LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5R9_LEIMA
TriTrypDb:
LmjF.32.0165 , LMJLV39_320006700 * , LMJSD75_320006800
Length:
91

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 2
GO:0020023 kinetoplast 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q5R9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 51 53 PF00675 0.588
CLV_NRD_NRD_1 68 70 PF00675 0.350
CLV_NRD_NRD_1 85 87 PF00675 0.450
DEG_Nend_Nbox_1 1 3 PF02207 0.534
LIG_FHA_1 55 61 PF00498 0.493
LIG_FHA_2 61 67 PF00498 0.570
LIG_LIR_Gen_1 40 49 PF02991 0.472
LIG_LIR_Nem_3 50 54 PF02991 0.439
LIG_SH2_CRK 51 55 PF00017 0.482
MOD_CK2_1 17 23 PF00069 0.504
MOD_CK2_1 34 40 PF00069 0.470
MOD_CK2_1 60 66 PF00069 0.485
MOD_Cter_Amidation 15 18 PF01082 0.490
MOD_GlcNHglycan 11 14 PF01048 0.559
MOD_GlcNHglycan 36 39 PF01048 0.435
MOD_GSK3_1 77 84 PF00069 0.550
MOD_N-GLC_2 73 75 PF02516 0.519
MOD_NEK2_1 1 6 PF00069 0.638
MOD_NEK2_1 54 59 PF00069 0.481
MOD_NEK2_1 77 82 PF00069 0.551
MOD_NEK2_2 81 86 PF00069 0.427
MOD_PKA_1 17 23 PF00069 0.490
MOD_PKA_2 2 8 PF00069 0.473
TRG_ENDOCYTIC_2 41 44 PF00928 0.407
TRG_ENDOCYTIC_2 51 54 PF00928 0.462
TRG_Pf-PMV_PEXEL_1 52 56 PF00026 0.513

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8J9 Leptomonas seymouri 75% 96%
A0A0S4ISH5 Bodo saltans 51% 99%
A0A1X0P6S9 Trypanosomatidae 56% 76%
A0A3Q8IGP9 Leishmania donovani 91% 100%
A0A422P0X8 Trypanosoma rangeli 56% 82%
A4HJZ7 Leishmania braziliensis 87% 100%
A4I7I0 Leishmania infantum 92% 100%
D0A083 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 94%
E9B2D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS