.479
LIG_SH3_3	668	674	PF00018	0.572
LIG_SH3_3	868	874	PF00018	0.403
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.501
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.478
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.297
LIG_SUMO_SIM_par_1	10	16	PF11976	0.469
LIG_SUMO_SIM_par_1	365	373	PF11976	0.454
LIG_SUMO_SIM_par_1	545	550	PF11976	0.405
LIG_SUMO_SIM_par_1	68	73	PF11976	0.566
LIG_SUMO_SIM_par_1	865	870	PF11976	0.453
LIG_TRAF2_1	57	60	PF00917	0.436
LIG_TYR_ITIM	540	545	PF00017	0.290
LIG_TYR_ITIM	72	77	PF00017	0.429
LIG_UBA3_1	1032	1041	PF00899	0.502
LIG_UBA3_1	208	215	PF00899	0.425
LIG_UBA3_1	590	598	PF00899	0.364
LIG_WRC_WIRS_1	26	31	PF05994	0.545
MOD_CDK_SPK_2	180	185	PF00069	0.622
MOD_CDK_SPK_2	189	194	PF00069	0.691
MOD_CDK_SPK_2	851	856	PF00069	0.426
MOD_CDK_SPxxK_3	276	283	PF00069	0.659
MOD_CDK_SPxxK_3	687	694	PF00069	0.351
MOD_CK1_1	1021	1027	PF00069	0.417
MOD_CK1_1	164	170	PF00069	0.628
MOD_CK1_1	189	195	PF00069	0.602
MOD_CK1_1	255	261	PF00069	0.494
MOD_CK1_1	402	408	PF00069	0.466
MOD_CK1_1	467	473	PF00069	0.358
MOD_CK1_1	530	536	PF00069	0.459
MOD_CK1_1	554	560	PF00069	0.377
MOD_CK1_1	673	679	PF00069	0.517
MOD_CK1_1	713	719	PF00069	0.390
MOD_CK1_1	886	892	PF00069	0.396
MOD_CK1_1	927	933	PF00069	0.517
MOD_CK2_1	1012	1018	PF00069	0.463
MOD_CK2_1	367	373	PF00069	0.479
MOD_CK2_1	385	391	PF00069	0.469
MOD_CK2_1	441	447	PF00069	0.387
MOD_CK2_1	510	516	PF00069	0.304
MOD_CK2_1	686	692	PF00069	0.565
MOD_CK2_1	7	13	PF00069	0.516
MOD_CK2_1	705	711	PF00069	0.240
MOD_CK2_1	769	775	PF00069	0.352
MOD_CK2_1	783	789	PF00069	0.392
MOD_CK2_1	79	85	PF00069	0.663
MOD_GlcNHglycan	15	18	PF01048	0.487
MOD_GlcNHglycan	194	197	PF01048	0.586
MOD_GlcNHglycan	284	287	PF01048	0.548
MOD_GlcNHglycan	346	349	PF01048	0.390
MOD_GlcNHglycan	397	400	PF01048	0.509
MOD_GlcNHglycan	52	55	PF01048	0.561
MOD_GlcNHglycan	564	567	PF01048	0.320
MOD_GlcNHglycan	571	574	PF01048	0.320
MOD_GlcNHglycan	663	666	PF01048	0.637
MOD_GlcNHglycan	752	755	PF01048	0.527
MOD_GlcNHglycan	841	844	PF01048	0.357
MOD_GlcNHglycan	905	908	PF01048	0.516
MOD_GlcNHglycan	965	968	PF01048	0.509
MOD_GlcNHglycan	969	972	PF01048	0.464
MOD_GSK3_1	1014	1021	PF00069	0.504
MOD_GSK3_1	32	39	PF00069	0.563
MOD_GSK3_1	340	347	PF00069	0.407
MOD_GSK3_1	395	402	PF00069	0.578
MOD_GSK3_1	530	537	PF00069	0.409
MOD_GSK3_1	550	557	PF00069	0.276
MOD_GSK3_1	608	615	PF00069	0.505
MOD_GSK3_1	657	664	PF00069	0.639
MOD_GSK3_1	761	768	PF00069	0.413
MOD_GSK3_1	820	827	PF00069	0.622
MOD_GSK3_1	924	931	PF00069	0.541
MOD_GSK3_1	959	966	PF00069	0.464
MOD_N-GLC_1	429	434	PF02516	0.440
MOD_N-GLC_1	511	516	PF02516	0.406
MOD_N-GLC_1	527	532	PF02516	0.224
MOD_N-GLC_1	562	567	PF02516	0.290
MOD_N-GLC_1	569	574	PF02516	0.290
MOD_N-GLC_1	63	68	PF02516	0.550
MOD_N-GLC_1	782	787	PF02516	0.347
MOD_N-GLC_1	944	949	PF02516	0.361
MOD_N-GLC_2	993	995	PF02516	0.347
MOD_NEK2_1	1012	1017	PF00069	0.520
MOD_NEK2_1	161	166	PF00069	0.643
MOD_NEK2_1	311	316	PF00069	0.366
MOD_NEK2_1	36	41	PF00069	0.531
MOD_NEK2_1	510	515	PF00069	0.220
MOD_NEK2_1	552	557	PF00069	0.407
MOD_NEK2_1	657	662	PF00069	0.555
MOD_NEK2_1	680	685	PF00069	0.351
MOD_NEK2_1	710	715	PF00069	0.356
MOD_NEK2_1	836	841	PF00069	0.363
MOD_NEK2_2	399	404	PF00069	0.404
MOD_NEK2_2	464	469	PF00069	0.505
MOD_NEK2_2	622	627	PF00069	0.271
MOD_NEK2_2	812	817	PF00069	0.475
MOD_NEK2_2	939	944	PF00069	0.447
MOD_PIKK_1	224	230	PF00454	0.504
MOD_PIKK_1	402	408	PF00454	0.466
MOD_PIKK_1	534	540	PF00454	0.278
MOD_PIKK_1	831	837	PF00454	0.544
MOD_PIKK_1	87	93	PF00454	0.596
MOD_PIKK_1	96	102	PF00454	0.573
MOD_PKA_1	661	667	PF00069	0.635
MOD_PKA_2	1018	1024	PF00069	0.426
MOD_PKA_2	282	288	PF00069	0.596
MOD_PKA_2	661	667	PF00069	0.635
MOD_Plk_1	399	405	PF00069	0.527
MOD_Plk_1	429	435	PF00069	0.438
MOD_Plk_1	510	516	PF00069	0.375
MOD_Plk_1	527	533	PF00069	0.197
MOD_Plk_1	782	788	PF00069	0.354
MOD_Plk_1	79	85	PF00069	0.547
MOD_Plk_1	944	950	PF00069	0.439
MOD_Plk_2-3	116	122	PF00069	0.537
MOD_Plk_2-3	32	38	PF00069	0.489
MOD_Plk_2-3	511	517	PF00069	0.405
MOD_Plk_2-3	7	13	PF00069	0.500
MOD_Plk_2-3	977	983	PF00069	0.476
MOD_Plk_4	1028	1034	PF00069	0.464
MOD_Plk_4	116	122	PF00069	0.537
MOD_Plk_4	186	192	PF00069	0.782
MOD_Plk_4	214	220	PF00069	0.394
MOD_Plk_4	294	300	PF00069	0.413
MOD_Plk_4	429	435	PF00069	0.438
MOD_Plk_4	564	570	PF00069	0.316
MOD_Plk_4	680	686	PF00069	0.344
MOD_Plk_4	7	13	PF00069	0.501
MOD_Plk_4	705	711	PF00069	0.452
MOD_Plk_4	726	732	PF00069	0.527
MOD_Plk_4	812	818	PF00069	0.593
MOD_Plk_4	872	878	PF00069	0.404
MOD_Plk_4	999	1005	PF00069	0.349
MOD_ProDKin_1	129	135	PF00069	0.642
MOD_ProDKin_1	180	186	PF00069	0.731
MOD_ProDKin_1	189	195	PF00069	0.608
MOD_ProDKin_1	276	282	PF00069	0.570
MOD_ProDKin_1	665	671	PF00069	0.677
MOD_ProDKin_1	687	693	PF00069	0.350
MOD_ProDKin_1	711	717	PF00069	0.476
MOD_ProDKin_1	761	767	PF00069	0.468
MOD_ProDKin_1	851	857	PF00069	0.578
MOD_ProDKin_1	867	873	PF00069	0.408
MOD_SUMO_for_1	319	322	PF00179	0.327
MOD_SUMO_for_1	57	60	PF00179	0.592
MOD_SUMO_rev_2	530	537	PF00179	0.366
MOD_SUMO_rev_2	55	63	PF00179	0.568
MOD_SUMO_rev_2	690	696	PF00179	0.357
MOD_SUMO_rev_2	848	854	PF00179	0.428
MOD_SUMO_rev_2	959	967	PF00179	0.534
TRG_DiLeu_BaEn_1	116	121	PF01217	0.594
TRG_DiLeu_BaEn_1	333	338	PF01217	0.429
TRG_DiLeu_BaEn_1	7	12	PF01217	0.498
TRG_DiLeu_BaEn_2	321	327	PF01217	0.423
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.469
TRG_ENDOCYTIC_2	243	246	PF00928	0.489
TRG_ENDOCYTIC_2	515	518	PF00928	0.315
TRG_ENDOCYTIC_2	542	545	PF00928	0.290
TRG_ENDOCYTIC_2	74	77	PF00928	0.432
TRG_ENDOCYTIC_2	934	937	PF00928	0.358
TRG_ENDOCYTIC_2	958	961	PF00928	0.462
TRG_ER_diArg_1	1025	1027	PF00400	0.383
TRG_ER_diArg_1	93	95	PF00400	0.533
TRG_NES_CRM1_1	409	423	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEV7	Leptomonas seymouri	77%	98%
A0A1X0P6M1	Trypanosomatidae	43%	91%
A0A3Q8IFW8	Leishmania donovani	95%	100%
A0A3R7KX09	Trypanosoma rangeli	45%	96%
A4HJZ4	Leishmania braziliensis	85%	100%
A4I7H7	Leishmania infantum	95%	100%
D0A079	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
E9B2D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%