Putative OSM3-like kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

OSM3-like kinesin, putative

Species:

Leishmania major

UniProt:

Q4Q5L5_LEIMA

TriTrypDb:

LmjF.32.0680 , LMJLV39_320012200 , LMJSD75_320012200

Length:

1117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	2
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5L5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	1028	1030	PF00675	0.558
CLV_NRD_NRD_1	198	200	PF00675	0.335
CLV_NRD_NRD_1	428	430	PF00675	0.640
CLV_NRD_NRD_1	434	436	PF00675	0.633
CLV_NRD_NRD_1	508	510	PF00675	0.630
CLV_NRD_NRD_1	523	525	PF00675	0.543
CLV_NRD_NRD_1	557	559	PF00675	0.649
CLV_NRD_NRD_1	696	698	PF00675	0.593
CLV_NRD_NRD_1	822	824	PF00675	0.525
CLV_NRD_NRD_1	850	852	PF00675	0.614
CLV_NRD_NRD_1	944	946	PF00675	0.612
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.558
CLV_PCSK_KEX2_1	198	200	PF00082	0.335
CLV_PCSK_KEX2_1	365	367	PF00082	0.658
CLV_PCSK_KEX2_1	434	436	PF00082	0.651
CLV_PCSK_KEX2_1	461	463	PF00082	0.560
CLV_PCSK_KEX2_1	523	525	PF00082	0.606
CLV_PCSK_KEX2_1	557	559	PF00082	0.527
CLV_PCSK_KEX2_1	626	628	PF00082	0.550
CLV_PCSK_KEX2_1	696	698	PF00082	0.555
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.658
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.584
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.569
CLV_PCSK_SKI1_1	1053	1057	PF00082	0.580
CLV_PCSK_SKI1_1	128	132	PF00082	0.348
CLV_PCSK_SKI1_1	135	139	PF00082	0.318
CLV_PCSK_SKI1_1	152	156	PF00082	0.271
CLV_PCSK_SKI1_1	18	22	PF00082	0.335
CLV_PCSK_SKI1_1	283	287	PF00082	0.447
CLV_PCSK_SKI1_1	330	334	PF00082	0.335
CLV_PCSK_SKI1_1	341	345	PF00082	0.465
CLV_PCSK_SKI1_1	408	412	PF00082	0.637
CLV_PCSK_SKI1_1	480	484	PF00082	0.786
CLV_PCSK_SKI1_1	509	513	PF00082	0.657
CLV_PCSK_SKI1_1	596	600	PF00082	0.502
CLV_PCSK_SKI1_1	623	627	PF00082	0.574
CLV_PCSK_SKI1_1	629	633	PF00082	0.529
CLV_PCSK_SKI1_1	67	71	PF00082	0.335
CLV_PCSK_SKI1_1	678	682	PF00082	0.521
CLV_PCSK_SKI1_1	818	822	PF00082	0.507
CLV_PCSK_SKI1_1	841	845	PF00082	0.487
DEG_APCC_DBOX_1	407	415	PF00400	0.632
DEG_APCC_DBOX_1	895	903	PF00400	0.525
DOC_CYCLIN_RxL_1	405	415	PF00134	0.638
DOC_CYCLIN_RxL_1	815	825	PF00134	0.509
DOC_MAPK_gen_1	138	146	PF00069	0.335
DOC_MAPK_gen_1	27	37	PF00069	0.346
DOC_MAPK_gen_1	364	372	PF00069	0.566
DOC_MAPK_gen_1	379	387	PF00069	0.564
DOC_MAPK_gen_1	450	459	PF00069	0.568
DOC_MAPK_gen_1	585	595	PF00069	0.658
DOC_MAPK_gen_1	621	630	PF00069	0.662
DOC_MAPK_gen_1	687	695	PF00069	0.496
DOC_MAPK_gen_1	696	702	PF00069	0.529
DOC_MAPK_MEF2A_6	262	271	PF00069	0.335
DOC_MAPK_MEF2A_6	30	37	PF00069	0.335
DOC_MAPK_MEF2A_6	365	374	PF00069	0.679
DOC_MAPK_MEF2A_6	588	597	PF00069	0.653
DOC_MAPK_MEF2A_6	623	632	PF00069	0.633
DOC_PP1_RVXF_1	306	313	PF00149	0.328
DOC_PP1_RVXF_1	490	497	PF00149	0.558
DOC_PP2B_LxvP_1	651	654	PF13499	0.725
DOC_SPAK_OSR1_1	697	701	PF12202	0.665
DOC_USP7_MATH_1	647	651	PF00917	0.730
DOC_USP7_MATH_1	782	786	PF00917	0.677
DOC_USP7_UBL2_3	1049	1053	PF12436	0.570
DOC_USP7_UBL2_3	480	484	PF12436	0.753
DOC_USP7_UBL2_3	581	585	PF12436	0.552
DOC_USP7_UBL2_3	592	596	PF12436	0.508
DOC_USP7_UBL2_3	601	605	PF12436	0.323
DOC_USP7_UBL2_3	617	621	PF12436	0.510
DOC_USP7_UBL2_3	841	845	PF12436	0.519
DOC_USP7_UBL2_3	848	852	PF12436	0.532
DOC_USP7_UBL2_3	985	989	PF12436	0.656
DOC_WW_Pin1_4	229	234	PF00397	0.355
DOC_WW_Pin1_4	290	295	PF00397	0.326
DOC_WW_Pin1_4	474	479	PF00397	0.748
LIG_14-3-3_CanoR_1	198	206	PF00244	0.335
LIG_14-3-3_CanoR_1	212	217	PF00244	0.335
LIG_14-3-3_CanoR_1	462	469	PF00244	0.606
LIG_14-3-3_CanoR_1	509	514	PF00244	0.559
LIG_14-3-3_CanoR_1	531	537	PF00244	0.635
LIG_14-3-3_CanoR_1	648	654	PF00244	0.767
LIG_14-3-3_CanoR_1	678	684	PF00244	0.641
LIG_14-3-3_CanoR_1	864	874	PF00244	0.591
LIG_14-3-3_CanoR_1	935	941	PF00244	0.612
LIG_14-3-3_CanoR_1	945	949	PF00244	0.553
LIG_Actin_WH2_2	378	395	PF00022	0.569
LIG_Actin_WH2_2	445	463	PF00022	0.602
LIG_Actin_WH2_2	757	774	PF00022	0.516
LIG_APCC_ABBA_1	1091	1096	PF00400	0.589
LIG_BRCT_BRCA1_1	168	172	PF00533	0.389
LIG_Clathr_ClatBox_1	32	36	PF01394	0.346
LIG_deltaCOP1_diTrp_1	487	496	PF00928	0.557
LIG_FHA_1	102	108	PF00498	0.335
LIG_FHA_1	134	140	PF00498	0.355
LIG_FHA_1	216	222	PF00498	0.335
LIG_FHA_1	235	241	PF00498	0.335
LIG_FHA_1	294	300	PF00498	0.335
LIG_FHA_1	37	43	PF00498	0.335
LIG_FHA_1	563	569	PF00498	0.657
LIG_FHA_1	771	777	PF00498	0.582
LIG_FHA_1	873	879	PF00498	0.617
LIG_FHA_2	181	187	PF00498	0.355
LIG_FHA_2	258	264	PF00498	0.335
LIG_FHA_2	274	280	PF00498	0.335
LIG_FHA_2	512	518	PF00498	0.548
LIG_FHA_2	617	623	PF00498	0.517
LIG_FHA_2	63	69	PF00498	0.335
LIG_FHA_2	713	719	PF00498	0.731
LIG_FHA_2	725	731	PF00498	0.616
LIG_FHA_2	920	926	PF00498	0.638
LIG_FHA_2	935	941	PF00498	0.418
LIG_GBD_Chelix_1	736	744	PF00786	0.668
LIG_Integrin_RGD_1	27	29	PF01839	0.335
LIG_LIR_Gen_1	121	130	PF02991	0.447
LIG_LIR_Gen_1	142	147	PF02991	0.335
LIG_LIR_Gen_1	309	317	PF02991	0.335
LIG_LIR_Gen_1	947	956	PF02991	0.514
LIG_LIR_Nem_3	121	127	PF02991	0.447
LIG_LIR_Nem_3	142	146	PF02991	0.335
LIG_LIR_Nem_3	309	315	PF02991	0.335
LIG_LIR_Nem_3	506	511	PF02991	0.642
LIG_LIR_Nem_3	947	951	PF02991	0.517
LIG_LRP6_Inhibitor_1	683	689	PF00058	0.642
LIG_NRBOX	855	861	PF00104	0.420
LIG_PCNA_PIPBox_1	116	125	PF02747	0.355
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.480
LIG_PCNA_yPIPBox_3	758	772	PF02747	0.531
LIG_PTB_Apo_2	453	460	PF02174	0.634
LIG_PTB_Apo_2	58	65	PF02174	0.335
LIG_RPA_C_Fungi	1023	1035	PF08784	0.659
LIG_SH2_CRK	948	952	PF00017	0.511
LIG_SH2_NCK_1	779	783	PF00017	0.678
LIG_SH2_PTP2	143	146	PF00017	0.335
LIG_SH2_SRC	497	500	PF00017	0.686
LIG_SH2_STAP1	1069	1073	PF00017	0.571
LIG_SH2_STAP1	521	525	PF00017	0.598
LIG_SH2_STAT3	884	887	PF00017	0.589
LIG_SH2_STAT3	920	923	PF00017	0.622
LIG_SH2_STAT5	1094	1097	PF00017	0.700
LIG_SH2_STAT5	122	125	PF00017	0.378
LIG_SH2_STAT5	143	146	PF00017	0.335
LIG_SH2_STAT5	173	176	PF00017	0.335
LIG_SH2_STAT5	497	500	PF00017	0.557
LIG_SH2_STAT5	513	516	PF00017	0.499
LIG_SH3_3	227	233	PF00018	0.335
LIG_SH3_3	41	47	PF00018	0.355
LIG_TRAF2_1	726	729	PF00917	0.627
LIG_TYR_ITIM	141	146	PF00017	0.335
LIG_UBA3_1	1079	1087	PF00899	0.552
LIG_UBA3_1	123	129	PF00899	0.378
LIG_UBA3_1	356	365	PF00899	0.516
LIG_UBA3_1	410	417	PF00899	0.630
LIG_WRC_WIRS_1	182	187	PF05994	0.378
MOD_CDC14_SPxK_1	477	480	PF00782	0.754
MOD_CDK_SPxK_1	474	480	PF00069	0.751
MOD_CK1_1	133	139	PF00069	0.415
MOD_CK1_1	210	216	PF00069	0.335
MOD_CK1_1	293	299	PF00069	0.331
MOD_CK1_1	440	446	PF00069	0.638
MOD_CK1_1	613	619	PF00069	0.579
MOD_CK1_1	649	655	PF00069	0.782
MOD_CK1_1	780	786	PF00069	0.708
MOD_CK1_1	97	103	PF00069	0.335
MOD_CK2_1	1078	1084	PF00069	0.550
MOD_CK2_1	1097	1103	PF00069	0.595
MOD_CK2_1	139	145	PF00069	0.335
MOD_CK2_1	180	186	PF00069	0.381
MOD_CK2_1	257	263	PF00069	0.335
MOD_CK2_1	3	9	PF00069	0.597
MOD_CK2_1	616	622	PF00069	0.636
MOD_CK2_1	679	685	PF00069	0.654
MOD_CK2_1	712	718	PF00069	0.701
MOD_CK2_1	724	730	PF00069	0.720
MOD_CK2_1	855	861	PF00069	0.488
MOD_CK2_1	919	925	PF00069	0.629
MOD_CK2_1	934	940	PF00069	0.419
MOD_GlcNHglycan	271	274	PF01048	0.319
MOD_GlcNHglycan	5	8	PF01048	0.645
MOD_GlcNHglycan	612	615	PF01048	0.551
MOD_GlcNHglycan	651	654	PF01048	0.710
MOD_GlcNHglycan	779	782	PF01048	0.663
MOD_GlcNHglycan	784	787	PF01048	0.657
MOD_GlcNHglycan	791	794	PF01048	0.651
MOD_GlcNHglycan	907	910	PF01048	0.573
MOD_GlcNHglycan	94	97	PF01048	0.335
MOD_GSK3_1	129	136	PF00069	0.335
MOD_GSK3_1	206	213	PF00069	0.337
MOD_GSK3_1	245	252	PF00069	0.335
MOD_GSK3_1	269	276	PF00069	0.325
MOD_GSK3_1	320	327	PF00069	0.335
MOD_GSK3_1	440	447	PF00069	0.634
MOD_GSK3_1	770	777	PF00069	0.536
MOD_GSK3_1	97	104	PF00069	0.335
MOD_N-GLC_1	166	171	PF02516	0.389
MOD_N-GLC_1	206	211	PF02516	0.337
MOD_N-GLC_1	254	259	PF02516	0.335
MOD_N-GLC_1	267	272	PF02516	0.335
MOD_N-GLC_1	320	325	PF02516	0.335
MOD_N-GLC_1	440	445	PF02516	0.607
MOD_N-GLC_1	60	65	PF02516	0.335
MOD_N-GLC_1	691	696	PF02516	0.474
MOD_N-GLC_1	846	851	PF02516	0.534
MOD_N-GLC_1	85	90	PF02516	0.335
MOD_NEK2_1	1022	1027	PF00069	0.684
MOD_NEK2_1	1086	1091	PF00069	0.621
MOD_NEK2_1	130	135	PF00069	0.378
MOD_NEK2_1	154	159	PF00069	0.355
MOD_NEK2_1	206	211	PF00069	0.355
MOD_NEK2_1	251	256	PF00069	0.348
MOD_NEK2_1	269	274	PF00069	0.245
MOD_NEK2_1	299	304	PF00069	0.335
MOD_NEK2_1	322	327	PF00069	0.447
MOD_NEK2_1	437	442	PF00069	0.649
MOD_NEK2_1	770	775	PF00069	0.524
MOD_NEK2_2	1108	1113	PF00069	0.682
MOD_NEK2_2	774	779	PF00069	0.657
MOD_NEK2_2	85	90	PF00069	0.335
MOD_PIKK_1	105	111	PF00454	0.411
MOD_PIKK_1	1097	1103	PF00454	0.662
MOD_PIKK_1	511	517	PF00454	0.697
MOD_PIKK_1	530	536	PF00454	0.343
MOD_PIKK_1	563	569	PF00454	0.539
MOD_PIKK_1	62	68	PF00454	0.335
MOD_PIKK_1	862	868	PF00454	0.603
MOD_PIKK_1	894	900	PF00454	0.640
MOD_PIKK_1	919	925	PF00454	0.657
MOD_PKA_1	128	134	PF00069	0.335
MOD_PKA_1	198	204	PF00069	0.335
MOD_PKA_1	483	489	PF00069	0.739
MOD_PKA_1	509	515	PF00069	0.631
MOD_PKA_2	198	204	PF00069	0.335
MOD_PKA_2	530	536	PF00069	0.673
MOD_PKA_2	556	562	PF00069	0.695
MOD_PKA_2	647	653	PF00069	0.795
MOD_PKA_2	688	694	PF00069	0.521
MOD_PKA_2	934	940	PF00069	0.613
MOD_PKA_2	944	950	PF00069	0.553
MOD_Plk_1	180	186	PF00069	0.378
MOD_Plk_1	267	273	PF00069	0.335
MOD_Plk_1	374	380	PF00069	0.631
MOD_Plk_1	444	450	PF00069	0.596
MOD_Plk_1	60	66	PF00069	0.335
MOD_Plk_1	691	697	PF00069	0.495
MOD_Plk_1	85	91	PF00069	0.335
MOD_Plk_1	862	868	PF00069	0.563
MOD_Plk_1	894	900	PF00069	0.611
MOD_Plk_2-3	181	187	PF00069	0.378
MOD_Plk_2-3	855	861	PF00069	0.576
MOD_Plk_4	139	145	PF00069	0.335
MOD_Plk_4	212	218	PF00069	0.335
MOD_Plk_4	273	279	PF00069	0.335
MOD_Plk_4	293	299	PF00069	0.335
MOD_Plk_4	306	312	PF00069	0.335
MOD_Plk_4	636	642	PF00069	0.748
MOD_Plk_4	679	685	PF00069	0.606
MOD_Plk_4	774	780	PF00069	0.490
MOD_Plk_4	85	91	PF00069	0.335
MOD_Plk_4	855	861	PF00069	0.654
MOD_ProDKin_1	229	235	PF00069	0.355
MOD_ProDKin_1	290	296	PF00069	0.326
MOD_ProDKin_1	474	480	PF00069	0.751
MOD_SUMO_for_1	902	905	PF00179	0.526
MOD_SUMO_rev_2	1081	1089	PF00179	0.561
MOD_SUMO_rev_2	121	130	PF00179	0.447
MOD_SUMO_rev_2	486	494	PF00179	0.586
MOD_SUMO_rev_2	602	607	PF00179	0.511
MOD_SUMO_rev_2	620	628	PF00179	0.630
MOD_SUMO_rev_2	849	853	PF00179	0.561
MOD_SUMO_rev_2	863	872	PF00179	0.617
TRG_DiLeu_BaEn_1	1075	1080	PF01217	0.544
TRG_DiLeu_BaEn_1	433	438	PF01217	0.649
TRG_DiLeu_BaEn_1	855	860	PF01217	0.419
TRG_DiLeu_BaEn_2	717	723	PF01217	0.702
TRG_DiLeu_BaEn_3	404	410	PF01217	0.611
TRG_DiLeu_BaEn_4	577	583	PF01217	0.642
TRG_ENDOCYTIC_2	1069	1072	PF00928	0.574
TRG_ENDOCYTIC_2	143	146	PF00928	0.335
TRG_ENDOCYTIC_2	768	771	PF00928	0.494
TRG_ENDOCYTIC_2	948	951	PF00928	0.539
TRG_ER_diArg_1	1028	1030	PF00400	0.558
TRG_ER_diArg_1	1112	1115	PF00400	0.655
TRG_ER_diArg_1	15	18	PF00400	0.370
TRG_ER_diArg_1	378	381	PF00400	0.577
TRG_ER_diArg_1	406	409	PF00400	0.569
TRG_ER_diArg_1	627	630	PF00400	0.613
TRG_ER_diArg_1	695	697	PF00400	0.514
TRG_NES_CRM1_1	361	376	PF08389	0.571
TRG_NLS_MonoExtN_4	623	630	PF00514	0.670
TRG_Pf-PMV_PEXEL_1	1028	1032	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	851	855	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	981	986	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCP7	Leptomonas seymouri	78%	100%
A0A1X0NUZ5	Trypanosomatidae	63%	100%
A0A3Q8IGL2	Leishmania donovani	98%	100%
A0A422NJK1	Trypanosoma rangeli	62%	100%
A4HK48	Leishmania braziliensis	88%	100%
A4I7L4	Leishmania infantum	98%	100%
D0A9T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B2J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B6A1	Trypanosoma cruzi	61%	100%