Uracil-DNA glycosylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q5Q3_LEIMA

TriTrypDb:

LmjF.32.0320 , LMJLV39_320008400 , LMJSD75_320008400

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	7
GO:0019104	DNA N-glycosylase activity	4	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.345
CLV_C14_Caspase3-7	51	55	PF00656	0.428
CLV_NRD_NRD_1	104	106	PF00675	0.522
CLV_NRD_NRD_1	108	110	PF00675	0.517
CLV_NRD_NRD_1	179	181	PF00675	0.485
CLV_NRD_NRD_1	202	204	PF00675	0.296
CLV_NRD_NRD_1	27	29	PF00675	0.510
CLV_PCSK_FUR_1	105	109	PF00082	0.527
CLV_PCSK_KEX2_1	104	106	PF00082	0.395
CLV_PCSK_KEX2_1	107	109	PF00082	0.427

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV6	Leptomonas seymouri	55%	90%
A0A3S7X534	Leishmania donovani	91%	100%
A4HK12	Leishmania braziliensis	81%	78%
A4I7J6	Leishmania infantum	91%	100%
E9B2F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%

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