Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5Q5_LEIMA

TriTrypDb:

LmjF.32.0300 , LMJLV39_320008200 , LMJSD75_320008200

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4Q5Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q5

Function

Biological processes
Term	Name	Level	Count
GO:0009314	response to radiation	3	7
GO:0009628	response to abiotic stimulus	2	7
GO:0010165	response to X-ray	5	7
GO:0010212	response to ionizing radiation	4	7
GO:0050896	response to stimulus	1	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.436
CLV_C14_Caspase3-7	34	38	PF00656	0.800
CLV_C14_Caspase3-7	65	69	PF00656	0.567
CLV_C14_Caspase3-7	654	658	PF00656	0.815
CLV_C14_Caspase3-7	664	668	PF00656	0.646
CLV_NRD_NRD_1	138	140	PF00675	0.642
CLV_NRD_NRD_1	141	143	PF00675	0.645
CLV_NRD_NRD_1	356	358	PF00675	0.612
CLV_NRD_NRD_1	390	392	PF00675	0.537
CLV_NRD_NRD_1	402	404	PF00675	0.590
CLV_NRD_NRD_1	588	590	PF00675	0.716
CLV_NRD_NRD_1	602	604	PF00675	0.767
CLV_NRD_NRD_1	607	609	PF00675	0.555
CLV_NRD_NRD_1	685	687	PF00675	0.795
CLV_NRD_NRD_1	744	746	PF00675	0.653
CLV_PCSK_FUR_1	139	143	PF00082	0.720
CLV_PCSK_FUR_1	683	687	PF00082	0.607
CLV_PCSK_KEX2_1	137	139	PF00082	0.737
CLV_PCSK_KEX2_1	141	143	PF00082	0.655
CLV_PCSK_KEX2_1	356	358	PF00082	0.612
CLV_PCSK_KEX2_1	390	392	PF00082	0.520
CLV_PCSK_KEX2_1	402	404	PF00082	0.572
CLV_PCSK_KEX2_1	587	589	PF00082	0.705
CLV_PCSK_KEX2_1	601	603	PF00082	0.765
CLV_PCSK_KEX2_1	607	609	PF00082	0.540
CLV_PCSK_KEX2_1	685	687	PF00082	0.608
CLV_PCSK_PC7_1	134	140	PF00082	0.733
CLV_PCSK_PC7_1	583	589	PF00082	0.681
CLV_PCSK_PC7_1	603	609	PF00082	0.507
CLV_PCSK_SKI1_1	107	111	PF00082	0.668
CLV_PCSK_SKI1_1	602	606	PF00082	0.602
CLV_PCSK_SKI1_1	659	663	PF00082	0.802
CLV_PCSK_SKI1_1	685	689	PF00082	0.722
CLV_PCSK_SKI1_1	741	745	PF00082	0.617
DEG_APCC_DBOX_1	140	148	PF00400	0.694
DEG_APCC_DBOX_1	73	81	PF00400	0.567
DEG_APCC_DBOX_1	744	752	PF00400	0.672
DEG_Nend_UBRbox_2	1	3	PF02207	0.759
DEG_SCF_FBW7_1	533	539	PF00400	0.715
DEG_SCF_FBW7_1	629	634	PF00400	0.742
DEG_SPOP_SBC_1	491	495	PF00917	0.590
DOC_CDC14_PxL_1	338	346	PF14671	0.541
DOC_CKS1_1	533	538	PF01111	0.701
DOC_CYCLIN_yCln2_LP_2	94	97	PF00134	0.795
DOC_MAPK_DCC_7	612	622	PF00069	0.587
DOC_MAPK_gen_1	50	57	PF00069	0.745
DOC_MAPK_HePTP_8	700	712	PF00069	0.595
DOC_MAPK_MEF2A_6	356	365	PF00069	0.650
DOC_MAPK_MEF2A_6	512	519	PF00069	0.532
DOC_MAPK_MEF2A_6	703	712	PF00069	0.594
DOC_PP2B_LxvP_1	224	227	PF13499	0.478
DOC_PP2B_LxvP_1	426	429	PF13499	0.610
DOC_PP2B_LxvP_1	94	97	PF13499	0.697
DOC_PP4_FxxP_1	123	126	PF00568	0.667
DOC_USP7_MATH_1	188	192	PF00917	0.520
DOC_USP7_MATH_1	307	311	PF00917	0.411
DOC_USP7_MATH_1	477	481	PF00917	0.707
DOC_USP7_MATH_1	490	494	PF00917	0.685
DOC_USP7_MATH_1	56	60	PF00917	0.674
DOC_USP7_MATH_1	674	678	PF00917	0.765
DOC_USP7_MATH_1	747	751	PF00917	0.681
DOC_WW_Pin1_4	481	486	PF00397	0.682
DOC_WW_Pin1_4	532	537	PF00397	0.456
DOC_WW_Pin1_4	627	632	PF00397	0.754
DOC_WW_Pin1_4	724	729	PF00397	0.696
LIG_14-3-3_CanoR_1	117	123	PF00244	0.741
LIG_14-3-3_CanoR_1	139	145	PF00244	0.590
LIG_14-3-3_CanoR_1	207	212	PF00244	0.329
LIG_14-3-3_CanoR_1	249	254	PF00244	0.371
LIG_14-3-3_CanoR_1	335	344	PF00244	0.456
LIG_14-3-3_CanoR_1	448	452	PF00244	0.607
LIG_14-3-3_CanoR_1	607	615	PF00244	0.752
LIG_14-3-3_CanoR_1	685	692	PF00244	0.840
LIG_14-3-3_CanoR_1	703	708	PF00244	0.749
LIG_14-3-3_CanoR_1	720	726	PF00244	0.824
LIG_APCC_ABBA_1	13	18	PF00400	0.690
LIG_APCC_ABBA_1	572	577	PF00400	0.664
LIG_BRCT_BRCA1_1	315	319	PF00533	0.431
LIG_BRCT_BRCA1_1	515	519	PF00533	0.619
LIG_BRCT_BRCA1_1	552	556	PF00533	0.815
LIG_EVH1_1	125	129	PF00568	0.619
LIG_FHA_1	450	456	PF00498	0.705
LIG_FHA_1	465	471	PF00498	0.656
LIG_FHA_1	564	570	PF00498	0.712
LIG_FHA_1	728	734	PF00498	0.682
LIG_FHA_2	131	137	PF00498	0.638
LIG_FHA_2	207	213	PF00498	0.363
LIG_FHA_2	436	442	PF00498	0.698
LIG_FHA_2	519	525	PF00498	0.551
LIG_FHA_2	662	668	PF00498	0.793
LIG_FHA_2	709	715	PF00498	0.781
LIG_GBD_Chelix_1	86	94	PF00786	0.574
LIG_LIR_Apic_2	121	126	PF02991	0.768
LIG_LIR_Gen_1	168	178	PF02991	0.502
LIG_LIR_Gen_1	260	271	PF02991	0.438
LIG_LIR_Gen_1	420	429	PF02991	0.681
LIG_LIR_Gen_1	577	585	PF02991	0.602
LIG_LIR_Gen_1	67	78	PF02991	0.801
LIG_LIR_Gen_1	750	758	PF02991	0.622
LIG_LIR_Nem_3	121	125	PF02991	0.738
LIG_LIR_Nem_3	168	173	PF02991	0.489
LIG_LIR_Nem_3	260	266	PF02991	0.397
LIG_LIR_Nem_3	316	322	PF02991	0.572
LIG_LIR_Nem_3	420	426	PF02991	0.653
LIG_LIR_Nem_3	450	454	PF02991	0.619
LIG_LIR_Nem_3	516	522	PF02991	0.582
LIG_LIR_Nem_3	524	529	PF02991	0.547
LIG_LIR_Nem_3	577	581	PF02991	0.590
LIG_LIR_Nem_3	67	73	PF02991	0.806
LIG_LIR_Nem_3	750	756	PF02991	0.621
LIG_MYND_3	226	230	PF01753	0.482
LIG_PTAP_UEV_1	484	489	PF05743	0.749
LIG_PTB_Apo_2	234	241	PF02174	0.489
LIG_SH2_CRK	423	427	PF00017	0.683
LIG_SH2_CRK	582	586	PF00017	0.665
LIG_SH2_NCK_1	263	267	PF00017	0.411
LIG_SH2_NCK_1	552	556	PF00017	0.691
LIG_SH2_STAP1	552	556	PF00017	0.713
LIG_SH2_STAT5	122	125	PF00017	0.669
LIG_SH2_STAT5	204	207	PF00017	0.602
LIG_SH2_STAT5	454	457	PF00017	0.644
LIG_SH2_STAT5	525	528	PF00017	0.536
LIG_SH2_STAT5	550	553	PF00017	0.717
LIG_SH3_1	498	504	PF00018	0.712
LIG_SH3_1	746	752	PF00018	0.679
LIG_SH3_2	544	549	PF14604	0.715
LIG_SH3_3	123	129	PF00018	0.625
LIG_SH3_3	482	488	PF00018	0.713
LIG_SH3_3	498	504	PF00018	0.503
LIG_SH3_3	512	518	PF00018	0.779
LIG_SH3_3	530	536	PF00018	0.390
LIG_SH3_3	538	544	PF00018	0.667
LIG_SH3_3	567	573	PF00018	0.708
LIG_SH3_3	613	619	PF00018	0.716
LIG_SH3_3	620	626	PF00018	0.691
LIG_SH3_3	70	76	PF00018	0.684
LIG_SH3_3	709	715	PF00018	0.765
LIG_SH3_3	722	728	PF00018	0.801
LIG_SH3_3	746	752	PF00018	0.679
LIG_SH3_4	43	50	PF00018	0.731
LIG_SUMO_SIM_par_1	241	246	PF11976	0.386
LIG_SUMO_SIM_par_1	255	260	PF11976	0.410
LIG_TRAF2_1	133	136	PF00917	0.735
LIG_TRAF2_1	644	647	PF00917	0.770
LIG_TRAF2_1	711	714	PF00917	0.757
LIG_TYR_ITIM	261	266	PF00017	0.411
LIG_TYR_ITIM	751	756	PF00017	0.623
LIG_WW_2	541	544	PF00397	0.804
LIG_WW_3	630	634	PF00397	0.788
MOD_CDK_SPK_2	532	537	PF00069	0.678
MOD_CDK_SPxK_1	627	633	PF00069	0.759
MOD_CK1_1	192	198	PF00069	0.500
MOD_CK1_1	248	254	PF00069	0.555
MOD_CK1_1	286	292	PF00069	0.446
MOD_CK1_1	462	468	PF00069	0.645
MOD_CK1_1	480	486	PF00069	0.620
MOD_CK1_1	506	512	PF00069	0.717
MOD_CK1_1	637	643	PF00069	0.769
MOD_CK1_1	677	683	PF00069	0.585
MOD_CK1_1	724	730	PF00069	0.721
MOD_CK2_1	110	116	PF00069	0.562
MOD_CK2_1	130	136	PF00069	0.410
MOD_CK2_1	171	177	PF00069	0.461
MOD_CK2_1	194	200	PF00069	0.483
MOD_CK2_1	238	244	PF00069	0.580
MOD_CK2_1	435	441	PF00069	0.628
MOD_CK2_1	462	468	PF00069	0.724
MOD_CK2_1	491	497	PF00069	0.815
MOD_CK2_1	518	524	PF00069	0.675
MOD_CK2_1	641	647	PF00069	0.772
MOD_CK2_1	708	714	PF00069	0.779
MOD_Cter_Amidation	585	588	PF01082	0.688
MOD_DYRK1A_RPxSP_1	627	631	PF00069	0.645
MOD_GlcNHglycan	112	115	PF01048	0.702
MOD_GlcNHglycan	173	176	PF01048	0.509
MOD_GlcNHglycan	21	24	PF01048	0.680
MOD_GlcNHglycan	296	300	PF01048	0.515
MOD_GlcNHglycan	352	355	PF01048	0.771
MOD_GlcNHglycan	485	488	PF01048	0.823
MOD_GlcNHglycan	553	556	PF01048	0.686
MOD_GlcNHglycan	58	61	PF01048	0.612
MOD_GlcNHglycan	635	639	PF01048	0.656
MOD_GlcNHglycan	705	708	PF01048	0.745
MOD_GSK3_1	188	195	PF00069	0.531
MOD_GSK3_1	203	210	PF00069	0.552
MOD_GSK3_1	243	250	PF00069	0.509
MOD_GSK3_1	307	314	PF00069	0.443
MOD_GSK3_1	471	478	PF00069	0.672
MOD_GSK3_1	532	539	PF00069	0.707
MOD_GSK3_1	602	609	PF00069	0.692
MOD_GSK3_1	627	634	PF00069	0.804
MOD_GSK3_1	637	644	PF00069	0.675
MOD_GSK3_1	85	92	PF00069	0.714
MOD_N-GLC_1	110	115	PF02516	0.626
MOD_N-GLC_1	331	336	PF02516	0.452
MOD_N-GLC_1	481	486	PF02516	0.685
MOD_NEK2_1	140	145	PF00069	0.586
MOD_NEK2_1	171	176	PF00069	0.497
MOD_NEK2_1	189	194	PF00069	0.522
MOD_NEK2_1	283	288	PF00069	0.465
MOD_NEK2_1	366	371	PF00069	0.472
MOD_NEK2_1	385	390	PF00069	0.322
MOD_NEK2_1	442	447	PF00069	0.660
MOD_NEK2_1	551	556	PF00069	0.714
MOD_NEK2_1	661	666	PF00069	0.796
MOD_NEK2_1	86	91	PF00069	0.716
MOD_NEK2_2	518	523	PF00069	0.560
MOD_PIKK_1	189	195	PF00454	0.511
MOD_PIKK_1	243	249	PF00454	0.420
MOD_PIKK_1	43	49	PF00454	0.693
MOD_PIKK_1	674	680	PF00454	0.739
MOD_PIKK_1	693	699	PF00454	0.836
MOD_PK_1	337	343	PF00069	0.596
MOD_PKA_1	587	593	PF00069	0.704
MOD_PKA_1	602	608	PF00069	0.560
MOD_PKA_1	685	691	PF00069	0.845
MOD_PKA_2	140	146	PF00069	0.691
MOD_PKA_2	206	212	PF00069	0.424
MOD_PKA_2	248	254	PF00069	0.402
MOD_PKA_2	336	342	PF00069	0.495
MOD_PKA_2	447	453	PF00069	0.647
MOD_PKA_2	587	593	PF00069	0.712
MOD_PKA_2	602	608	PF00069	0.595
MOD_PKA_2	685	691	PF00069	0.644
MOD_PKB_1	335	343	PF00069	0.592
MOD_PKB_1	587	595	PF00069	0.632
MOD_PKB_1	683	691	PF00069	0.727
MOD_Plk_1	110	116	PF00069	0.621
MOD_Plk_1	182	188	PF00069	0.530
MOD_Plk_1	50	56	PF00069	0.596
MOD_Plk_2-3	435	441	PF00069	0.581
MOD_Plk_4	252	258	PF00069	0.467
MOD_Plk_4	90	96	PF00069	0.805
MOD_ProDKin_1	481	487	PF00069	0.682
MOD_ProDKin_1	532	538	PF00069	0.473
MOD_ProDKin_1	627	633	PF00069	0.758
MOD_ProDKin_1	724	730	PF00069	0.690
MOD_SUMO_rev_2	653	661	PF00179	0.604
TRG_DiLeu_BaEn_1	230	235	PF01217	0.433
TRG_DiLeu_BaEn_4	135	141	PF01217	0.733
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.526
TRG_ENDOCYTIC_2	122	125	PF00928	0.669
TRG_ENDOCYTIC_2	263	266	PF00928	0.411
TRG_ENDOCYTIC_2	423	426	PF00928	0.681
TRG_ENDOCYTIC_2	575	578	PF00928	0.609
TRG_ENDOCYTIC_2	582	585	PF00928	0.595
TRG_ENDOCYTIC_2	753	756	PF00928	0.627
TRG_ER_diArg_1	137	139	PF00400	0.737
TRG_ER_diArg_1	140	142	PF00400	0.668
TRG_ER_diArg_1	335	338	PF00400	0.574
TRG_ER_diArg_1	355	357	PF00400	0.635
TRG_ER_diArg_1	389	391	PF00400	0.626
TRG_ER_diArg_1	402	404	PF00400	0.602
TRG_ER_diArg_1	587	589	PF00400	0.727
TRG_ER_diArg_1	600	603	PF00400	0.719
TRG_ER_diArg_1	685	687	PF00400	0.608
TRG_ER_diArg_1	717	720	PF00400	0.782
TRG_NES_CRM1_1	215	230	PF08389	0.486
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F9	Leptomonas seymouri	44%	96%
A0A3Q8IIZ4	Leishmania donovani	88%	100%
A4HK10	Leishmania braziliensis	68%	86%
A4I7J4	Leishmania infantum	88%	100%
E9B2F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%