Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5P9_LEIMA

TriTrypDb:

LmjF.32.0360 , LMJLV39_320008800 , LMJSD75_320008800

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030990	intraciliary transport particle	2	2
GO:0032991	protein-containing complex	1	2

Expansion

Sequence features

Q4Q5P9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5P9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.659
CLV_NRD_NRD_1	18	20	PF00675	0.417
CLV_NRD_NRD_1	236	238	PF00675	0.572
CLV_NRD_NRD_1	249	251	PF00675	0.508
CLV_PCSK_FUR_1	149	153	PF00082	0.589
CLV_PCSK_KEX2_1	151	153	PF00082	0.645
CLV_PCSK_KEX2_1	18	20	PF00082	0.419
CLV_PCSK_KEX2_1	249	251	PF00082	0.629
CLV_PCSK_KEX2_1	340	342	PF00082	0.678
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.641
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.678
CLV_PCSK_SKI1_1	152	156	PF00082	0.660
CLV_PCSK_SKI1_1	237	241	PF00082	0.589
CLV_PCSK_SKI1_1	249	253	PF00082	0.507
DEG_APCC_DBOX_1	248	256	PF00400	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.552
DOC_ANK_TNKS_1	94	101	PF00023	0.619
DOC_CYCLIN_RxL_1	128	136	PF00134	0.446
DOC_USP7_MATH_1	284	288	PF00917	0.632
DOC_USP7_MATH_1	313	317	PF00917	0.680
DOC_USP7_MATH_1	99	103	PF00917	0.697
DOC_WW_Pin1_4	153	158	PF00397	0.676
DOC_WW_Pin1_4	343	348	PF00397	0.651
LIG_14-3-3_CanoR_1	140	146	PF00244	0.481
LIG_14-3-3_CanoR_1	152	157	PF00244	0.551
LIG_14-3-3_CanoR_1	18	22	PF00244	0.435
LIG_14-3-3_CanoR_1	237	244	PF00244	0.611
LIG_14-3-3_CanoR_1	293	297	PF00244	0.598
LIG_14-3-3_CanoR_1	90	99	PF00244	0.790
LIG_Clathr_ClatBox_1	132	136	PF01394	0.446
LIG_CSL_BTD_1	305	308	PF09270	0.638
LIG_FHA_2	202	208	PF00498	0.498
LIG_FHA_2	230	236	PF00498	0.488
LIG_LIR_Apic_2	294	299	PF02991	0.634
LIG_LIR_Apic_2	60	66	PF02991	0.644
LIG_LIR_LC3C_4	323	328	PF02991	0.621
LIG_MYND_1	343	347	PF01753	0.562
LIG_NRBOX	128	134	PF00104	0.421
LIG_NRBOX	251	257	PF00104	0.592
LIG_PTAP_UEV_1	307	312	PF05743	0.565
LIG_SH2_SRC	296	299	PF00017	0.600
LIG_SH2_STAT3	5	8	PF00017	0.556
LIG_SH2_STAT5	169	172	PF00017	0.666
LIG_SH2_STAT5	87	90	PF00017	0.583
LIG_SH3_3	213	219	PF00018	0.589
LIG_SH3_3	302	308	PF00018	0.693
LIG_SH3_3	58	64	PF00018	0.620
LIG_SUMO_SIM_par_1	130	136	PF11976	0.446
LIG_UBA3_1	132	138	PF00899	0.449
LIG_WRC_WIRS_1	56	61	PF05994	0.602
MOD_CDK_SPxxK_3	153	160	PF00069	0.489
MOD_CK1_1	156	162	PF00069	0.668
MOD_CK1_1	17	23	PF00069	0.442
MOD_CK1_1	201	207	PF00069	0.477
MOD_CK1_1	316	322	PF00069	0.710
MOD_CK2_1	107	113	PF00069	0.571
MOD_CK2_1	180	186	PF00069	0.750
MOD_CK2_1	201	207	PF00069	0.502
MOD_CK2_1	275	281	PF00069	0.705
MOD_GlcNHglycan	170	173	PF01048	0.621
MOD_GlcNHglycan	180	183	PF01048	0.665
MOD_GlcNHglycan	200	203	PF01048	0.638
MOD_GlcNHglycan	277	280	PF01048	0.649
MOD_GlcNHglycan	311	314	PF01048	0.638
MOD_GlcNHglycan	337	340	PF01048	0.677
MOD_GlcNHglycan	35	38	PF01048	0.613
MOD_GlcNHglycan	50	53	PF01048	0.547
MOD_GSK3_1	107	114	PF00069	0.667
MOD_GSK3_1	152	159	PF00069	0.633
MOD_GSK3_1	178	185	PF00069	0.621
MOD_GSK3_1	194	201	PF00069	0.491
MOD_GSK3_1	309	316	PF00069	0.689
MOD_GSK3_1	85	92	PF00069	0.644
MOD_N-GLC_1	107	112	PF02516	0.641
MOD_N-GLC_1	152	157	PF02516	0.620
MOD_N-GLC_1	67	72	PF02516	0.497
MOD_N-GLC_1	90	95	PF02516	0.688
MOD_N-GLC_2	42	44	PF02516	0.550
MOD_N-GLC_2	45	47	PF02516	0.540
MOD_NEK2_1	1	6	PF00069	0.540
MOD_NEK2_1	14	19	PF00069	0.340
MOD_NEK2_1	178	183	PF00069	0.697
MOD_NEK2_1	26	31	PF00069	0.462
MOD_NEK2_1	285	290	PF00069	0.667
MOD_NEK2_1	33	38	PF00069	0.473
MOD_NEK2_1	72	77	PF00069	0.541
MOD_NEK2_2	107	112	PF00069	0.634
MOD_PIKK_1	138	144	PF00454	0.573
MOD_PIKK_1	26	32	PF00454	0.533
MOD_PIKK_1	313	319	PF00454	0.762
MOD_PIKK_1	99	105	PF00454	0.619
MOD_PKA_1	237	243	PF00069	0.578
MOD_PKA_2	17	23	PF00069	0.455
MOD_PKA_2	292	298	PF00069	0.632
MOD_PKA_2	89	95	PF00069	0.608
MOD_Plk_1	67	73	PF00069	0.602
MOD_Plk_4	194	200	PF00069	0.529
MOD_ProDKin_1	153	159	PF00069	0.679
MOD_ProDKin_1	343	349	PF00069	0.653
MOD_SUMO_rev_2	130	139	PF00179	0.424
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.421
TRG_NES_CRM1_1	125	136	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J4	Leptomonas seymouri	59%	98%
A0A1X0P6Q1	Trypanosomatidae	36%	86%
A0A3Q8IGR0	Leishmania donovani	94%	100%
A0A3R7RRK4	Trypanosoma rangeli	36%	92%
A4HK16	Leishmania braziliensis	78%	100%
A4I7K0	Leishmania infantum	95%	100%
D0A0A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B2F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%