Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5R5_LEIMA

TriTrypDb:

LmjF.32.0200 , LMJLV39_320007100 , LMJSD75_320007200

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.637
CLV_C14_Caspase3-7	356	360	PF00656	0.619
CLV_NRD_NRD_1	142	144	PF00675	0.487
CLV_NRD_NRD_1	175	177	PF00675	0.476
CLV_NRD_NRD_1	272	274	PF00675	0.478
CLV_NRD_NRD_1	57	59	PF00675	0.437
CLV_PCSK_KEX2_1	142	144	PF00082	0.487
CLV_PCSK_KEX2_1	149	151	PF00082	0.470
CLV_PCSK_KEX2_1	175	177	PF00082	0.476
CLV_PCSK_KEX2_1	272	274	PF00082	0.478
CLV_PCSK_KEX2_1	57	59	PF00082	0.437
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.470
CLV_PCSK_SKI1_1	142	146	PF00082	0.480
CLV_PCSK_SKI1_1	175	179	PF00082	0.479
CLV_PCSK_SKI1_1	222	226	PF00082	0.530
CLV_PCSK_SKI1_1	282	286	PF00082	0.545
CLV_PCSK_SKI1_1	85	89	PF00082	0.493
DEG_APCC_DBOX_1	271	279	PF00400	0.487
DEG_APCC_KENBOX_2	242	246	PF00400	0.522
DOC_CKS1_1	218	223	PF01111	0.566
DOC_CYCLIN_RxL_1	261	270	PF00134	0.648
DOC_MAPK_gen_1	149	155	PF00069	0.476
DOC_PP2B_LxvP_1	248	251	PF13499	0.544
DOC_USP7_MATH_1	133	137	PF00917	0.568
DOC_USP7_MATH_1	2	6	PF00917	0.516
DOC_USP7_MATH_1	253	257	PF00917	0.660
DOC_USP7_MATH_1	334	338	PF00917	0.661
DOC_USP7_MATH_1	34	38	PF00917	0.530
DOC_WW_Pin1_4	202	207	PF00397	0.617
DOC_WW_Pin1_4	217	222	PF00397	0.626
DOC_WW_Pin1_4	249	254	PF00397	0.600
DOC_WW_Pin1_4	301	306	PF00397	0.717
DOC_WW_Pin1_4	315	320	PF00397	0.760
LIG_14-3-3_CanoR_1	123	127	PF00244	0.482
LIG_14-3-3_CanoR_1	212	221	PF00244	0.611
LIG_14-3-3_CanoR_1	272	276	PF00244	0.478
LIG_14-3-3_CanoR_1	320	328	PF00244	0.678
LIG_14-3-3_CanoR_1	332	341	PF00244	0.566
LIG_14-3-3_CanoR_1	66	71	PF00244	0.516
LIG_Actin_WH2_2	70	87	PF00022	0.469
LIG_DLG_GKlike_1	66	73	PF00625	0.520
LIG_EH1_1	17	25	PF00400	0.476
LIG_FHA_1	157	163	PF00498	0.488
LIG_FHA_1	272	278	PF00498	0.569
LIG_FHA_1	343	349	PF00498	0.568
LIG_FHA_1	350	356	PF00498	0.650
LIG_FHA_1	47	53	PF00498	0.474
LIG_FHA_2	260	266	PF00498	0.584
LIG_FHA_2	283	289	PF00498	0.562
LIG_FHA_2	306	312	PF00498	0.636
LIG_FHA_2	337	343	PF00498	0.460
LIG_GBD_Chelix_1	169	177	PF00786	0.474
LIG_LIR_Apic_2	125	129	PF02991	0.489
LIG_LIR_Gen_1	182	191	PF02991	0.465
LIG_LIR_Nem_3	182	188	PF02991	0.479
LIG_SH2_CRK	185	189	PF00017	0.473
LIG_SH2_NCK_1	185	189	PF00017	0.467
LIG_SH2_STAP1	185	189	PF00017	0.467
LIG_SH3_1	247	253	PF00018	0.498
LIG_SH3_3	247	253	PF00018	0.673
LIG_SH3_3	299	305	PF00018	0.791
LIG_SH3_3	313	319	PF00018	0.594
LIG_SH3_3	322	328	PF00018	0.570
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.585
LIG_SUMO_SIM_par_1	12	17	PF11976	0.476
LIG_SUMO_SIM_par_1	28	33	PF11976	0.595
LIG_SUMO_SIM_par_1	280	288	PF11976	0.593
LIG_TRAF2_1	285	288	PF00917	0.780
MOD_CDC14_SPxK_1	205	208	PF00782	0.616
MOD_CDK_SPK_2	217	222	PF00069	0.580
MOD_CDK_SPK_2	315	320	PF00069	0.675
MOD_CDK_SPxK_1	202	208	PF00069	0.621
MOD_CK1_1	199	205	PF00069	0.786
MOD_CK1_1	46	52	PF00069	0.466
MOD_CK1_1	69	75	PF00069	0.483
MOD_CK2_1	122	128	PF00069	0.671
MOD_CK2_1	133	139	PF00069	0.478
MOD_CK2_1	158	164	PF00069	0.637
MOD_CK2_1	259	265	PF00069	0.663
MOD_CK2_1	282	288	PF00069	0.697
MOD_CK2_1	334	340	PF00069	0.573
MOD_CK2_1	73	79	PF00069	0.607
MOD_GlcNHglycan	202	205	PF01048	0.639
MOD_GlcNHglycan	257	262	PF01048	0.542
MOD_GlcNHglycan	336	339	PF01048	0.728
MOD_GlcNHglycan	36	39	PF01048	0.555
MOD_GSK3_1	156	163	PF00069	0.467
MOD_GSK3_1	196	203	PF00069	0.633
MOD_GSK3_1	207	214	PF00069	0.640
MOD_GSK3_1	249	256	PF00069	0.627
MOD_GSK3_1	278	285	PF00069	0.597
MOD_GSK3_1	30	37	PF00069	0.563
MOD_GSK3_1	301	308	PF00069	0.585
MOD_GSK3_1	69	76	PF00069	0.548
MOD_N-GLC_1	349	354	PF02516	0.480
MOD_N-GLC_1	73	78	PF02516	0.465
MOD_NEK2_1	16	21	PF00069	0.468
MOD_NEK2_1	277	282	PF00069	0.606
MOD_NEK2_1	30	35	PF00069	0.580
MOD_NEK2_1	73	78	PF00069	0.579
MOD_NEK2_2	2	7	PF00069	0.512
MOD_PIKK_1	156	162	PF00454	0.490
MOD_PIKK_1	232	238	PF00454	0.495
MOD_PIKK_1	320	326	PF00454	0.582
MOD_PIKK_1	46	52	PF00454	0.542
MOD_PIKK_1	87	93	PF00454	0.640
MOD_PKA_2	122	128	PF00069	0.480
MOD_PKA_2	207	213	PF00069	0.644
MOD_PKA_2	271	277	PF00069	0.495
MOD_PKA_2	278	284	PF00069	0.580
MOD_Plk_1	342	348	PF00069	0.493
MOD_Plk_1	43	49	PF00069	0.505
MOD_Plk_1	73	79	PF00069	0.462
MOD_Plk_2-3	114	120	PF00069	0.620
MOD_Plk_2-3	122	128	PF00069	0.659
MOD_Plk_2-3	354	360	PF00069	0.588
MOD_ProDKin_1	202	208	PF00069	0.621
MOD_ProDKin_1	217	223	PF00069	0.620
MOD_ProDKin_1	249	255	PF00069	0.596
MOD_ProDKin_1	301	307	PF00069	0.717
MOD_ProDKin_1	315	321	PF00069	0.760
MOD_SUMO_rev_2	110	118	PF00179	0.605
TRG_DiLeu_BaEn_2	342	348	PF01217	0.493
TRG_DiLeu_BaEn_4	79	85	PF01217	0.532
TRG_ENDOCYTIC_2	185	188	PF00928	0.480
TRG_ER_diArg_1	141	143	PF00400	0.491
TRG_ER_diArg_1	150	153	PF00400	0.475
TRG_ER_diArg_1	175	177	PF00400	0.476
TRG_ER_diArg_1	271	273	PF00400	0.477
TRG_ER_diArg_1	56	58	PF00400	0.447
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME2	Leptomonas seymouri	63%	83%
A0A3S7X529	Leishmania donovani	93%	100%
A4HK01	Leishmania braziliensis	67%	100%
A4I7I4	Leishmania infantum	92%	100%
E9B2E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%