LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5Q6_LEIMA
TriTrypDb:
LmjF.32.0290 , LMJLV39_320008100 * , LMJSD75_320008100
Length:
343

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

Q4Q5Q6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 187 191 PF00656 0.767
CLV_C14_Caspase3-7 217 221 PF00656 0.767
CLV_C14_Caspase3-7 233 237 PF00656 0.605
CLV_C14_Caspase3-7 279 283 PF00656 0.671
CLV_NRD_NRD_1 156 158 PF00675 0.457
CLV_NRD_NRD_1 303 305 PF00675 0.438
CLV_PCSK_KEX2_1 142 144 PF00082 0.544
CLV_PCSK_KEX2_1 156 158 PF00082 0.413
CLV_PCSK_KEX2_1 303 305 PF00082 0.434
CLV_PCSK_KEX2_1 62 64 PF00082 0.357
CLV_PCSK_PC1ET2_1 142 144 PF00082 0.522
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.357
CLV_PCSK_SKI1_1 112 116 PF00082 0.395
CLV_PCSK_SKI1_1 303 307 PF00082 0.471
DEG_APCC_DBOX_1 160 168 PF00400 0.668
DEG_Nend_UBRbox_1 1 4 PF02207 0.650
DEG_SPOP_SBC_1 198 202 PF00917 0.729
DOC_ANK_TNKS_1 260 267 PF00023 0.630
DOC_CYCLIN_RxL_1 109 119 PF00134 0.574
DOC_CYCLIN_yClb3_PxF_3 38 44 PF00134 0.632
DOC_MAPK_gen_1 13 22 PF00069 0.667
DOC_MAPK_MEF2A_6 13 22 PF00069 0.667
DOC_PP1_RVXF_1 140 147 PF00149 0.672
DOC_PP4_FxxP_1 146 149 PF00568 0.644
DOC_PP4_FxxP_1 227 230 PF00568 0.714
DOC_USP7_MATH_1 183 187 PF00917 0.733
DOC_USP7_MATH_1 198 202 PF00917 0.655
DOC_USP7_MATH_1 256 260 PF00917 0.680
DOC_USP7_MATH_1 271 275 PF00917 0.650
DOC_WW_Pin1_4 14 19 PF00397 0.645
DOC_WW_Pin1_4 177 182 PF00397 0.716
DOC_WW_Pin1_4 199 204 PF00397 0.814
LIG_14-3-3_CanoR_1 105 111 PF00244 0.676
LIG_14-3-3_CanoR_1 143 147 PF00244 0.779
LIG_14-3-3_CanoR_1 161 165 PF00244 0.619
LIG_14-3-3_CanoR_1 303 312 PF00244 0.660
LIG_CSL_BTD_1 36 39 PF09270 0.674
LIG_deltaCOP1_diTrp_1 35 44 PF00928 0.628
LIG_FHA_1 224 230 PF00498 0.762
LIG_FHA_1 3 9 PF00498 0.638
LIG_FHA_2 108 114 PF00498 0.584
LIG_FHA_2 233 239 PF00498 0.693
LIG_FHA_2 30 36 PF00498 0.643
LIG_LIR_Apic_2 145 149 PF02991 0.643
LIG_LIR_Apic_2 226 230 PF02991 0.714
LIG_LIR_Nem_3 108 114 PF02991 0.579
LIG_LIR_Nem_3 306 311 PF02991 0.604
LIG_LIR_Nem_3 335 340 PF02991 0.325
LIG_LIR_Nem_3 35 40 PF02991 0.676
LIG_MYND_1 38 42 PF01753 0.635
LIG_PDZ_Class_2 338 343 PF00595 0.457
LIG_Pex14_1 312 316 PF04695 0.482
LIG_Pex14_2 111 115 PF04695 0.574
LIG_Pex14_2 55 59 PF04695 0.552
LIG_Pex14_2 80 84 PF04695 0.551
LIG_SH2_CRK 298 302 PF00017 0.628
LIG_SH2_CRK 317 321 PF00017 0.411
LIG_SH2_NCK_1 76 80 PF00017 0.634
LIG_SH2_SRC 76 79 PF00017 0.562
LIG_SH2_STAP1 76 80 PF00017 0.556
LIG_SH2_STAT5 340 343 PF00017 0.458
LIG_SH3_3 15 21 PF00018 0.771
LIG_SH3_3 36 42 PF00018 0.622
LIG_SUMO_SIM_par_1 208 214 PF11976 0.744
LIG_TRAF2_1 128 131 PF00917 0.600
LIG_TRAF2_1 230 233 PF00917 0.685
LIG_TYR_ITIM 247 252 PF00017 0.577
LIG_WRC_WIRS_1 224 229 PF05994 0.643
LIG_WRC_WIRS_1 41 46 PF05994 0.521
MOD_CK1_1 104 110 PF00069 0.632
MOD_CK1_1 163 169 PF00069 0.598
MOD_CK1_1 211 217 PF00069 0.679
MOD_CK1_1 255 261 PF00069 0.602
MOD_CK2_1 107 113 PF00069 0.473
MOD_CK2_1 29 35 PF00069 0.519
MOD_GlcNHglycan 122 125 PF01048 0.465
MOD_GlcNHglycan 186 189 PF01048 0.679
MOD_GlcNHglycan 244 247 PF01048 0.549
MOD_GlcNHglycan 254 257 PF01048 0.588
MOD_GlcNHglycan 258 261 PF01048 0.608
MOD_GlcNHglycan 262 265 PF01048 0.604
MOD_GlcNHglycan 298 301 PF01048 0.542
MOD_GlcNHglycan 71 74 PF01048 0.539
MOD_GSK3_1 179 186 PF00069 0.748
MOD_GSK3_1 238 245 PF00069 0.598
MOD_GSK3_1 252 259 PF00069 0.589
MOD_GSK3_1 260 267 PF00069 0.600
MOD_LATS_1 140 146 PF00433 0.566
MOD_NEK2_1 252 257 PF00069 0.676
MOD_NEK2_1 29 34 PF00069 0.542
MOD_PIKK_1 20 26 PF00454 0.539
MOD_PKA_1 142 148 PF00069 0.557
MOD_PKA_1 303 309 PF00069 0.503
MOD_PKA_2 104 110 PF00069 0.602
MOD_PKA_2 12 18 PF00069 0.608
MOD_PKA_2 142 148 PF00069 0.659
MOD_PKA_2 155 161 PF00069 0.460
MOD_PKA_2 192 198 PF00069 0.745
MOD_PKA_2 242 248 PF00069 0.583
MOD_PKA_2 260 266 PF00069 0.603
MOD_PKA_2 280 286 PF00069 0.566
MOD_PKA_2 303 309 PF00069 0.637
MOD_Plk_1 107 113 PF00069 0.441
MOD_Plk_2-3 232 238 PF00069 0.553
MOD_Plk_4 205 211 PF00069 0.632
MOD_ProDKin_1 14 20 PF00069 0.546
MOD_ProDKin_1 177 183 PF00069 0.643
MOD_ProDKin_1 199 205 PF00069 0.785
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.524
TRG_DiLeu_BaLyEn_6 36 41 PF01217 0.508
TRG_ENDOCYTIC_2 249 252 PF00928 0.578
TRG_ENDOCYTIC_2 317 320 PF00928 0.321
TRG_ENDOCYTIC_2 340 343 PF00928 0.569
TRG_ER_diArg_1 155 157 PF00400 0.571
TRG_ER_diArg_1 302 304 PF00400 0.540

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF27 Leptomonas seymouri 55% 100%
A0A3Q8IFN5 Leishmania donovani 93% 100%
A4HK09 Leishmania braziliensis 82% 100%
A4I7J3 Leishmania infantum 93% 100%
E9B2F0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS