WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5N8_LEIMA

TriTrypDb:

LmjF.32.0470 , LMJLV39_320009900 , LMJSD75_320009900

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4Q5N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.834
CLV_C14_Caspase3-7	196	200	PF00656	0.685
CLV_C14_Caspase3-7	203	207	PF00656	0.667
CLV_C14_Caspase3-7	352	356	PF00656	0.533
CLV_C14_Caspase3-7	442	446	PF00656	0.736
CLV_C14_Caspase3-7	700	704	PF00656	0.511
CLV_NRD_NRD_1	234	236	PF00675	0.607
CLV_NRD_NRD_1	292	294	PF00675	0.544
CLV_NRD_NRD_1	307	309	PF00675	0.406
CLV_NRD_NRD_1	384	386	PF00675	0.648
CLV_NRD_NRD_1	398	400	PF00675	0.700
CLV_NRD_NRD_1	496	498	PF00675	0.477
CLV_NRD_NRD_1	745	747	PF00675	0.522
CLV_NRD_NRD_1	868	870	PF00675	0.435
CLV_PCSK_KEX2_1	234	236	PF00082	0.616
CLV_PCSK_KEX2_1	250	252	PF00082	0.493
CLV_PCSK_KEX2_1	292	294	PF00082	0.500
CLV_PCSK_KEX2_1	307	309	PF00082	0.435
CLV_PCSK_KEX2_1	377	379	PF00082	0.562
CLV_PCSK_KEX2_1	398	400	PF00082	0.608
CLV_PCSK_KEX2_1	64	66	PF00082	0.470
CLV_PCSK_KEX2_1	745	747	PF00082	0.507
CLV_PCSK_KEX2_1	799	801	PF00082	0.448
CLV_PCSK_KEX2_1	868	870	PF00082	0.435
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.583
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.623
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.470
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.448
CLV_PCSK_SKI1_1	151	155	PF00082	0.596
CLV_PCSK_SKI1_1	257	261	PF00082	0.537
CLV_PCSK_SKI1_1	381	385	PF00082	0.607
CLV_PCSK_SKI1_1	712	716	PF00082	0.499
CLV_PCSK_SKI1_1	773	777	PF00082	0.428
CLV_PCSK_SKI1_1	97	101	PF00082	0.411
CLV_Separin_Metazoa	382	386	PF03568	0.550
DEG_APCC_DBOX_1	252	260	PF00400	0.529
DEG_SPOP_SBC_1	431	435	PF00917	0.657
DOC_ANK_TNKS_1	518	525	PF00023	0.531
DOC_CKS1_1	754	759	PF01111	0.523
DOC_CYCLIN_RxL_1	686	697	PF00134	0.410
DOC_CYCLIN_RxL_1	799	810	PF00134	0.408
DOC_MAPK_DCC_7	819	828	PF00069	0.519
DOC_MAPK_gen_1	250	260	PF00069	0.545
DOC_MAPK_gen_1	508	518	PF00069	0.518
DOC_MAPK_gen_1	94	104	PF00069	0.389
DOC_MAPK_MEF2A_6	251	260	PF00069	0.438
DOC_MAPK_MEF2A_6	417	424	PF00069	0.725
DOC_MAPK_MEF2A_6	819	828	PF00069	0.502
DOC_PP1_RVXF_1	802	809	PF00149	0.484
DOC_USP7_MATH_1	153	157	PF00917	0.688
DOC_USP7_MATH_1	183	187	PF00917	0.771
DOC_USP7_MATH_1	283	287	PF00917	0.496
DOC_USP7_MATH_1	303	307	PF00917	0.385
DOC_USP7_MATH_1	367	371	PF00917	0.481
DOC_USP7_MATH_1	431	435	PF00917	0.657
DOC_USP7_MATH_1	522	526	PF00917	0.551
DOC_USP7_MATH_1	874	878	PF00917	0.522
DOC_WW_Pin1_4	177	182	PF00397	0.762
DOC_WW_Pin1_4	388	393	PF00397	0.647
DOC_WW_Pin1_4	427	432	PF00397	0.724
DOC_WW_Pin1_4	436	441	PF00397	0.762
DOC_WW_Pin1_4	566	571	PF00397	0.441
DOC_WW_Pin1_4	682	687	PF00397	0.604
DOC_WW_Pin1_4	753	758	PF00397	0.548
LIG_14-3-3_CanoR_1	398	406	PF00244	0.749
LIG_14-3-3_CanoR_1	581	587	PF00244	0.550
LIG_14-3-3_CanoR_1	712	720	PF00244	0.514
LIG_14-3-3_CanoR_1	746	754	PF00244	0.500
LIG_APCC_ABBA_1	539	544	PF00400	0.617
LIG_BIR_II_1	1	5	PF00653	0.446
LIG_BIR_III_2	178	182	PF00653	0.759
LIG_BRCT_BRCA1_1	390	394	PF00533	0.656
LIG_BRCT_BRCA1_1	450	454	PF00533	0.691
LIG_BRCT_BRCA1_1	854	858	PF00533	0.531
LIG_Clathr_ClatBox_1	837	841	PF01394	0.431
LIG_CtBP_PxDLS_1	130	134	PF00389	0.593
LIG_deltaCOP1_diTrp_1	461	465	PF00928	0.621
LIG_deltaCOP1_diTrp_1	793	797	PF00928	0.502
LIG_FHA_1	109	115	PF00498	0.563
LIG_FHA_1	124	130	PF00498	0.479
LIG_FHA_1	314	320	PF00498	0.421
LIG_FHA_1	507	513	PF00498	0.515
LIG_FHA_1	582	588	PF00498	0.493
LIG_FHA_1	685	691	PF00498	0.495
LIG_FHA_1	754	760	PF00498	0.588
LIG_FHA_1	774	780	PF00498	0.198
LIG_FHA_2	105	111	PF00498	0.537
LIG_FHA_2	170	176	PF00498	0.681
LIG_FHA_2	20	26	PF00498	0.618
LIG_FHA_2	33	39	PF00498	0.302
LIG_FHA_2	423	429	PF00498	0.692
LIG_FHA_2	500	506	PF00498	0.557
LIG_FHA_2	698	704	PF00498	0.507
LIG_FHA_2	713	719	PF00498	0.423
LIG_GBD_Chelix_1	114	122	PF00786	0.445
LIG_GBD_Chelix_1	771	779	PF00786	0.478
LIG_LIR_Gen_1	309	319	PF02991	0.329
LIG_LIR_Gen_1	544	552	PF02991	0.458
LIG_LIR_Gen_1	562	573	PF02991	0.257
LIG_LIR_Gen_1	793	802	PF02991	0.501
LIG_LIR_Gen_1	855	866	PF02991	0.517
LIG_LIR_Nem_3	273	278	PF02991	0.519
LIG_LIR_Nem_3	309	314	PF02991	0.417
LIG_LIR_Nem_3	540	545	PF02991	0.511
LIG_LIR_Nem_3	562	568	PF02991	0.432
LIG_LIR_Nem_3	793	797	PF02991	0.502
LIG_NRBOX	255	261	PF00104	0.526
LIG_NRBOX	331	337	PF00104	0.454
LIG_NRBOX	706	712	PF00104	0.400
LIG_NRBOX	774	780	PF00104	0.515
LIG_PDZ_Class_1	874	879	PF00595	0.537
LIG_Pex14_2	808	812	PF04695	0.487
LIG_Pex14_2	844	848	PF04695	0.606
LIG_SH2_CRK	275	279	PF00017	0.511
LIG_SH2_SRC	607	610	PF00017	0.348
LIG_SH2_SRC	739	742	PF00017	0.511
LIG_SH2_STAP1	415	419	PF00017	0.712
LIG_SH2_STAP1	607	611	PF00017	0.520
LIG_SH2_STAP1	613	617	PF00017	0.481
LIG_SH2_STAT3	602	605	PF00017	0.594
LIG_SH2_STAT5	304	307	PF00017	0.463
LIG_SH2_STAT5	565	568	PF00017	0.494
LIG_SH2_STAT5	611	614	PF00017	0.441
LIG_SH2_STAT5	739	742	PF00017	0.511
LIG_SH3_3	468	474	PF00018	0.575
LIG_SH3_3	676	682	PF00018	0.542
LIG_SH3_3	762	768	PF00018	0.467
LIG_SH3_3	780	786	PF00018	0.336
LIG_SUMO_SIM_par_1	110	119	PF11976	0.518
LIG_SUMO_SIM_par_1	280	286	PF11976	0.434
LIG_SUMO_SIM_par_1	420	425	PF11976	0.684
LIG_SUMO_SIM_par_1	473	478	PF11976	0.580
LIG_SUMO_SIM_par_1	584	590	PF11976	0.518
LIG_TRAF2_1	215	218	PF00917	0.736
LIG_TRAF2_1	343	346	PF00917	0.535
LIG_TRAF2_1	435	438	PF00917	0.804
LIG_TRAF2_1	716	719	PF00917	0.479
LIG_TRAF2_1	721	724	PF00917	0.442
MOD_CDK_SPxxK_3	682	689	PF00069	0.560
MOD_CK1_1	163	169	PF00069	0.671
MOD_CK1_1	19	25	PF00069	0.458
MOD_CK1_1	306	312	PF00069	0.446
MOD_CK1_1	32	38	PF00069	0.325
MOD_CK1_1	430	436	PF00069	0.745
MOD_CK1_1	439	445	PF00069	0.625
MOD_CK1_1	585	591	PF00069	0.442
MOD_CK1_1	77	83	PF00069	0.627
MOD_CK2_1	197	203	PF00069	0.784
MOD_CK2_1	212	218	PF00069	0.590
MOD_CK2_1	309	315	PF00069	0.522
MOD_CK2_1	32	38	PF00069	0.496
MOD_CK2_1	340	346	PF00069	0.539
MOD_CK2_1	357	363	PF00069	0.451
MOD_CK2_1	367	373	PF00069	0.496
MOD_CK2_1	422	428	PF00069	0.734
MOD_CK2_1	431	437	PF00069	0.757
MOD_CK2_1	499	505	PF00069	0.520
MOD_CK2_1	712	718	PF00069	0.492
MOD_CK2_1	77	83	PF00069	0.585
MOD_CK2_1	85	91	PF00069	0.507
MOD_CMANNOS	462	465	PF00535	0.619
MOD_GlcNHglycan	155	158	PF01048	0.695
MOD_GlcNHglycan	18	21	PF01048	0.549
MOD_GlcNHglycan	199	202	PF01048	0.791
MOD_GlcNHglycan	285	288	PF01048	0.509
MOD_GlcNHglycan	308	311	PF01048	0.425
MOD_GlcNHglycan	32	35	PF01048	0.525
MOD_GlcNHglycan	402	405	PF01048	0.698
MOD_GlcNHglycan	451	454	PF01048	0.665
MOD_GlcNHglycan	525	528	PF01048	0.623
MOD_GlcNHglycan	623	626	PF01048	0.541
MOD_GlcNHglycan	730	733	PF01048	0.392
MOD_GlcNHglycan	79	82	PF01048	0.596
MOD_GlcNHglycan	841	844	PF01048	0.568
MOD_GSK3_1	179	186	PF00069	0.729
MOD_GSK3_1	309	316	PF00069	0.511
MOD_GSK3_1	400	407	PF00069	0.676
MOD_GSK3_1	427	434	PF00069	0.738
MOD_GSK3_1	445	452	PF00069	0.502
MOD_GSK3_1	489	496	PF00069	0.575
MOD_GSK3_1	581	588	PF00069	0.510
MOD_GSK3_1	603	610	PF00069	0.510
MOD_GSK3_1	654	661	PF00069	0.468
MOD_GSK3_1	680	687	PF00069	0.661
MOD_GSK3_1	749	756	PF00069	0.500
MOD_GSK3_1	75	82	PF00069	0.587
MOD_GSK3_1	848	855	PF00069	0.610
MOD_GSK3_1	98	105	PF00069	0.475
MOD_N-GLC_1	102	107	PF02516	0.439
MOD_N-GLC_1	163	168	PF02516	0.668
MOD_N-GLC_1	582	587	PF02516	0.443
MOD_N-GLC_1	747	752	PF02516	0.488
MOD_NEK2_1	104	109	PF00069	0.261
MOD_NEK2_1	30	35	PF00069	0.574
MOD_NEK2_1	357	362	PF00069	0.464
MOD_NEK2_1	47	52	PF00069	0.363
MOD_NEK2_1	615	620	PF00069	0.444
MOD_NEK2_1	658	663	PF00069	0.453
MOD_NEK2_1	727	732	PF00069	0.443
MOD_NEK2_1	747	752	PF00069	0.488
MOD_NEK2_1	830	835	PF00069	0.572
MOD_NEK2_1	848	853	PF00069	0.428
MOD_NEK2_1	85	90	PF00069	0.570
MOD_NEK2_1	98	103	PF00069	0.374
MOD_NEK2_2	481	486	PF00069	0.485
MOD_PK_1	398	404	PF00069	0.649
MOD_PKA_1	398	404	PF00069	0.678
MOD_PKA_2	306	312	PF00069	0.412
MOD_PKA_2	357	363	PF00069	0.528
MOD_PKA_2	397	403	PF00069	0.702
MOD_Plk_1	109	115	PF00069	0.482
MOD_Plk_1	163	169	PF00069	0.709
MOD_Plk_1	47	53	PF00069	0.542
MOD_Plk_1	582	588	PF00069	0.436
MOD_Plk_1	718	724	PF00069	0.460
MOD_Plk_2-3	169	175	PF00069	0.722
MOD_Plk_2-3	212	218	PF00069	0.646
MOD_Plk_2-3	697	703	PF00069	0.567
MOD_Plk_2-3	718	724	PF00069	0.452
MOD_Plk_4	109	115	PF00069	0.513
MOD_Plk_4	163	169	PF00069	0.735
MOD_Plk_4	313	319	PF00069	0.421
MOD_Plk_4	537	543	PF00069	0.610
MOD_Plk_4	582	588	PF00069	0.532
MOD_Plk_4	607	613	PF00069	0.486
MOD_Plk_4	784	790	PF00069	0.525
MOD_Plk_4	793	799	PF00069	0.454
MOD_Plk_4	807	813	PF00069	0.352
MOD_Plk_4	833	839	PF00069	0.467
MOD_ProDKin_1	177	183	PF00069	0.763
MOD_ProDKin_1	388	394	PF00069	0.651
MOD_ProDKin_1	427	433	PF00069	0.726
MOD_ProDKin_1	436	442	PF00069	0.762
MOD_ProDKin_1	566	572	PF00069	0.439
MOD_ProDKin_1	682	688	PF00069	0.590
MOD_ProDKin_1	753	759	PF00069	0.548
MOD_SUMO_rev_2	119	129	PF00179	0.553
MOD_SUMO_rev_2	192	200	PF00179	0.791
MOD_SUMO_rev_2	224	233	PF00179	0.612
MOD_SUMO_rev_2	56	66	PF00179	0.531
TRG_DiLeu_BaEn_1	255	260	PF01217	0.611
TRG_DiLeu_BaEn_1	38	43	PF01217	0.497
TRG_DiLeu_BaEn_2	792	798	PF01217	0.497
TRG_DiLeu_BaEn_2	861	867	PF01217	0.324
TRG_DiLeu_BaEn_4	643	649	PF01217	0.478
TRG_DiLeu_BaEn_4	723	729	PF01217	0.535
TRG_DiLeu_LyEn_5	723	728	PF01217	0.539
TRG_ENDOCYTIC_2	275	278	PF00928	0.507
TRG_ENDOCYTIC_2	565	568	PF00928	0.389
TRG_ER_diArg_1	234	237	PF00400	0.601
TRG_ER_diArg_1	665	668	PF00400	0.527
TRG_ER_diArg_1	744	746	PF00400	0.505
TRG_ER_diArg_1	867	869	PF00400	0.436
TRG_NLS_Bipartite_1	234	254	PF00514	0.469
TRG_NLS_MonoExtC_3	249	255	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	627	632	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM54	Leptomonas seymouri	47%	83%
A0A1X0P6G6	Trypanosomatidae	27%	78%
A0A3Q8IFP5	Leishmania donovani	93%	83%
A0A422N1D3	Trypanosoma rangeli	29%	80%
A4HK27	Leishmania braziliensis	76%	100%
A4I7L1	Leishmania infantum	94%	93%
D0A0B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
E9B2G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%