LeishMANIAdb
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Sulfite exporter TauE/SafE family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sulfite exporter TauE/SafE family protein
Gene product:
sulfite exporter TauE/SafE, putative
Species:
Leishmania major
UniProt:
Q4Q5M9_LEIMA
TriTrypDb:
LmjF.32.0540 , LMJLV39_320010800 * , LMJSD75_320010800
Length:
511

Annotations

LeishMANIAdb annotations

Related to plant TauE sulfite exporters. Due to a re-entrant loop, the number of full TM segments is only 10

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 12, no: 0
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0000151 ubiquitin ligase complex 3 2
GO:0016020 membrane 2 13
GO:0031461 cullin-RING ubiquitin ligase complex 4 2
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 6 2
GO:0032991 protein-containing complex 1 2
GO:0080008 Cul4-RING E3 ubiquitin ligase complex 5 2
GO:0110165 cellular anatomical entity 1 13
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1990234 transferase complex 3 2

Expansion

Sequence features

Q4Q5M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M9

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0016567 protein ubiquitination 7 2
GO:0019538 protein metabolic process 3 2
GO:0032446 protein modification by small protein conjugation 6 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0044238 primary metabolic process 2 2
GO:0070647 protein modification by small protein conjugation or removal 5 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 233 237 PF00656 0.689
CLV_NRD_NRD_1 347 349 PF00675 0.248
CLV_NRD_NRD_1 460 462 PF00675 0.199
CLV_NRD_NRD_1 77 79 PF00675 0.359
CLV_PCSK_KEX2_1 459 461 PF00082 0.294
CLV_PCSK_PC1ET2_1 459 461 PF00082 0.294
CLV_PCSK_SKI1_1 198 202 PF00082 0.285
CLV_PCSK_SKI1_1 255 259 PF00082 0.512
CLV_PCSK_SKI1_1 265 269 PF00082 0.525
CLV_PCSK_SKI1_1 52 56 PF00082 0.359
CLV_PCSK_SKI1_1 8 12 PF00082 0.520
CLV_PCSK_SKI1_1 83 87 PF00082 0.533
CLV_PCSK_SKI1_1 92 96 PF00082 0.488
DEG_APCC_DBOX_1 197 205 PF00400 0.238
DEG_APCC_DBOX_1 343 351 PF00400 0.406
DEG_APCC_DBOX_1 459 467 PF00400 0.399
DEG_APCC_DBOX_1 91 99 PF00400 0.215
DEG_SCF_FBW7_1 274 281 PF00400 0.692
DOC_CKS1_1 275 280 PF01111 0.690
DOC_CYCLIN_yCln2_LP_2 174 180 PF00134 0.264
DOC_MAPK_gen_1 459 468 PF00069 0.391
DOC_MAPK_gen_1 8 18 PF00069 0.348
DOC_MAPK_MEF2A_6 11 20 PF00069 0.366
DOC_MAPK_MEF2A_6 198 206 PF00069 0.238
DOC_MAPK_NFAT4_5 198 206 PF00069 0.254
DOC_PP2B_LxvP_1 174 177 PF13499 0.265
DOC_USP7_MATH_1 129 133 PF00917 0.492
DOC_USP7_MATH_1 158 162 PF00917 0.464
DOC_USP7_MATH_1 32 36 PF00917 0.276
DOC_USP7_MATH_1 377 381 PF00917 0.340
DOC_USP7_MATH_1 418 422 PF00917 0.243
DOC_WW_Pin1_4 274 279 PF00397 0.643
LIG_14-3-3_CanoR_1 315 320 PF00244 0.275
LIG_14-3-3_CanoR_1 365 371 PF00244 0.426
LIG_14-3-3_CanoR_1 83 89 PF00244 0.323
LIG_Actin_WH2_2 182 200 PF00022 0.245
LIG_BRCT_BRCA1_1 298 302 PF00533 0.197
LIG_BRCT_BRCA1_1 336 340 PF00533 0.393
LIG_BRCT_BRCA1_1 34 38 PF00533 0.215
LIG_BRCT_BRCA1_1 469 473 PF00533 0.455
LIG_EH1_1 88 96 PF00400 0.159
LIG_eIF4E_1 169 175 PF01652 0.423
LIG_eIF4E_1 325 331 PF01652 0.316
LIG_FHA_1 144 150 PF00498 0.523
LIG_FHA_1 314 320 PF00498 0.475
LIG_FHA_1 38 44 PF00498 0.248
LIG_FHA_1 412 418 PF00498 0.225
LIG_FHA_1 426 432 PF00498 0.293
LIG_FHA_2 359 365 PF00498 0.400
LIG_GBD_Chelix_1 16 24 PF00786 0.359
LIG_GBD_Chelix_1 306 314 PF00786 0.265
LIG_LIR_Apic_2 159 165 PF02991 0.479
LIG_LIR_Gen_1 213 221 PF02991 0.613
LIG_LIR_Gen_1 299 310 PF02991 0.367
LIG_LIR_Gen_1 413 423 PF02991 0.207
LIG_LIR_Gen_1 84 91 PF02991 0.261
LIG_LIR_LC3C_4 428 433 PF02991 0.393
LIG_LIR_Nem_3 299 305 PF02991 0.367
LIG_LIR_Nem_3 367 373 PF02991 0.449
LIG_LIR_Nem_3 413 419 PF02991 0.207
LIG_LIR_Nem_3 434 438 PF02991 0.416
LIG_LIR_Nem_3 84 88 PF02991 0.261
LIG_LRP6_Inhibitor_1 453 459 PF00058 0.199
LIG_LYPXL_yS_3 370 373 PF13949 0.437
LIG_NRBOX 198 204 PF00104 0.258
LIG_NRBOX 305 311 PF00104 0.299
LIG_PCNA_yPIPBox_3 451 461 PF02747 0.399
LIG_Pex14_2 415 419 PF04695 0.262
LIG_Pex14_2 435 439 PF04695 0.164
LIG_Pex14_2 85 89 PF04695 0.279
LIG_PTB_Apo_2 165 172 PF02174 0.404
LIG_PTB_Phospho_1 165 171 PF10480 0.404
LIG_SH2_CRK 169 173 PF00017 0.412
LIG_SH2_CRK 488 492 PF00017 0.308
LIG_SH2_GRB2like 341 344 PF00017 0.508
LIG_SH2_SRC 465 468 PF00017 0.370
LIG_SH2_STAP1 488 492 PF00017 0.254
LIG_SH2_STAT3 293 296 PF00017 0.605
LIG_SH2_STAT5 150 153 PF00017 0.514
LIG_SH2_STAT5 171 174 PF00017 0.238
LIG_SH2_STAT5 317 320 PF00017 0.334
LIG_SH2_STAT5 341 344 PF00017 0.492
LIG_SH2_STAT5 457 460 PF00017 0.506
LIG_SH2_STAT5 465 468 PF00017 0.344
LIG_SH3_3 326 332 PF00018 0.393
LIG_SH3_3 365 371 PF00018 0.479
LIG_SUMO_SIM_anti_2 105 110 PF11976 0.320
LIG_SUMO_SIM_anti_2 270 277 PF11976 0.705
LIG_SUMO_SIM_par_1 201 207 PF11976 0.381
LIG_TRAF2_1 294 297 PF00917 0.569
LIG_TRAF2_1 402 405 PF00917 0.209
LIG_TYR_ITIM 167 172 PF00017 0.404
LIG_TYR_ITIM 368 373 PF00017 0.437
LIG_TYR_ITIM 463 468 PF00017 0.479
LIG_UBA3_1 454 459 PF00899 0.492
LIG_WRC_WIRS_1 412 417 PF05994 0.262
LIG_WRC_WIRS_1 82 87 PF05994 0.266
MOD_CK1_1 213 219 PF00069 0.600
MOD_CK1_1 245 251 PF00069 0.783
MOD_CK1_1 27 33 PF00069 0.333
MOD_CK1_1 281 287 PF00069 0.702
MOD_CK1_1 407 413 PF00069 0.216
MOD_CK1_1 493 499 PF00069 0.327
MOD_CK1_1 84 90 PF00069 0.204
MOD_CK2_1 27 33 PF00069 0.231
MOD_CK2_1 358 364 PF00069 0.351
MOD_GlcNHglycan 131 134 PF01048 0.252
MOD_GlcNHglycan 138 141 PF01048 0.236
MOD_GlcNHglycan 27 30 PF01048 0.412
MOD_GlcNHglycan 379 382 PF01048 0.396
MOD_GlcNHglycan 409 412 PF01048 0.439
MOD_GlcNHglycan 446 449 PF01048 0.309
MOD_GlcNHglycan 488 491 PF01048 0.468
MOD_GSK3_1 228 235 PF00069 0.604
MOD_GSK3_1 238 245 PF00069 0.664
MOD_GSK3_1 251 258 PF00069 0.637
MOD_GSK3_1 27 34 PF00069 0.402
MOD_GSK3_1 274 281 PF00069 0.655
MOD_GSK3_1 356 363 PF00069 0.503
MOD_GSK3_1 406 413 PF00069 0.226
MOD_GSK3_1 486 493 PF00069 0.350
MOD_N-GLC_1 237 242 PF02516 0.521
MOD_NEK2_1 136 141 PF00069 0.432
MOD_NEK2_1 180 185 PF00069 0.304
MOD_NEK2_1 24 29 PF00069 0.319
MOD_NEK2_1 257 262 PF00069 0.635
MOD_NEK2_1 358 363 PF00069 0.468
MOD_NEK2_1 425 430 PF00069 0.312
MOD_NEK2_1 444 449 PF00069 0.169
MOD_NEK2_2 411 416 PF00069 0.223
MOD_NEK2_2 96 101 PF00069 0.193
MOD_PIKK_1 134 140 PF00454 0.404
MOD_PIKK_1 249 255 PF00454 0.653
MOD_PIKK_1 288 294 PF00454 0.582
MOD_PIKK_1 37 43 PF00454 0.237
MOD_PIKK_1 491 497 PF00454 0.290
MOD_PKA_2 364 370 PF00069 0.441
MOD_Plk_1 158 164 PF00069 0.448
MOD_Plk_1 296 302 PF00069 0.474
MOD_Plk_1 404 410 PF00069 0.179
MOD_Plk_4 170 176 PF00069 0.240
MOD_Plk_4 180 186 PF00069 0.235
MOD_Plk_4 204 210 PF00069 0.289
MOD_Plk_4 334 340 PF00069 0.349
MOD_Plk_4 411 417 PF00069 0.212
MOD_Plk_4 418 424 PF00069 0.210
MOD_Plk_4 427 433 PF00069 0.217
MOD_Plk_4 467 473 PF00069 0.301
MOD_Plk_4 475 481 PF00069 0.301
MOD_Plk_4 496 502 PF00069 0.301
MOD_Plk_4 84 90 PF00069 0.253
MOD_Plk_4 96 102 PF00069 0.257
MOD_ProDKin_1 274 280 PF00069 0.644
MOD_SUMO_rev_2 47 56 PF00179 0.248
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.423
TRG_DiLeu_BaLyEn_6 195 200 PF01217 0.344
TRG_ENDOCYTIC_2 150 153 PF00928 0.514
TRG_ENDOCYTIC_2 169 172 PF00928 0.404
TRG_ENDOCYTIC_2 370 373 PF00928 0.435
TRG_ENDOCYTIC_2 465 468 PF00928 0.370
TRG_ENDOCYTIC_2 488 491 PF00928 0.277
TRG_ER_diArg_1 5 8 PF00400 0.444
TRG_Pf-PMV_PEXEL_1 255 259 PF00026 0.419
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.344
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.308

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P810 Leptomonas seymouri 64% 100%
A0A0S4IUN5 Bodo saltans 35% 96%
A0A0S4IWE0 Bodo saltans 38% 97%
A0A1X0NUS8 Trypanosomatidae 47% 100%
A0A3Q8IGK2 Leishmania donovani 90% 100%
A0A3R7KFU6 Trypanosoma rangeli 45% 100%
A0A3R7KMV5 Trypanosoma rangeli 46% 100%
A4HK28 Leishmania braziliensis 69% 100%
A4I7M8 Leishmania infantum 90% 100%
E9B2H7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
F4I8X6 Arabidopsis thaliana 22% 100%
Q8L7A0 Arabidopsis thaliana 24% 100%
Q8S9J0 Arabidopsis thaliana 22% 100%
V5BFC3 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS