TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5P4_LEIMA

TriTrypDb:

LmjF.32.0410 , LMJLV39_320009300 , LMJSD75_320009300

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	730	734	PF00656	0.605
CLV_NRD_NRD_1	182	184	PF00675	0.409
CLV_NRD_NRD_1	372	374	PF00675	0.527
CLV_NRD_NRD_1	397	399	PF00675	0.495
CLV_NRD_NRD_1	459	461	PF00675	0.409
CLV_NRD_NRD_1	51	53	PF00675	0.555
CLV_NRD_NRD_1	517	519	PF00675	0.493
CLV_NRD_NRD_1	673	675	PF00675	0.682
CLV_NRD_NRD_1	756	758	PF00675	0.677
CLV_NRD_NRD_1	94	96	PF00675	0.636
CLV_PCSK_KEX2_1	182	184	PF00082	0.424
CLV_PCSK_KEX2_1	372	374	PF00082	0.527
CLV_PCSK_KEX2_1	397	399	PF00082	0.495
CLV_PCSK_KEX2_1	459	461	PF00082	0.409
CLV_PCSK_KEX2_1	517	519	PF00082	0.493
CLV_PCSK_KEX2_1	53	55	PF00082	0.559
CLV_PCSK_KEX2_1	57	59	PF00082	0.506
CLV_PCSK_KEX2_1	673	675	PF00082	0.699
CLV_PCSK_KEX2_1	756	758	PF00082	0.620
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.672
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.620
CLV_PCSK_SKI1_1	152	156	PF00082	0.599
CLV_PCSK_SKI1_1	198	202	PF00082	0.483
CLV_PCSK_SKI1_1	237	241	PF00082	0.469
CLV_PCSK_SKI1_1	482	486	PF00082	0.527
CLV_PCSK_SKI1_1	54	58	PF00082	0.619
CLV_PCSK_SKI1_1	655	659	PF00082	0.614
CLV_PCSK_SKI1_1	674	678	PF00082	0.620
CLV_Separin_Metazoa	179	183	PF03568	0.488
CLV_Separin_Metazoa	332	336	PF03568	0.500
DEG_APCC_DBOX_1	151	159	PF00400	0.595
DEG_APCC_DBOX_1	265	273	PF00400	0.514
DEG_COP1_1	561	571	PF00400	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.752
DEG_SPOP_SBC_1	357	361	PF00917	0.540
DOC_CDC14_PxL_1	303	311	PF14671	0.650
DOC_CKS1_1	509	514	PF01111	0.534
DOC_CYCLIN_RxL_1	266	278	PF00134	0.502
DOC_MAPK_gen_1	182	189	PF00069	0.473
DOC_MAPK_gen_1	479	488	PF00069	0.468
DOC_MAPK_MEF2A_6	482	490	PF00069	0.425
DOC_PP4_FxxP_1	33	36	PF00568	0.708
DOC_PP4_FxxP_1	648	651	PF00568	0.628
DOC_PP4_FxxP_1	699	702	PF00568	0.665
DOC_USP7_MATH_1	103	107	PF00917	0.577
DOC_USP7_MATH_1	171	175	PF00917	0.565
DOC_USP7_MATH_1	308	312	PF00917	0.671
DOC_USP7_MATH_1	315	319	PF00917	0.678
DOC_USP7_MATH_1	489	493	PF00917	0.566
DOC_USP7_MATH_1	675	679	PF00917	0.743
DOC_USP7_MATH_1	91	95	PF00917	0.633
DOC_USP7_UBL2_3	53	57	PF12436	0.585
DOC_WW_Pin1_4	31	36	PF00397	0.774
DOC_WW_Pin1_4	508	513	PF00397	0.543
DOC_WW_Pin1_4	9	14	PF00397	0.773
LIG_14-3-3_CanoR_1	218	225	PF00244	0.457
LIG_14-3-3_CanoR_1	295	303	PF00244	0.671
LIG_14-3-3_CanoR_1	372	381	PF00244	0.558
LIG_14-3-3_CanoR_1	397	401	PF00244	0.496
LIG_14-3-3_CanoR_1	459	464	PF00244	0.392
LIG_14-3-3_CanoR_1	531	535	PF00244	0.524
LIG_14-3-3_CanoR_1	655	661	PF00244	0.610
LIG_APCC_ABBAyCdc20_2	466	472	PF00400	0.493
LIG_BIR_III_4	17	21	PF00653	0.701
LIG_BRCT_BRCA1_1	460	464	PF00533	0.531
LIG_deltaCOP1_diTrp_1	476	484	PF00928	0.521
LIG_deltaCOP1_diTrp_1	61	68	PF00928	0.616
LIG_EH1_1	575	583	PF00400	0.451
LIG_FHA_1	184	190	PF00498	0.474
LIG_FHA_1	292	298	PF00498	0.620
LIG_FHA_1	358	364	PF00498	0.608
LIG_FHA_1	483	489	PF00498	0.432
LIG_FHA_1	563	569	PF00498	0.655
LIG_FHA_1	620	626	PF00498	0.570
LIG_FHA_1	657	663	PF00498	0.589
LIG_FHA_2	118	124	PF00498	0.488
LIG_FHA_2	362	368	PF00498	0.547
LIG_FHA_2	453	459	PF00498	0.551
LIG_FHA_2	559	565	PF00498	0.650
LIG_FHA_2	77	83	PF00498	0.616
LIG_GBD_Chelix_1	407	415	PF00786	0.501
LIG_GBD_Chelix_1	625	633	PF00786	0.529
LIG_Integrin_RGD_1	164	166	PF01839	0.497
LIG_LIR_Apic_2	508	512	PF02991	0.508
LIG_LIR_Apic_2	645	651	PF02991	0.628
LIG_LIR_Apic_2	697	702	PF02991	0.699
LIG_LIR_Apic_2	70	74	PF02991	0.686
LIG_LIR_Gen_1	236	246	PF02991	0.533
LIG_LIR_Gen_1	483	491	PF02991	0.494
LIG_LIR_Gen_1	545	555	PF02991	0.392
LIG_LIR_Gen_1	61	71	PF02991	0.423
LIG_LIR_Gen_1	627	638	PF02991	0.472
LIG_LIR_Gen_1	710	721	PF02991	0.498
LIG_LIR_Gen_1	722	732	PF02991	0.458
LIG_LIR_Nem_3	230	235	PF02991	0.388
LIG_LIR_Nem_3	343	349	PF02991	0.402
LIG_LIR_Nem_3	376	381	PF02991	0.459
LIG_LIR_Nem_3	483	487	PF02991	0.475
LIG_LIR_Nem_3	492	497	PF02991	0.590
LIG_LIR_Nem_3	508	513	PF02991	0.449
LIG_LIR_Nem_3	545	550	PF02991	0.387
LIG_LIR_Nem_3	61	67	PF02991	0.523
LIG_LIR_Nem_3	710	716	PF02991	0.471
LIG_LIR_Nem_3	722	727	PF02991	0.487
LIG_LIR_Nem_3	733	738	PF02991	0.445
LIG_MYND_1	616	620	PF01753	0.482
LIG_NRBOX	268	274	PF00104	0.412
LIG_NRP_CendR_1	757	760	PF00754	0.640
LIG_PALB2_WD40_1	505	513	PF16756	0.554
LIG_Pex14_2	731	735	PF04695	0.523
LIG_PTB_Apo_2	382	389	PF02174	0.459
LIG_PTB_Apo_2	583	590	PF02174	0.391
LIG_PTB_Phospho_1	382	388	PF10480	0.463
LIG_PTB_Phospho_1	583	589	PF10480	0.516
LIG_REV1ctd_RIR_1	598	607	PF16727	0.332
LIG_SH2_CRK	713	717	PF00017	0.490
LIG_SH2_GRB2like	594	597	PF00017	0.463
LIG_SH2_SRC	388	391	PF00017	0.482
LIG_SH2_SRC	392	395	PF00017	0.495
LIG_SH2_STAP1	111	115	PF00017	0.570
LIG_SH2_STAP1	235	239	PF00017	0.457
LIG_SH2_STAP1	379	383	PF00017	0.432
LIG_SH2_STAP1	392	396	PF00017	0.369
LIG_SH2_STAP1	470	474	PF00017	0.384
LIG_SH2_STAP1	547	551	PF00017	0.434
LIG_SH2_STAP1	594	598	PF00017	0.424
LIG_SH2_STAP1	630	634	PF00017	0.557
LIG_SH2_STAP1	80	84	PF00017	0.660
LIG_SH2_STAT3	470	473	PF00017	0.497
LIG_SH2_STAT5	215	218	PF00017	0.441
LIG_SH2_STAT5	341	344	PF00017	0.399
LIG_SH2_STAT5	346	349	PF00017	0.364
LIG_SH2_STAT5	351	354	PF00017	0.369
LIG_SH2_STAT5	388	391	PF00017	0.416
LIG_SH2_STAT5	414	417	PF00017	0.457
LIG_SH2_STAT5	425	428	PF00017	0.423
LIG_SH2_STAT5	630	633	PF00017	0.446
LIG_SH2_STAT5	706	709	PF00017	0.566
LIG_SH3_3	490	496	PF00018	0.571
LIG_SH3_3	8	14	PF00018	0.769
LIG_SUMO_SIM_anti_2	186	191	PF11976	0.551
LIG_SUMO_SIM_anti_2	329	336	PF11976	0.567
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.484
LIG_SUMO_SIM_par_1	156	161	PF11976	0.536
LIG_SUMO_SIM_par_1	271	278	PF11976	0.561
LIG_SUMO_SIM_par_1	485	492	PF11976	0.434
LIG_SUMO_SIM_par_1	658	665	PF11976	0.593
LIG_TYR_ITIM	704	709	PF00017	0.500
LIG_UBA3_1	411	419	PF00899	0.529
LIG_WW_1	74	77	PF00397	0.614
MOD_CK1_1	34	40	PF00069	0.720
MOD_CK1_1	359	365	PF00069	0.548
MOD_CK1_1	377	383	PF00069	0.480
MOD_CK1_1	529	535	PF00069	0.597
MOD_CK1_1	661	667	PF00069	0.598
MOD_CK1_1	691	697	PF00069	0.718
MOD_CK1_1	751	757	PF00069	0.491
MOD_CK2_1	217	223	PF00069	0.444
MOD_CK2_1	326	332	PF00069	0.552
MOD_CK2_1	361	367	PF00069	0.538
MOD_CK2_1	452	458	PF00069	0.550
MOD_CK2_1	67	73	PF00069	0.618
MOD_Cter_Amidation	27	30	PF01082	0.751
MOD_Cter_Amidation	754	757	PF01082	0.582
MOD_GlcNHglycan	105	108	PF01048	0.624
MOD_GlcNHglycan	111	114	PF01048	0.566
MOD_GlcNHglycan	251	254	PF01048	0.475
MOD_GlcNHglycan	310	313	PF01048	0.665
MOD_GlcNHglycan	335	338	PF01048	0.429
MOD_GlcNHglycan	364	367	PF01048	0.515
MOD_GlcNHglycan	37	40	PF01048	0.776
MOD_GlcNHglycan	446	449	PF01048	0.508
MOD_GlcNHglycan	668	671	PF01048	0.642
MOD_GlcNHglycan	690	693	PF01048	0.728
MOD_GlcNHglycan	695	699	PF01048	0.704
MOD_GlcNHglycan	753	756	PF01048	0.525
MOD_GSK3_1	117	124	PF00069	0.462
MOD_GSK3_1	279	286	PF00069	0.488
MOD_GSK3_1	31	38	PF00069	0.732
MOD_GSK3_1	322	329	PF00069	0.530
MOD_GSK3_1	357	364	PF00069	0.534
MOD_GSK3_1	373	380	PF00069	0.505
MOD_GSK3_1	388	395	PF00069	0.451
MOD_GSK3_1	454	461	PF00069	0.526
MOD_GSK3_1	526	533	PF00069	0.625
MOD_GSK3_1	558	565	PF00069	0.634
MOD_GSK3_1	63	70	PF00069	0.579
MOD_GSK3_1	656	663	PF00069	0.641
MOD_GSK3_1	9	16	PF00069	0.815
MOD_N-GLC_1	201	206	PF02516	0.416
MOD_NEK2_1	201	206	PF00069	0.419
MOD_NEK2_1	217	222	PF00069	0.378
MOD_NEK2_1	249	254	PF00069	0.421
MOD_NEK2_1	280	285	PF00069	0.521
MOD_NEK2_1	302	307	PF00069	0.692
MOD_NEK2_1	333	338	PF00069	0.508
MOD_NEK2_1	340	345	PF00069	0.406
MOD_NEK2_1	629	634	PF00069	0.476
MOD_NEK2_1	660	665	PF00069	0.603
MOD_NEK2_1	76	81	PF00069	0.670
MOD_NEK2_2	392	397	PF00069	0.479
MOD_PIKK_1	158	164	PF00454	0.525
MOD_PIKK_1	283	289	PF00454	0.603
MOD_PIKK_1	317	323	PF00454	0.717
MOD_PKA_1	373	379	PF00069	0.476
MOD_PKA_1	459	465	PF00069	0.401
MOD_PKA_2	217	223	PF00069	0.448
MOD_PKA_2	24	30	PF00069	0.775
MOD_PKA_2	396	402	PF00069	0.494
MOD_PKA_2	458	464	PF00069	0.399
MOD_PKA_2	530	536	PF00069	0.587
MOD_Plk_1	392	398	PF00069	0.539
MOD_Plk_1	482	488	PF00069	0.375
MOD_Plk_4	140	146	PF00069	0.517
MOD_Plk_4	211	217	PF00069	0.496
MOD_Plk_4	374	380	PF00069	0.537
MOD_Plk_4	459	465	PF00069	0.397
MOD_Plk_4	489	495	PF00069	0.385
MOD_Plk_4	530	536	PF00069	0.608
MOD_Plk_4	63	69	PF00069	0.587
MOD_Plk_4	636	642	PF00069	0.537
MOD_Plk_4	662	668	PF00069	0.648
MOD_Plk_4	719	725	PF00069	0.491
MOD_ProDKin_1	31	37	PF00069	0.774
MOD_ProDKin_1	508	514	PF00069	0.538
MOD_ProDKin_1	9	15	PF00069	0.775
MOD_SUMO_for_1	745	748	PF00179	0.626
TRG_DiLeu_BaEn_1	150	155	PF01217	0.599
TRG_DiLeu_BaEn_1	55	60	PF01217	0.569
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.510
TRG_DiLeu_BaLyEn_6	700	705	PF01217	0.632
TRG_ENDOCYTIC_2	238	241	PF00928	0.425
TRG_ENDOCYTIC_2	346	349	PF00928	0.370
TRG_ENDOCYTIC_2	378	381	PF00928	0.506
TRG_ENDOCYTIC_2	547	550	PF00928	0.381
TRG_ENDOCYTIC_2	630	633	PF00928	0.431
TRG_ENDOCYTIC_2	706	709	PF00928	0.495
TRG_ENDOCYTIC_2	713	716	PF00928	0.456
TRG_ER_diArg_1	181	183	PF00400	0.424
TRG_ER_diArg_1	371	373	PF00400	0.521
TRG_ER_diArg_1	396	398	PF00400	0.494
TRG_ER_diArg_1	516	518	PF00400	0.467
TRG_ER_diArg_1	522	525	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEY9	Leptomonas seymouri	61%	97%
A0A0S4IK45	Bodo saltans	23%	100%
A0A1X0P7J0	Trypanosomatidae	33%	100%
A0A3S7X563	Leishmania donovani	95%	100%
A0A422N1G1	Trypanosoma rangeli	34%	100%
A4HK21	Leishmania braziliensis	81%	99%
A4I7K5	Leishmania infantum	95%	100%
D0A0B0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B2G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BWW5	Trypanosoma cruzi	34%	100%