RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5M7_LEIMA

TriTrypDb:

LmjF.32.0560 , LMJLV39_320011000 , LMJSD75_320011000

Length:

178

Annotations

LeishMANIAdb annotations

Might be a component of some unusual ubiquitin ligase (due to its C-terminal RING domain). Probably membrane-associated, although a purely cytoplasmic protein cannot be excluded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q5M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.465
CLV_PCSK_FUR_1	77	81	PF00082	0.469
CLV_PCSK_KEX2_1	77	79	PF00082	0.465
CLV_PCSK_SKI1_1	109	113	PF00082	0.508
DOC_CYCLIN_RxL_1	106	115	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.674
DOC_MAPK_gen_1	89	97	PF00069	0.692
DOC_PP1_RVXF_1	45	51	PF00149	0.444
DOC_USP7_MATH_1	10	14	PF00917	0.488
DOC_USP7_MATH_1	91	95	PF00917	0.657
DOC_WW_Pin1_4	112	117	PF00397	0.689
DOC_WW_Pin1_4	25	30	PF00397	0.440
LIG_14-3-3_CanoR_1	92	96	PF00244	0.656
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_FHA_1	139	145	PF00498	0.572
LIG_FHA_1	38	44	PF00498	0.561
LIG_FHA_2	33	39	PF00498	0.376
LIG_GBD_Chelix_1	61	69	PF00786	0.405
LIG_Integrin_isoDGR_2	129	131	PF01839	0.430
LIG_LIR_Nem_3	160	164	PF02991	0.566
LIG_LIR_Nem_3	28	33	PF02991	0.475
LIG_LIR_Nem_3	71	76	PF02991	0.356
LIG_PDZ_Class_2	173	178	PF00595	0.644
LIG_REV1ctd_RIR_1	72	83	PF16727	0.502
LIG_SH2_STAT5	161	164	PF00017	0.567
LIG_SH2_STAT5	73	76	PF00017	0.405
LIG_SH3_3	100	106	PF00018	0.676
LIG_SH3_3	118	124	PF00018	0.674
LIG_SH3_3	139	145	PF00018	0.572
LIG_TYR_ITSM	69	76	PF00017	0.356
MOD_CK2_1	19	25	PF00069	0.390
MOD_CK2_1	32	38	PF00069	0.469
MOD_GlcNHglycan	12	15	PF01048	0.661
MOD_GlcNHglycan	35	38	PF01048	0.719
MOD_GlcNHglycan	5	8	PF01048	0.724
MOD_GlcNHglycan	52	55	PF01048	0.602
MOD_GSK3_1	10	17	PF00069	0.537
MOD_GSK3_1	110	117	PF00069	0.713
MOD_GSK3_1	153	160	PF00069	0.593
MOD_GSK3_1	33	40	PF00069	0.557
MOD_N-GLC_1	101	106	PF02516	0.409
MOD_NEK2_1	3	8	PF00069	0.523
MOD_NEK2_1	42	47	PF00069	0.470
MOD_NEK2_1	68	73	PF00069	0.356
MOD_NEK2_1	85	90	PF00069	0.660
MOD_NEK2_2	37	42	PF00069	0.448
MOD_NEK2_2	91	96	PF00069	0.661
MOD_PIKK_1	19	25	PF00454	0.405
MOD_PKA_2	91	97	PF00069	0.678
MOD_Plk_1	37	43	PF00069	0.482
MOD_Plk_4	138	144	PF00069	0.575
MOD_Plk_4	37	43	PF00069	0.482
MOD_Plk_4	68	74	PF00069	0.356
MOD_ProDKin_1	112	118	PF00069	0.688
MOD_ProDKin_1	25	31	PF00069	0.439
TRG_DiLeu_BaEn_2	37	43	PF01217	0.482
TRG_ENDOCYTIC_2	161	164	PF00928	0.564
TRG_ENDOCYTIC_2	73	76	PF00928	0.405
TRG_ER_diArg_1	172	175	PF00400	0.608
TRG_ER_diArg_1	76	79	PF00400	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5B4	Leishmania donovani	92%	100%
A4HK37	Leishmania braziliensis	76%	100%
A4I7M6	Leishmania infantum	92%	100%
E9B2H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%