Kinesin motor domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin motor domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q5P3_LEIMA

TriTrypDb:

LmjF.32.0420 , LMJLV39_320009400 , LMJSD75_320009400

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5P3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	13
GO:0007018	microtubule-based movement	3	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003774	cytoskeletal motor activity	1	13
GO:0003777	microtubule motor activity	2	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0005524	ATP binding	5	13
GO:0008017	microtubule binding	5	13
GO:0008092	cytoskeletal protein binding	3	13
GO:0015631	tubulin binding	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.355
CLV_C14_Caspase3-7	162	166	PF00656	0.141
CLV_C14_Caspase3-7	2	6	PF00656	0.648
CLV_NRD_NRD_1	127	129	PF00675	0.418
CLV_NRD_NRD_1	213	215	PF00675	0.433
CLV_NRD_NRD_1	216	218	PF00675	0.391
CLV_NRD_NRD_1	247	249	PF00675	0.450
CLV_NRD_NRD_1	456	458	PF00675	0.575
CLV_NRD_NRD_1	500	502	PF00675	0.439
CLV_NRD_NRD_1	518	520	PF00675	0.427
CLV_NRD_NRD_1	658	660	PF00675	0.543
CLV_NRD_NRD_1	666	668	PF00675	0.501
CLV_PCSK_FUR_1	214	218	PF00082	0.450
CLV_PCSK_FUR_1	294	298	PF00082	0.352
CLV_PCSK_KEX2_1	127	129	PF00082	0.418
CLV_PCSK_KEX2_1	213	215	PF00082	0.381
CLV_PCSK_KEX2_1	216	218	PF00082	0.353
CLV_PCSK_KEX2_1	247	249	PF00082	0.450
CLV_PCSK_KEX2_1	296	298	PF00082	0.327
CLV_PCSK_KEX2_1	500	502	PF00082	0.425
CLV_PCSK_KEX2_1	518	520	PF00082	0.317
CLV_PCSK_KEX2_1	660	662	PF00082	0.549
CLV_PCSK_KEX2_1	665	667	PF00082	0.522
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.352
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.622
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.606
CLV_PCSK_PC7_1	123	129	PF00082	0.472
CLV_PCSK_PC7_1	661	667	PF00082	0.631
CLV_PCSK_SKI1_1	123	127	PF00082	0.373
CLV_PCSK_SKI1_1	243	247	PF00082	0.338
CLV_PCSK_SKI1_1	267	271	PF00082	0.394
CLV_PCSK_SKI1_1	362	366	PF00082	0.431
CLV_PCSK_SKI1_1	458	462	PF00082	0.514
CLV_PCSK_SKI1_1	466	470	PF00082	0.429
CLV_PCSK_SKI1_1	622	626	PF00082	0.569
DEG_APCC_DBOX_1	185	193	PF00400	0.396
DEG_APCC_DBOX_1	552	560	PF00400	0.472
DEG_SPOP_SBC_1	169	173	PF00917	0.394
DEG_SPOP_SBC_1	697	701	PF00917	0.748
DOC_CYCLIN_RxL_1	120	130	PF00134	0.393
DOC_MAPK_gen_1	221	231	PF00069	0.319
DOC_MAPK_gen_1	454	462	PF00069	0.572
DOC_MAPK_MEF2A_6	224	233	PF00069	0.323
DOC_PP1_RVXF_1	43	50	PF00149	0.445
DOC_PP1_RVXF_1	455	462	PF00149	0.602
DOC_PP1_RVXF_1	664	671	PF00149	0.631
DOC_PP4_FxxP_1	109	112	PF00568	0.472
DOC_USP7_MATH_1	112	116	PF00917	0.461
DOC_USP7_MATH_1	168	172	PF00917	0.425
DOC_USP7_MATH_1	434	438	PF00917	0.689
DOC_USP7_MATH_1	706	710	PF00917	0.700
DOC_WW_Pin1_4	108	113	PF00397	0.472
DOC_WW_Pin1_4	3	8	PF00397	0.702
DOC_WW_Pin1_4	442	447	PF00397	0.730
DOC_WW_Pin1_4	512	517	PF00397	0.450
DOC_WW_Pin1_4	693	698	PF00397	0.795
LIG_14-3-3_CanoR_1	133	140	PF00244	0.423
LIG_14-3-3_CanoR_1	186	196	PF00244	0.463
LIG_14-3-3_CanoR_1	247	252	PF00244	0.323
LIG_14-3-3_CanoR_1	25	34	PF00244	0.548
LIG_14-3-3_CanoR_1	322	330	PF00244	0.408
LIG_14-3-3_CanoR_1	407	416	PF00244	0.535
LIG_14-3-3_CanoR_1	686	690	PF00244	0.753
LIG_BIR_II_1	1	5	PF00653	0.746
LIG_BIR_III_4	450	454	PF00653	0.550
LIG_BRCT_BRCA1_1	138	142	PF00533	0.461
LIG_BRCT_BRCA1_1	313	317	PF00533	0.323
LIG_Clathr_ClatBox_1	233	237	PF01394	0.472
LIG_deltaCOP1_diTrp_1	471	479	PF00928	0.352
LIG_deltaCOP1_diTrp_1	588	594	PF00928	0.336
LIG_FHA_1	103	109	PF00498	0.323
LIG_FHA_1	33	39	PF00498	0.605
LIG_FHA_1	350	356	PF00498	0.377
LIG_FHA_1	454	460	PF00498	0.550
LIG_FHA_1	504	510	PF00498	0.327
LIG_FHA_1	75	81	PF00498	0.450
LIG_FHA_2	119	125	PF00498	0.370
LIG_FHA_2	371	377	PF00498	0.555
LIG_FHA_2	408	414	PF00498	0.513
LIG_FHA_2	583	589	PF00498	0.467
LIG_FHA_2	625	631	PF00498	0.494
LIG_FHA_2	674	680	PF00498	0.632
LIG_FHA_2	697	703	PF00498	0.634
LIG_Integrin_isoDGR_2	498	500	PF01839	0.394
LIG_LIR_Apic_2	107	112	PF02991	0.472
LIG_LIR_Apic_2	60	66	PF02991	0.391
LIG_LIR_Gen_1	182	192	PF02991	0.307
LIG_LIR_Gen_1	199	207	PF02991	0.338
LIG_LIR_Gen_1	320	331	PF02991	0.323
LIG_LIR_Gen_1	60	69	PF02991	0.393
LIG_LIR_Gen_1	679	684	PF02991	0.675
LIG_LIR_Gen_1	73	83	PF02991	0.260
LIG_LIR_Nem_3	124	129	PF02991	0.415
LIG_LIR_Nem_3	182	187	PF02991	0.395
LIG_LIR_Nem_3	199	203	PF02991	0.212
LIG_LIR_Nem_3	320	326	PF02991	0.336
LIG_LIR_Nem_3	514	520	PF02991	0.446
LIG_LIR_Nem_3	577	582	PF02991	0.445
LIG_LIR_Nem_3	588	593	PF02991	0.284
LIG_LIR_Nem_3	60	64	PF02991	0.393
LIG_LIR_Nem_3	676	680	PF02991	0.576
LIG_LIR_Nem_3	73	78	PF02991	0.260
LIG_PCNA_PIPBox_1	119	128	PF02747	0.450
LIG_PCNA_yPIPBox_3	119	133	PF02747	0.450
LIG_PCNA_yPIPBox_3	297	311	PF02747	0.450
LIG_Pex14_1	589	593	PF04695	0.343
LIG_Pex14_2	590	594	PF04695	0.418
LIG_SH2_CRK	323	327	PF00017	0.450
LIG_SH2_CRK	361	365	PF00017	0.529
LIG_SH2_CRK	517	521	PF00017	0.545
LIG_SH2_STAP1	219	223	PF00017	0.450
LIG_SH2_STAP1	323	327	PF00017	0.450
LIG_SH2_STAP1	59	63	PF00017	0.339
LIG_SH2_STAT3	219	222	PF00017	0.450
LIG_SH2_STAT3	301	304	PF00017	0.238
LIG_SH2_STAT3	470	473	PF00017	0.323
LIG_SH2_STAT5	188	191	PF00017	0.430
LIG_SH2_STAT5	323	326	PF00017	0.450
LIG_SH2_STAT5	401	404	PF00017	0.626
LIG_SH2_STAT5	560	563	PF00017	0.418
LIG_SH2_STAT5	607	610	PF00017	0.357
LIG_SH2_STAT5	63	66	PF00017	0.354
LIG_SH3_3	638	644	PF00018	0.609
LIG_SH3_3	7	13	PF00018	0.640
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.370
LIG_SUMO_SIM_par_1	370	376	PF11976	0.427
LIG_TRAF2_1	28	31	PF00917	0.560
LIG_TRAF2_1	410	413	PF00917	0.562
LIG_UBA3_1	416	422	PF00899	0.481
LIG_WRC_WIRS_1	233	238	PF05994	0.238
MOD_CDC14_SPxK_1	515	518	PF00782	0.541
MOD_CDK_SPxK_1	512	518	PF00069	0.555
MOD_CDK_SPxxK_3	512	519	PF00069	0.445
MOD_CK1_1	190	196	PF00069	0.458
MOD_CK1_1	232	238	PF00069	0.467
MOD_CK1_1	349	355	PF00069	0.378
MOD_CK2_1	108	114	PF00069	0.387
MOD_CK2_1	118	124	PF00069	0.362
MOD_CK2_1	140	146	PF00069	0.387
MOD_CK2_1	25	31	PF00069	0.564
MOD_CK2_1	344	350	PF00069	0.433
MOD_CK2_1	370	376	PF00069	0.527
MOD_CK2_1	407	413	PF00069	0.510
MOD_CK2_1	536	542	PF00069	0.364
MOD_CK2_1	696	702	PF00069	0.604
MOD_Cter_Amidation	498	501	PF01082	0.450
MOD_GlcNHglycan	114	117	PF01048	0.440
MOD_GlcNHglycan	404	407	PF01048	0.664
MOD_GlcNHglycan	436	439	PF01048	0.707
MOD_GlcNHglycan	669	673	PF01048	0.623
MOD_GlcNHglycan	90	93	PF01048	0.399
MOD_GSK3_1	104	111	PF00069	0.431
MOD_GSK3_1	132	139	PF00069	0.434
MOD_GSK3_1	247	254	PF00069	0.421
MOD_GSK3_1	321	328	PF00069	0.323
MOD_GSK3_1	344	351	PF00069	0.450
MOD_GSK3_1	532	539	PF00069	0.394
MOD_GSK3_1	693	700	PF00069	0.764
MOD_N-GLC_1	112	117	PF02516	0.452
MOD_N-GLC_1	276	281	PF02516	0.352
MOD_N-GLC_1	569	574	PF02516	0.510
MOD_N-GLC_2	430	432	PF02516	0.482
MOD_N-GLC_2	574	576	PF02516	0.529
MOD_N-GLC_2	685	687	PF02516	0.498
MOD_NEK2_1	187	192	PF00069	0.400
MOD_NEK2_1	251	256	PF00069	0.472
MOD_NEK2_1	402	407	PF00069	0.650
MOD_NEK2_1	582	587	PF00069	0.471
MOD_NEK2_1	668	673	PF00069	0.513
MOD_NEK2_1	691	696	PF00069	0.563
MOD_NEK2_2	503	508	PF00069	0.439
MOD_PIKK_1	271	277	PF00454	0.472
MOD_PIKK_1	300	306	PF00454	0.376
MOD_PIKK_1	32	38	PF00454	0.584
MOD_PIKK_1	321	327	PF00454	0.370
MOD_PIKK_1	532	538	PF00454	0.450
MOD_PKA_1	247	253	PF00069	0.450
MOD_PKA_2	132	138	PF00069	0.453
MOD_PKA_2	247	253	PF00069	0.418
MOD_PKA_2	321	327	PF00069	0.433
MOD_PKA_2	453	459	PF00069	0.553
MOD_PKA_2	509	515	PF00069	0.560
MOD_PKA_2	532	538	PF00069	0.430
MOD_PKA_2	582	588	PF00069	0.518
MOD_PKA_2	685	691	PF00069	0.747
MOD_PKB_1	23	31	PF00069	0.485
MOD_Plk_1	136	142	PF00069	0.450
MOD_Plk_1	159	165	PF00069	0.238
MOD_Plk_1	569	575	PF00069	0.319
MOD_Plk_2-3	159	165	PF00069	0.238
MOD_Plk_2-3	344	350	PF00069	0.450
MOD_Plk_4	104	110	PF00069	0.323
MOD_Plk_4	148	154	PF00069	0.404
MOD_Plk_4	202	208	PF00069	0.394
MOD_Plk_4	229	235	PF00069	0.458
MOD_Plk_4	247	253	PF00069	0.189
MOD_Plk_4	278	284	PF00069	0.358
MOD_Plk_4	313	319	PF00069	0.323
MOD_Plk_4	503	509	PF00069	0.299
MOD_Plk_4	673	679	PF00069	0.626
MOD_Plk_4	708	714	PF00069	0.632
MOD_ProDKin_1	108	114	PF00069	0.472
MOD_ProDKin_1	3	9	PF00069	0.694
MOD_ProDKin_1	442	448	PF00069	0.723
MOD_ProDKin_1	512	518	PF00069	0.447
MOD_ProDKin_1	693	699	PF00069	0.796
TRG_AP2beta_CARGO_1	124	133	PF09066	0.394
TRG_DiLeu_BaEn_1	376	381	PF01217	0.471
TRG_DiLeu_BaEn_1	81	86	PF01217	0.370
TRG_DiLeu_BaEn_2	394	400	PF01217	0.371
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.472
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.552
TRG_DiLeu_LyEn_5	376	381	PF01217	0.519
TRG_ENDOCYTIC_2	144	147	PF00928	0.382
TRG_ENDOCYTIC_2	323	326	PF00928	0.450
TRG_ENDOCYTIC_2	361	364	PF00928	0.523
TRG_ENDOCYTIC_2	517	520	PF00928	0.555
TRG_ENDOCYTIC_2	680	683	PF00928	0.651
TRG_ER_diArg_1	126	128	PF00400	0.418
TRG_ER_diArg_1	17	20	PF00400	0.433
TRG_ER_diArg_1	213	216	PF00400	0.394
TRG_ER_diArg_1	246	248	PF00400	0.450
TRG_ER_diArg_1	377	380	PF00400	0.531
TRG_ER_diArg_1	517	519	PF00400	0.559
TRG_ER_diArg_1	659	662	PF00400	0.601
TRG_ER_diArg_1	666	668	PF00400	0.556
TRG_NLS_MonoExtC_3	658	664	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F2	Leptomonas seymouri	69%	97%
A0A0S4IK37	Bodo saltans	41%	100%
A0A0S4INH0	Bodo saltans	41%	100%
A0A1X0P6P1	Trypanosomatidae	45%	100%
A0A3S7X544	Leishmania donovani	95%	100%
A0A422N1G2	Trypanosoma rangeli	46%	100%
A4HK22	Leishmania braziliensis	85%	100%
A4I7K6	Leishmania infantum	95%	100%
D0A0B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B2G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5C1Q9	Trypanosoma cruzi	47%	100%