ARID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5M5_LEIMA

TriTrypDb:

LmjF.32.0580 , LMJLV39_320011200 , LMJSD75_320011200

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.805
CLV_C14_Caspase3-7	408	412	PF00656	0.655
CLV_C14_Caspase3-7	60	64	PF00656	0.501
CLV_NRD_NRD_1	257	259	PF00675	0.745
CLV_NRD_NRD_1	382	384	PF00675	0.816
CLV_NRD_NRD_1	428	430	PF00675	0.821
CLV_NRD_NRD_1	472	474	PF00675	0.675
CLV_NRD_NRD_1	476	478	PF00675	0.660
CLV_NRD_NRD_1	549	551	PF00675	0.704
CLV_NRD_NRD_1	90	92	PF00675	0.489
CLV_PCSK_FUR_1	378	382	PF00082	0.755
CLV_PCSK_FUR_1	87	91	PF00082	0.601
CLV_PCSK_KEX2_1	114	116	PF00082	0.644
CLV_PCSK_KEX2_1	241	243	PF00082	0.636
CLV_PCSK_KEX2_1	378	380	PF00082	0.743
CLV_PCSK_KEX2_1	381	383	PF00082	0.745
CLV_PCSK_KEX2_1	427	429	PF00082	0.832
CLV_PCSK_KEX2_1	472	474	PF00082	0.731
CLV_PCSK_KEX2_1	476	478	PF00082	0.721
CLV_PCSK_KEX2_1	549	551	PF00082	0.735
CLV_PCSK_KEX2_1	582	584	PF00082	0.532
CLV_PCSK_KEX2_1	89	91	PF00082	0.496
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.644
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.738
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.745
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.735
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.504
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.496
CLV_PCSK_PC7_1	378	384	PF00082	0.737
CLV_PCSK_PC7_1	472	478	PF00082	0.748
CLV_PCSK_SKI1_1	115	119	PF00082	0.557
CLV_PCSK_SKI1_1	129	133	PF00082	0.665
CLV_PCSK_SKI1_1	147	151	PF00082	0.749
CLV_PCSK_SKI1_1	229	233	PF00082	0.834
CLV_PCSK_SKI1_1	551	555	PF00082	0.834
CLV_PCSK_SKI1_1	78	82	PF00082	0.514
DOC_MAPK_MEF2A_6	485	494	PF00069	0.678
DOC_PP4_MxPP_1	123	126	PF00568	0.663
DOC_USP7_MATH_1	154	158	PF00917	0.767
DOC_USP7_MATH_1	2	6	PF00917	0.625
DOC_USP7_MATH_1	216	220	PF00917	0.754
DOC_USP7_MATH_1	346	350	PF00917	0.702
DOC_USP7_MATH_1	423	427	PF00917	0.646
DOC_USP7_MATH_1	461	465	PF00917	0.777
DOC_USP7_MATH_1	513	517	PF00917	0.699
DOC_USP7_MATH_1	54	58	PF00917	0.663
DOC_USP7_MATH_1	558	562	PF00917	0.768
DOC_USP7_UBL2_3	114	118	PF12436	0.653
DOC_USP7_UBL2_3	474	478	PF12436	0.749
DOC_WW_Pin1_4	131	136	PF00397	0.755
DOC_WW_Pin1_4	137	142	PF00397	0.673
DOC_WW_Pin1_4	152	157	PF00397	0.580
DOC_WW_Pin1_4	241	246	PF00397	0.727
DOC_WW_Pin1_4	436	441	PF00397	0.799
DOC_WW_Pin1_4	518	523	PF00397	0.760
LIG_14-3-3_CanoR_1	129	135	PF00244	0.731
LIG_14-3-3_CanoR_1	348	352	PF00244	0.571
LIG_14-3-3_CanoR_1	356	364	PF00244	0.653
LIG_14-3-3_CanoR_1	78	83	PF00244	0.524
LIG_Actin_WH2_2	64	80	PF00022	0.620
LIG_BIR_III_2	153	157	PF00653	0.626
LIG_BRCT_BRCA1_1	266	270	PF00533	0.616
LIG_BRCT_BRCA1_1	490	494	PF00533	0.647
LIG_deltaCOP1_diTrp_1	33	42	PF00928	0.494
LIG_FHA_1	17	23	PF00498	0.481
LIG_FHA_1	60	66	PF00498	0.456
LIG_FHA_1	71	77	PF00498	0.517
LIG_FHA_1	94	100	PF00498	0.559
LIG_FHA_2	185	191	PF00498	0.733
LIG_FHA_2	195	201	PF00498	0.596
LIG_FHA_2	387	393	PF00498	0.714
LIG_FHA_2	411	417	PF00498	0.710
LIG_Integrin_RGD_1	383	385	PF01839	0.629
LIG_LIR_Apic_2	249	255	PF02991	0.776
LIG_LIR_Apic_2	282	288	PF02991	0.576
LIG_LIR_Apic_2	497	503	PF02991	0.686
LIG_LIR_Gen_1	271	278	PF02991	0.415
LIG_LIR_Gen_1	51	59	PF02991	0.535
LIG_LIR_Gen_1	95	106	PF02991	0.496
LIG_LIR_LC3C_4	349	354	PF02991	0.664
LIG_LIR_Nem_3	110	116	PF02991	0.363
LIG_LIR_Nem_3	305	310	PF02991	0.584
LIG_LIR_Nem_3	33	38	PF02991	0.613
LIG_LIR_Nem_3	51	56	PF02991	0.356
LIG_LIR_Nem_3	95	101	PF02991	0.497
LIG_LYPXL_S_1	43	47	PF13949	0.486
LIG_LYPXL_yS_3	44	47	PF13949	0.499
LIG_PDZ_Class_3	581	586	PF00595	0.640
LIG_Pex14_1	272	276	PF04695	0.513
LIG_PTAP_UEV_1	155	160	PF05743	0.698
LIG_SH2_CRK	252	256	PF00017	0.766
LIG_SH2_CRK	500	504	PF00017	0.675
LIG_SH2_NCK_1	500	504	PF00017	0.675
LIG_SH2_PTP2	98	101	PF00017	0.473
LIG_SH2_STAP1	66	70	PF00017	0.499
LIG_SH2_STAT5	276	279	PF00017	0.523
LIG_SH2_STAT5	285	288	PF00017	0.427
LIG_SH2_STAT5	535	538	PF00017	0.619
LIG_SH2_STAT5	98	101	PF00017	0.473
LIG_SH3_3	122	128	PF00018	0.607
LIG_SH3_3	153	159	PF00018	0.818
LIG_SH3_3	319	325	PF00018	0.532
LIG_SH3_3	73	79	PF00018	0.538
LIG_SH3_3	96	102	PF00018	0.481
LIG_SUMO_SIM_anti_2	349	355	PF11976	0.563
LIG_SUMO_SIM_par_1	148	153	PF11976	0.712
LIG_SUMO_SIM_par_1	349	355	PF11976	0.563
LIG_TRAF2_1	102	105	PF00917	0.492
LIG_TRAF2_1	390	393	PF00917	0.704
LIG_TYR_ITSM	94	101	PF00017	0.479
LIG_WW_3	126	130	PF00397	0.704
MOD_CDK_SPxK_1	241	247	PF00069	0.730
MOD_CK1_1	133	139	PF00069	0.822
MOD_CK1_1	177	183	PF00069	0.751
MOD_CK1_1	184	190	PF00069	0.671
MOD_CK1_1	214	220	PF00069	0.782
MOD_CK1_1	236	242	PF00069	0.759
MOD_CK1_1	388	394	PF00069	0.716
MOD_CK1_1	410	416	PF00069	0.709
MOD_CK1_1	516	522	PF00069	0.770
MOD_CK2_1	133	139	PF00069	0.731
MOD_CK2_1	184	190	PF00069	0.740
MOD_CK2_1	194	200	PF00069	0.653
MOD_CK2_1	386	392	PF00069	0.717
MOD_CK2_1	410	416	PF00069	0.796
MOD_CK2_1	54	60	PF00069	0.521
MOD_Cter_Amidation	87	90	PF01082	0.602
MOD_GlcNHglycan	135	138	PF01048	0.784
MOD_GlcNHglycan	156	159	PF01048	0.751
MOD_GlcNHglycan	183	186	PF01048	0.746
MOD_GlcNHglycan	200	206	PF01048	0.804
MOD_GlcNHglycan	218	221	PF01048	0.746
MOD_GlcNHglycan	324	328	PF01048	0.571
MOD_GlcNHglycan	338	341	PF01048	0.671
MOD_GlcNHglycan	463	466	PF01048	0.814
MOD_GlcNHglycan	468	471	PF01048	0.757
MOD_GlcNHglycan	55	59	PF01048	0.541
MOD_GSK3_1	12	19	PF00069	0.609
MOD_GSK3_1	129	136	PF00069	0.825
MOD_GSK3_1	148	155	PF00069	0.827
MOD_GSK3_1	174	181	PF00069	0.721
MOD_GSK3_1	211	218	PF00069	0.723
MOD_GSK3_1	229	236	PF00069	0.693
MOD_GSK3_1	313	320	PF00069	0.537
MOD_GSK3_1	352	359	PF00069	0.622
MOD_GSK3_1	367	374	PF00069	0.718
MOD_GSK3_1	521	528	PF00069	0.575
MOD_GSK3_1	531	538	PF00069	0.564
MOD_GSK3_1	54	61	PF00069	0.495
MOD_LATS_1	227	233	PF00433	0.757
MOD_N-GLC_1	232	237	PF02516	0.602
MOD_N-GLC_1	317	322	PF02516	0.545
MOD_N-GLC_1	48	53	PF02516	0.523
MOD_NEK2_1	119	124	PF00069	0.632
MOD_NEK2_1	178	183	PF00069	0.720
MOD_NEK2_1	311	316	PF00069	0.527
MOD_NEK2_1	352	357	PF00069	0.560
MOD_NEK2_1	565	570	PF00069	0.672
MOD_PIKK_1	178	184	PF00454	0.781
MOD_PKA_1	258	264	PF00069	0.643
MOD_PKA_1	549	555	PF00069	0.737
MOD_PKA_2	246	252	PF00069	0.686
MOD_PKA_2	279	285	PF00069	0.525
MOD_PKA_2	347	353	PF00069	0.597
MOD_PKA_2	355	361	PF00069	0.624
MOD_PKA_2	371	377	PF00069	0.724
MOD_PKA_2	549	555	PF00069	0.674
MOD_Plk_1	119	125	PF00069	0.639
MOD_Plk_1	16	22	PF00069	0.495
MOD_Plk_1	232	238	PF00069	0.602
MOD_Plk_1	565	571	PF00069	0.646
MOD_Plk_1	94	100	PF00069	0.538
MOD_Plk_2-3	405	411	PF00069	0.800
MOD_Plk_4	145	151	PF00069	0.788
MOD_Plk_4	16	22	PF00069	0.495
MOD_Plk_4	174	180	PF00069	0.792
MOD_Plk_4	247	253	PF00069	0.796
MOD_Plk_4	347	353	PF00069	0.576
MOD_Plk_4	521	527	PF00069	0.619
MOD_Plk_4	565	571	PF00069	0.646
MOD_Plk_4	94	100	PF00069	0.506
MOD_ProDKin_1	131	137	PF00069	0.754
MOD_ProDKin_1	152	158	PF00069	0.820
MOD_ProDKin_1	241	247	PF00069	0.730
MOD_ProDKin_1	436	442	PF00069	0.801
MOD_ProDKin_1	518	524	PF00069	0.752
MOD_SUMO_for_1	117	120	PF00179	0.571
MOD_SUMO_for_1	514	517	PF00179	0.730
MOD_SUMO_rev_2	104	109	PF00179	0.493
MOD_SUMO_rev_2	139	149	PF00179	0.832
MOD_SUMO_rev_2	163	172	PF00179	0.760
MOD_SUMO_rev_2	33	38	PF00179	0.612
TRG_DiLeu_BaEn_4	104	110	PF01217	0.494
TRG_ENDOCYTIC_2	44	47	PF00928	0.499
TRG_ENDOCYTIC_2	98	101	PF00928	0.414
TRG_ER_diArg_1	378	381	PF00400	0.758
TRG_ER_diArg_1	427	429	PF00400	0.832
TRG_NES_CRM1_1	108	120	PF08389	0.630
TRG_NLS_MonoCore_2	450	455	PF00514	0.763
TRG_NLS_MonoCore_2	88	93	PF00514	0.488
TRG_NLS_MonoExtC_3	450	456	PF00514	0.731
TRG_NLS_MonoExtN_4	546	553	PF00514	0.817
TRG_NLS_MonoExtN_4	87	93	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J1	Leptomonas seymouri	53%	99%
A0A3S5H7R3	Leishmania donovani	94%	100%
A4HK39	Leishmania braziliensis	76%	100%
A4I7M4	Leishmania infantum	94%	100%
E9B2I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%