U6 snRNA-associated Sm-like protein LSm4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U6 snRNA-associated Sm-like protein LSm4p

Species:

Leishmania major

UniProt:

Q4Q5L1_LEIMA

TriTrypDb:

LmjF.32.0715 , LMJLV39_320012700 , LMJSD75_320012700

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	2
GO:0005681	spliceosomal complex	3	4
GO:0005688	U6 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	4
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

Q4Q5L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5L1

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	2
GO:0000956	nuclear-transcribed mRNA catabolic process	7	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006401	RNA catabolic process	5	4
GO:0006402	mRNA catabolic process	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009892	negative regulation of metabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010468	regulation of gene expression	5	4
GO:0010605	negative regulation of macromolecule metabolic process	5	4
GO:0010629	negative regulation of gene expression	6	4
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0019222	regulation of metabolic process	3	4
GO:0019439	aromatic compound catabolic process	4	4
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0033962	P-body assembly	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034655	nucleobase-containing compound catabolic process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0044270	cellular nitrogen compound catabolic process	4	4
GO:0046483	heterocycle metabolic process	3	4
GO:0046700	heterocycle catabolic process	4	4
GO:0048519	negative regulation of biological process	3	4
GO:0050789	regulation of biological process	2	4
GO:0060255	regulation of macromolecule metabolic process	4	4
GO:0065003	protein-containing complex assembly	5	2
GO:0065007	biological regulation	1	4
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	4
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	4
GO:0140694	non-membrane-bounded organelle assembly	6	2
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901361	organic cyclic compound catabolic process	4	4
GO:1901575	organic substance catabolic process	3	4
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0008380	RNA splicing	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0017069	snRNA binding	5	2
GO:0017070	U6 snRNA binding	6	2
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.488
CLV_C14_Caspase3-7	98	102	PF00656	0.488
CLV_NRD_NRD_1	164	166	PF00675	0.777
CLV_NRD_NRD_1	175	177	PF00675	0.605
CLV_NRD_NRD_1	49	51	PF00675	0.508
CLV_NRD_NRD_1	78	80	PF00675	0.706
CLV_PCSK_KEX2_1	164	166	PF00082	0.571
CLV_PCSK_KEX2_1	185	187	PF00082	0.617
CLV_PCSK_KEX2_1	49	51	PF00082	0.683
CLV_PCSK_KEX2_1	5	7	PF00082	0.488
CLV_PCSK_KEX2_1	78	80	PF00082	0.706
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.571
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.617
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.488
CLV_PCSK_SKI1_1	79	83	PF00082	0.475
CLV_Separin_Metazoa	85	89	PF03568	0.323
DOC_ANK_TNKS_1	124	131	PF00023	0.488
DOC_CDC14_PxL_1	156	164	PF14671	0.411
DOC_CKS1_1	80	85	PF01111	0.447
DOC_MAPK_DCC_7	78	86	PF00069	0.458
DOC_MAPK_gen_1	111	120	PF00069	0.488
DOC_MAPK_gen_1	78	86	PF00069	0.458
DOC_MAPK_gen_1	88	97	PF00069	0.443
DOC_MAPK_MEF2A_6	111	120	PF00069	0.488
DOC_MAPK_MEF2A_6	91	99	PF00069	0.488
DOC_PP1_RVXF_1	3	10	PF00149	0.441
DOC_PP4_FxxP_1	13	16	PF00568	0.485
DOC_PP4_FxxP_1	36	39	PF00568	0.518
DOC_USP7_MATH_1	167	171	PF00917	0.581
DOC_WW_Pin1_4	17	22	PF00397	0.481
DOC_WW_Pin1_4	35	40	PF00397	0.455
DOC_WW_Pin1_4	79	84	PF00397	0.463
LIG_14-3-3_CanoR_1	142	147	PF00244	0.488
LIG_14-3-3_CanoR_1	150	157	PF00244	0.410
LIG_14-3-3_CanoR_1	22	29	PF00244	0.449
LIG_14-3-3_CanoR_1	6	16	PF00244	0.480
LIG_14-3-3_CanoR_1	73	77	PF00244	0.528
LIG_Actin_WH2_2	56	71	PF00022	0.446
LIG_ActinCP_TwfCPI_2	13	22	PF01115	0.439
LIG_deltaCOP1_diTrp_1	131	140	PF00928	0.576
LIG_FHA_1	63	69	PF00498	0.555
LIG_FHA_2	124	130	PF00498	0.488
LIG_FHA_2	173	179	PF00498	0.574
LIG_FHA_2	80	86	PF00498	0.442
LIG_LIR_Apic_2	10	16	PF02991	0.483
LIG_LIR_Apic_2	35	39	PF02991	0.450
LIG_LIR_Gen_1	8	17	PF02991	0.477
LIG_LIR_Nem_3	8	12	PF02991	0.477
LIG_NRP_CendR_1	186	189	PF00754	0.507
LIG_Pex14_1	9	13	PF04695	0.439
LIG_Pex14_2	13	17	PF04695	0.439
LIG_Pex14_2	72	76	PF04695	0.491
LIG_REV1ctd_RIR_1	11	15	PF16727	0.439
LIG_SH3_3	154	160	PF00018	0.483
LIG_SH3_3	77	83	PF00018	0.488
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.421
LIG_WRPW_2	14	17	PF00400	0.440
MOD_CDK_SPK_2	17	22	PF00069	0.442
MOD_CDK_SPxxK_3	35	42	PF00069	0.463
MOD_CK1_1	24	30	PF00069	0.451
MOD_CK1_1	35	41	PF00069	0.531
MOD_CK2_1	172	178	PF00069	0.572
MOD_CK2_1	79	85	PF00069	0.457
MOD_Cter_Amidation	183	186	PF01082	0.627
MOD_DYRK1A_RPxSP_1	79	83	PF00069	0.475
MOD_GlcNHglycan	153	156	PF01048	0.532
MOD_GSK3_1	101	108	PF00069	0.488
MOD_GSK3_1	129	136	PF00069	0.458
MOD_GSK3_1	17	24	PF00069	0.500
MOD_GSK3_1	34	41	PF00069	0.458
MOD_GSK3_1	52	59	PF00069	0.625
MOD_GSK3_1	64	71	PF00069	0.581
MOD_N-GLC_1	105	110	PF02516	0.288
MOD_NEK2_1	151	156	PF00069	0.451
MOD_NEK2_1	68	73	PF00069	0.536
MOD_NEK2_1	7	12	PF00069	0.516
MOD_OFUCOSY	25	31	PF10250	0.467
MOD_PK_1	142	148	PF00069	0.488
MOD_PK_1	177	183	PF00069	0.624
MOD_PK_1	93	99	PF00069	0.488
MOD_PKA_1	5	11	PF00069	0.484
MOD_PKA_2	149	155	PF00069	0.439
MOD_PKA_2	21	27	PF00069	0.444
MOD_PKA_2	5	11	PF00069	0.484
MOD_PKA_2	72	78	PF00069	0.714
MOD_Plk_1	177	183	PF00069	0.624
MOD_Plk_1	93	99	PF00069	0.488
MOD_Plk_4	105	111	PF00069	0.488
MOD_Plk_4	129	135	PF00069	0.488
MOD_Plk_4	24	30	PF00069	0.524
MOD_Plk_4	56	62	PF00069	0.576
MOD_ProDKin_1	17	23	PF00069	0.480
MOD_ProDKin_1	35	41	PF00069	0.459
MOD_ProDKin_1	79	85	PF00069	0.457
TRG_ER_diArg_1	186	189	PF00400	0.507
TRG_ER_diArg_1	78	80	PF00400	0.593
TRG_NLS_MonoCore_2	184	189	PF00514	0.574
TRG_NLS_MonoExtC_3	184	189	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I7N8	Leishmania infantum	91%	96%
E9B2J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%