Putative phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q5L9_LEIMA

TriTrypDb:

LmjF.32.0640 , LMJLV39_320011800 , LMJSD75_320011800

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5L9

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	2
GO:0016311	dephosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004721	phosphoprotein phosphatase activity	3	10
GO:0004725	protein tyrosine phosphatase activity	4	10
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016791	phosphatase activity	5	10
GO:0042578	phosphoric ester hydrolase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.561
CLV_C14_Caspase3-7	42	46	PF00656	0.654
CLV_C14_Caspase3-7	597	601	PF00656	0.781
CLV_NRD_NRD_1	229	231	PF00675	0.444
CLV_NRD_NRD_1	31	33	PF00675	0.780
CLV_NRD_NRD_1	343	345	PF00675	0.417
CLV_NRD_NRD_1	37	39	PF00675	0.759
CLV_NRD_NRD_1	399	401	PF00675	0.538
CLV_NRD_NRD_1	509	511	PF00675	0.783
CLV_NRD_NRD_1	579	581	PF00675	0.715
CLV_NRD_NRD_1	585	587	PF00675	0.751
CLV_PCSK_KEX2_1	31	33	PF00082	0.781
CLV_PCSK_KEX2_1	342	344	PF00082	0.429
CLV_PCSK_KEX2_1	37	39	PF00082	0.758
CLV_PCSK_KEX2_1	399	401	PF00082	0.578
CLV_PCSK_KEX2_1	489	491	PF00082	0.499
CLV_PCSK_KEX2_1	509	511	PF00082	0.777
CLV_PCSK_KEX2_1	579	581	PF00082	0.715
CLV_PCSK_KEX2_1	585	587	PF00082	0.751
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.781
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.513
CLV_PCSK_SKI1_1	119	123	PF00082	0.431
CLV_PCSK_SKI1_1	279	283	PF00082	0.377
CLV_PCSK_SKI1_1	316	320	PF00082	0.532
CLV_PCSK_SKI1_1	399	403	PF00082	0.505
CLV_PCSK_SKI1_1	462	466	PF00082	0.528
CLV_PCSK_SKI1_1	486	490	PF00082	0.474
DEG_APCC_DBOX_1	315	323	PF00400	0.520
DEG_APCC_DBOX_1	406	414	PF00400	0.418
DEG_MDM2_SWIB_1	463	471	PF02201	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DEG_SCF_FBW7_1	521	528	PF00400	0.613
DEG_SPOP_SBC_1	520	524	PF00917	0.788
DOC_CYCLIN_RxL_1	298	310	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	402	408	PF00134	0.493
DOC_MAPK_gen_1	190	197	PF00069	0.401
DOC_MAPK_gen_1	404	414	PF00069	0.395
DOC_MAPK_MEF2A_6	390	398	PF00069	0.534
DOC_PP2B_LxvP_1	518	521	PF13499	0.735
DOC_PP4_FxxP_1	165	168	PF00568	0.432
DOC_PP4_FxxP_1	554	557	PF00568	0.586
DOC_SPAK_OSR1_1	344	348	PF12202	0.467
DOC_USP7_MATH_1	102	106	PF00917	0.406
DOC_USP7_MATH_1	318	322	PF00917	0.484
DOC_USP7_MATH_1	492	496	PF00917	0.404
DOC_USP7_MATH_1	508	512	PF00917	0.611
DOC_USP7_MATH_1	525	529	PF00917	0.611
DOC_USP7_MATH_1	595	599	PF00917	0.705
DOC_USP7_UBL2_3	190	194	PF12436	0.369
DOC_USP7_UBL2_3	25	29	PF12436	0.726
DOC_USP7_UBL2_3	31	35	PF12436	0.662
DOC_WW_Pin1_4	366	371	PF00397	0.437
DOC_WW_Pin1_4	450	455	PF00397	0.526
DOC_WW_Pin1_4	509	514	PF00397	0.729
DOC_WW_Pin1_4	521	526	PF00397	0.580
LIG_14-3-3_CanoR_1	101	107	PF00244	0.404
LIG_14-3-3_CanoR_1	255	262	PF00244	0.404
LIG_14-3-3_CanoR_1	346	351	PF00244	0.490
LIG_14-3-3_CanoR_1	365	370	PF00244	0.429
LIG_14-3-3_CanoR_1	407	411	PF00244	0.400
LIG_14-3-3_CanoR_1	509	513	PF00244	0.725
LIG_14-3-3_CanoR_1	516	521	PF00244	0.724
LIG_14-3-3_CanoR_1	549	557	PF00244	0.722
LIG_14-3-3_CanoR_1	593	603	PF00244	0.784
LIG_APCC_ABBA_1	280	285	PF00400	0.432
LIG_APCC_ABBAyCdc20_2	279	285	PF00400	0.387
LIG_BRCT_BRCA1_1	256	260	PF00533	0.433
LIG_BRCT_BRCA1_1	414	418	PF00533	0.495
LIG_BRCT_BRCA1_1	550	554	PF00533	0.534
LIG_eIF4E_1	290	296	PF01652	0.477
LIG_FHA_1	120	126	PF00498	0.457
LIG_FHA_1	515	521	PF00498	0.783
LIG_FHA_2	560	566	PF00498	0.687
LIG_LIR_Apic_2	161	166	PF02991	0.425
LIG_LIR_Apic_2	551	557	PF02991	0.552
LIG_LIR_Gen_1	69	78	PF02991	0.497
LIG_LIR_Nem_3	104	110	PF02991	0.453
LIG_LIR_Nem_3	161	165	PF02991	0.440
LIG_LIR_Nem_3	288	293	PF02991	0.383
LIG_LIR_Nem_3	415	420	PF02991	0.365
LIG_LIR_Nem_3	473	478	PF02991	0.471
LIG_LIR_Nem_3	6	12	PF02991	0.666
LIG_LYPXL_yS_3	110	113	PF13949	0.501
LIG_MLH1_MIPbox_1	414	418	PF16413	0.306
LIG_NRBOX	300	306	PF00104	0.420
LIG_NRP_CendR_1	602	605	PF00754	0.812
LIG_Pex14_2	245	249	PF04695	0.344
LIG_Pex14_2	441	445	PF04695	0.559
LIG_Pex14_2	463	467	PF04695	0.382
LIG_PTB_Apo_2	428	435	PF02174	0.496
LIG_SH2_CRK	290	294	PF00017	0.376
LIG_SH2_CRK	478	482	PF00017	0.572
LIG_SH2_CRK	9	13	PF00017	0.792
LIG_SH2_GRB2like	475	478	PF00017	0.452
LIG_SH2_NCK_1	478	482	PF00017	0.530
LIG_SH2_SRC	214	217	PF00017	0.444
LIG_SH2_STAP1	216	220	PF00017	0.344
LIG_SH2_STAT5	214	217	PF00017	0.372
LIG_SH2_STAT5	475	478	PF00017	0.420
LIG_Sin3_3	225	232	PF02671	0.408
LIG_SUMO_SIM_anti_2	222	230	PF11976	0.402
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.431
LIG_SUMO_SIM_par_1	516	524	PF11976	0.734
LIG_SUMO_SIM_par_1	555	566	PF11976	0.657
LIG_TRAF2_1	389	392	PF00917	0.642
LIG_TYR_ITIM	108	113	PF00017	0.481
LIG_UBA3_1	300	309	PF00899	0.430
LIG_WRC_WIRS_1	355	360	PF05994	0.406
LIG_WRC_WIRS_1	438	443	PF05994	0.539
LIG_WW_3	506	510	PF00397	0.743
MOD_CDK_SPxxK_3	450	457	PF00069	0.515
MOD_CDK_SPxxK_3	509	516	PF00069	0.615
MOD_CK1_1	14	20	PF00069	0.716
MOD_CK1_1	145	151	PF00069	0.501
MOD_CK1_1	354	360	PF00069	0.391
MOD_CK1_1	366	372	PF00069	0.376
MOD_CK1_1	511	517	PF00069	0.754
MOD_CK1_1	519	525	PF00069	0.760
MOD_CK1_1	545	551	PF00069	0.722
MOD_CK2_1	158	164	PF00069	0.442
MOD_CK2_1	386	392	PF00069	0.661
MOD_CK2_1	450	456	PF00069	0.485
MOD_CK2_1	520	526	PF00069	0.752
MOD_CK2_1	559	565	PF00069	0.694
MOD_Cter_Amidation	583	586	PF01082	0.550
MOD_GlcNHglycan	143	147	PF01048	0.517
MOD_GlcNHglycan	15	19	PF01048	0.628
MOD_GlcNHglycan	324	327	PF01048	0.490
MOD_GlcNHglycan	333	336	PF01048	0.426
MOD_GlcNHglycan	414	417	PF01048	0.355
MOD_GlcNHglycan	539	542	PF01048	0.721
MOD_GlcNHglycan	597	600	PF01048	0.590
MOD_GSK3_1	141	148	PF00069	0.443
MOD_GSK3_1	318	325	PF00069	0.444
MOD_GSK3_1	366	373	PF00069	0.445
MOD_GSK3_1	380	387	PF00069	0.487
MOD_GSK3_1	516	523	PF00069	0.774
MOD_GSK3_1	559	566	PF00069	0.729
MOD_GSK3_1	96	103	PF00069	0.389
MOD_LATS_1	117	123	PF00433	0.557
MOD_N-GLC_1	119	124	PF02516	0.467
MOD_N-GLC_1	305	310	PF02516	0.427
MOD_NEK2_1	203	208	PF00069	0.344
MOD_NEK2_1	289	294	PF00069	0.473
MOD_NEK2_1	296	301	PF00069	0.403
MOD_NEK2_1	364	369	PF00069	0.495
MOD_NEK2_1	384	389	PF00069	0.298
MOD_NEK2_1	412	417	PF00069	0.368
MOD_NEK2_1	418	423	PF00069	0.390
MOD_NEK2_1	493	498	PF00069	0.478
MOD_NEK2_1	499	504	PF00069	0.497
MOD_NEK2_1	542	547	PF00069	0.708
MOD_NEK2_1	55	60	PF00069	0.545
MOD_NEK2_2	102	107	PF00069	0.406
MOD_NEK2_2	484	489	PF00069	0.523
MOD_PIKK_1	214	220	PF00454	0.444
MOD_PIKK_1	254	260	PF00454	0.448
MOD_PIKK_1	543	549	PF00454	0.764
MOD_PIKK_1	96	102	PF00454	0.389
MOD_PK_1	346	352	PF00069	0.530
MOD_PK_1	516	522	PF00069	0.618
MOD_PKA_1	31	37	PF00069	0.808
MOD_PKA_1	579	585	PF00069	0.744
MOD_PKA_2	100	106	PF00069	0.400
MOD_PKA_2	254	260	PF00069	0.416
MOD_PKA_2	31	37	PF00069	0.775
MOD_PKA_2	364	370	PF00069	0.465
MOD_PKA_2	384	390	PF00069	0.306
MOD_PKA_2	406	412	PF00069	0.399
MOD_PKA_2	508	514	PF00069	0.764
MOD_PKA_2	548	554	PF00069	0.718
MOD_PKA_2	579	585	PF00069	0.712
MOD_PKB_1	344	352	PF00069	0.556
MOD_Plk_1	329	335	PF00069	0.555
MOD_Plk_1	351	357	PF00069	0.415
MOD_Plk_4	102	108	PF00069	0.435
MOD_Plk_4	296	302	PF00069	0.458
MOD_Plk_4	351	357	PF00069	0.411
MOD_Plk_4	493	499	PF00069	0.511
MOD_Plk_4	55	61	PF00069	0.553
MOD_ProDKin_1	366	372	PF00069	0.434
MOD_ProDKin_1	450	456	PF00069	0.517
MOD_ProDKin_1	509	515	PF00069	0.729
MOD_ProDKin_1	521	527	PF00069	0.582
MOD_SUMO_rev_2	561	568	PF00179	0.756
MOD_SUMO_rev_2	597	603	PF00179	0.743
TRG_DiLeu_BaEn_1	224	229	PF01217	0.401
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.414
TRG_ENDOCYTIC_2	110	113	PF00928	0.426
TRG_ENDOCYTIC_2	162	165	PF00928	0.415
TRG_ENDOCYTIC_2	290	293	PF00928	0.363
TRG_ENDOCYTIC_2	478	481	PF00928	0.512
TRG_ENDOCYTIC_2	9	12	PF00928	0.679
TRG_ER_diArg_1	277	280	PF00400	0.413
TRG_ER_diArg_1	342	344	PF00400	0.431
TRG_ER_diArg_1	36	38	PF00400	0.610
TRG_ER_diArg_1	398	400	PF00400	0.578
TRG_ER_diArg_1	508	510	PF00400	0.789
TRG_ER_diArg_1	578	580	PF00400	0.710
TRG_ER_diArg_1	585	588	PF00400	0.758
TRG_ER_diArg_1	591	594	PF00400	0.782
TRG_NES_CRM1_1	263	276	PF08389	0.483
TRG_NLS_MonoCore_2	27	32	PF00514	0.772
TRG_NLS_MonoExtC_3	229	234	PF00514	0.444
TRG_NLS_MonoExtC_3	27	32	PF00514	0.789
TRG_NLS_MonoExtN_4	25	32	PF00514	0.751

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW9	Leptomonas seymouri	75%	99%
A0A0S4KLI7	Bodo saltans	46%	100%
A0A1X0NUR4	Trypanosomatidae	66%	100%
A0A3Q8IG01	Leishmania donovani	96%	100%
A4HK44	Leishmania braziliensis	84%	100%
A4I7L8	Leishmania infantum	96%	100%
D0A9T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%