Replication termination factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtf2 RING-finger, putative

Species:

Leishmania major

UniProt:

Q4Q5N7_LEIMA

TriTrypDb:

LmjF.32.0473 , LMJLV39_320010000 , LMJSD75_320010000

Length:

206

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q5N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006274	DNA replication termination	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0022402	cell cycle process	2	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1902294	cell cycle DNA replication termination	3	10
GO:1902317	nuclear DNA replication termination	4	10
GO:1902979	mitotic DNA replication termination	4	10
GO:1903047	mitotic cell cycle process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.450
CLV_NRD_NRD_1	80	82	PF00675	0.298
CLV_PCSK_KEX2_1	11	13	PF00082	0.258
CLV_PCSK_KEX2_1	194	196	PF00082	0.458
CLV_PCSK_KEX2_1	198	200	PF00082	0.464
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.258
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.450
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.436
CLV_PCSK_PC7_1	190	196	PF00082	0.466
CLV_PCSK_SKI1_1	12	16	PF00082	0.258
CLV_PCSK_SKI1_1	99	103	PF00082	0.328
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.475
DOC_PP2B_LxvP_1	56	59	PF13499	0.529
DOC_USP7_MATH_1	20	24	PF00917	0.396
DOC_USP7_UBL2_3	194	198	PF12436	0.501
DOC_USP7_UBL2_3	35	39	PF12436	0.525
DOC_USP7_UBL2_3	95	99	PF12436	0.514
LIG_14-3-3_CanoR_1	19	27	PF00244	0.498
LIG_14-3-3_CanoR_1	45	53	PF00244	0.475
LIG_LIR_Gen_1	122	130	PF02991	0.558
LIG_LIR_Gen_1	168	179	PF02991	0.473
LIG_LIR_Nem_3	122	127	PF02991	0.529
LIG_LIR_Nem_3	132	136	PF02991	0.458
LIG_LIR_Nem_3	161	167	PF02991	0.544
LIG_LIR_Nem_3	168	174	PF02991	0.411
LIG_LIR_Nem_3	83	89	PF02991	0.558
LIG_Pex14_2	133	137	PF04695	0.458
LIG_SH2_CRK	124	128	PF00017	0.558
LIG_SH2_CRK	86	90	PF00017	0.485
LIG_SH2_NCK_1	124	128	PF00017	0.521
LIG_SH2_PTP2	171	174	PF00017	0.438
LIG_SH2_STAT5	171	174	PF00017	0.438
LIG_SH2_STAT5	21	24	PF00017	0.529
LIG_SH2_STAT5	77	80	PF00017	0.529
LIG_SH3_3	114	120	PF00018	0.514
LIG_SH3_3	157	163	PF00018	0.529
LIG_SH3_5	120	124	PF00018	0.514
LIG_TYR_ITSM	120	127	PF00017	0.514
LIG_WRC_WIRS_1	130	135	PF05994	0.498
LIG_WRC_WIRS_1	167	172	PF05994	0.493
MOD_CK1_1	113	119	PF00069	0.519
MOD_CK1_1	125	131	PF00069	0.524
MOD_CK1_1	144	150	PF00069	0.403
MOD_CK1_1	37	43	PF00069	0.535
MOD_CK1_1	70	76	PF00069	0.529
MOD_CK1_1	85	91	PF00069	0.493
MOD_GlcNHglycan	127	130	PF01048	0.284
MOD_GlcNHglycan	143	146	PF01048	0.286
MOD_GlcNHglycan	22	25	PF01048	0.320
MOD_GlcNHglycan	28	31	PF01048	0.325
MOD_GSK3_1	119	126	PF00069	0.497
MOD_GSK3_1	144	151	PF00069	0.508
MOD_GSK3_1	33	40	PF00069	0.568
MOD_N-GLC_1	148	153	PF02516	0.287
MOD_NEK2_1	15	20	PF00069	0.458
MOD_NEK2_2	166	171	PF00069	0.547
MOD_PIKK_1	153	159	PF00454	0.529
MOD_PIKK_1	34	40	PF00454	0.544
MOD_PKA_1	99	105	PF00069	0.561
MOD_PKA_2	44	50	PF00069	0.459
MOD_Plk_1	122	128	PF00069	0.525
MOD_Plk_4	129	135	PF00069	0.529
MOD_Plk_4	166	172	PF00069	0.601
MOD_Plk_4	184	190	PF00069	0.324
MOD_Plk_4	70	76	PF00069	0.512
MOD_SUMO_rev_2	151	156	PF00179	0.529
MOD_SUMO_rev_2	88	96	PF00179	0.524
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.428
TRG_ENDOCYTIC_2	124	127	PF00928	0.558
TRG_ENDOCYTIC_2	171	174	PF00928	0.426
TRG_ENDOCYTIC_2	86	89	PF00928	0.555
TRG_ER_diArg_1	196	199	PF00400	0.469
TRG_NLS_MonoExtC_3	193	198	PF00514	0.438
TRG_NLS_MonoExtN_4	194	201	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEQ3	Leptomonas seymouri	58%	100%
A0A0S4J1X6	Bodo saltans	30%	100%
A0A1X0P6S0	Trypanosomatidae	42%	95%
A0A3R7N309	Trypanosoma rangeli	39%	94%
A0A3S7X5A4	Leishmania donovani	94%	100%
A4HK35	Leishmania braziliensis	79%	100%
A4I7N6	Leishmania infantum	94%	100%
D0A0B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	94%
E9B2G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q10154	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	86%