LeishMANIAdb
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Secondary thiamine-phosphate synthase enzyme

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secondary thiamine-phosphate synthase enzyme
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5N6_LEIMA
TriTrypDb:
LmjF.32.0477 , LMJLV39_320010100 * , LMJSD75_320010100
Length:
101

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5N6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 35 37 PF00082 0.582
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.582
DEG_APCC_DBOX_1 58 66 PF00400 0.527
DEG_Nend_UBRbox_1 1 4 PF02207 0.575
DOC_MAPK_gen_1 91 100 PF00069 0.495
DOC_USP7_MATH_1 90 94 PF00917 0.609
DOC_WW_Pin1_4 86 91 PF00397 0.588
LIG_BRCT_BRCA1_1 65 69 PF00533 0.576
LIG_FHA_1 5 11 PF00498 0.513
LIG_FHA_1 53 59 PF00498 0.591
LIG_LIR_Gen_1 25 34 PF02991 0.503
LIG_LIR_Nem_3 25 31 PF02991 0.491
LIG_PCNA_yPIPBox_3 24 36 PF02747 0.563
LIG_SH2_NCK_1 28 32 PF00017 0.503
MOD_CDK_SPK_2 86 91 PF00069 0.506
MOD_CK1_1 40 46 PF00069 0.595
MOD_CK1_1 93 99 PF00069 0.572
MOD_CK2_1 14 20 PF00069 0.549
MOD_CK2_1 47 53 PF00069 0.513
MOD_CK2_1 86 92 PF00069 0.597
MOD_GlcNHglycan 77 81 PF01048 0.589
MOD_GSK3_1 10 17 PF00069 0.568
MOD_GSK3_1 86 93 PF00069 0.607
MOD_N-GLC_1 75 80 PF02516 0.466
MOD_NEK2_1 1 6 PF00069 0.556
MOD_NEK2_1 47 52 PF00069 0.499
MOD_PKA_2 90 96 PF00069 0.625
MOD_Plk_4 10 16 PF00069 0.496
MOD_Plk_4 53 59 PF00069 0.534
MOD_Plk_4 93 99 PF00069 0.682
MOD_ProDKin_1 86 92 PF00069 0.597
MOD_SUMO_rev_2 87 96 PF00179 0.530
TRG_ENDOCYTIC_2 28 31 PF00928 0.489
TRG_ENDOCYTIC_2 85 88 PF00928 0.425
TRG_ER_diArg_1 44 47 PF00400 0.345

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P7X3 Trypanosomatidae 32% 85%
A0A3S7X569 Leishmania donovani 91% 100%
A0A422N1C7 Trypanosoma rangeli 32% 80%
A4I7N5 Leishmania infantum 91% 100%
D0A0C0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 81%
E9AIU8 Leishmania braziliensis 86% 100%
E9B2H0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS