Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5Q0_LEIMA

TriTrypDb:

LmjF.32.0350 , LMJLV39_320008700 , LMJSD75_320008700

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q5Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5Q0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.542
CLV_NRD_NRD_1	100	102	PF00675	0.361
CLV_NRD_NRD_1	126	128	PF00675	0.476
CLV_NRD_NRD_1	83	85	PF00675	0.609
CLV_PCSK_KEX2_1	126	128	PF00082	0.516
CLV_PCSK_KEX2_1	440	442	PF00082	0.526
CLV_PCSK_KEX2_1	454	456	PF00082	0.420
CLV_PCSK_KEX2_1	82	84	PF00082	0.633
CLV_PCSK_KEX2_1	99	101	PF00082	0.379
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.509
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.555
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.633
CLV_PCSK_SKI1_1	126	130	PF00082	0.627
CLV_PCSK_SKI1_1	370	374	PF00082	0.659
CLV_PCSK_SKI1_1	385	389	PF00082	0.635
CLV_PCSK_SKI1_1	463	467	PF00082	0.518
CLV_PCSK_SKI1_1	59	63	PF00082	0.521
CLV_PCSK_SKI1_1	84	88	PF00082	0.517
DEG_APCC_DBOX_1	100	108	PF00400	0.463
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DOC_MAPK_gen_1	123	131	PF00069	0.508
DOC_MAPK_gen_1	379	389	PF00069	0.652
DOC_MAPK_gen_1	82	91	PF00069	0.609
DOC_MAPK_gen_1	99	110	PF00069	0.383
DOC_PP2B_LxvP_1	129	132	PF13499	0.559
DOC_USP7_MATH_1	194	198	PF00917	0.651
DOC_USP7_MATH_1	251	255	PF00917	0.660
DOC_USP7_MATH_1	26	30	PF00917	0.605
DOC_USP7_MATH_1	292	296	PF00917	0.732
DOC_USP7_MATH_1	317	321	PF00917	0.651
DOC_USP7_MATH_1	391	395	PF00917	0.631
DOC_USP7_MATH_1	40	44	PF00917	0.579
DOC_USP7_MATH_1	461	465	PF00917	0.648
DOC_USP7_UBL2_3	450	454	PF12436	0.564
DOC_USP7_UBL2_3	66	70	PF12436	0.519
DOC_WW_Pin1_4	143	148	PF00397	0.717
DOC_WW_Pin1_4	165	170	PF00397	0.698
DOC_WW_Pin1_4	247	252	PF00397	0.564
DOC_WW_Pin1_4	370	375	PF00397	0.664
LIG_14-3-3_CanoR_1	11	15	PF00244	0.559
LIG_14-3-3_CanoR_1	161	169	PF00244	0.716
LIG_14-3-3_CanoR_1	172	179	PF00244	0.612
LIG_14-3-3_CanoR_1	300	305	PF00244	0.669
LIG_14-3-3_CanoR_1	335	341	PF00244	0.708
LIG_BRCT_BRCA1_1	253	257	PF00533	0.614
LIG_BRCT_BRCA1_1	280	284	PF00533	0.567
LIG_BRCT_BRCA1_1	332	336	PF00533	0.707
LIG_Clathr_ClatBox_1	107	111	PF01394	0.473
LIG_eIF4E_1	207	213	PF01652	0.450
LIG_FHA_1	258	264	PF00498	0.653
LIG_FHA_1	309	315	PF00498	0.641
LIG_FHA_1	358	364	PF00498	0.645
LIG_FHA_1	384	390	PF00498	0.654
LIG_FHA_2	274	280	PF00498	0.557
LIG_FHA_2	347	353	PF00498	0.538
LIG_FHA_2	429	435	PF00498	0.501
LIG_LIR_Gen_1	29	37	PF02991	0.471
LIG_LIR_Nem_3	359	364	PF02991	0.554
LIG_PAM2_1	22	34	PF00658	0.486
LIG_PDZ_Class_2	465	470	PF00595	0.518
LIG_Pex14_2	336	340	PF04695	0.710
LIG_SH2_STAP1	421	425	PF00017	0.537
LIG_SH2_STAP1	457	461	PF00017	0.478
LIG_SH2_STAT3	14	17	PF00017	0.575
LIG_SH2_STAT5	14	17	PF00017	0.416
LIG_SH2_STAT5	9	12	PF00017	0.419
LIG_SH3_3	260	266	PF00018	0.608
LIG_SH3_3	311	317	PF00018	0.581
LIG_SH3_3	413	419	PF00018	0.640
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.431
LIG_SUMO_SIM_par_1	106	111	PF11976	0.469
LIG_TRAF2_1	132	135	PF00917	0.581
LIG_TRAF2_1	349	352	PF00917	0.610
MOD_CDK_SPxxK_3	165	172	PF00069	0.741
MOD_CK1_1	146	152	PF00069	0.711
MOD_CK1_1	154	160	PF00069	0.722
MOD_CK1_1	171	177	PF00069	0.445
MOD_CK1_1	299	305	PF00069	0.753
MOD_CK1_1	346	352	PF00069	0.623
MOD_CK1_1	394	400	PF00069	0.643
MOD_CK2_1	150	156	PF00069	0.697
MOD_CK2_1	273	279	PF00069	0.540
MOD_CK2_1	346	352	PF00069	0.615
MOD_CK2_1	390	396	PF00069	0.769
MOD_CK2_1	40	46	PF00069	0.419
MOD_GlcNHglycan	139	142	PF01048	0.746
MOD_GlcNHglycan	163	166	PF01048	0.634
MOD_GlcNHglycan	173	176	PF01048	0.435
MOD_GlcNHglycan	247	250	PF01048	0.628
MOD_GlcNHglycan	279	283	PF01048	0.687
MOD_GlcNHglycan	294	297	PF01048	0.621
MOD_GlcNHglycan	326	329	PF01048	0.755
MOD_GlcNHglycan	345	348	PF01048	0.733
MOD_GlcNHglycan	423	426	PF01048	0.546
MOD_GlcNHglycan	463	466	PF01048	0.514
MOD_GSK3_1	137	144	PF00069	0.777
MOD_GSK3_1	146	153	PF00069	0.676
MOD_GSK3_1	161	168	PF00069	0.714
MOD_GSK3_1	195	202	PF00069	0.561
MOD_GSK3_1	247	254	PF00069	0.603
MOD_GSK3_1	292	299	PF00069	0.594
MOD_GSK3_1	390	397	PF00069	0.696
MOD_GSK3_1	417	424	PF00069	0.558
MOD_GSK3_1	457	464	PF00069	0.570
MOD_GSK3_1	48	55	PF00069	0.441
MOD_N-GLC_1	284	289	PF02516	0.719
MOD_N-GLC_1	394	399	PF02516	0.659
MOD_NEK2_1	212	217	PF00069	0.503
MOD_NEK2_1	257	262	PF00069	0.510
MOD_NEK2_1	284	289	PF00069	0.676
MOD_NEK2_1	336	341	PF00069	0.620
MOD_NEK2_1	427	432	PF00069	0.505
MOD_NEK2_1	52	57	PF00069	0.460
MOD_NEK2_1	61	66	PF00069	0.485
MOD_NEK2_1	77	82	PF00069	0.508
MOD_NEK2_2	383	388	PF00069	0.603
MOD_NEK2_2	48	53	PF00069	0.484
MOD_PIKK_1	212	218	PF00454	0.561
MOD_PIKK_1	273	279	PF00454	0.750
MOD_PKA_1	217	223	PF00069	0.534
MOD_PKA_2	10	16	PF00069	0.558
MOD_PKA_2	150	156	PF00069	0.772
MOD_PKA_2	160	166	PF00069	0.677
MOD_PKA_2	171	177	PF00069	0.617
MOD_PKA_2	299	305	PF00069	0.721
MOD_PKA_2	336	342	PF00069	0.692
MOD_Plk_1	20	26	PF00069	0.683
MOD_Plk_1	284	290	PF00069	0.558
MOD_Plk_1	394	400	PF00069	0.647
MOD_Plk_4	26	32	PF00069	0.565
MOD_ProDKin_1	143	149	PF00069	0.717
MOD_ProDKin_1	165	171	PF00069	0.693
MOD_ProDKin_1	247	253	PF00069	0.564
MOD_ProDKin_1	370	376	PF00069	0.665
MOD_SUMO_rev_2	434	442	PF00179	0.609
MOD_SUMO_rev_2	79	89	PF00179	0.626
TRG_DiLeu_BaEn_4	124	130	PF01217	0.668
TRG_ER_diArg_1	98	101	PF00400	0.498
TRG_NLS_MonoExtC_3	216	221	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE29	Leptomonas seymouri	67%	99%
A0A1X0P7K1	Trypanosomatidae	36%	100%
A0A3Q8ICW8	Leishmania donovani	96%	100%
A0A3R7NTG2	Trypanosoma rangeli	35%	100%
A4HK15	Leishmania braziliensis	82%	100%
A4I7J9	Leishmania infantum	96%	100%
D0A0A1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B2F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BS76	Trypanosoma cruzi	35%	100%