WW domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1279), putative

Species:

Leishmania major

UniProt:

Q4Q5P1_LEIMA

TriTrypDb:

LmjF.32.0440 , LMJLV39_320009600 , LMJSD75_320009600

Length:

291

Annotations

LeishMANIAdb annotations

Homologous to animal FAM210 mitochondrial proteins. This protein might have a mitochondrial transit signal.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q5P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.408
CLV_PCSK_KEX2_1	212	214	PF00082	0.514
CLV_PCSK_KEX2_1	223	225	PF00082	0.571
CLV_PCSK_KEX2_1	55	57	PF00082	0.408
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.514
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.444
DEG_APCC_DBOX_1	196	204	PF00400	0.321
DEG_Nend_UBRbox_1	1	4	PF02207	0.622
DOC_CDC14_PxL_1	1	9	PF14671	0.540
DOC_MAPK_gen_1	212	219	PF00069	0.314
DOC_MAPK_gen_1	8	16	PF00069	0.687
DOC_MAPK_HePTP_8	236	248	PF00069	0.299
DOC_MAPK_MEF2A_6	229	237	PF00069	0.246
DOC_MAPK_MEF2A_6	239	248	PF00069	0.207
DOC_PP1_RVXF_1	78	84	PF00149	0.599
DOC_USP7_MATH_1	40	44	PF00917	0.734
DOC_USP7_UBL2_3	155	159	PF12436	0.538
DOC_WW_Pin1_4	29	34	PF00397	0.673
DOC_WW_Pin1_4	56	61	PF00397	0.608
DOC_WW_Pin1_4	72	77	PF00397	0.601
LIG_14-3-3_CanoR_1	135	143	PF00244	0.699
LIG_14-3-3_CanoR_1	24	33	PF00244	0.593
LIG_14-3-3_CanoR_1	8	16	PF00244	0.619
LIG_BIR_III_4	128	132	PF00653	0.513
LIG_BRCT_BRCA1_1	205	209	PF00533	0.264
LIG_CtBP_PxDLS_1	50	56	PF00389	0.637
LIG_deltaCOP1_diTrp_1	103	112	PF00928	0.588
LIG_eIF4E_1	170	176	PF01652	0.416
LIG_FHA_1	128	134	PF00498	0.650
LIG_FHA_1	228	234	PF00498	0.239
LIG_FHA_1	99	105	PF00498	0.501
LIG_FHA_2	136	142	PF00498	0.704
LIG_FHA_2	30	36	PF00498	0.744
LIG_FHA_2	65	71	PF00498	0.661
LIG_LIR_Apic_2	103	109	PF02991	0.500
LIG_LIR_Nem_3	114	119	PF02991	0.513
LIG_LIR_Nem_3	265	271	PF02991	0.522
LIG_NRBOX	15	21	PF00104	0.585
LIG_PCNA_yPIPBox_3	183	197	PF02747	0.283
LIG_Pex14_1	83	87	PF04695	0.500
LIG_Pex14_2	112	116	PF04695	0.479
LIG_Pex14_2	227	231	PF04695	0.264
LIG_Pex14_2	64	68	PF04695	0.646
LIG_SH2_CRK	96	100	PF00017	0.491
LIG_SH2_GRB2like	96	99	PF00017	0.493
LIG_SH2_SRC	178	181	PF00017	0.244
LIG_SH2_SRC	96	99	PF00017	0.576
LIG_SH2_STAP1	87	91	PF00017	0.612
LIG_SH2_STAT5	178	181	PF00017	0.244
LIG_SH2_STAT5	194	197	PF00017	0.244
LIG_SH3_3	70	76	PF00018	0.613
LIG_SH3_4	93	100	PF00018	0.586
LIG_TRAF2_1	60	63	PF00917	0.599
LIG_TYR_ITIM	176	181	PF00017	0.244
LIG_UBA3_1	267	272	PF00899	0.555
MOD_CK1_1	137	143	PF00069	0.655
MOD_CK1_1	26	32	PF00069	0.750
MOD_CK1_1	43	49	PF00069	0.666
MOD_CK2_1	135	141	PF00069	0.650
MOD_CK2_1	29	35	PF00069	0.607
MOD_CK2_1	64	70	PF00069	0.620
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.554
MOD_GlcNHglycan	11	14	PF01048	0.464
MOD_GlcNHglycan	251	254	PF01048	0.283
MOD_GlcNHglycan	38	41	PF01048	0.494
MOD_GlcNHglycan	42	45	PF01048	0.446
MOD_GSK3_1	133	140	PF00069	0.621
MOD_GSK3_1	144	151	PF00069	0.687
MOD_GSK3_1	227	234	PF00069	0.235
MOD_GSK3_1	24	31	PF00069	0.647
MOD_GSK3_1	263	270	PF00069	0.638
MOD_GSK3_1	36	43	PF00069	0.712
MOD_GSK3_1	98	105	PF00069	0.508
MOD_N-GLC_1	182	187	PF02516	0.283
MOD_N-GLC_1	219	224	PF02516	0.482
MOD_N-GLC_1	29	34	PF02516	0.545
MOD_NEK2_1	102	107	PF00069	0.569
MOD_NEK2_1	119	124	PF00069	0.569
MOD_NEK2_1	134	139	PF00069	0.542
MOD_NEK2_1	203	208	PF00069	0.321
MOD_NEK2_1	227	232	PF00069	0.227
MOD_NEK2_1	246	251	PF00069	0.445
MOD_NEK2_1	274	279	PF00069	0.550
MOD_PKA_2	134	140	PF00069	0.622
MOD_PKA_2	23	29	PF00069	0.701
MOD_Plk_1	102	108	PF00069	0.524
MOD_Plk_1	182	188	PF00069	0.283
MOD_Plk_2-3	85	91	PF00069	0.524
MOD_Plk_4	102	108	PF00069	0.446
MOD_Plk_4	15	21	PF00069	0.653
MOD_Plk_4	227	233	PF00069	0.232
MOD_Plk_4	263	269	PF00069	0.618
MOD_Plk_4	43	49	PF00069	0.624
MOD_ProDKin_1	29	35	PF00069	0.677
MOD_ProDKin_1	56	62	PF00069	0.613
MOD_ProDKin_1	72	78	PF00069	0.596
MOD_SUMO_rev_2	206	214	PF00179	0.321
MOD_SUMO_rev_2	215	225	PF00179	0.278
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.406
TRG_ENDOCYTIC_2	178	181	PF00928	0.244
TRG_ENDOCYTIC_2	96	99	PF00928	0.493
TRG_ER_diArg_1	5	8	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I946	Leptomonas seymouri	62%	98%
A0A0S4J0N1	Bodo saltans	40%	100%
A0A1X0P6G8	Trypanosomatidae	42%	96%
A0A3Q8IKN2	Leishmania donovani	95%	100%
A0A3R7LL16	Trypanosoma rangeli	44%	100%
A4HK24	Leishmania braziliensis	81%	100%
A4I7K8	Leishmania infantum	94%	100%
D0A0B3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	84%
E9B2G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BS86	Trypanosoma cruzi	41%	95%