Putative serine/threonine-protein kinase Nek1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine/threonine-protein kinase NEK16, putative

Species:

Leishmania major

UniProt:

Q4Q5Q9_LEIMA

TriTrypDb:

LmjF.32.0260 , LMJLV39_320007800 , LMJSD75_320007800

Length:

1349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q5Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1286	1290	PF00656	0.571
CLV_NRD_NRD_1	1087	1089	PF00675	0.646
CLV_NRD_NRD_1	1167	1169	PF00675	0.586
CLV_NRD_NRD_1	22	24	PF00675	0.312
CLV_NRD_NRD_1	231	233	PF00675	0.312
CLV_NRD_NRD_1	259	261	PF00675	0.539
CLV_NRD_NRD_1	293	295	PF00675	0.698
CLV_NRD_NRD_1	444	446	PF00675	0.570
CLV_NRD_NRD_1	478	480	PF00675	0.468
CLV_NRD_NRD_1	504	506	PF00675	0.540

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J6	Leptomonas seymouri	53%	100%
A0A3S7X553	Leishmania donovani	92%	99%
A4HK07	Leishmania braziliensis	73%	97%
A4I7J0	Leishmania infantum	92%	99%
E9B2E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%

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