LeishMANIAdb
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Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Calponin-homology (CH) domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q5M3_LEIMA
TriTrypDb:
LmjF.32.0600 , LMJLV39_320011400 , LMJSD75_320011400 *
Length:
811

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M3

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 1
GO:0009987 cellular process 1 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 35 39 PF00656 0.461
CLV_C14_Caspase3-7 676 680 PF00656 0.426
CLV_NRD_NRD_1 161 163 PF00675 0.599
CLV_NRD_NRD_1 202 204 PF00675 0.486
CLV_NRD_NRD_1 209 211 PF00675 0.546
CLV_NRD_NRD_1 352 354 PF00675 0.673
CLV_NRD_NRD_1 611 613 PF00675 0.415
CLV_NRD_NRD_1 694 696 PF00675 0.469
CLV_PCSK_FUR_1 206 210 PF00082 0.557
CLV_PCSK_KEX2_1 161 163 PF00082 0.599
CLV_PCSK_KEX2_1 208 210 PF00082 0.529
CLV_PCSK_KEX2_1 283 285 PF00082 0.410
CLV_PCSK_KEX2_1 352 354 PF00082 0.578
CLV_PCSK_KEX2_1 611 613 PF00082 0.415
CLV_PCSK_KEX2_1 694 696 PF00082 0.469
CLV_PCSK_PC1ET2_1 283 285 PF00082 0.363
CLV_PCSK_SKI1_1 147 151 PF00082 0.474
CLV_PCSK_SKI1_1 209 213 PF00082 0.538
CLV_PCSK_SKI1_1 304 308 PF00082 0.401
CLV_PCSK_SKI1_1 318 322 PF00082 0.496
CLV_PCSK_SKI1_1 523 527 PF00082 0.609
DEG_APCC_DBOX_1 146 154 PF00400 0.466
DEG_APCC_DBOX_1 207 215 PF00400 0.487
DEG_APCC_DBOX_1 359 367 PF00400 0.517
DOC_CKS1_1 475 480 PF01111 0.761
DOC_CKS1_1 632 637 PF01111 0.463
DOC_CYCLIN_RxL_1 203 215 PF00134 0.548
DOC_CYCLIN_RxL_1 520 530 PF00134 0.522
DOC_MAPK_gen_1 206 214 PF00069 0.511
DOC_MAPK_gen_1 355 363 PF00069 0.621
DOC_MAPK_gen_1 432 441 PF00069 0.627
DOC_MAPK_gen_1 520 528 PF00069 0.523
DOC_MAPK_MEF2A_6 432 441 PF00069 0.557
DOC_PP1_RVXF_1 316 322 PF00149 0.520
DOC_PP2B_LxvP_1 417 420 PF13499 0.548
DOC_PP2B_LxvP_1 510 513 PF13499 0.547
DOC_PP2B_LxvP_1 526 529 PF13499 0.584
DOC_USP7_MATH_1 128 132 PF00917 0.641
DOC_USP7_MATH_1 15 19 PF00917 0.567
DOC_USP7_MATH_1 238 242 PF00917 0.476
DOC_USP7_MATH_1 278 282 PF00917 0.406
DOC_USP7_MATH_1 430 434 PF00917 0.691
DOC_USP7_MATH_1 527 531 PF00917 0.658
DOC_USP7_MATH_1 683 687 PF00917 0.398
DOC_USP7_MATH_1 721 725 PF00917 0.499
DOC_USP7_MATH_1 781 785 PF00917 0.474
DOC_USP7_UBL2_3 289 293 PF12436 0.422
DOC_WW_Pin1_4 116 121 PF00397 0.515
DOC_WW_Pin1_4 420 425 PF00397 0.642
DOC_WW_Pin1_4 474 479 PF00397 0.602
DOC_WW_Pin1_4 50 55 PF00397 0.434
DOC_WW_Pin1_4 535 540 PF00397 0.622
DOC_WW_Pin1_4 549 554 PF00397 0.555
DOC_WW_Pin1_4 631 636 PF00397 0.466
DOC_WW_Pin1_4 739 744 PF00397 0.416
DOC_WW_Pin1_4 777 782 PF00397 0.422
DOC_WW_Pin1_4 794 799 PF00397 0.393
DOC_WW_Pin1_4 92 97 PF00397 0.406
LIG_14-3-3_CanoR_1 213 221 PF00244 0.452
LIG_14-3-3_CanoR_1 242 246 PF00244 0.442
LIG_14-3-3_CanoR_1 304 313 PF00244 0.369
LIG_14-3-3_CanoR_1 4 9 PF00244 0.546
LIG_14-3-3_CanoR_1 66 75 PF00244 0.510
LIG_14-3-3_CanoR_1 694 702 PF00244 0.470
LIG_14-3-3_CanoR_1 77 87 PF00244 0.372
LIG_APCC_ABBA_1 21 26 PF00400 0.598
LIG_BIR_III_4 411 415 PF00653 0.576
LIG_BRCT_BRCA1_1 449 453 PF00533 0.545
LIG_BRCT_BRCA1_1 530 534 PF00533 0.643
LIG_BRCT_BRCA1_2 530 536 PF00533 0.600
LIG_CaM_IQ_9 563 579 PF13499 0.580
LIG_deltaCOP1_diTrp_1 182 190 PF00928 0.486
LIG_deltaCOP1_diTrp_1 308 313 PF00928 0.430
LIG_deltaCOP1_diTrp_1 764 772 PF00928 0.402
LIG_FHA_1 335 341 PF00498 0.551
LIG_FHA_1 380 386 PF00498 0.593
LIG_FHA_1 424 430 PF00498 0.661
LIG_FHA_1 652 658 PF00498 0.457
LIG_FHA_1 710 716 PF00498 0.394
LIG_FHA_1 781 787 PF00498 0.408
LIG_FHA_1 96 102 PF00498 0.535
LIG_FHA_2 213 219 PF00498 0.455
LIG_FHA_2 310 316 PF00498 0.487
LIG_FHA_2 740 746 PF00498 0.417
LIG_LIR_Apic_2 403 409 PF02991 0.630
LIG_LIR_Apic_2 773 779 PF02991 0.390
LIG_LIR_Gen_1 182 191 PF02991 0.545
LIG_LIR_Gen_1 262 271 PF02991 0.475
LIG_LIR_Gen_1 651 661 PF02991 0.395
LIG_LIR_Gen_1 681 692 PF02991 0.431
LIG_LIR_Gen_1 765 776 PF02991 0.349
LIG_LIR_Gen_1 780 790 PF02991 0.401
LIG_LIR_Gen_1 797 807 PF02991 0.337
LIG_LIR_Nem_3 192 196 PF02991 0.473
LIG_LIR_Nem_3 262 267 PF02991 0.480
LIG_LIR_Nem_3 38 44 PF02991 0.402
LIG_LIR_Nem_3 463 468 PF02991 0.531
LIG_LIR_Nem_3 531 537 PF02991 0.605
LIG_LIR_Nem_3 558 564 PF02991 0.534
LIG_LIR_Nem_3 626 632 PF02991 0.618
LIG_LIR_Nem_3 651 656 PF02991 0.397
LIG_LIR_Nem_3 681 687 PF02991 0.424
LIG_LIR_Nem_3 765 771 PF02991 0.341
LIG_LIR_Nem_3 780 785 PF02991 0.420
LIG_LIR_Nem_3 797 803 PF02991 0.319
LIG_MYND_1 474 478 PF01753 0.550
LIG_MYND_1 92 96 PF01753 0.398
LIG_NRBOX 709 715 PF00104 0.394
LIG_NRBOX 730 736 PF00104 0.375
LIG_PCNA_PIPBox_1 247 256 PF02747 0.431
LIG_PCNA_PIPBox_1 303 312 PF02747 0.426
LIG_PCNA_yPIPBox_3 103 117 PF02747 0.480
LIG_PCNA_yPIPBox_3 242 254 PF02747 0.437
LIG_PCNA_yPIPBox_3 34 42 PF02747 0.479
LIG_Pex14_1 768 772 PF04695 0.398
LIG_Pex14_2 223 227 PF04695 0.489
LIG_SH2_CRK 51 55 PF00017 0.433
LIG_SH2_PTP2 13 16 PF00017 0.566
LIG_SH2_PTP2 776 779 PF00017 0.403
LIG_SH2_SRC 13 16 PF00017 0.566
LIG_SH2_SRC 24 27 PF00017 0.527
LIG_SH2_SRC 43 46 PF00017 0.338
LIG_SH2_SRC 776 779 PF00017 0.403
LIG_SH2_STAT5 115 118 PF00017 0.492
LIG_SH2_STAT5 13 16 PF00017 0.566
LIG_SH2_STAT5 339 342 PF00017 0.560
LIG_SH2_STAT5 43 46 PF00017 0.460
LIG_SH2_STAT5 586 589 PF00017 0.511
LIG_SH2_STAT5 605 608 PF00017 0.405
LIG_SH2_STAT5 659 662 PF00017 0.384
LIG_SH2_STAT5 716 719 PF00017 0.387
LIG_SH2_STAT5 776 779 PF00017 0.391
LIG_SH2_STAT5 79 82 PF00017 0.409
LIG_SH3_3 440 446 PF00018 0.587
LIG_SH3_3 468 474 PF00018 0.532
LIG_SH3_3 625 631 PF00018 0.408
LIG_SH3_3 9 15 PF00018 0.604
LIG_SUMO_SIM_anti_2 597 603 PF11976 0.479
LIG_TRAF2_1 23 26 PF00917 0.545
LIG_TRAF2_1 686 689 PF00917 0.379
LIG_TRFH_1 739 743 PF08558 0.387
LIG_UBA3_1 713 720 PF00899 0.391
MOD_CDK_SPxK_1 631 637 PF00069 0.465
MOD_CK1_1 126 132 PF00069 0.681
MOD_CK1_1 192 198 PF00069 0.527
MOD_CK1_1 241 247 PF00069 0.501
MOD_CK1_1 348 354 PF00069 0.666
MOD_CK1_1 393 399 PF00069 0.646
MOD_CK1_1 400 406 PF00069 0.604
MOD_CK1_1 418 424 PF00069 0.537
MOD_CK1_1 667 673 PF00069 0.430
MOD_CK1_1 780 786 PF00069 0.405
MOD_CK1_1 95 101 PF00069 0.477
MOD_CK2_1 212 218 PF00069 0.457
MOD_CK2_1 309 315 PF00069 0.541
MOD_CK2_1 594 600 PF00069 0.539
MOD_CK2_1 683 689 PF00069 0.444
MOD_CK2_1 739 745 PF00069 0.406
MOD_CMANNOS 310 313 PF00535 0.428
MOD_GlcNHglycan 17 20 PF01048 0.568
MOD_GlcNHglycan 347 350 PF01048 0.624
MOD_GlcNHglycan 392 395 PF01048 0.604
MOD_GlcNHglycan 503 506 PF01048 0.549
MOD_GlcNHglycan 665 669 PF01048 0.428
MOD_GlcNHglycan 772 775 PF01048 0.366
MOD_GlcNHglycan 807 810 PF01048 0.481
MOD_GSK3_1 116 123 PF00069 0.525
MOD_GSK3_1 237 244 PF00069 0.516
MOD_GSK3_1 304 311 PF00069 0.381
MOD_GSK3_1 341 348 PF00069 0.518
MOD_GSK3_1 393 400 PF00069 0.647
MOD_GSK3_1 428 435 PF00069 0.538
MOD_GSK3_1 448 455 PF00069 0.608
MOD_GSK3_1 497 504 PF00069 0.548
MOD_GSK3_1 693 700 PF00069 0.416
MOD_GSK3_1 777 784 PF00069 0.415
MOD_N-GLC_1 331 336 PF02516 0.557
MOD_N-GLC_1 341 346 PF02516 0.545
MOD_N-GLC_1 721 726 PF02516 0.486
MOD_NEK2_1 113 118 PF00069 0.478
MOD_NEK2_1 212 217 PF00069 0.474
MOD_NEK2_1 223 228 PF00069 0.521
MOD_NEK2_1 285 290 PF00069 0.469
MOD_NEK2_1 388 393 PF00069 0.730
MOD_NEK2_1 453 458 PF00069 0.517
MOD_NEK2_1 492 497 PF00069 0.538
MOD_NEK2_1 498 503 PF00069 0.534
MOD_NEK2_1 678 683 PF00069 0.405
MOD_NEK2_1 770 775 PF00069 0.401
MOD_NEK2_1 78 83 PF00069 0.466
MOD_NEK2_2 278 283 PF00069 0.368
MOD_NEK2_2 448 453 PF00069 0.542
MOD_NEK2_2 506 511 PF00069 0.533
MOD_NEK2_2 586 591 PF00069 0.560
MOD_PIKK_1 135 141 PF00454 0.499
MOD_PIKK_1 155 161 PF00454 0.360
MOD_PIKK_1 299 305 PF00454 0.496
MOD_PIKK_1 379 385 PF00454 0.590
MOD_PIKK_1 528 534 PF00454 0.614
MOD_PIKK_1 618 624 PF00454 0.423
MOD_PIKK_1 721 727 PF00454 0.482
MOD_PK_1 624 630 PF00069 0.398
MOD_PKA_2 212 218 PF00069 0.504
MOD_PKA_2 241 247 PF00069 0.443
MOD_PKA_2 693 699 PF00069 0.474
MOD_Plk_1 314 320 PF00069 0.576
MOD_Plk_1 331 337 PF00069 0.508
MOD_Plk_1 678 684 PF00069 0.406
MOD_Plk_1 721 727 PF00069 0.482
MOD_Plk_1 747 753 PF00069 0.484
MOD_Plk_4 241 247 PF00069 0.501
MOD_Plk_4 26 32 PF00069 0.650
MOD_Plk_4 36 42 PF00069 0.385
MOD_Plk_4 432 438 PF00069 0.762
MOD_Plk_4 448 454 PF00069 0.544
MOD_Plk_4 467 473 PF00069 0.466
MOD_Plk_4 498 504 PF00069 0.503
MOD_Plk_4 506 512 PF00069 0.503
MOD_Plk_4 624 630 PF00069 0.398
MOD_Plk_4 709 715 PF00069 0.363
MOD_Plk_4 729 735 PF00069 0.304
MOD_Plk_4 781 787 PF00069 0.446
MOD_ProDKin_1 116 122 PF00069 0.519
MOD_ProDKin_1 420 426 PF00069 0.644
MOD_ProDKin_1 474 480 PF00069 0.602
MOD_ProDKin_1 50 56 PF00069 0.434
MOD_ProDKin_1 535 541 PF00069 0.623
MOD_ProDKin_1 549 555 PF00069 0.551
MOD_ProDKin_1 631 637 PF00069 0.465
MOD_ProDKin_1 739 745 PF00069 0.417
MOD_ProDKin_1 777 783 PF00069 0.417
MOD_ProDKin_1 794 800 PF00069 0.387
MOD_ProDKin_1 92 98 PF00069 0.408
MOD_SUMO_rev_2 164 174 PF00179 0.443
MOD_SUMO_rev_2 257 262 PF00179 0.411
TRG_DiLeu_BaEn_1 315 320 PF01217 0.501
TRG_DiLeu_BaEn_3 25 31 PF01217 0.505
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.532
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.562
TRG_DiLeu_BaLyEn_6 788 793 PF01217 0.419
TRG_ENDOCYTIC_2 13 16 PF00928 0.566
TRG_ENDOCYTIC_2 264 267 PF00928 0.483
TRG_ENDOCYTIC_2 465 468 PF00928 0.591
TRG_ENDOCYTIC_2 684 687 PF00928 0.437
TRG_ER_diArg_1 160 162 PF00400 0.596
TRG_ER_diArg_1 206 209 PF00400 0.497
TRG_ER_diArg_1 352 355 PF00400 0.730
TRG_ER_diArg_1 610 612 PF00400 0.418
TRG_ER_diArg_1 65 68 PF00400 0.456
TRG_ER_diArg_1 693 695 PF00400 0.474
TRG_NES_CRM1_1 767 778 PF08389 0.299
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 304 308 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 791 795 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9Y4 Leptomonas seymouri 55% 97%
A0A3Q8IFA7 Leishmania donovani 94% 100%
A4I7M2 Leishmania infantum 94% 100%
E9AIU9 Leishmania braziliensis 78% 100%
E9B2I3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS