DUF3444 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5N5_LEIMA

TriTrypDb:

LmjF.32.0480 , LMJLV39_320010200 , LMJSD75_320010200

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.646
CLV_C14_Caspase3-7	312	316	PF00656	0.722
CLV_C14_Caspase3-7	325	329	PF00656	0.759
CLV_NRD_NRD_1	375	377	PF00675	0.634
CLV_NRD_NRD_1	71	73	PF00675	0.599
CLV_NRD_NRD_1	82	84	PF00675	0.583
CLV_PCSK_KEX2_1	145	147	PF00082	0.525
CLV_PCSK_KEX2_1	263	265	PF00082	0.555
CLV_PCSK_KEX2_1	375	377	PF00082	0.634
CLV_PCSK_KEX2_1	71	73	PF00082	0.567
CLV_PCSK_KEX2_1	76	78	PF00082	0.518
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.540
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.607
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.514
CLV_PCSK_PC7_1	72	78	PF00082	0.570
CLV_PCSK_SKI1_1	151	155	PF00082	0.599
CLV_PCSK_SKI1_1	177	181	PF00082	0.432
DEG_APCC_DBOX_1	176	184	PF00400	0.428
DEG_COP1_1	287	297	PF00400	0.564
DEG_Nend_UBRbox_3	1	3	PF02207	0.519
DEG_SCF_FBW7_2	186	192	PF00400	0.486
DEG_SCF_TRCP1_1	328	334	PF00400	0.691
DOC_CKS1_1	186	191	PF01111	0.488
DOC_PP1_RVXF_1	17	24	PF00149	0.703
DOC_USP7_MATH_1	135	139	PF00917	0.617
DOC_USP7_MATH_1	168	172	PF00917	0.674
DOC_USP7_MATH_1	6	10	PF00917	0.755
DOC_USP7_MATH_2	119	125	PF00917	0.623
DOC_WW_Pin1_4	161	166	PF00397	0.509
DOC_WW_Pin1_4	185	190	PF00397	0.583
DOC_WW_Pin1_4	346	351	PF00397	0.741
LIG_14-3-3_CanoR_1	19	24	PF00244	0.796
LIG_14-3-3_CanoR_1	252	256	PF00244	0.491
LIG_14-3-3_CanoR_1	269	275	PF00244	0.470
LIG_14-3-3_CanoR_1	302	310	PF00244	0.639
LIG_14-3-3_CanoR_1	320	325	PF00244	0.559
LIG_14-3-3_CanoR_1	39	48	PF00244	0.655
LIG_14-3-3_CanoR_1	71	75	PF00244	0.579
LIG_APCC_ABBA_1	198	203	PF00400	0.493
LIG_BRCT_BRCA1_1	36	40	PF00533	0.717
LIG_FHA_1	186	192	PF00498	0.533
LIG_FHA_1	224	230	PF00498	0.489
LIG_FHA_1	354	360	PF00498	0.644
LIG_FHA_2	158	164	PF00498	0.501
LIG_FHA_2	214	220	PF00498	0.477
LIG_FHA_2	26	32	PF00498	0.698
LIG_FHA_2	285	291	PF00498	0.501
LIG_FHA_2	5	11	PF00498	0.723
LIG_FHA_2	63	69	PF00498	0.647
LIG_LIR_Gen_1	105	115	PF02991	0.558
LIG_LIR_Gen_1	278	288	PF02991	0.507
LIG_LIR_Gen_1	349	359	PF02991	0.692
LIG_LIR_Nem_3	105	111	PF02991	0.521
LIG_LIR_Nem_3	278	284	PF02991	0.516
LIG_LIR_Nem_3	287	292	PF02991	0.484
LIG_LIR_Nem_3	349	355	PF02991	0.711
LIG_LIR_Nem_3	73	78	PF02991	0.468
LIG_NRBOX	178	184	PF00104	0.470
LIG_SH2_CRK	197	201	PF00017	0.535
LIG_SH2_CRK	75	79	PF00017	0.371
LIG_SH2_STAT3	57	60	PF00017	0.728
LIG_SH2_STAT3	85	88	PF00017	0.524
LIG_SH2_STAT5	214	217	PF00017	0.388
LIG_SH2_STAT5	256	259	PF00017	0.467
LIG_SH2_STAT5	281	284	PF00017	0.449
LIG_SH3_3	285	291	PF00018	0.415
LIG_SH3_3	334	340	PF00018	0.682
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.416
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.292
LIG_SUMO_SIM_par_1	280	287	PF11976	0.474
LIG_SUMO_SIM_par_1	290	296	PF11976	0.540
LIG_TRAF2_1	119	122	PF00917	0.564
LIG_TYR_ITIM	279	284	PF00017	0.518
LIG_UBA3_1	107	114	PF00899	0.498
LIG_WW_3	13	17	PF00397	0.640
MOD_CK1_1	124	130	PF00069	0.652
MOD_CK1_1	303	309	PF00069	0.613
MOD_CK1_1	322	328	PF00069	0.493
MOD_CK1_1	329	335	PF00069	0.659
MOD_CK1_1	4	10	PF00069	0.813
MOD_CK1_1	41	47	PF00069	0.625
MOD_CK1_1	50	56	PF00069	0.683
MOD_CK2_1	157	163	PF00069	0.549
MOD_CK2_1	213	219	PF00069	0.446
MOD_CK2_1	25	31	PF00069	0.776
MOD_CK2_1	303	309	PF00069	0.651
MOD_CK2_1	375	381	PF00069	0.533
MOD_CK2_1	4	10	PF00069	0.693
MOD_CK2_1	62	68	PF00069	0.690
MOD_Cter_Amidation	143	146	PF01082	0.531
MOD_Cter_Amidation	246	249	PF01082	0.549
MOD_GlcNHglycan	126	129	PF01048	0.646
MOD_GlcNHglycan	133	136	PF01048	0.565
MOD_GlcNHglycan	142	145	PF01048	0.511
MOD_GlcNHglycan	238	241	PF01048	0.569
MOD_GlcNHglycan	3	6	PF01048	0.710
MOD_GlcNHglycan	325	328	PF01048	0.672
MOD_GlcNHglycan	331	334	PF01048	0.708
MOD_GlcNHglycan	54	57	PF01048	0.684
MOD_GSK3_1	120	127	PF00069	0.650
MOD_GSK3_1	131	138	PF00069	0.473
MOD_GSK3_1	157	164	PF00069	0.492
MOD_GSK3_1	229	236	PF00069	0.525
MOD_GSK3_1	251	258	PF00069	0.487
MOD_GSK3_1	316	323	PF00069	0.683
MOD_GSK3_1	34	41	PF00069	0.614
MOD_N-GLC_1	1	6	PF02516	0.586
MOD_N-GLC_1	300	305	PF02516	0.727
MOD_NEK2_1	1	6	PF00069	0.764
MOD_NEK2_1	140	145	PF00069	0.582
MOD_NEK2_1	229	234	PF00069	0.526
MOD_NEK2_1	250	255	PF00069	0.518
MOD_NEK2_1	284	289	PF00069	0.469
MOD_NEK2_1	300	305	PF00069	0.536
MOD_NEK2_2	25	30	PF00069	0.696
MOD_NEK2_2	270	275	PF00069	0.433
MOD_PIKK_1	34	40	PF00454	0.749
MOD_PKA_1	375	381	PF00069	0.622
MOD_PKA_2	251	257	PF00069	0.468
MOD_PKA_2	270	276	PF00069	0.465
MOD_PKA_2	319	325	PF00069	0.690
MOD_PKA_2	375	381	PF00069	0.548
MOD_PKA_2	38	44	PF00069	0.676
MOD_PKA_2	50	56	PF00069	0.675
MOD_PKA_2	70	76	PF00069	0.567
MOD_Plk_1	120	126	PF00069	0.672
MOD_Plk_1	25	31	PF00069	0.709
MOD_Plk_1	277	283	PF00069	0.327
MOD_Plk_2-3	157	163	PF00069	0.578
MOD_Plk_4	121	127	PF00069	0.724
MOD_Plk_4	135	141	PF00069	0.375
MOD_Plk_4	169	175	PF00069	0.538
MOD_Plk_4	178	184	PF00069	0.425
MOD_Plk_4	229	235	PF00069	0.538
MOD_Plk_4	251	257	PF00069	0.430
MOD_Plk_4	270	276	PF00069	0.423
MOD_Plk_4	277	283	PF00069	0.433
MOD_ProDKin_1	161	167	PF00069	0.507
MOD_ProDKin_1	185	191	PF00069	0.489
MOD_ProDKin_1	346	352	PF00069	0.738
MOD_SUMO_for_1	153	156	PF00179	0.610
MOD_SUMO_rev_2	4	14	PF00179	0.730
TRG_DiLeu_BaEn_1	278	283	PF01217	0.520
TRG_DiLeu_BaEn_3	120	126	PF01217	0.642
TRG_DiLeu_BaEn_4	121	127	PF01217	0.606
TRG_ENDOCYTIC_2	197	200	PF00928	0.474
TRG_ENDOCYTIC_2	281	284	PF00928	0.467
TRG_ENDOCYTIC_2	75	78	PF00928	0.403
TRG_ER_diArg_1	375	377	PF00400	0.637
TRG_ER_diArg_1	70	72	PF00400	0.616
TRG_NLS_MonoExtC_3	150	155	PF00514	0.665
TRG_NLS_MonoExtN_4	150	155	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX2	Leptomonas seymouri	77%	99%
A0A0S4J1T4	Bodo saltans	39%	79%
A0A1X0P7I4	Trypanosomatidae	51%	98%
A0A3Q8IT20	Leishmania donovani	96%	100%
A0A422N1D9	Trypanosoma rangeli	49%	98%
A4HK34	Leishmania braziliensis	83%	100%
A4I7N4	Leishmania infantum	96%	100%
D0A0C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9B2H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BWX0	Trypanosoma cruzi	51%	98%