WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5M2_LEIMA

TriTrypDb:

LmjF.32.0610 , LMJLV39_320011500 , LMJSD75_320011500

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031080	nuclear pore outer ring	3	2
GO:0032991	protein-containing complex	1	2
GO:0035859	Seh1-associated complex	2	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4Q5M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5M2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006950	response to stress	2	2
GO:0007154	cell communication	2	2
GO:0008104	protein localization	4	11
GO:0009267	cellular response to starvation	4	2
GO:0009605	response to external stimulus	2	2
GO:0009966	regulation of signal transduction	4	11
GO:0009967	positive regulation of signal transduction	5	11
GO:0009987	cellular process	1	11
GO:0009991	response to extracellular stimulus	3	2
GO:0010646	regulation of cell communication	4	11
GO:0010647	positive regulation of cell communication	5	11
GO:0015031	protein transport	4	11
GO:0023051	regulation of signaling	3	11
GO:0023056	positive regulation of signaling	4	11
GO:0031667	response to nutrient levels	4	2
GO:0031668	cellular response to extracellular stimulus	3	2
GO:0031669	cellular response to nutrient levels	4	2
GO:0032006	regulation of TOR signaling	6	11
GO:0032008	positive regulation of TOR signaling	7	11
GO:0033036	macromolecule localization	2	11
GO:0033554	cellular response to stress	3	2
GO:0034198	cellular response to amino acid starvation	5	2
GO:0042594	response to starvation	3	2
GO:0045184	establishment of protein localization	3	11
GO:0048518	positive regulation of biological process	3	11
GO:0048522	positive regulation of cellular process	4	11
GO:0048583	regulation of response to stimulus	3	11
GO:0048584	positive regulation of response to stimulus	4	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0050896	response to stimulus	1	2
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051716	cellular response to stimulus	2	2
GO:0065007	biological regulation	1	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071496	cellular response to external stimulus	3	2
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:1902531	regulation of intracellular signal transduction	5	11
GO:1902533	positive regulation of intracellular signal transduction	6	11
GO:1903432	regulation of TORC1 signaling	7	11
GO:1904263	positive regulation of TORC1 signaling	8	11
GO:1990928	response to amino acid starvation	4	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.750
CLV_NRD_NRD_1	277	279	PF00675	0.509
CLV_NRD_NRD_1	336	338	PF00675	0.411
CLV_NRD_NRD_1	38	40	PF00675	0.554
CLV_PCSK_KEX2_1	189	191	PF00082	0.747
CLV_PCSK_KEX2_1	277	279	PF00082	0.509
CLV_PCSK_KEX2_1	305	307	PF00082	0.555
CLV_PCSK_KEX2_1	336	338	PF00082	0.411
CLV_PCSK_KEX2_1	38	40	PF00082	0.554
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.588
CLV_PCSK_SKI1_1	222	226	PF00082	0.470
CLV_PCSK_SKI1_1	234	238	PF00082	0.432
CLV_PCSK_SKI1_1	239	243	PF00082	0.179
CLV_PCSK_SKI1_1	3	7	PF00082	0.497
CLV_PCSK_SKI1_1	98	102	PF00082	0.509
DEG_APCC_DBOX_1	277	285	PF00400	0.463
DEG_APCC_DBOX_1	97	105	PF00400	0.538
DOC_MAPK_gen_1	277	284	PF00069	0.430
DOC_MAPK_gen_1	336	343	PF00069	0.357
DOC_MAPK_MEF2A_6	336	345	PF00069	0.567
DOC_MAPK_RevD_3	290	306	PF00069	0.526
DOC_PP4_FxxP_1	122	125	PF00568	0.411
DOC_PP4_FxxP_1	311	314	PF00568	0.392
DOC_USP7_MATH_1	170	174	PF00917	0.583
DOC_USP7_MATH_1	19	23	PF00917	0.470
DOC_USP7_MATH_1	195	199	PF00917	0.736
DOC_USP7_MATH_1	25	29	PF00917	0.454
DOC_WW_Pin1_4	104	109	PF00397	0.499
DOC_WW_Pin1_4	157	162	PF00397	0.493
DOC_WW_Pin1_4	193	198	PF00397	0.624
DOC_WW_Pin1_4	296	301	PF00397	0.371
LIG_14-3-3_CanoR_1	222	227	PF00244	0.422
LIG_14-3-3_CanoR_1	261	265	PF00244	0.533
LIG_14-3-3_CanoR_1	3	12	PF00244	0.224
LIG_14-3-3_CanoR_1	324	329	PF00244	0.432
LIG_14-3-3_CanoR_1	336	343	PF00244	0.467
LIG_14-3-3_CanoR_1	38	42	PF00244	0.491
LIG_Actin_WH2_2	245	263	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_BRCT_BRCA1_1	231	235	PF00533	0.475
LIG_BRCT_BRCA1_1	243	247	PF00533	0.448
LIG_BRCT_BRCA1_1	287	291	PF00533	0.423
LIG_BRCT_BRCA1_2	243	249	PF00533	0.307
LIG_FHA_1	133	139	PF00498	0.341
LIG_FHA_1	221	227	PF00498	0.450
LIG_FHA_1	30	36	PF00498	0.529
LIG_FHA_1	336	342	PF00498	0.539
LIG_LIR_Apic_2	119	125	PF02991	0.383
LIG_LIR_Apic_2	309	314	PF02991	0.391
LIG_LIR_Gen_1	244	255	PF02991	0.462
LIG_LIR_Gen_1	307	315	PF02991	0.477
LIG_LIR_Gen_1	82	92	PF02991	0.401
LIG_LIR_Nem_3	103	109	PF02991	0.519
LIG_LIR_Nem_3	232	238	PF02991	0.413
LIG_LIR_Nem_3	244	250	PF02991	0.348
LIG_LIR_Nem_3	307	311	PF02991	0.505
LIG_LIR_Nem_3	353	357	PF02991	0.412
LIG_LIR_Nem_3	82	87	PF02991	0.349
LIG_Pex14_1	84	88	PF04695	0.341
LIG_Pex14_2	311	315	PF04695	0.512
LIG_REV1ctd_RIR_1	233	243	PF16727	0.426
LIG_SH2_CRK	128	132	PF00017	0.531
LIG_SH2_CRK	238	242	PF00017	0.444
LIG_SH2_CRK	88	92	PF00017	0.412
LIG_SH2_SRC	11	14	PF00017	0.540
LIG_SH2_STAP1	112	116	PF00017	0.450
LIG_SH2_STAT5	11	14	PF00017	0.540
LIG_SH2_STAT5	240	243	PF00017	0.400
LIG_SH2_STAT5	330	333	PF00017	0.359
LIG_SH2_STAT5	86	89	PF00017	0.350
LIG_SH3_3	144	150	PF00018	0.506
LIG_SH3_3	44	50	PF00018	0.545
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.437
LIG_SUMO_SIM_par_1	223	230	PF11976	0.454
LIG_SUMO_SIM_par_1	280	286	PF11976	0.439
MOD_CDC14_SPxK_1	107	110	PF00782	0.513
MOD_CDK_SPxK_1	104	110	PF00069	0.504
MOD_CK1_1	134	140	PF00069	0.325
MOD_CK1_1	181	187	PF00069	0.668
MOD_CK1_1	198	204	PF00069	0.742
MOD_CK1_1	26	32	PF00069	0.497
MOD_CK1_1	270	276	PF00069	0.469
MOD_CK1_1	283	289	PF00069	0.300
MOD_CK2_1	283	289	PF00069	0.457
MOD_CK2_1	298	304	PF00069	0.547
MOD_CK2_1	90	96	PF00069	0.511
MOD_Cter_Amidation	275	278	PF01082	0.538
MOD_GlcNHglycan	172	175	PF01048	0.609
MOD_GlcNHglycan	18	22	PF01048	0.260
MOD_GlcNHglycan	180	183	PF01048	0.619
MOD_GlcNHglycan	191	196	PF01048	0.699
MOD_GlcNHglycan	197	200	PF01048	0.656
MOD_GlcNHglycan	206	209	PF01048	0.358
MOD_GlcNHglycan	218	221	PF01048	0.377
MOD_GlcNHglycan	231	234	PF01048	0.388
MOD_GlcNHglycan	262	265	PF01048	0.507
MOD_GlcNHglycan	318	321	PF01048	0.389
MOD_GlcNHglycan	56	60	PF01048	0.459
MOD_GSK3_1	19	26	PF00069	0.474
MOD_GSK3_1	191	198	PF00069	0.701
MOD_GSK3_1	204	211	PF00069	0.426
MOD_GSK3_1	216	223	PF00069	0.450
MOD_GSK3_1	3	10	PF00069	0.332
MOD_GSK3_1	318	325	PF00069	0.396
MOD_GSK3_1	96	103	PF00069	0.500
MOD_N-GLC_1	267	272	PF02516	0.464
MOD_NEK2_1	100	105	PF00069	0.530
MOD_NEK2_1	131	136	PF00069	0.324
MOD_NEK2_1	204	209	PF00069	0.591
MOD_NEK2_1	23	28	PF00069	0.460
MOD_NEK2_1	248	253	PF00069	0.526
MOD_NEK2_1	260	265	PF00069	0.534
MOD_NEK2_1	75	80	PF00069	0.336
MOD_OFUCOSY	267	274	PF10250	0.421
MOD_PIKK_1	3	9	PF00454	0.425
MOD_PIKK_1	335	341	PF00454	0.557
MOD_PKA_2	260	266	PF00069	0.525
MOD_PKA_2	323	329	PF00069	0.493
MOD_PKA_2	335	341	PF00069	0.454
MOD_PKA_2	37	43	PF00069	0.487
MOD_Plk_1	220	226	PF00069	0.457
MOD_Plk_1	267	273	PF00069	0.368
MOD_Plk_1	29	35	PF00069	0.526
MOD_Plk_2-3	304	310	PF00069	0.535
MOD_Plk_4	19	25	PF00069	0.506
MOD_Plk_4	243	249	PF00069	0.486
MOD_Plk_4	324	330	PF00069	0.405
MOD_Plk_4	7	13	PF00069	0.512
MOD_ProDKin_1	104	110	PF00069	0.504
MOD_ProDKin_1	157	163	PF00069	0.499
MOD_ProDKin_1	193	199	PF00069	0.624
MOD_ProDKin_1	296	302	PF00069	0.380
MOD_SUMO_rev_2	299	307	PF00179	0.524
TRG_DiLeu_BaEn_1	96	101	PF01217	0.540
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.644
TRG_DiLeu_LyEn_5	71	76	PF01217	0.429
TRG_ENDOCYTIC_2	128	131	PF00928	0.538
TRG_ENDOCYTIC_2	238	241	PF00928	0.417
TRG_ENDOCYTIC_2	88	91	PF00928	0.405
TRG_ER_diArg_1	277	279	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM52	Leptomonas seymouri	76%	96%
A0A1X0NW55	Trypanosomatidae	48%	100%
A0A3Q8IKQ4	Leishmania donovani	97%	100%
A0A3S5IRB2	Trypanosoma rangeli	46%	100%
A4HK41	Leishmania braziliensis	88%	98%
A4I7M1	Leishmania infantum	97%	100%
A7YY75	Bos taurus	24%	100%
C1BK83	Osmerus mordax	26%	100%
D0A9S7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B2I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4FZW5	Xenopus laevis	24%	100%
Q54DS8	Dictyostelium discoideum	23%	100%
Q5RAN6	Pongo abelii	24%	100%
Q5U4Y8	Xenopus tropicalis	24%	100%
Q5XFW8	Rattus norvegicus	25%	100%
Q6BZX5	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	100%
Q6FNV4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q6GNF1	Xenopus laevis	23%	100%
Q6TGU2	Danio rerio	26%	100%
Q75BS2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	100%
Q7K2X8	Drosophila melanogaster	26%	100%
Q96EE3	Homo sapiens	24%	100%
Q9D1M0	Mus musculus	26%	100%
V5BFB9	Trypanosoma cruzi	46%	100%