Lem3 cdc50 family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LEM3 (ligand-effect modulator 3) family / CDC50 family, putative

Species:

Leishmania major

UniProt:

Q4Q5N2_LEIMA

TriTrypDb:

LmjF.32.0510 , LMJLV39_320010500 , LMJSD75_320010500

Length:

363

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	3
GO:0005794	Golgi apparatus	5	3
GO:0005886	plasma membrane	3	3
GO:0016020	membrane	2	21
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	21

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Expansion

Sequence features

Q4Q5N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5N2

Function

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Biological processes
Term	Name	Level	Count
GO:0033036	macromolecule localization	2	21
GO:0051179	localization	1	21

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	124	128	PF00082	0.513
CLV_PCSK_SKI1_1	207	211	PF00082	0.553
CLV_PCSK_SKI1_1	97	101	PF00082	0.504
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.286
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.309
DOC_MAPK_FxFP_2	149	152	PF00069	0.306
DOC_MAPK_gen_1	284	293	PF00069	0.327
DOC_MAPK_MEF2A_6	284	293	PF00069	0.293
DOC_PP1_RVXF_1	56	62	PF00149	0.283
DOC_PP1_RVXF_1	95	101	PF00149	0.316

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG2	Leptomonas seymouri	32%	87%
A0A0N1PDQ9	Leptomonas seymouri	62%	100%
A0A0S4IMK4	Bodo saltans	32%	90%
A0A0S4J4T1	Bodo saltans	40%	96%
A0A0S4JB98	Bodo saltans	30%	90%
A0A0S4JJY0	Bodo saltans	30%	90%
A0A0S4JQR9	Bodo saltans	32%	69%
A0A1X0NHQ5	Trypanosomatidae	31%	76%
A0A1X0NV71	Trypanosomatidae	40%	96%
A0A1X0P5L3	Trypanosomatidae	32%	91%

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