Rtt106 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histone chaperone Rttp106-like, putative

Species:

Leishmania major

UniProt:

Q4Q5R4_LEIMA

TriTrypDb:

LmjF.32.0210 , LMJLV39_320007200 , LMJSD75_320007300

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:1990904	ribonucleoprotein complex	2	2
GO:0005634	nucleus	5	2
GO:0005694	chromosome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R4

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	2
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006260	DNA replication	5	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	4
GO:0019843	rRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4
GO:0003677	DNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.533
CLV_C14_Caspase3-7	429	433	PF00656	0.607
CLV_C14_Caspase3-7	540	544	PF00656	0.529
CLV_NRD_NRD_1	476	478	PF00675	0.571
CLV_NRD_NRD_1	531	533	PF00675	0.478
CLV_PCSK_KEX2_1	29	31	PF00082	0.490
CLV_PCSK_KEX2_1	478	480	PF00082	0.606
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.390
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.603
CLV_PCSK_SKI1_1	114	118	PF00082	0.402
CLV_PCSK_SKI1_1	310	314	PF00082	0.379
CLV_PCSK_SKI1_1	329	333	PF00082	0.521
CLV_PCSK_SKI1_1	341	345	PF00082	0.464
CLV_PCSK_SKI1_1	363	367	PF00082	0.221
CLV_PCSK_SKI1_1	402	406	PF00082	0.230
CLV_PCSK_SKI1_1	54	58	PF00082	0.315
DEG_COP1_1	290	300	PF00400	0.467
DOC_CYCLIN_RxL_1	278	288	PF00134	0.523
DOC_CYCLIN_RxL_1	362	372	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.420
DOC_MAPK_DCC_7	96	104	PF00069	0.412
DOC_MAPK_gen_1	29	37	PF00069	0.522
DOC_MAPK_MEF2A_6	54	61	PF00069	0.364
DOC_MAPK_MEF2A_6	72	79	PF00069	0.465
DOC_MAPK_MEF2A_6	96	104	PF00069	0.412
DOC_PP1_RVXF_1	365	371	PF00149	0.511
DOC_PP1_RVXF_1	91	98	PF00149	0.400
DOC_PP2B_LxvP_1	283	286	PF13499	0.547
DOC_PP2B_LxvP_1	38	41	PF13499	0.492
DOC_PP2B_LxvP_1	57	60	PF13499	0.421
DOC_PP4_FxxP_1	97	100	PF00568	0.365
DOC_SPAK_OSR1_1	96	100	PF12202	0.369
DOC_USP7_MATH_1	149	153	PF00917	0.582
DOC_USP7_MATH_1	298	302	PF00917	0.390
DOC_USP7_MATH_1	433	437	PF00917	0.603
DOC_USP7_MATH_1	63	67	PF00917	0.426
DOC_USP7_UBL2_3	17	21	PF12436	0.602
DOC_USP7_UBL2_3	240	244	PF12436	0.461
DOC_USP7_UBL2_3	313	317	PF12436	0.455
DOC_USP7_UBL2_3	398	402	PF12436	0.499
DOC_USP7_UBL2_3	42	46	PF12436	0.592
DOC_USP7_UBL2_3	480	484	PF12436	0.623
DOC_USP7_UBL2_3	490	494	PF12436	0.466
DOC_USP7_UBL2_3	496	500	PF12436	0.577
DOC_USP7_UBL2_3	502	506	PF12436	0.586
DOC_USP7_UBL2_3	508	512	PF12436	0.560
DOC_USP7_UBL2_3	514	518	PF12436	0.511
DOC_USP7_UBL2_3	520	524	PF12436	0.618
DOC_USP7_UBL2_3	526	530	PF12436	0.593
DOC_WW_Pin1_4	218	223	PF00397	0.440
LIG_14-3-3_CanoR_1	246	254	PF00244	0.336
LIG_14-3-3_CanoR_1	80	90	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BRCT_BRCA1_1	93	97	PF00533	0.381
LIG_FHA_1	156	162	PF00498	0.506
LIG_FHA_1	221	227	PF00498	0.486
LIG_FHA_1	280	286	PF00498	0.601
LIG_FHA_1	364	370	PF00498	0.493
LIG_FHA_1	385	391	PF00498	0.472
LIG_FHA_2	163	169	PF00498	0.433
LIG_FHA_2	260	266	PF00498	0.478
LIG_FHA_2	273	279	PF00498	0.330
LIG_FHA_2	427	433	PF00498	0.602
LIG_FHA_2	443	449	PF00498	0.672
LIG_FHA_2	459	465	PF00498	0.486
LIG_FHA_2	69	75	PF00498	0.437
LIG_LIR_Apic_2	94	100	PF02991	0.385
LIG_LIR_Gen_1	165	174	PF02991	0.440
LIG_LIR_Gen_1	183	189	PF02991	0.323
LIG_LIR_Gen_1	247	258	PF02991	0.324
LIG_LIR_Gen_1	356	365	PF02991	0.511
LIG_LIR_Nem_3	165	169	PF02991	0.382
LIG_LIR_Nem_3	175	181	PF02991	0.279
LIG_LIR_Nem_3	183	188	PF02991	0.272
LIG_LIR_Nem_3	247	253	PF02991	0.364
LIG_LIR_Nem_3	309	315	PF02991	0.464
LIG_LIR_Nem_3	327	331	PF02991	0.416
LIG_LIR_Nem_3	356	361	PF02991	0.496
LIG_LIR_Nem_3	6	11	PF02991	0.428
LIG_MYND_1	294	298	PF01753	0.517
LIG_PCNA_PIPBox_1	337	346	PF02747	0.460
LIG_PDZ_Class_1	539	544	PF00595	0.497
LIG_PTB_Apo_2	352	359	PF02174	0.511
LIG_PTB_Apo_2	45	52	PF02174	0.514
LIG_PTB_Phospho_1	45	51	PF10480	0.514
LIG_SH2_CRK	178	182	PF00017	0.315
LIG_SH2_CRK	185	189	PF00017	0.310
LIG_SH2_CRK	321	325	PF00017	0.467
LIG_SH2_CRK	328	332	PF00017	0.495
LIG_SH2_PTP2	234	237	PF00017	0.302
LIG_SH2_SRC	456	459	PF00017	0.554
LIG_SH2_STAT3	127	130	PF00017	0.540
LIG_SH2_STAT5	219	222	PF00017	0.491
LIG_SH2_STAT5	234	237	PF00017	0.323
LIG_SH2_STAT5	352	355	PF00017	0.447
LIG_SH2_STAT5	360	363	PF00017	0.560
LIG_SH2_STAT5	403	406	PF00017	0.456
LIG_SH2_STAT5	419	422	PF00017	0.371
LIG_SH2_STAT5	51	54	PF00017	0.563
LIG_SH3_3	12	18	PF00018	0.427
LIG_SH3_3	292	298	PF00018	0.431
LIG_SH3_3	49	55	PF00018	0.558
LIG_SH3_4	17	24	PF00018	0.624
LIG_TRAF2_1	222	225	PF00917	0.547
LIG_TRAF2_1	409	412	PF00917	0.511
LIG_TYR_ITSM	246	253	PF00017	0.422
LIG_UBA3_1	37	44	PF00899	0.451
LIG_UBA3_1	416	425	PF00899	0.433
LIG_WRC_WIRS_1	163	168	PF05994	0.452
LIG_WRC_WIRS_1	200	205	PF05994	0.356
MOD_CK1_1	172	178	PF00069	0.338
MOD_CK1_1	330	336	PF00069	0.519
MOD_CK1_1	451	457	PF00069	0.596
MOD_CK1_1	68	74	PF00069	0.448
MOD_CK2_1	201	207	PF00069	0.245
MOD_CK2_1	218	224	PF00069	0.607
MOD_CK2_1	259	265	PF00069	0.453
MOD_CK2_1	272	278	PF00069	0.348
MOD_CK2_1	442	448	PF00069	0.715
MOD_CK2_1	456	462	PF00069	0.420
MOD_GlcNHglycan	136	139	PF01048	0.529
MOD_GlcNHglycan	151	154	PF01048	0.525
MOD_GlcNHglycan	174	177	PF01048	0.350
MOD_GlcNHglycan	197	200	PF01048	0.473
MOD_GlcNHglycan	300	303	PF01048	0.375
MOD_GlcNHglycan	355	358	PF01048	0.230
MOD_GlcNHglycan	382	385	PF01048	0.254
MOD_GlcNHglycan	405	408	PF01048	0.272
MOD_GlcNHglycan	61	64	PF01048	0.496
MOD_GlcNHglycan	65	68	PF01048	0.421
MOD_GSK3_1	195	202	PF00069	0.474
MOD_GSK3_1	298	305	PF00069	0.361
MOD_GSK3_1	327	334	PF00069	0.435
MOD_GSK3_1	380	387	PF00069	0.449
MOD_GSK3_1	388	395	PF00069	0.454
MOD_GSK3_1	415	422	PF00069	0.535
MOD_GSK3_1	55	62	PF00069	0.446
MOD_GSK3_1	63	70	PF00069	0.441
MOD_N-GLC_1	279	284	PF02516	0.541
MOD_N-GLC_2	101	103	PF02516	0.433
MOD_NEK2_1	11	16	PF00069	0.521
MOD_NEK2_1	201	206	PF00069	0.378
MOD_NEK2_1	308	313	PF00069	0.428
MOD_NEK2_1	388	393	PF00069	0.420
MOD_PIKK_1	272	278	PF00454	0.425
MOD_PIKK_1	333	339	PF00454	0.428
MOD_PKA_1	193	199	PF00069	0.468
MOD_PKA_2	245	251	PF00069	0.424
MOD_PKA_2	302	308	PF00069	0.350
MOD_Plk_1	279	285	PF00069	0.453
MOD_Plk_1	73	79	PF00069	0.400
MOD_Plk_2-3	19	25	PF00069	0.559
MOD_Plk_2-3	443	449	PF00069	0.691
MOD_Plk_2-3	458	464	PF00069	0.563
MOD_Plk_4	120	126	PF00069	0.498
MOD_Plk_4	327	333	PF00069	0.413
MOD_Plk_4	388	394	PF00069	0.475
MOD_Plk_4	415	421	PF00069	0.499
MOD_ProDKin_1	218	224	PF00069	0.446
MOD_SUMO_for_1	16	19	PF00179	0.607
MOD_SUMO_for_1	20	23	PF00179	0.593
MOD_SUMO_for_1	409	412	PF00179	0.511
MOD_SUMO_rev_2	14	22	PF00179	0.584
MOD_SUMO_rev_2	266	275	PF00179	0.401
TRG_DiLeu_BaEn_1	412	417	PF01217	0.417
TRG_ENDOCYTIC_2	178	181	PF00928	0.316
TRG_ENDOCYTIC_2	185	188	PF00928	0.312
TRG_ENDOCYTIC_2	234	237	PF00928	0.325
TRG_ENDOCYTIC_2	250	253	PF00928	0.423
TRG_ENDOCYTIC_2	321	324	PF00928	0.475
TRG_ENDOCYTIC_2	328	331	PF00928	0.486
TRG_NLS_MonoCore_2	476	481	PF00514	0.716
TRG_NLS_MonoExtC_3	476	481	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG07	Leptomonas seymouri	80%	100%
A0A0S4IUW8	Bodo saltans	33%	100%
A0A1X0P6K5	Trypanosomatidae	42%	93%
A0A3Q8IGI0	Leishmania donovani	95%	100%
A0A422P127	Trypanosoma rangeli	45%	97%
A4HK02	Leishmania braziliensis	87%	100%
A4I7I5	Leishmania infantum	95%	100%
D0A088	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9B2E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O01683	Caenorhabditis elegans	24%	79%
O94529	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q04636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
Q04678	Gallus gallus	23%	77%
Q04931	Rattus norvegicus	23%	77%
Q05153	Arabidopsis thaliana	21%	84%
Q08943	Mus musculus	23%	77%
Q08945	Homo sapiens	22%	77%
Q2USL9	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	23%	94%
Q4IJU0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	22%	96%
Q4WGK6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	95%
Q5AYE3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	95%
Q6CWD7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	98%
Q6FKI2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q756X6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q7RWW0	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	20%	96%
Q9LEF5	Zea mays	23%	85%
Q9LGR0	Oryza sativa subsp. japonica	23%	85%