Uracil-DNA glycosylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5Q3_LEIMA

TriTrypDb:

LmjF.32.0320 , LMJLV39_320008400 , LMJSD75_320008400

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.345
CLV_C14_Caspase3-7	51	55	PF00656	0.428
CLV_NRD_NRD_1	104	106	PF00675	0.522
CLV_NRD_NRD_1	108	110	PF00675	0.517
CLV_NRD_NRD_1	179	181	PF00675	0.485
CLV_NRD_NRD_1	202	204	PF00675	0.296
CLV_NRD_NRD_1	27	29	PF00675	0.510
CLV_PCSK_FUR_1	105	109	PF00082	0.527
CLV_PCSK_KEX2_1	104	106	PF00082	0.395
CLV_PCSK_KEX2_1	107	109	PF00082	0.427
CLV_PCSK_KEX2_1	179	181	PF00082	0.485
CLV_PCSK_KEX2_1	202	204	PF00082	0.296
CLV_PCSK_KEX2_1	27	29	PF00082	0.408
CLV_PCSK_KEX2_1	72	74	PF00082	0.471
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.485
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.471
CLV_PCSK_PC7_1	104	110	PF00082	0.379
CLV_PCSK_SKI1_1	128	132	PF00082	0.374
CLV_PCSK_SKI1_1	16	20	PF00082	0.492
DEG_Nend_UBRbox_2	1	3	PF02207	0.458
DOC_CYCLIN_RxL_1	209	223	PF00134	0.398
DOC_MAPK_FxFP_2	32	35	PF00069	0.345
DOC_MAPK_gen_1	224	232	PF00069	0.381
DOC_PP1_RVXF_1	14	20	PF00149	0.444
DOC_PP1_RVXF_1	26	33	PF00149	0.421
DOC_PP1_RVXF_1	85	92	PF00149	0.439
DOC_PP2B_LxvP_1	236	239	PF13499	0.480
DOC_PP4_FxxP_1	32	35	PF00568	0.345
DOC_PP4_FxxP_1	67	70	PF00568	0.554
DOC_USP7_MATH_1	211	215	PF00917	0.389
DOC_USP7_MATH_1	239	243	PF00917	0.551
DOC_USP7_MATH_1	61	65	PF00917	0.490
DOC_USP7_MATH_1	68	72	PF00917	0.495
DOC_USP7_UBL2_3	220	224	PF12436	0.382
DOC_WW_Pin1_4	131	136	PF00397	0.382
DOC_WW_Pin1_4	66	71	PF00397	0.589
LIG_14-3-3_CanoR_1	109	118	PF00244	0.593
LIG_14-3-3_CanoR_1	209	219	PF00244	0.411
LIG_BRCT_BRCA1_1	28	32	PF00533	0.471
LIG_BRCT_BRCA1_1	63	67	PF00533	0.556
LIG_deltaCOP1_diTrp_1	40	49	PF00928	0.334
LIG_FHA_1	122	128	PF00498	0.451
LIG_FHA_1	141	147	PF00498	0.381
LIG_FHA_1	78	84	PF00498	0.533
LIG_FHA_2	110	116	PF00498	0.509
LIG_FHA_2	161	167	PF00498	0.546
LIG_LIR_Apic_2	29	35	PF02991	0.380
LIG_LIR_Apic_2	64	70	PF02991	0.548
LIG_LIR_Nem_3	22	26	PF02991	0.350
LIG_LIR_Nem_3	40	45	PF02991	0.336
LIG_MAD2	16	24	PF02301	0.401
LIG_NRBOX	147	153	PF00104	0.346
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.365
LIG_Pex14_2	19	23	PF04695	0.339
LIG_SH2_CRK	182	186	PF00017	0.431
LIG_SH2_CRK	208	212	PF00017	0.343
LIG_SH2_NCK_1	182	186	PF00017	0.493
LIG_SH2_NCK_1	50	54	PF00017	0.413
LIG_SH2_SRC	50	53	PF00017	0.378
LIG_SH2_STAP1	57	61	PF00017	0.357
LIG_SH2_STAT5	57	60	PF00017	0.523
LIG_SH3_3	3	9	PF00018	0.406
LIG_SUMO_SIM_par_1	142	149	PF11976	0.349
MOD_CDC14_SPxK_1	69	72	PF00782	0.482
MOD_CDK_SPxK_1	66	72	PF00069	0.475
MOD_CDK_SPxxK_3	66	73	PF00069	0.529
MOD_CK1_1	113	119	PF00069	0.325
MOD_CK1_1	71	77	PF00069	0.545
MOD_CK2_1	113	119	PF00069	0.371
MOD_CK2_1	160	166	PF00069	0.471
MOD_Cter_Amidation	177	180	PF01082	0.497
MOD_GlcNHglycan	112	115	PF01048	0.514
MOD_GlcNHglycan	153	158	PF01048	0.394
MOD_GlcNHglycan	241	244	PF01048	0.591
MOD_GlcNHglycan	59	62	PF01048	0.481
MOD_GlcNHglycan	73	76	PF01048	0.606
MOD_GSK3_1	109	116	PF00069	0.395
MOD_GSK3_1	142	149	PF00069	0.352
MOD_GSK3_1	153	160	PF00069	0.410
MOD_GSK3_1	57	64	PF00069	0.517
MOD_NEK2_1	121	126	PF00069	0.385
MOD_NEK2_1	146	151	PF00069	0.347
MOD_NEK2_1	19	24	PF00069	0.413
MOD_NEK2_1	91	96	PF00069	0.347
MOD_NEK2_2	62	67	PF00069	0.462
MOD_PIKK_1	91	97	PF00454	0.424
MOD_PK_1	180	186	PF00069	0.365
MOD_PKA_1	180	186	PF00069	0.365
MOD_PKA_2	26	32	PF00069	0.472
MOD_PKB_1	107	115	PF00069	0.445
MOD_Plk_4	146	152	PF00069	0.345
MOD_Plk_4	157	163	PF00069	0.382
MOD_Plk_4	62	68	PF00069	0.564
MOD_ProDKin_1	131	137	PF00069	0.375
MOD_ProDKin_1	66	72	PF00069	0.593
MOD_SUMO_for_1	219	222	PF00179	0.398
TRG_ER_diArg_1	104	107	PF00400	0.405
TRG_ER_diArg_1	108	110	PF00400	0.441
TRG_ER_diArg_1	201	203	PF00400	0.280
TRG_ER_diArg_1	26	28	PF00400	0.395
TRG_NLS_MonoExtN_4	176	183	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV6	Leptomonas seymouri	55%	90%
A0A3S7X534	Leishmania donovani	91%	100%
A4HK12	Leishmania braziliensis	81%	78%
A4I7J6	Leishmania infantum	91%	100%
E9B2F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%