ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5N3_LEIMA

TriTrypDb:

LmjF.32.0500 , LMJLV39_320010400 , LMJSD75_320010400

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.388
CLV_NRD_NRD_1	16	18	PF00675	0.665
CLV_PCSK_SKI1_1	199	203	PF00082	0.506
CLV_PCSK_SKI1_1	235	239	PF00082	0.668
CLV_PCSK_SKI1_1	4	8	PF00082	0.596
DEG_MDM2_SWIB_1	118	125	PF02201	0.548
DOC_CYCLIN_RxL_1	31	42	PF00134	0.504
DOC_MAPK_gen_1	103	110	PF00069	0.590
DOC_MAPK_gen_1	79	88	PF00069	0.570
DOC_MAPK_JIP1_4	32	38	PF00069	0.488
DOC_MAPK_MEF2A_6	103	110	PF00069	0.533
DOC_MAPK_MEF2A_6	117	125	PF00069	0.399
DOC_MAPK_MEF2A_6	67	76	PF00069	0.472
DOC_MAPK_NFAT4_5	103	111	PF00069	0.501
DOC_MIT_MIM_1	113	121	PF04212	0.510
DOC_PP1_RVXF_1	32	39	PF00149	0.586
DOC_SPAK_OSR1_1	117	121	PF12202	0.542
DOC_USP7_MATH_1	2	6	PF00917	0.639
DOC_USP7_MATH_1	49	53	PF00917	0.538
DOC_USP7_MATH_1	60	64	PF00917	0.416
DOC_USP7_UBL2_3	79	83	PF12436	0.512
LIG_14-3-3_CanoR_1	32	37	PF00244	0.448
LIG_14-3-3_CterR_2	257	260	PF00244	0.667
LIG_APCC_ABBA_1	72	77	PF00400	0.380
LIG_Clathr_ClatBox_1	149	153	PF01394	0.428
LIG_FHA_1	200	206	PF00498	0.403
LIG_FHA_1	8	14	PF00498	0.653
LIG_FHA_2	10	16	PF00498	0.710
LIG_G3BP_FGDF_1	179	184	PF02136	0.436
LIG_LIR_Gen_1	119	128	PF02991	0.499
LIG_LIR_Gen_1	202	212	PF02991	0.406
LIG_LIR_Gen_1	89	100	PF02991	0.502
LIG_LIR_Nem_3	119	125	PF02991	0.393
LIG_LIR_Nem_3	135	141	PF02991	0.395
LIG_LIR_Nem_3	180	184	PF02991	0.452
LIG_LIR_Nem_3	202	207	PF02991	0.411
LIG_NRBOX	105	111	PF00104	0.497
LIG_PDZ_Class_2	255	260	PF00595	0.615
LIG_Pex14_2	118	122	PF04695	0.536
LIG_REV1ctd_RIR_1	236	244	PF16727	0.694
LIG_SH2_CRK	255	259	PF00017	0.607
LIG_SH2_CRK	50	54	PF00017	0.485
LIG_SH2_STAP1	50	54	PF00017	0.485
LIG_SH2_STAT5	146	149	PF00017	0.386
LIG_SH2_STAT5	204	207	PF00017	0.397
LIG_SH2_STAT5	70	73	PF00017	0.545
LIG_SH3_3	240	246	PF00018	0.685
LIG_SUMO_SIM_par_1	187	193	PF11976	0.379
LIG_TYR_ITIM	253	258	PF00017	0.489
LIG_UBA3_1	100	105	PF00899	0.566
LIG_WRC_WIRS_1	181	186	PF05994	0.441
MOD_CK1_1	39	45	PF00069	0.517
MOD_CK1_1	5	11	PF00069	0.622
MOD_CK2_1	184	190	PF00069	0.394
MOD_GlcNHglycan	175	179	PF01048	0.568
MOD_GlcNHglycan	217	220	PF01048	0.536
MOD_GlcNHglycan	4	7	PF01048	0.556
MOD_GlcNHglycan	56	60	PF01048	0.550
MOD_GSK3_1	170	177	PF00069	0.496
MOD_GSK3_1	180	187	PF00069	0.370
MOD_GSK3_1	195	202	PF00069	0.323
MOD_GSK3_1	32	39	PF00069	0.573
MOD_GSK3_1	5	12	PF00069	0.693
MOD_NEK2_1	145	150	PF00069	0.440
MOD_NEK2_1	184	189	PF00069	0.395
MOD_NEK2_1	36	41	PF00069	0.461
MOD_PIKK_1	61	67	PF00454	0.500
MOD_PIKK_1	7	13	PF00454	0.739
MOD_PKB_1	32	40	PF00069	0.494
MOD_Plk_1	229	235	PF00069	0.633
MOD_Plk_4	153	159	PF00069	0.462
MOD_Plk_4	184	190	PF00069	0.428
MOD_Plk_4	49	55	PF00069	0.540
MOD_Plk_4	91	97	PF00069	0.412
MOD_SUMO_for_1	78	81	PF00179	0.580
MOD_SUMO_rev_2	15	19	PF00179	0.433
MOD_SUMO_rev_2	73	80	PF00179	0.485
TRG_DiLeu_BaEn_1	153	158	PF01217	0.603
TRG_ENDOCYTIC_2	138	141	PF00928	0.402
TRG_ENDOCYTIC_2	146	149	PF00928	0.394
TRG_ENDOCYTIC_2	204	207	PF00928	0.431
TRG_ENDOCYTIC_2	255	258	PF00928	0.600
TRG_ENDOCYTIC_2	50	53	PF00928	0.404
TRG_NES_CRM1_1	66	77	PF08389	0.371
TRG_NES_CRM1_1	98	113	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NW65	Trypanosomatidae	37%	100%
A0A3S7X585	Leishmania donovani	90%	100%
A0A422NJP5	Trypanosoma rangeli	36%	100%
A4HK32	Leishmania braziliensis	73%	100%
A4I7N2	Leishmania infantum	90%	100%
D0A9R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B2H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%