Heat shock protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Heat shock protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5R6_LEIMA

TriTrypDb:

LmjF.32.0190 , LMJLV39_320007000 , LMJSD75_320007100

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q5R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0044183	protein folding chaperone	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140657	ATP-dependent activity	1	7
GO:0140662	ATP-dependent protein folding chaperone	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.487
CLV_C14_Caspase3-7	331	335	PF00656	0.434
CLV_C14_Caspase3-7	590	594	PF00656	0.697
CLV_C14_Caspase3-7	88	92	PF00656	0.505
CLV_NRD_NRD_1	264	266	PF00675	0.604
CLV_NRD_NRD_1	353	355	PF00675	0.446
CLV_NRD_NRD_1	397	399	PF00675	0.328
CLV_NRD_NRD_1	557	559	PF00675	0.587
CLV_PCSK_KEX2_1	264	266	PF00082	0.604
CLV_PCSK_KEX2_1	353	355	PF00082	0.446
CLV_PCSK_KEX2_1	397	399	PF00082	0.342
CLV_PCSK_SKI1_1	197	201	PF00082	0.353
CLV_PCSK_SKI1_1	206	210	PF00082	0.353
CLV_PCSK_SKI1_1	311	315	PF00082	0.474
CLV_PCSK_SKI1_1	353	357	PF00082	0.468
CLV_PCSK_SKI1_1	398	402	PF00082	0.341
CLV_PCSK_SKI1_1	506	510	PF00082	0.503
CLV_PCSK_SKI1_1	640	644	PF00082	0.536
CLV_PCSK_SKI1_1	665	669	PF00082	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.406
DEG_SPOP_SBC_1	19	23	PF00917	0.561
DEG_SPOP_SBC_1	191	195	PF00917	0.592
DOC_CKS1_1	753	758	PF01111	0.523
DOC_CYCLIN_RxL_1	350	360	PF00134	0.581
DOC_CYCLIN_RxL_1	394	405	PF00134	0.311
DOC_MAPK_MEF2A_6	197	204	PF00069	0.338
DOC_MAPK_MEF2A_6	394	403	PF00069	0.457
DOC_MAPK_MEF2A_6	730	738	PF00069	0.421
DOC_MAPK_NFAT4_5	197	205	PF00069	0.460
DOC_PP1_RVXF_1	137	144	PF00149	0.512
DOC_PP1_RVXF_1	221	228	PF00149	0.500
DOC_PP2B_LxvP_1	202	205	PF13499	0.403
DOC_PP4_FxxP_1	356	359	PF00568	0.544
DOC_USP7_MATH_1	10	14	PF00917	0.442
DOC_USP7_MATH_1	103	107	PF00917	0.677
DOC_USP7_MATH_1	19	23	PF00917	0.516
DOC_USP7_MATH_1	191	195	PF00917	0.582
DOC_USP7_MATH_1	212	216	PF00917	0.522
DOC_USP7_MATH_1	231	235	PF00917	0.494
DOC_USP7_MATH_1	27	31	PF00917	0.243
DOC_USP7_MATH_1	357	361	PF00917	0.565
DOC_USP7_MATH_1	39	43	PF00917	0.306
DOC_USP7_MATH_1	390	394	PF00917	0.489
DOC_USP7_MATH_1	446	450	PF00917	0.519
DOC_USP7_MATH_1	635	639	PF00917	0.462
DOC_USP7_MATH_1	691	695	PF00917	0.467
DOC_USP7_MATH_1	85	89	PF00917	0.433
DOC_USP7_UBL2_3	559	563	PF12436	0.596
DOC_WW_Pin1_4	355	360	PF00397	0.543
DOC_WW_Pin1_4	44	49	PF00397	0.317
DOC_WW_Pin1_4	499	504	PF00397	0.457
DOC_WW_Pin1_4	655	660	PF00397	0.572
DOC_WW_Pin1_4	701	706	PF00397	0.628
DOC_WW_Pin1_4	752	757	PF00397	0.576
LIG_14-3-3_CanoR_1	221	226	PF00244	0.514
LIG_14-3-3_CanoR_1	268	274	PF00244	0.525
LIG_14-3-3_CanoR_1	558	564	PF00244	0.651
LIG_14-3-3_CanoR_1	690	699	PF00244	0.462
LIG_APCC_ABBA_1	668	673	PF00400	0.472
LIG_BIR_III_2	31	35	PF00653	0.320
LIG_BIR_III_4	673	677	PF00653	0.549
LIG_BRCT_BRCA1_1	244	248	PF00533	0.345
LIG_BRCT_BRCA1_1	359	363	PF00533	0.545
LIG_BRCT_BRCA1_1	607	611	PF00533	0.519
LIG_BRCT_BRCA1_1	761	765	PF00533	0.559
LIG_CSL_BTD_1	656	659	PF09270	0.578
LIG_deltaCOP1_diTrp_1	450	457	PF00928	0.369
LIG_deltaCOP1_diTrp_1	470	476	PF00928	0.549
LIG_deltaCOP1_diTrp_1	504	509	PF00928	0.295
LIG_eIF4E_1	427	433	PF01652	0.519
LIG_FHA_1	108	114	PF00498	0.532
LIG_FHA_1	136	142	PF00498	0.572
LIG_FHA_1	199	205	PF00498	0.319
LIG_FHA_1	24	30	PF00498	0.421
LIG_FHA_1	242	248	PF00498	0.421
LIG_FHA_1	382	388	PF00498	0.545
LIG_FHA_1	433	439	PF00498	0.432
LIG_FHA_1	45	51	PF00498	0.413
LIG_FHA_1	477	483	PF00498	0.430
LIG_FHA_1	491	497	PF00498	0.474
LIG_FHA_1	621	627	PF00498	0.595
LIG_FHA_1	629	635	PF00498	0.409
LIG_FHA_1	662	668	PF00498	0.408
LIG_FHA_1	753	759	PF00498	0.532
LIG_FHA_2	107	113	PF00498	0.536
LIG_FHA_2	184	190	PF00498	0.669
LIG_FHA_2	253	259	PF00498	0.481
LIG_FHA_2	469	475	PF00498	0.576
LIG_FHA_2	52	58	PF00498	0.320
LIG_FHA_2	582	588	PF00498	0.516
LIG_FHA_2	658	664	PF00498	0.600
LIG_FHA_2	96	102	PF00498	0.712
LIG_LIR_Gen_1	11	20	PF02991	0.484
LIG_LIR_Gen_1	161	171	PF02991	0.368
LIG_LIR_Gen_1	360	369	PF02991	0.550
LIG_LIR_Gen_1	577	587	PF02991	0.594
LIG_LIR_Gen_1	761	767	PF02991	0.388
LIG_LIR_LC3C_4	201	204	PF02991	0.445
LIG_LIR_Nem_3	11	17	PF02991	0.471
LIG_LIR_Nem_3	161	167	PF02991	0.397
LIG_LIR_Nem_3	322	327	PF02991	0.551
LIG_LIR_Nem_3	360	366	PF02991	0.555
LIG_LIR_Nem_3	449	454	PF02991	0.414
LIG_LIR_Nem_3	577	583	PF02991	0.581
LIG_LIR_Nem_3	761	766	PF02991	0.419
LIG_NRBOX	491	497	PF00104	0.474
LIG_NRBOX	638	644	PF00104	0.515
LIG_Pex14_1	472	476	PF04695	0.542
LIG_SH2_CRK	207	211	PF00017	0.407
LIG_SH2_NCK_1	257	261	PF00017	0.450
LIG_SH2_NCK_1	82	86	PF00017	0.474
LIG_SH2_PTP2	14	17	PF00017	0.469
LIG_SH2_SRC	617	620	PF00017	0.492
LIG_SH2_STAP1	2	6	PF00017	0.369
LIG_SH2_STAP1	763	767	PF00017	0.382
LIG_SH2_STAP1	82	86	PF00017	0.399
LIG_SH2_STAT3	348	351	PF00017	0.498
LIG_SH2_STAT3	546	549	PF00017	0.421
LIG_SH2_STAT3	68	71	PF00017	0.383
LIG_SH2_STAT5	14	17	PF00017	0.469
LIG_SH2_STAT5	145	148	PF00017	0.492
LIG_SH2_STAT5	170	173	PF00017	0.444
LIG_SH2_STAT5	324	327	PF00017	0.507
LIG_SH2_STAT5	546	549	PF00017	0.394
LIG_SH2_STAT5	617	620	PF00017	0.393
LIG_SH2_STAT5	669	672	PF00017	0.392
LIG_SH2_STAT5	78	81	PF00017	0.331
LIG_SH3_3	297	303	PF00018	0.527
LIG_SH3_3	497	503	PF00018	0.372
LIG_SH3_3	650	656	PF00018	0.465
LIG_SH3_3	736	742	PF00018	0.559
LIG_SH3_3	750	756	PF00018	0.415
LIG_Sin3_3	695	702	PF02671	0.434
LIG_SUMO_SIM_par_1	276	281	PF11976	0.363
LIG_TRAF2_1	260	263	PF00917	0.498
LIG_TRAF2_1	54	57	PF00917	0.320
LIG_UBA3_1	453	459	PF00899	0.360
LIG_WRC_WIRS_1	154	159	PF05994	0.466
MOD_CDC14_SPxK_1	358	361	PF00782	0.565
MOD_CDK_SPxK_1	355	361	PF00069	0.540
MOD_CDK_SPxxK_3	499	506	PF00069	0.458
MOD_CDK_SPxxK_3	658	665	PF00069	0.490
MOD_CK1_1	106	112	PF00069	0.618
MOD_CK1_1	13	19	PF00069	0.343
MOD_CK1_1	156	162	PF00069	0.458
MOD_CK1_1	21	27	PF00069	0.348
MOD_CK1_1	409	415	PF00069	0.522
MOD_CK1_1	499	505	PF00069	0.431
MOD_CK1_1	554	560	PF00069	0.569
MOD_CK1_1	658	664	PF00069	0.588
MOD_CK1_1	679	685	PF00069	0.625
MOD_CK2_1	468	474	PF00069	0.489
MOD_CK2_1	51	57	PF00069	0.414
MOD_CK2_1	589	595	PF00069	0.716
MOD_CK2_1	657	663	PF00069	0.599
MOD_CK2_1	725	731	PF00069	0.497
MOD_CK2_1	758	764	PF00069	0.522
MOD_CK2_1	95	101	PF00069	0.642
MOD_GlcNHglycan	135	138	PF01048	0.614
MOD_GlcNHglycan	158	161	PF01048	0.407
MOD_GlcNHglycan	194	197	PF01048	0.547
MOD_GlcNHglycan	214	217	PF01048	0.456
MOD_GlcNHglycan	330	333	PF01048	0.426
MOD_GlcNHglycan	41	44	PF01048	0.312
MOD_GlcNHglycan	559	562	PF01048	0.636
MOD_GlcNHglycan	607	610	PF01048	0.586
MOD_GlcNHglycan	645	648	PF01048	0.474
MOD_GlcNHglycan	681	684	PF01048	0.660
MOD_GlcNHglycan	693	696	PF01048	0.463
MOD_GSK3_1	103	110	PF00069	0.727
MOD_GSK3_1	129	136	PF00069	0.543
MOD_GSK3_1	18	25	PF00069	0.467
MOD_GSK3_1	242	249	PF00069	0.376
MOD_GSK3_1	287	294	PF00069	0.413
MOD_GSK3_1	372	379	PF00069	0.580
MOD_GSK3_1	4	11	PF00069	0.331
MOD_GSK3_1	432	439	PF00069	0.428
MOD_GSK3_1	601	608	PF00069	0.570
MOD_GSK3_1	620	627	PF00069	0.414
MOD_GSK3_1	657	664	PF00069	0.644
MOD_GSK3_1	748	755	PF00069	0.591
MOD_N-GLC_1	242	247	PF02516	0.423
MOD_N-GLC_1	39	44	PF02516	0.424
MOD_NEK2_1	153	158	PF00069	0.581
MOD_NEK2_1	182	187	PF00069	0.543
MOD_NEK2_1	198	203	PF00069	0.507
MOD_NEK2_1	242	247	PF00069	0.447
MOD_NEK2_1	287	292	PF00069	0.298
MOD_NEK2_1	432	437	PF00069	0.415
MOD_NEK2_1	476	481	PF00069	0.346
MOD_NEK2_1	496	501	PF00069	0.356
MOD_NEK2_1	516	521	PF00069	0.421
MOD_NEK2_1	551	556	PF00069	0.570
MOD_NEK2_1	643	648	PF00069	0.465
MOD_NEK2_1	714	719	PF00069	0.461
MOD_NEK2_1	8	13	PF00069	0.346
MOD_NEK2_2	536	541	PF00069	0.536
MOD_NEK2_2	635	640	PF00069	0.554
MOD_PIKK_1	129	135	PF00454	0.484
MOD_PIKK_1	258	264	PF00454	0.438
MOD_PIKK_1	347	353	PF00454	0.467
MOD_PIKK_1	432	438	PF00454	0.479
MOD_PIKK_1	628	634	PF00454	0.480
MOD_PK_1	172	178	PF00069	0.456
MOD_PK_1	740	746	PF00069	0.553
MOD_PKA_1	406	412	PF00069	0.522
MOD_PKA_2	129	135	PF00069	0.495
MOD_PKA_2	554	560	PF00069	0.649
MOD_Plk_1	172	178	PF00069	0.481
MOD_Plk_1	242	248	PF00069	0.420
MOD_Plk_1	516	522	PF00069	0.496
MOD_Plk_1	621	627	PF00069	0.584
MOD_Plk_2-3	144	150	PF00069	0.562
MOD_Plk_2-3	589	595	PF00069	0.611
MOD_Plk_4	10	16	PF00069	0.391
MOD_Plk_4	153	159	PF00069	0.445
MOD_Plk_4	198	204	PF00069	0.324
MOD_Plk_4	242	248	PF00069	0.367
MOD_Plk_4	287	293	PF00069	0.418
MOD_Plk_4	476	482	PF00069	0.396
MOD_Plk_4	516	522	PF00069	0.428
MOD_Plk_4	575	581	PF00069	0.579
MOD_Plk_4	598	604	PF00069	0.683
MOD_Plk_4	748	754	PF00069	0.556
MOD_ProDKin_1	355	361	PF00069	0.540
MOD_ProDKin_1	44	50	PF00069	0.317
MOD_ProDKin_1	499	505	PF00069	0.453
MOD_ProDKin_1	655	661	PF00069	0.570
MOD_ProDKin_1	701	707	PF00069	0.635
MOD_ProDKin_1	752	758	PF00069	0.569
TRG_DiLeu_BaEn_1	428	433	PF01217	0.525
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.504
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.445
TRG_ENDOCYTIC_2	14	17	PF00928	0.469
TRG_ENDOCYTIC_2	310	313	PF00928	0.531
TRG_ENDOCYTIC_2	324	327	PF00928	0.553
TRG_ENDOCYTIC_2	427	430	PF00928	0.529
TRG_ENDOCYTIC_2	617	620	PF00928	0.442
TRG_ENDOCYTIC_2	763	766	PF00928	0.415
TRG_ER_diArg_1	264	266	PF00400	0.604
TRG_ER_diArg_1	353	355	PF00400	0.446
TRG_ER_diArg_1	396	398	PF00400	0.348
TRG_ER_FFAT_2	152	162	PF00635	0.506
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAW3	Leptomonas seymouri	67%	98%
A0A0S4IR51	Bodo saltans	25%	100%
A0A1X0P6L7	Trypanosomatidae	32%	89%
A0A3R7RRJ4	Trypanosoma rangeli	33%	93%
A0A3S7X511	Leishmania donovani	93%	100%
A4HK00	Leishmania braziliensis	79%	100%
A4I7I3	Leishmania infantum	93%	100%
D0A086	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
E9B2E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5C1N9	Trypanosoma cruzi	34%	100%