Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5Q1_LEIMA

TriTrypDb:

LmjF.32.0340 , LMJLV39_320008600 , LMJSD75_320008600

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.664
CLV_C14_Caspase3-7	151	155	PF00656	0.444
CLV_NRD_NRD_1	133	135	PF00675	0.587
CLV_NRD_NRD_1	162	164	PF00675	0.628
CLV_NRD_NRD_1	181	183	PF00675	0.282
CLV_NRD_NRD_1	46	48	PF00675	0.455
CLV_NRD_NRD_1	462	464	PF00675	0.799
CLV_NRD_NRD_1	488	490	PF00675	0.647
CLV_NRD_NRD_1	538	540	PF00675	0.757
CLV_NRD_NRD_1	612	614	PF00675	0.721
CLV_PCSK_FUR_1	179	183	PF00082	0.523
CLV_PCSK_KEX2_1	133	135	PF00082	0.587
CLV_PCSK_KEX2_1	162	164	PF00082	0.639
CLV_PCSK_KEX2_1	181	183	PF00082	0.302
CLV_PCSK_KEX2_1	46	48	PF00082	0.455
CLV_PCSK_KEX2_1	490	492	PF00082	0.632
CLV_PCSK_KEX2_1	538	540	PF00082	0.757
CLV_PCSK_PC1ET2_1	490	492	PF00082	0.745
CLV_PCSK_SKI1_1	196	200	PF00082	0.503
CLV_PCSK_SKI1_1	311	315	PF00082	0.493
CLV_PCSK_SKI1_1	463	467	PF00082	0.798
CLV_Separin_Metazoa	125	129	PF03568	0.624
CLV_Separin_Metazoa	460	464	PF03568	0.596
DEG_COP1_1	60	71	PF00400	0.609
DEG_SCF_FBW7_1	465	472	PF00400	0.735
DEG_SCF_FBW7_2	544	551	PF00400	0.587
DEG_SPOP_SBC_1	205	209	PF00917	0.638
DEG_SPOP_SBC_1	573	577	PF00917	0.767
DOC_CKS1_1	276	281	PF01111	0.675
DOC_CKS1_1	466	471	PF01111	0.755
DOC_CYCLIN_RxL_1	308	317	PF00134	0.502
DOC_CYCLIN_RxL_1	460	468	PF00134	0.560
DOC_MAPK_gen_1	179	189	PF00069	0.565
DOC_MAPK_MEF2A_6	182	191	PF00069	0.555
DOC_PP4_FxxP_1	466	469	PF00568	0.799
DOC_USP7_MATH_1	205	209	PF00917	0.597
DOC_USP7_MATH_1	367	371	PF00917	0.717
DOC_USP7_MATH_1	372	376	PF00917	0.720
DOC_USP7_MATH_1	407	411	PF00917	0.702
DOC_USP7_MATH_1	513	517	PF00917	0.719
DOC_USP7_MATH_1	526	530	PF00917	0.563
DOC_USP7_MATH_1	53	57	PF00917	0.729
DOC_USP7_MATH_1	555	559	PF00917	0.808
DOC_USP7_MATH_1	567	571	PF00917	0.703
DOC_USP7_MATH_1	573	577	PF00917	0.676
DOC_USP7_MATH_1	584	588	PF00917	0.671
DOC_USP7_MATH_1	594	598	PF00917	0.770
DOC_USP7_MATH_1	89	93	PF00917	0.630
DOC_WW_Pin1_4	140	145	PF00397	0.660
DOC_WW_Pin1_4	275	280	PF00397	0.653
DOC_WW_Pin1_4	424	429	PF00397	0.781
DOC_WW_Pin1_4	433	438	PF00397	0.654
DOC_WW_Pin1_4	465	470	PF00397	0.681
DOC_WW_Pin1_4	531	536	PF00397	0.752
DOC_WW_Pin1_4	544	549	PF00397	0.591
DOC_WW_Pin1_4	601	606	PF00397	0.633
LIG_14-3-3_CanoR_1	114	123	PF00244	0.664
LIG_14-3-3_CanoR_1	166	172	PF00244	0.491
LIG_14-3-3_CanoR_1	182	188	PF00244	0.326
LIG_14-3-3_CanoR_1	250	258	PF00244	0.478
LIG_14-3-3_CanoR_1	360	364	PF00244	0.698
LIG_14-3-3_CanoR_1	432	440	PF00244	0.709
LIG_14-3-3_CanoR_1	448	452	PF00244	0.697
LIG_14-3-3_CanoR_1	491	496	PF00244	0.750
LIG_14-3-3_CanoR_1	538	544	PF00244	0.823
LIG_14-3-3_CanoR_1	600	605	PF00244	0.718
LIG_Actin_WH2_2	32	48	PF00022	0.400
LIG_BIR_II_1	1	5	PF00653	0.464
LIG_BIR_III_1	1	5	PF00653	0.464
LIG_BIR_III_3	1	5	PF00653	0.464
LIG_BRCT_BRCA1_1	24	28	PF00533	0.694
LIG_BRCT_BRCA1_1	407	411	PF00533	0.754
LIG_EVH1_1	466	470	PF00568	0.802
LIG_FHA_1	159	165	PF00498	0.618
LIG_FHA_1	258	264	PF00498	0.486
LIG_FHA_1	440	446	PF00498	0.718
LIG_FHA_1	62	68	PF00498	0.636
LIG_FHA_2	120	126	PF00498	0.633
LIG_FHA_2	170	176	PF00498	0.483
LIG_FHA_2	235	241	PF00498	0.569
LIG_FHA_2	336	342	PF00498	0.571
LIG_FHA_2	372	378	PF00498	0.641
LIG_FHA_2	518	524	PF00498	0.672
LIG_KLC1_Yacidic_2	332	337	PF13176	0.554
LIG_LIR_Apic_2	20	24	PF02991	0.700
LIG_LIR_Apic_2	273	279	PF02991	0.630
LIG_LIR_Apic_2	361	366	PF02991	0.717
LIG_LIR_Gen_1	122	131	PF02991	0.682
LIG_LIR_Gen_1	25	36	PF02991	0.509
LIG_LIR_Gen_1	281	290	PF02991	0.477
LIG_LIR_Gen_1	317	327	PF02991	0.415
LIG_LIR_Gen_1	519	528	PF02991	0.711
LIG_LIR_Nem_3	122	126	PF02991	0.686
LIG_LIR_Nem_3	25	31	PF02991	0.548
LIG_LIR_Nem_3	317	322	PF02991	0.421
LIG_LIR_Nem_3	328	334	PF02991	0.432
LIG_LIR_Nem_3	519	524	PF02991	0.735
LIG_Pex14_1	325	329	PF04695	0.529
LIG_Pex14_2	319	323	PF04695	0.436
LIG_RPA_C_Fungi	73	85	PF08784	0.553
LIG_SH2_CRK	21	25	PF00017	0.662
LIG_SH2_CRK	363	367	PF00017	0.744
LIG_SH2_NCK_1	21	25	PF00017	0.662
LIG_SH2_NCK_1	276	280	PF00017	0.667
LIG_SH2_NCK_1	363	367	PF00017	0.627
LIG_SH2_SRC	192	195	PF00017	0.567
LIG_SH2_SRC	21	24	PF00017	0.746
LIG_SH2_STAP1	331	335	PF00017	0.516
LIG_SH2_STAT5	329	332	PF00017	0.545
LIG_SH2_STAT5	335	338	PF00017	0.579
LIG_SH3_1	464	470	PF00018	0.757
LIG_SH3_1	614	620	PF00018	0.755
LIG_SH3_3	398	404	PF00018	0.720
LIG_SH3_3	416	422	PF00018	0.577
LIG_SH3_3	434	440	PF00018	0.492
LIG_SH3_3	464	470	PF00018	0.713
LIG_SH3_3	499	505	PF00018	0.739
LIG_SH3_3	576	582	PF00018	0.743
LIG_SH3_3	614	620	PF00018	0.783
LIG_SH3_4	614	621	PF00018	0.670
LIG_SUMO_SIM_par_1	254	260	PF11976	0.560
LIG_TRAF2_1	122	125	PF00917	0.695
LIG_TRAF2_1	375	378	PF00917	0.701
LIG_TRFH_1	411	415	PF08558	0.558
LIG_WRC_WIRS_1	319	324	PF05994	0.427
MOD_CDK_SPK_2	601	606	PF00069	0.585
MOD_CDK_SPxxK_3	531	538	PF00069	0.756
MOD_CK1_1	17	23	PF00069	0.673
MOD_CK1_1	257	263	PF00069	0.540
MOD_CK1_1	303	309	PF00069	0.520
MOD_CK1_1	361	367	PF00069	0.540
MOD_CK1_1	450	456	PF00069	0.724
MOD_CK1_1	516	522	PF00069	0.768
MOD_CK1_1	533	539	PF00069	0.738
MOD_CK1_1	599	605	PF00069	0.764
MOD_CK1_1	6	12	PF00069	0.744
MOD_CK1_1	61	67	PF00069	0.690
MOD_CK2_1	119	125	PF00069	0.593
MOD_CK2_1	169	175	PF00069	0.465
MOD_CK2_1	234	240	PF00069	0.550
MOD_CK2_1	314	320	PF00069	0.461
MOD_CK2_1	335	341	PF00069	0.710
MOD_CK2_1	371	377	PF00069	0.776
MOD_CK2_1	517	523	PF00069	0.766
MOD_GlcNHglycan	104	107	PF01048	0.524
MOD_GlcNHglycan	16	19	PF01048	0.526
MOD_GlcNHglycan	251	254	PF01048	0.537
MOD_GlcNHglycan	316	319	PF01048	0.569
MOD_GlcNHglycan	369	372	PF01048	0.693
MOD_GlcNHglycan	373	377	PF01048	0.696
MOD_GlcNHglycan	381	384	PF01048	0.675
MOD_GlcNHglycan	387	390	PF01048	0.602
MOD_GlcNHglycan	405	408	PF01048	0.676
MOD_GlcNHglycan	453	456	PF01048	0.720
MOD_GlcNHglycan	457	460	PF01048	0.668
MOD_GlcNHglycan	471	474	PF01048	0.611
MOD_GlcNHglycan	511	514	PF01048	0.763
MOD_GlcNHglycan	523	527	PF01048	0.595
MOD_GlcNHglycan	528	531	PF01048	0.535
MOD_GlcNHglycan	54	58	PF01048	0.779
MOD_GlcNHglycan	585	589	PF01048	0.708
MOD_GlcNHglycan	60	63	PF01048	0.732
MOD_GlcNHglycan	86	89	PF01048	0.580
MOD_GlcNHglycan	91	94	PF01048	0.591
MOD_GSK3_1	129	136	PF00069	0.719
MOD_GSK3_1	303	310	PF00069	0.475
MOD_GSK3_1	314	321	PF00069	0.528
MOD_GSK3_1	367	374	PF00069	0.654
MOD_GSK3_1	403	410	PF00069	0.597
MOD_GSK3_1	420	427	PF00069	0.740
MOD_GSK3_1	447	454	PF00069	0.697
MOD_GSK3_1	465	472	PF00069	0.657
MOD_GSK3_1	509	516	PF00069	0.731
MOD_GSK3_1	522	529	PF00069	0.632
MOD_GSK3_1	53	60	PF00069	0.777
MOD_GSK3_1	533	540	PF00069	0.755
MOD_GSK3_1	550	557	PF00069	0.671
MOD_GSK3_1	596	603	PF00069	0.729
MOD_GSK3_1	6	13	PF00069	0.668
MOD_GSK3_1	80	87	PF00069	0.505
MOD_GSK3_1	89	96	PF00069	0.527
MOD_GSK3_1	98	105	PF00069	0.481
MOD_N-GLC_1	480	485	PF02516	0.819
MOD_NEK2_1	167	172	PF00069	0.576
MOD_NEK2_1	183	188	PF00069	0.473
MOD_NEK2_1	234	239	PF00069	0.409
MOD_NEK2_1	314	319	PF00069	0.412
MOD_NEK2_1	358	363	PF00069	0.624
MOD_NEK2_1	396	401	PF00069	0.684
MOD_NEK2_1	451	456	PF00069	0.678
MOD_NEK2_1	480	485	PF00069	0.819
MOD_NEK2_1	511	516	PF00069	0.734
MOD_NEK2_1	517	522	PF00069	0.673
MOD_NEK2_1	524	529	PF00069	0.628
MOD_NEK2_2	318	323	PF00069	0.543
MOD_PIKK_1	533	539	PF00454	0.594
MOD_PKA_1	133	139	PF00069	0.739
MOD_PKA_1	490	496	PF00069	0.814
MOD_PKA_2	133	139	PF00069	0.739
MOD_PKA_2	249	255	PF00069	0.477
MOD_PKA_2	359	365	PF00069	0.639
MOD_PKA_2	379	385	PF00069	0.465
MOD_PKA_2	431	437	PF00069	0.720
MOD_PKA_2	447	453	PF00069	0.681
MOD_PKA_2	455	461	PF00069	0.737
MOD_PKA_2	490	496	PF00069	0.825
MOD_PKA_2	537	543	PF00069	0.823
MOD_PKA_2	58	64	PF00069	0.550
MOD_PKA_2	599	605	PF00069	0.814
MOD_PKB_1	489	497	PF00069	0.740
MOD_Plk_1	99	105	PF00069	0.699
MOD_Plk_4	254	260	PF00069	0.560
MOD_Plk_4	300	306	PF00069	0.600
MOD_Plk_4	318	324	PF00069	0.319
MOD_Plk_4	391	397	PF00069	0.727
MOD_Plk_4	447	453	PF00069	0.756
MOD_ProDKin_1	140	146	PF00069	0.662
MOD_ProDKin_1	275	281	PF00069	0.662
MOD_ProDKin_1	424	430	PF00069	0.781
MOD_ProDKin_1	433	439	PF00069	0.651
MOD_ProDKin_1	465	471	PF00069	0.682
MOD_ProDKin_1	531	537	PF00069	0.753
MOD_ProDKin_1	544	550	PF00069	0.588
MOD_ProDKin_1	601	607	PF00069	0.640
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.417
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.742
TRG_ENDOCYTIC_2	244	247	PF00928	0.576
TRG_ENDOCYTIC_2	282	285	PF00928	0.467
TRG_ER_diArg_1	162	164	PF00400	0.603
TRG_ER_diArg_1	181	183	PF00400	0.285
TRG_ER_diArg_1	45	47	PF00400	0.445
TRG_ER_diArg_1	488	491	PF00400	0.647
TRG_NLS_MonoCore_2	488	493	PF00514	0.669
TRG_NLS_MonoCore_2	612	617	PF00514	0.647
TRG_NLS_MonoExtC_3	612	617	PF00514	0.700
TRG_NLS_MonoExtN_4	487	494	PF00514	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IT10	Leishmania donovani	86%	70%
A0A3R7N1Q3	Trypanosoma rangeli	27%	72%
A4HK14	Leishmania braziliensis	66%	70%
A4I7J8	Leishmania infantum	86%	78%
D0A0A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	72%
E9B2F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	96%
V5C1Q2	Trypanosoma cruzi	28%	73%