Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5R1_LEIMA

TriTrypDb:

LmjF.32.0240 , LMJLV39_320007600 , LMJSD75_320007600

Length:

1085

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

Q4Q5R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5R1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.596
CLV_C14_Caspase3-7	850	854	PF00656	0.664
CLV_C14_Caspase3-7	887	891	PF00656	0.511
CLV_C14_Caspase3-7	953	957	PF00656	0.711
CLV_NRD_NRD_1	1042	1044	PF00675	0.663
CLV_NRD_NRD_1	696	698	PF00675	0.471
CLV_NRD_NRD_1	703	705	PF00675	0.478
CLV_NRD_NRD_1	723	725	PF00675	0.557
CLV_NRD_NRD_1	737	739	PF00675	0.514
CLV_NRD_NRD_1	762	764	PF00675	0.605
CLV_NRD_NRD_1	767	769	PF00675	0.635
CLV_NRD_NRD_1	837	839	PF00675	0.694
CLV_NRD_NRD_1	976	978	PF00675	0.597
CLV_PCSK_FUR_1	834	838	PF00082	0.581
CLV_PCSK_KEX2_1	1042	1044	PF00082	0.663
CLV_PCSK_KEX2_1	659	661	PF00082	0.468
CLV_PCSK_KEX2_1	696	698	PF00082	0.471
CLV_PCSK_KEX2_1	702	704	PF00082	0.489
CLV_PCSK_KEX2_1	739	741	PF00082	0.528
CLV_PCSK_KEX2_1	762	764	PF00082	0.605
CLV_PCSK_KEX2_1	767	769	PF00082	0.635
CLV_PCSK_KEX2_1	836	838	PF00082	0.686
CLV_PCSK_KEX2_1	976	978	PF00082	0.645
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.458
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.528
CLV_PCSK_PC7_1	699	705	PF00082	0.412
CLV_PCSK_PC7_1	763	769	PF00082	0.646
CLV_PCSK_PC7_1	972	978	PF00082	0.589
CLV_PCSK_SKI1_1	1081	1085	PF00082	0.616
CLV_PCSK_SKI1_1	424	428	PF00082	0.507
CLV_PCSK_SKI1_1	643	647	PF00082	0.497
CLV_PCSK_SKI1_1	662	666	PF00082	0.547
CLV_Separin_Metazoa	730	734	PF03568	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.415
DEG_SCF_FBW7_1	259	264	PF00400	0.414
DEG_SPOP_SBC_1	1015	1019	PF00917	0.514
DOC_CKS1_1	573	578	PF01111	0.514
DOC_CKS1_1	67	72	PF01111	0.475
DOC_CKS1_1	793	798	PF01111	0.521
DOC_CYCLIN_RxL_1	169	179	PF00134	0.361
DOC_CYCLIN_RxL_1	421	430	PF00134	0.541
DOC_CYCLIN_yClb5_NLxxxL_5	108	117	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	913	919	PF00134	0.563
DOC_MAPK_gen_1	151	159	PF00069	0.546
DOC_MAPK_gen_1	410	419	PF00069	0.616
DOC_MAPK_gen_1	6	15	PF00069	0.402
DOC_PP1_RVXF_1	10	16	PF00149	0.479
DOC_PP2B_LxvP_1	235	238	PF13499	0.592
DOC_PP2B_LxvP_1	457	460	PF13499	0.602
DOC_PP2B_LxvP_1	822	825	PF13499	0.637
DOC_PP2B_LxvP_1	913	916	PF13499	0.605
DOC_PP4_FxxP_1	159	162	PF00568	0.361
DOC_PP4_FxxP_1	980	983	PF00568	0.699
DOC_PP4_MxPP_1	917	920	PF00568	0.572
DOC_USP7_MATH_1	140	144	PF00917	0.558
DOC_USP7_MATH_1	145	149	PF00917	0.438
DOC_USP7_MATH_1	241	245	PF00917	0.524
DOC_USP7_MATH_1	254	258	PF00917	0.625
DOC_USP7_MATH_1	261	265	PF00917	0.558
DOC_USP7_MATH_1	306	310	PF00917	0.479
DOC_USP7_MATH_1	373	377	PF00917	0.748
DOC_USP7_MATH_1	435	439	PF00917	0.677
DOC_USP7_MATH_1	490	494	PF00917	0.716
DOC_USP7_MATH_1	499	503	PF00917	0.555
DOC_USP7_MATH_1	523	527	PF00917	0.779
DOC_USP7_MATH_1	556	560	PF00917	0.676
DOC_USP7_MATH_1	670	674	PF00917	0.459
DOC_USP7_MATH_1	705	709	PF00917	0.578
DOC_USP7_MATH_1	766	770	PF00917	0.679
DOC_USP7_MATH_1	83	87	PF00917	0.527
DOC_USP7_MATH_1	840	844	PF00917	0.713
DOC_USP7_MATH_1	987	991	PF00917	0.668
DOC_WW_Pin1_4	1041	1046	PF00397	0.805
DOC_WW_Pin1_4	209	214	PF00397	0.543
DOC_WW_Pin1_4	257	262	PF00397	0.586
DOC_WW_Pin1_4	294	299	PF00397	0.422
DOC_WW_Pin1_4	572	577	PF00397	0.541
DOC_WW_Pin1_4	66	71	PF00397	0.398
DOC_WW_Pin1_4	750	755	PF00397	0.604
DOC_WW_Pin1_4	792	797	PF00397	0.603
DOC_WW_Pin1_4	838	843	PF00397	0.670
DOC_WW_Pin1_4	845	850	PF00397	0.637
DOC_WW_Pin1_4	868	873	PF00397	0.600
DOC_WW_Pin1_4	959	964	PF00397	0.636
DOC_WW_Pin1_4	975	980	PF00397	0.635
LIG_14-3-3_CanoR_1	1006	1014	PF00244	0.593
LIG_14-3-3_CanoR_1	1016	1023	PF00244	0.650
LIG_14-3-3_CanoR_1	350	355	PF00244	0.640
LIG_14-3-3_CanoR_1	434	443	PF00244	0.685
LIG_14-3-3_CanoR_1	522	532	PF00244	0.693
LIG_14-3-3_CanoR_1	58	64	PF00244	0.363
LIG_14-3-3_CanoR_1	66	70	PF00244	0.402
LIG_14-3-3_CanoR_1	762	770	PF00244	0.609
LIG_14-3-3_CanoR_1	977	983	PF00244	0.617
LIG_Actin_WH2_2	382	398	PF00022	0.502
LIG_Actin_WH2_2	43	60	PF00022	0.347
LIG_Actin_WH2_2	786	801	PF00022	0.532
LIG_Actin_WH2_2	802	820	PF00022	0.539
LIG_BIR_III_4	1047	1051	PF00653	0.736
LIG_BIR_III_4	1071	1075	PF00653	0.632
LIG_BIR_III_4	16	20	PF00653	0.455
LIG_BRCT_BRCA1_1	1061	1065	PF00533	0.596
LIG_BRCT_BRCA1_1	826	830	PF00533	0.656
LIG_FHA_1	100	106	PF00498	0.395
LIG_FHA_1	1026	1032	PF00498	0.688
LIG_FHA_1	1055	1061	PF00498	0.716
LIG_FHA_1	144	150	PF00498	0.625
LIG_FHA_1	313	319	PF00498	0.608
LIG_FHA_1	343	349	PF00498	0.580
LIG_FHA_1	613	619	PF00498	0.490
LIG_FHA_1	663	669	PF00498	0.531
LIG_FHA_1	793	799	PF00498	0.595
LIG_FHA_1	924	930	PF00498	0.630
LIG_FHA_2	1054	1060	PF00498	0.674
LIG_FHA_2	1062	1068	PF00498	0.633
LIG_FHA_2	268	274	PF00498	0.423
LIG_FHA_2	578	584	PF00498	0.583
LIG_FHA_2	776	782	PF00498	0.646
LIG_FHA_2	848	854	PF00498	0.731
LIG_FHA_2	933	939	PF00498	0.618
LIG_HCF-1_HBM_1	783	786	PF13415	0.614
LIG_LIR_Apic_2	571	576	PF02991	0.555
LIG_LIR_Apic_2	978	983	PF02991	0.697
LIG_LIR_Gen_1	107	117	PF02991	0.326
LIG_LIR_Gen_1	388	399	PF02991	0.464
LIG_LIR_Gen_1	68	79	PF02991	0.434
LIG_LIR_Nem_3	107	113	PF02991	0.348
LIG_LIR_Nem_3	388	394	PF02991	0.476
LIG_LIR_Nem_3	631	636	PF02991	0.525
LIG_LIR_Nem_3	68	74	PF02991	0.404
LIG_LIR_Nem_3	783	789	PF02991	0.590
LIG_MYND_1	447	451	PF01753	0.592
LIG_NRBOX	148	154	PF00104	0.471
LIG_NRBOX	421	427	PF00104	0.499
LIG_NRBOX	884	890	PF00104	0.515
LIG_OCRL_FandH_1	109	121	PF00620	0.415
LIG_Pex14_2	159	163	PF04695	0.293
LIG_PTAP_UEV_1	450	455	PF05743	0.682
LIG_SH2_CRK	391	395	PF00017	0.461
LIG_SH2_CRK	71	75	PF00017	0.432
LIG_SH2_NCK_1	752	756	PF00017	0.575
LIG_SH2_STAP1	391	395	PF00017	0.461
LIG_SH2_STAT5	574	577	PF00017	0.553
LIG_SH2_STAT5	786	789	PF00017	0.611
LIG_SH2_STAT5	805	808	PF00017	0.557
LIG_SH3_3	445	451	PF00018	0.593
LIG_SH3_3	526	532	PF00018	0.604
LIG_SH3_3	790	796	PF00018	0.530
LIG_SH3_3	909	915	PF00018	0.581
LIG_SH3_5	857	861	PF00018	0.644
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.353
LIG_SUMO_SIM_anti_2	297	303	PF11976	0.453
LIG_TRAF2_1	369	372	PF00917	0.512
LIG_TRAF2_1	742	745	PF00917	0.537
LIG_TRAF2_1	779	782	PF00917	0.587
LIG_TYR_ITIM	389	394	PF00017	0.462
LIG_UBA3_1	440	444	PF00899	0.545
LIG_WRC_WIRS_1	113	118	PF05994	0.347
MOD_CDK_SPxxK_3	66	73	PF00069	0.440
MOD_CDK_SPxxK_3	792	799	PF00069	0.600
MOD_CDK_SPxxK_3	838	845	PF00069	0.651
MOD_CK1_1	143	149	PF00069	0.482
MOD_CK1_1	208	214	PF00069	0.454
MOD_CK1_1	255	261	PF00069	0.630
MOD_CK1_1	297	303	PF00069	0.439
MOD_CK1_1	401	407	PF00069	0.484
MOD_CK1_1	524	530	PF00069	0.578
MOD_CK1_1	540	546	PF00069	0.682
MOD_CK1_1	548	554	PF00069	0.603
MOD_CK1_1	559	565	PF00069	0.602
MOD_CK1_1	577	583	PF00069	0.429
MOD_CK1_1	718	724	PF00069	0.675
MOD_CK1_1	775	781	PF00069	0.623
MOD_CK1_1	826	832	PF00069	0.597
MOD_CK1_1	848	854	PF00069	0.725
MOD_CK1_1	881	887	PF00069	0.557
MOD_CK1_1	978	984	PF00069	0.695
MOD_CK1_1	990	996	PF00069	0.550
MOD_CK2_1	1053	1059	PF00069	0.765
MOD_CK2_1	112	118	PF00069	0.361
MOD_CK2_1	183	189	PF00069	0.411
MOD_CK2_1	267	273	PF00069	0.489
MOD_CK2_1	366	372	PF00069	0.516
MOD_CK2_1	577	583	PF00069	0.549
MOD_CK2_1	775	781	PF00069	0.629
MOD_CK2_1	791	797	PF00069	0.588
MOD_CK2_1	826	832	PF00069	0.706
MOD_CK2_1	881	887	PF00069	0.557
MOD_CK2_1	932	938	PF00069	0.720
MOD_Cter_Amidation	834	837	PF01082	0.583
MOD_Cter_Amidation	974	977	PF01082	0.567
MOD_GlcNHglycan	1007	1010	PF01048	0.458
MOD_GlcNHglycan	1018	1021	PF01048	0.567
MOD_GlcNHglycan	140	143	PF01048	0.476
MOD_GlcNHglycan	165	168	PF01048	0.560
MOD_GlcNHglycan	197	200	PF01048	0.387
MOD_GlcNHglycan	243	246	PF01048	0.564
MOD_GlcNHglycan	28	31	PF01048	0.530
MOD_GlcNHglycan	308	311	PF01048	0.499
MOD_GlcNHglycan	345	348	PF01048	0.546
MOD_GlcNHglycan	44	47	PF01048	0.462
MOD_GlcNHglycan	451	454	PF01048	0.697
MOD_GlcNHglycan	500	504	PF01048	0.741
MOD_GlcNHglycan	545	548	PF01048	0.775
MOD_GlcNHglycan	550	553	PF01048	0.613
MOD_GlcNHglycan	558	561	PF01048	0.696
MOD_GlcNHglycan	568	571	PF01048	0.533
MOD_GlcNHglycan	576	579	PF01048	0.416
MOD_GlcNHglycan	707	710	PF01048	0.636
MOD_GlcNHglycan	717	720	PF01048	0.575
MOD_GlcNHglycan	764	767	PF01048	0.549
MOD_GlcNHglycan	826	829	PF01048	0.624
MOD_GlcNHglycan	850	853	PF01048	0.734
MOD_GlcNHglycan	956	960	PF01048	0.731
MOD_GlcNHglycan	973	976	PF01048	0.502
MOD_GlcNHglycan	988	992	PF01048	0.598
MOD_GlcNHglycan	993	996	PF01048	0.681
MOD_GSK3_1	1054	1061	PF00069	0.670
MOD_GSK3_1	183	190	PF00069	0.454
MOD_GSK3_1	205	212	PF00069	0.627
MOD_GSK3_1	215	222	PF00069	0.462
MOD_GSK3_1	255	262	PF00069	0.547
MOD_GSK3_1	381	388	PF00069	0.661
MOD_GSK3_1	521	528	PF00069	0.580
MOD_GSK3_1	532	539	PF00069	0.636
MOD_GSK3_1	662	669	PF00069	0.481
MOD_GSK3_1	714	721	PF00069	0.587
MOD_GSK3_1	762	769	PF00069	0.661
MOD_GSK3_1	826	833	PF00069	0.627
MOD_GSK3_1	879	886	PF00069	0.724
MOD_GSK3_1	928	935	PF00069	0.636
MOD_GSK3_1	955	962	PF00069	0.659
MOD_GSK3_1	971	978	PF00069	0.623
MOD_GSK3_1	987	994	PF00069	0.560
MOD_N-GLC_1	176	181	PF02516	0.370
MOD_N-GLC_1	868	873	PF02516	0.600
MOD_NEK2_1	1014	1019	PF00069	0.602
MOD_NEK2_1	163	168	PF00069	0.417
MOD_NEK2_1	176	181	PF00069	0.391
MOD_NEK2_1	183	188	PF00069	0.472
MOD_NEK2_1	233	238	PF00069	0.535
MOD_NEK2_1	267	272	PF00069	0.489
MOD_NEK2_1	312	317	PF00069	0.585
MOD_NEK2_1	417	422	PF00069	0.511
MOD_NEK2_1	427	432	PF00069	0.687
MOD_NEK2_1	545	550	PF00069	0.713
MOD_NEK2_1	57	62	PF00069	0.345
MOD_NEK2_1	586	591	PF00069	0.520
MOD_NEK2_1	646	651	PF00069	0.533
MOD_NEK2_1	74	79	PF00069	0.590
MOD_NEK2_1	830	835	PF00069	0.714
MOD_NEK2_1	971	976	PF00069	0.657
MOD_PIKK_1	252	258	PF00454	0.601
MOD_PIKK_1	809	815	PF00454	0.554
MOD_PIKK_1	840	846	PF00454	0.679
MOD_PK_1	350	356	PF00069	0.528
MOD_PKA_1	762	768	PF00069	0.549
MOD_PKA_2	1005	1011	PF00069	0.664
MOD_PKA_2	1015	1021	PF00069	0.644
MOD_PKA_2	187	193	PF00069	0.416
MOD_PKA_2	433	439	PF00069	0.677
MOD_PKA_2	521	527	PF00069	0.584
MOD_PKA_2	57	63	PF00069	0.362
MOD_PKA_2	65	71	PF00069	0.394
MOD_PKA_2	74	80	PF00069	0.474
MOD_PKA_2	762	768	PF00069	0.624
MOD_PKA_2	772	778	PF00069	0.782
MOD_PKA_2	971	977	PF00069	0.703
MOD_Plk_1	143	149	PF00069	0.550
MOD_Plk_1	183	189	PF00069	0.460
MOD_Plk_1	219	225	PF00069	0.546
MOD_Plk_1	23	29	PF00069	0.424
MOD_Plk_1	284	290	PF00069	0.426
MOD_Plk_1	624	630	PF00069	0.452
MOD_Plk_1	634	640	PF00069	0.445
MOD_Plk_1	646	652	PF00069	0.491
MOD_Plk_1	662	668	PF00069	0.392
MOD_Plk_1	818	824	PF00069	0.524
MOD_Plk_1	878	884	PF00069	0.583
MOD_Plk_4	112	118	PF00069	0.394
MOD_Plk_4	297	303	PF00069	0.467
MOD_Plk_4	381	387	PF00069	0.526
MOD_Plk_4	540	546	PF00069	0.542
MOD_Plk_4	91	97	PF00069	0.350
MOD_Plk_4	928	934	PF00069	0.635
MOD_ProDKin_1	1041	1047	PF00069	0.808
MOD_ProDKin_1	209	215	PF00069	0.539
MOD_ProDKin_1	257	263	PF00069	0.569
MOD_ProDKin_1	294	300	PF00069	0.419
MOD_ProDKin_1	572	578	PF00069	0.541
MOD_ProDKin_1	66	72	PF00069	0.406
MOD_ProDKin_1	750	756	PF00069	0.605
MOD_ProDKin_1	792	798	PF00069	0.602
MOD_ProDKin_1	838	844	PF00069	0.672
MOD_ProDKin_1	845	851	PF00069	0.638
MOD_ProDKin_1	868	874	PF00069	0.597
MOD_ProDKin_1	959	965	PF00069	0.631
MOD_ProDKin_1	975	981	PF00069	0.635
MOD_SUMO_for_1	757	760	PF00179	0.671
MOD_SUMO_rev_2	588	597	PF00179	0.518
MOD_SUMO_rev_2	743	749	PF00179	0.562
TRG_DiLeu_BaEn_1	326	331	PF01217	0.465
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.473
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.625
TRG_ENDOCYTIC_2	391	394	PF00928	0.474
TRG_ENDOCYTIC_2	587	590	PF00928	0.482
TRG_ENDOCYTIC_2	71	74	PF00928	0.423
TRG_ENDOCYTIC_2	786	789	PF00928	0.597
TRG_ER_diArg_1	153	156	PF00400	0.535
TRG_ER_diArg_1	38	41	PF00400	0.304
TRG_ER_diArg_1	701	704	PF00400	0.488
TRG_ER_diArg_1	737	740	PF00400	0.520
TRG_ER_diArg_1	761	763	PF00400	0.636
TRG_ER_diArg_1	834	837	PF00400	0.652
TRG_NES_CRM1_1	313	326	PF08389	0.539
TRG_NES_CRM1_1	416	429	PF08389	0.524
TRG_NES_CRM1_1	42	56	PF08389	0.399
TRG_NLS_Bipartite_1	724	742	PF00514	0.525
TRG_NLS_MonoExtC_3	723	728	PF00514	0.567
TRG_NLS_MonoExtC_3	737	743	PF00514	0.520
TRG_NLS_MonoExtN_4	724	729	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	1001	1005	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	768	772	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P868	Leptomonas seymouri	48%	100%
A0A3S7X576	Leishmania donovani	91%	100%
A4HK05	Leishmania braziliensis	73%	100%
A4I7I8	Leishmania infantum	91%	100%
E9B2E5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%