Ribosomal_S4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5L4_LEIMA

TriTrypDb:

LmjF.32.0690 , LMJLV39_320012300 , LMJSD75_320012300

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	11
GO:0034457	Mpp10 complex	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4Q5L4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5L4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0030515	snoRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.311
CLV_NRD_NRD_1	55	57	PF00675	0.266
CLV_NRD_NRD_1	90	92	PF00675	0.245
CLV_PCSK_FUR_1	29	33	PF00082	0.576
CLV_PCSK_KEX2_1	152	154	PF00082	0.333
CLV_PCSK_KEX2_1	28	30	PF00082	0.553
CLV_PCSK_KEX2_1	31	33	PF00082	0.571
CLV_PCSK_KEX2_1	90	92	PF00082	0.245
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.362
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.555
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.570
CLV_PCSK_PC7_1	86	92	PF00082	0.245
CLV_PCSK_SKI1_1	160	164	PF00082	0.441
CLV_PCSK_SKI1_1	49	53	PF00082	0.297
CLV_PCSK_SKI1_1	56	60	PF00082	0.245
CLV_PCSK_SKI1_1	9	13	PF00082	0.666
DOC_CYCLIN_RxL_1	43	55	PF00134	0.516
DOC_MAPK_gen_1	90	98	PF00069	0.445
DOC_PP1_RVXF_1	47	54	PF00149	0.581
DOC_PP4_FxxP_1	192	195	PF00568	0.395
DOC_USP7_MATH_1	110	114	PF00917	0.436
DOC_USP7_UBL2_3	57	61	PF12436	0.459
DOC_USP7_UBL2_3	8	12	PF12436	0.617
DOC_WW_Pin1_4	33	38	PF00397	0.583
LIG_14-3-3_CanoR_1	100	110	PF00244	0.481
LIG_14-3-3_CanoR_1	116	124	PF00244	0.386
LIG_14-3-3_CanoR_1	181	190	PF00244	0.396
LIG_CSL_BTD_1	203	206	PF09270	0.390
LIG_deltaCOP1_diTrp_1	70	76	PF00928	0.456
LIG_FHA_1	118	124	PF00498	0.445
LIG_FHA_1	182	188	PF00498	0.387
LIG_LIR_Apic_2	189	195	PF02991	0.398
LIG_LIR_Apic_2	70	75	PF02991	0.445
LIG_LIR_Gen_1	215	224	PF02991	0.558
LIG_LIR_Nem_3	63	67	PF02991	0.445
LIG_LIR_Nem_3	87	92	PF02991	0.445
LIG_PCNA_PIPBox_1	121	130	PF02747	0.456
LIG_PCNA_yPIPBox_3	114	128	PF02747	0.456
LIG_Pex14_1	72	76	PF04695	0.443
LIG_SH2_CRK	92	96	PF00017	0.506
LIG_SH2_NCK_1	35	39	PF00017	0.718
LIG_SH2_SRC	108	111	PF00017	0.445
LIG_SH2_STAT5	108	111	PF00017	0.493
LIG_SH2_STAT5	201	204	PF00017	0.440
LIG_SH2_STAT5	35	38	PF00017	0.738
LIG_UBA3_1	158	163	PF00899	0.484
LIG_WRC_WIRS_1	214	219	PF05994	0.438
MOD_CK1_1	30	36	PF00069	0.586
MOD_CK1_1	39	45	PF00069	0.558
MOD_GSK3_1	23	30	PF00069	0.561
MOD_LATS_1	179	185	PF00433	0.379
MOD_NEK2_1	76	81	PF00069	0.456
MOD_PIKK_1	101	107	PF00454	0.512
MOD_PIKK_1	117	123	PF00454	0.354
MOD_PIKK_1	182	188	PF00454	0.388
MOD_PIKK_1	36	42	PF00454	0.700
MOD_PK_1	23	29	PF00069	0.681
MOD_PKA_2	2	8	PF00069	0.548
MOD_Plk_4	154	160	PF00069	0.323
MOD_Plk_4	200	206	PF00069	0.413
MOD_ProDKin_1	33	39	PF00069	0.581
MOD_SUMO_for_1	22	25	PF00179	0.577
MOD_SUMO_rev_2	4	11	PF00179	0.683
TRG_ENDOCYTIC_2	92	95	PF00928	0.445
TRG_ER_diArg_1	153	155	PF00400	0.312
TRG_ER_diArg_1	89	91	PF00400	0.445
TRG_NES_CRM1_1	121	135	PF08389	0.450
TRG_NLS_MonoExtC_3	151	156	PF00514	0.367
TRG_NLS_MonoExtC_3	27	32	PF00514	0.577
TRG_NLS_MonoExtN_4	28	35	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.217
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6R7	Leptomonas seymouri	93%	100%
A0A0S4J7A8	Bodo saltans	72%	100%
A0A1X0NWD6	Trypanosomatidae	76%	100%
A0A3S7X5B1	Leishmania donovani	98%	100%
A0A422NJJ3	Trypanosoma rangeli	74%	100%
A4I7L3	Leishmania infantum	99%	100%
A5UN53	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	26%	100%
D0A9T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9B2J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O01513	Caenorhabditis elegans	36%	100%
O13835	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O26142	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
P32899	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q01688	Pneumocystis carinii	42%	100%
Q3T0M3	Bos taurus	43%	100%
Q921Y2	Mus musculus	44%	100%
Q97B95	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	25%	100%
Q9NV31	Homo sapiens	44%	100%
V5BFB6	Trypanosoma cruzi	76%	100%