Putative ras-related rab-4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-related protein Rab4, putative

Species:

Leishmania major

UniProt:

Q4Q5N4_LEIMA

TriTrypDb:

LmjF.32.0490 , LMJLV39_320010300 , LMJSD75_320010300

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q5N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N4

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0030100	regulation of endocytosis	5	2
GO:0032879	regulation of localization	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051049	regulation of transport	4	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	167	171	PF00082	0.288
CLV_PCSK_SKI1_1	71	75	PF00082	0.388
CLV_PCSK_SKI1_1	79	83	PF00082	0.300
DEG_SCF_TRCP1_1	16	22	PF00400	0.288
DOC_MAPK_gen_1	167	175	PF00069	0.367
DOC_MAPK_MEF2A_6	4	13	PF00069	0.339
DOC_USP7_MATH_1	193	197	PF00917	0.654
LIG_14-3-3_CanoR_1	69	74	PF00244	0.288
LIG_14-3-3_CanoR_1	93	97	PF00244	0.267
LIG_BIR_II_1	1	5	PF00653	0.439

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z9	Leptomonas seymouri	28%	86%
A0A0N0P3A0	Leptomonas seymouri	36%	75%
A0A0N0P3G2	Leptomonas seymouri	28%	100%
A0A0N0P633	Leptomonas seymouri	24%	100%
A0A0N0P6K4	Leptomonas seymouri	28%	94%
A0A0N0P6P8	Leptomonas seymouri	52%	97%
A0A0N0P8G7	Leptomonas seymouri	40%	94%
A0A0N0P8I1	Leptomonas seymouri	36%	91%
A0A0N0P971	Leptomonas seymouri	30%	95%
A0A0N1HU31	Leptomonas seymouri	26%	82%

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