Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, flagellar outer arm, putative

Species:

Leishmania major

UniProt:

Q4Q5R2_LEIMA

TriTrypDb:

LmjF.32.0230 , LMJLV39_320007500 , LMJSD75_320007500

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 3
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005874	microtubule	6	12
GO:0005875	microtubule associated complex	2	12
GO:0005929	cilium	4	7
GO:0030286	dynein complex	3	12
GO:0031514	motile cilium	5	7
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	7
GO:1902494	catalytic complex	2	12

Expansion

Sequence features

Q4Q5R2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R2

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.641
DOC_USP7_UBL2_3	46	50	PF12436	0.433
DOC_USP7_UBL2_3	7	11	PF12436	0.433
LIG_LIR_Gen_1	55	64	PF02991	0.433
LIG_LIR_Gen_1	72	83	PF02991	0.433
LIG_LIR_Nem_3	55	59	PF02991	0.433
LIG_LIR_Nem_3	72	78	PF02991	0.433
LIG_SH2_STAT3	79	82	PF00017	0.461
LIG_SH2_STAT5	43	46	PF00017	0.444
LIG_SH2_STAT5	77	80	PF00017	0.511
LIG_WRC_WIRS_1	64	69	PF05994	0.535
MOD_CK1_1	66	72	PF00069	0.433
MOD_Plk_1	24	30	PF00069	0.543
MOD_Plk_4	63	69	PF00069	0.443
MOD_SUMO_for_1	44	47	PF00179	0.433
TRG_ENDOCYTIC_2	77	80	PF00928	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0W1	Leptomonas seymouri	99%	100%
A0A0N1I1Z7	Leptomonas seymouri	51%	100%
A0A0N1PBY8	Leptomonas seymouri	49%	100%
A0A0N1PCF1	Leptomonas seymouri	38%	85%
A0A0N1PCX2	Leptomonas seymouri	40%	81%
A0A0S4IS05	Bodo saltans	62%	100%
A0A0S4IUR3	Bodo saltans	80%	100%
A0A0S4J005	Bodo saltans	58%	69%
A0A0S4J1R8	Bodo saltans	81%	100%
A0A0S4JE57	Bodo saltans	56%	100%
A0A0S4JH61	Bodo saltans	81%	72%
A0A0S4JHJ3	Bodo saltans	28%	67%
A0A0S4JKR9	Bodo saltans	38%	90%
A0A0S4JQ28	Bodo saltans	54%	100%
A0A1X0P6I9	Trypanosomatidae	36%	76%
A0A1X0P8I8	Trypanosomatidae	41%	81%
A0A3Q8IDB7	Leishmania donovani	39%	81%
A0A3Q8IDX2	Leishmania donovani	51%	100%
A0A3Q8IJ25	Leishmania donovani	34%	71%
A0A3R7KXV2	Trypanosoma rangeli	40%	81%
A0A3S5H7E1	Leishmania donovani	52%	100%
A0A3S5H7R1	Leishmania donovani	99%	100%
A0A3S7WNY4	Leishmania donovani	48%	100%
A0A3S7WTY9	Leishmania donovani	41%	81%
A0A422NC25	Trypanosoma rangeli	53%	84%
A0A422NHE2	Trypanosoma rangeli	39%	81%
A4F4L4	Sus scrofa	39%	87%
A4H453	Leishmania braziliensis	49%	100%
A4H8L8	Leishmania braziliensis	40%	81%
A4HA47	Leishmania braziliensis	39%	81%
A4HDX3	Leishmania braziliensis	49%	100%
A4HGR7	Leishmania braziliensis	50%	100%
A4HK04	Leishmania braziliensis	99%	100%
A4HSD6	Leishmania infantum	48%	100%
A4HWY9	Leishmania infantum	41%	81%
A4HYB3	Leishmania infantum	39%	81%
A4I168	Leishmania infantum	52%	100%
A4I3U2	Leishmania infantum	51%	100%
A4I7I7	Leishmania infantum	99%	100%
A4IDJ0	Leishmania infantum	34%	71%
C9ZPY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A0N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	70%
D0A2J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	81%
D0A385	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
D0A5F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A5K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9AKB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AQQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	81%
E9AS46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	81%
E9AXA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B034	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B2E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O02414	Heliocidaris crassispina	77%	100%
O94111	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	68%	97%
O96015	Homo sapiens	39%	87%
O96860	Drosophila melanogaster	75%	100%
P61273	Macaca fascicularis	76%	100%
P61285	Bos taurus	76%	100%
P63167	Homo sapiens	76%	100%
P63168	Mus musculus	76%	100%
P63169	Oryctolagus cuniculus	76%	100%
P63170	Rattus norvegicus	76%	100%
Q02647	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	99%
Q21557	Caenorhabditis elegans	38%	100%
Q22799	Caenorhabditis elegans	78%	100%
Q24117	Drosophila melanogaster	76%	100%
Q32KN5	Bos taurus	39%	87%
Q39579	Chlamydomonas reinhardtii	40%	76%
Q39580	Chlamydomonas reinhardtii	73%	100%
Q3MHR3	Bos taurus	78%	100%
Q4Q852	Leishmania major	51%	100%
Q4QA70	Leishmania major	51%	100%
Q4QDC0	Leishmania major	40%	81%
Q4QES6	Leishmania major	40%	81%
Q4QJJ6	Leishmania major	49%	100%
Q6BZF8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	48%	100%
Q6CWX4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	100%
Q6FUJ0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q759T0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	46%	100%
Q78P75	Rattus norvegicus	78%	100%
Q86A88	Dictyostelium discoideum	62%	100%
Q94748	Schistosoma mansoni	61%	100%
Q94758	Schistosoma mansoni	64%	100%
Q96FJ2	Homo sapiens	78%	100%
Q9D0M5	Mus musculus	78%	100%
Q9DCM4	Mus musculus	39%	87%
Q9UR05	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	70%	100%
V5AV01	Trypanosoma cruzi	49%	100%
V5BSX5	Trypanosoma cruzi	88%	100%
V5BV95	Trypanosoma cruzi	40%	81%
V5BXL9	Trypanosoma cruzi	53%	100%