LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

J domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
J domain-containing protein
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4Q5M4_LEIMA
TriTrypDb:
LmjF.32.0590 , LMJLV39_320011300 , LMJSD75_320011300
Length:
316

Annotations

LeishMANIAdb annotations

A tail-anchored chaperone, with homology to ER-associated (secreted) heat shock proteins (plant ERDJ3). However, this subfamily appears to be oriented towards the cytoplasm.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q5M4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 100 102 PF00675 0.381
CLV_NRD_NRD_1 137 139 PF00675 0.463
CLV_NRD_NRD_1 153 155 PF00675 0.468
CLV_NRD_NRD_1 193 195 PF00675 0.364
CLV_NRD_NRD_1 209 211 PF00675 0.367
CLV_NRD_NRD_1 230 232 PF00675 0.380
CLV_NRD_NRD_1 253 255 PF00675 0.324
CLV_NRD_NRD_1 5 7 PF00675 0.535
CLV_PCSK_FUR_1 3 7 PF00082 0.482
CLV_PCSK_KEX2_1 100 102 PF00082 0.363
CLV_PCSK_KEX2_1 137 139 PF00082 0.463
CLV_PCSK_KEX2_1 153 155 PF00082 0.499
CLV_PCSK_KEX2_1 230 232 PF00082 0.380
CLV_PCSK_KEX2_1 310 312 PF00082 0.627
CLV_PCSK_KEX2_1 5 7 PF00082 0.535
CLV_PCSK_PC1ET2_1 310 312 PF00082 0.627
CLV_PCSK_SKI1_1 156 160 PF00082 0.470
CLV_PCSK_SKI1_1 17 21 PF00082 0.394
CLV_PCSK_SKI1_1 195 199 PF00082 0.433
CLV_PCSK_SKI1_1 23 27 PF00082 0.379
CLV_PCSK_SKI1_1 278 282 PF00082 0.287
CLV_PCSK_SKI1_1 311 315 PF00082 0.650
CLV_PCSK_SKI1_1 89 93 PF00082 0.252
CLV_Separin_Metazoa 227 231 PF03568 0.542
DEG_APCC_KENBOX_2 91 95 PF00400 0.508
DOC_AGCK_PIF_1 296 301 PF00069 0.513
DOC_CKS1_1 33 38 PF01111 0.560
DOC_MAPK_gen_1 291 299 PF00069 0.374
DOC_USP7_MATH_1 121 125 PF00917 0.746
DOC_USP7_MATH_1 146 150 PF00917 0.607
DOC_USP7_MATH_1 175 179 PF00917 0.589
DOC_USP7_MATH_1 236 240 PF00917 0.537
DOC_USP7_MATH_1 74 78 PF00917 0.452
DOC_USP7_UBL2_3 191 195 PF12436 0.654
DOC_USP7_UBL2_3 211 215 PF12436 0.411
DOC_WW_Pin1_4 32 37 PF00397 0.552
LIG_14-3-3_CanoR_1 153 159 PF00244 0.604
LIG_14-3-3_CanoR_1 194 200 PF00244 0.547
LIG_14-3-3_CanoR_1 210 214 PF00244 0.501
LIG_14-3-3_CanoR_1 231 241 PF00244 0.559
LIG_14-3-3_CanoR_1 262 268 PF00244 0.536
LIG_14-3-3_CanoR_1 51 56 PF00244 0.447
LIG_14-3-3_CterR_2 311 316 PF00244 0.436
LIG_Actin_WH2_2 195 212 PF00022 0.525
LIG_Actin_WH2_2 217 232 PF00022 0.531
LIG_BRCT_BRCA1_1 21 25 PF00533 0.513
LIG_BRCT_BRCA1_1 58 62 PF00533 0.452
LIG_deltaCOP1_diTrp_1 10 20 PF00928 0.546
LIG_deltaCOP1_diTrp_1 206 213 PF00928 0.519
LIG_FHA_1 153 159 PF00498 0.666
LIG_FHA_1 302 308 PF00498 0.419
LIG_FHA_2 196 202 PF00498 0.552
LIG_FHA_2 32 38 PF00498 0.647
LIG_FHA_2 51 57 PF00498 0.354
LIG_IBAR_NPY_1 40 42 PF08397 0.441
LIG_LIR_Gen_1 10 20 PF02991 0.612
LIG_LIR_Gen_1 258 268 PF02991 0.545
LIG_LIR_LC3C_4 64 67 PF02991 0.452
LIG_LIR_Nem_3 10 16 PF02991 0.628
LIG_LIR_Nem_3 162 168 PF02991 0.526
LIG_LIR_Nem_3 258 263 PF02991 0.546
LIG_LIR_Nem_3 277 283 PF02991 0.525
LIG_LIR_Nem_3 59 65 PF02991 0.477
LIG_Pex14_1 295 299 PF04695 0.378
LIG_REV1ctd_RIR_1 190 199 PF16727 0.543
LIG_SH2_CRK 88 92 PF00017 0.484
LIG_SH2_STAP1 183 187 PF00017 0.506
LIG_SH3_1 30 36 PF00018 0.541
LIG_SH3_1 68 74 PF00018 0.484
LIG_SH3_3 30 36 PF00018 0.572
LIG_SH3_3 68 74 PF00018 0.452
LIG_SUMO_SIM_anti_2 285 291 PF11976 0.388
LIG_SUMO_SIM_par_1 43 48 PF11976 0.466
LIG_TYR_ITIM 86 91 PF00017 0.502
LIG_WRC_WIRS_1 245 250 PF05994 0.525
MOD_CDK_SPxxK_3 32 39 PF00069 0.555
MOD_CK1_1 140 146 PF00069 0.692
MOD_CK1_1 247 253 PF00069 0.587
MOD_CK1_1 267 273 PF00069 0.472
MOD_CK2_1 121 127 PF00069 0.664
MOD_CK2_1 154 160 PF00069 0.570
MOD_CK2_1 195 201 PF00069 0.568
MOD_CK2_1 31 37 PF00069 0.598
MOD_CK2_1 51 57 PF00069 0.345
MOD_GlcNHglycan 131 134 PF01048 0.400
MOD_GlcNHglycan 195 198 PF01048 0.406
MOD_GlcNHglycan 234 237 PF01048 0.383
MOD_GSK3_1 232 239 PF00069 0.567
MOD_GSK3_1 244 251 PF00069 0.516
MOD_GSK3_1 297 304 PF00069 0.533
MOD_GSK3_1 47 54 PF00069 0.436
MOD_N-GLC_1 301 306 PF02516 0.626
MOD_NEK2_1 129 134 PF00069 0.599
MOD_NEK2_1 152 157 PF00069 0.644
MOD_NEK2_1 193 198 PF00069 0.555
MOD_NEK2_1 209 214 PF00069 0.498
MOD_NEK2_1 248 253 PF00069 0.554
MOD_NEK2_1 301 306 PF00069 0.346
MOD_NEK2_1 45 50 PF00069 0.452
MOD_NEK2_2 105 110 PF00069 0.642
MOD_PIKK_1 249 255 PF00454 0.553
MOD_PIKK_1 261 267 PF00454 0.499
MOD_PKA_1 137 143 PF00069 0.630
MOD_PKA_1 230 236 PF00069 0.629
MOD_PKA_2 121 127 PF00069 0.628
MOD_PKA_2 137 143 PF00069 0.680
MOD_PKA_2 152 158 PF00069 0.639
MOD_PKA_2 193 199 PF00069 0.548
MOD_PKA_2 209 215 PF00069 0.503
MOD_PKA_2 230 236 PF00069 0.676
MOD_PKA_2 261 267 PF00069 0.529
MOD_PKA_2 50 56 PF00069 0.447
MOD_Plk_1 105 111 PF00069 0.636
MOD_Plk_1 200 206 PF00069 0.521
MOD_Plk_1 301 307 PF00069 0.458
MOD_Plk_1 45 51 PF00069 0.452
MOD_Plk_4 209 215 PF00069 0.523
MOD_Plk_4 282 288 PF00069 0.406
MOD_ProDKin_1 32 38 PF00069 0.554
TRG_DiLeu_BaEn_2 276 282 PF01217 0.508
TRG_ENDOCYTIC_2 42 45 PF00928 0.453
TRG_ENDOCYTIC_2 88 91 PF00928 0.484
TRG_ER_diArg_1 152 154 PF00400 0.709
TRG_ER_diArg_1 229 231 PF00400 0.558
TRG_ER_diArg_1 4 6 PF00400 0.716
TRG_ER_diArg_1 99 101 PF00400 0.582
TRG_Pf-PMV_PEXEL_1 156 160 PF00026 0.354
TRG_Pf-PMV_PEXEL_1 254 258 PF00026 0.315
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I888 Leptomonas seymouri 82% 100%
A0A0S4KIH6 Bodo saltans 61% 98%
A0A1X0NV04 Trypanosomatidae 63% 100%
A0A3R7NF81 Trypanosoma rangeli 60% 100%
A0A3S7X5A0 Leishmania donovani 96% 100%
A4HK40 Leishmania braziliensis 90% 100%
A4I7M3 Leishmania infantum 96% 100%
D0A9S5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9B2I2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5AQU3 Trypanosoma cruzi 61% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS