Outer_row_dynein-

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Outer_row_dynein-

Gene product:

Outer row dynein-assembly protein 7

Species:

Leishmania major

UniProt:

Q4Q5K9_LEIMA

TriTrypDb:

LmjF.32.0730 , LMJLV39_320012900 , LMJSD75_320012900

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	11
GO:0044297	cell body	2	2
GO:0110165	cellular anatomical entity	1	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q5K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5K9

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0036158	outer dynein arm assembly	7	11
GO:0036159	inner dynein arm assembly	7	11
GO:0043933	protein-containing complex organization	4	11
GO:0044458	motile cilium assembly	7	2
GO:0044782	cilium organization	5	2
GO:0048870	cell motility	2	2
GO:0060271	cilium assembly	6	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0065003	protein-containing complex assembly	5	11
GO:0070286	axonemal dynein complex assembly	6	11
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0044877	protein-containing complex binding	2	11
GO:0070840	dynein complex binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.506
CLV_C14_Caspase3-7	65	69	PF00656	0.339
CLV_NRD_NRD_1	246	248	PF00675	0.358
CLV_NRD_NRD_1	269	271	PF00675	0.379
CLV_NRD_NRD_1	326	328	PF00675	0.445
CLV_NRD_NRD_1	339	341	PF00675	0.414
CLV_NRD_NRD_1	388	390	PF00675	0.502
CLV_NRD_NRD_1	412	414	PF00675	0.730
CLV_NRD_NRD_1	563	565	PF00675	0.646
CLV_NRD_NRD_1	569	571	PF00675	0.635
CLV_NRD_NRD_1	589	591	PF00675	0.355
CLV_PCSK_FUR_1	337	341	PF00082	0.575
CLV_PCSK_KEX2_1	246	248	PF00082	0.376
CLV_PCSK_KEX2_1	269	271	PF00082	0.379
CLV_PCSK_KEX2_1	294	296	PF00082	0.528
CLV_PCSK_KEX2_1	326	328	PF00082	0.426
CLV_PCSK_KEX2_1	337	339	PF00082	0.452
CLV_PCSK_KEX2_1	388	390	PF00082	0.537
CLV_PCSK_KEX2_1	568	570	PF00082	0.591
CLV_PCSK_KEX2_1	589	591	PF00082	0.611
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.528
CLV_PCSK_PC7_1	564	570	PF00082	0.513
CLV_PCSK_SKI1_1	262	266	PF00082	0.397
CLV_PCSK_SKI1_1	269	273	PF00082	0.383
CLV_PCSK_SKI1_1	379	383	PF00082	0.562
CLV_PCSK_SKI1_1	529	533	PF00082	0.736
CLV_PCSK_SKI1_1	540	544	PF00082	0.619
CLV_PCSK_SKI1_1	67	71	PF00082	0.502
DEG_SCF_TRCP1_1	420	426	PF00400	0.528
DOC_CDC14_PxL_1	250	258	PF14671	0.406
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.599
DOC_MAPK_gen_1	243	253	PF00069	0.406
DOC_MAPK_gen_1	544	553	PF00069	0.429
DOC_MAPK_MEF2A_6	246	253	PF00069	0.367
DOC_MAPK_MEF2A_6	544	553	PF00069	0.429
DOC_MAPK_MEF2A_6	67	75	PF00069	0.367
DOC_MAPK_NFAT4_5	246	254	PF00069	0.399
DOC_PP1_RVXF_1	46	52	PF00149	0.328
DOC_PP2B_LxvP_1	208	211	PF13499	0.477
DOC_PP2B_LxvP_1	251	254	PF13499	0.414
DOC_PP2B_LxvP_1	468	471	PF13499	0.588
DOC_PP2B_LxvP_1	472	475	PF13499	0.571
DOC_USP7_MATH_1	158	162	PF00917	0.522
DOC_USP7_MATH_1	226	230	PF00917	0.356
DOC_USP7_MATH_1	347	351	PF00917	0.563
DOC_USP7_MATH_1	401	405	PF00917	0.415
DOC_USP7_MATH_1	69	73	PF00917	0.270
DOC_WW_Pin1_4	444	449	PF00397	0.591
DOC_WW_Pin1_4	470	475	PF00397	0.602
LIG_14-3-3_CanoR_1	529	538	PF00244	0.614
LIG_14-3-3_CanoR_1	589	594	PF00244	0.618
LIG_14-3-3_CanoR_1	81	87	PF00244	0.410
LIG_APCC_ABBA_1	41	46	PF00400	0.421
LIG_BIR_II_1	1	5	PF00653	0.456
LIG_Clathr_ClatBox_1	482	486	PF01394	0.577
LIG_deltaCOP1_diTrp_1	577	586	PF00928	0.532
LIG_FHA_1	170	176	PF00498	0.704
LIG_FHA_1	203	209	PF00498	0.622
LIG_FHA_1	297	303	PF00498	0.483
LIG_FHA_1	3	9	PF00498	0.379
LIG_FHA_1	318	324	PF00498	0.589
LIG_FHA_1	85	91	PF00498	0.328
LIG_FHA_2	125	131	PF00498	0.471
LIG_FHA_2	141	147	PF00498	0.217
LIG_FHA_2	152	158	PF00498	0.482
LIG_FHA_2	179	185	PF00498	0.609
LIG_FHA_2	255	261	PF00498	0.443
LIG_FHA_2	287	293	PF00498	0.442
LIG_FHA_2	382	388	PF00498	0.566
LIG_FHA_2	452	458	PF00498	0.706
LIG_FHA_2	464	470	PF00498	0.583
LIG_LIR_Gen_1	146	155	PF02991	0.375
LIG_LIR_Gen_1	42	52	PF02991	0.356
LIG_LIR_Gen_1	577	588	PF02991	0.583
LIG_LIR_Nem_3	146	152	PF02991	0.367
LIG_LIR_Nem_3	42	47	PF02991	0.372
LIG_LIR_Nem_3	577	583	PF02991	0.538
LIG_LRP6_Inhibitor_1	75	81	PF00058	0.410
LIG_MYND_1	470	474	PF01753	0.495
LIG_NRBOX	478	484	PF00104	0.655
LIG_SH2_CRK	19	23	PF00017	0.359
LIG_SH2_SRC	374	377	PF00017	0.367
LIG_SH2_STAP1	392	396	PF00017	0.613
LIG_SH2_STAT5	102	105	PF00017	0.279
LIG_SH2_STAT5	232	235	PF00017	0.365
LIG_SH2_STAT5	258	261	PF00017	0.366
LIG_SH2_STAT5	44	47	PF00017	0.328
LIG_SH3_3	260	266	PF00018	0.467
LIG_SH3_3	468	474	PF00018	0.709
LIG_SUMO_SIM_par_1	301	307	PF11976	0.314
LIG_TRAF2_1	405	408	PF00917	0.674
MOD_CK1_1	115	121	PF00069	0.469
MOD_CK1_1	141	147	PF00069	0.447
MOD_CK1_1	178	184	PF00069	0.578
MOD_CK1_1	193	199	PF00069	0.447
MOD_CK1_1	350	356	PF00069	0.356
MOD_CK1_1	458	464	PF00069	0.715
MOD_CK1_1	473	479	PF00069	0.568
MOD_CK1_1	58	64	PF00069	0.505
MOD_CK1_1	82	88	PF00069	0.285
MOD_CK2_1	124	130	PF00069	0.434
MOD_CK2_1	151	157	PF00069	0.470
MOD_CK2_1	286	292	PF00069	0.441
MOD_CK2_1	381	387	PF00069	0.543
MOD_CK2_1	463	469	PF00069	0.788
MOD_CK2_1	58	64	PF00069	0.410
MOD_GlcNHglycan	160	163	PF01048	0.610
MOD_GlcNHglycan	177	180	PF01048	0.660
MOD_GlcNHglycan	195	198	PF01048	0.731
MOD_GlcNHglycan	349	352	PF01048	0.506
MOD_GlcNHglycan	403	406	PF01048	0.504
MOD_GlcNHglycan	420	423	PF01048	0.769
MOD_GlcNHglycan	429	432	PF01048	0.708
MOD_GlcNHglycan	506	509	PF01048	0.542
MOD_GlcNHglycan	59	63	PF01048	0.496
MOD_GSK3_1	115	122	PF00069	0.313
MOD_GSK3_1	141	148	PF00069	0.317
MOD_GSK3_1	423	430	PF00069	0.683
MOD_GSK3_1	451	458	PF00069	0.626
MOD_GSK3_1	460	467	PF00069	0.687
MOD_GSK3_1	470	477	PF00069	0.593
MOD_GSK3_1	504	511	PF00069	0.672
MOD_GSK3_1	58	65	PF00069	0.457
MOD_GSK3_1	82	89	PF00069	0.322
MOD_N-GLC_1	504	509	PF02516	0.466
MOD_N-GLC_1	96	101	PF02516	0.279
MOD_NEK2_1	119	124	PF00069	0.317
MOD_NEK2_1	138	143	PF00069	0.331
MOD_NEK2_1	166	171	PF00069	0.504
MOD_NEK2_1	451	456	PF00069	0.748
MOD_NEK2_1	525	530	PF00069	0.574
MOD_NEK2_1	531	536	PF00069	0.476
MOD_NEK2_1	79	84	PF00069	0.410
MOD_NEK2_1	86	91	PF00069	0.410
MOD_NEK2_1	96	101	PF00069	0.279
MOD_NEK2_2	102	107	PF00069	0.410
MOD_NEK2_2	69	74	PF00069	0.234
MOD_PIKK_1	332	338	PF00454	0.518
MOD_PIKK_1	589	595	PF00454	0.706
MOD_PIKK_1	62	68	PF00454	0.435
MOD_PKA_1	269	275	PF00069	0.482
MOD_PKA_1	568	574	PF00069	0.554
MOD_PKA_1	589	595	PF00069	0.594
MOD_PKA_2	175	181	PF00069	0.605
MOD_PKA_2	269	275	PF00069	0.527
MOD_PKA_2	286	292	PF00069	0.441
MOD_PKA_2	317	323	PF00069	0.500
MOD_PKA_2	455	461	PF00069	0.636
MOD_PKA_2	568	574	PF00069	0.540
MOD_PKA_2	589	595	PF00069	0.629
MOD_Plk_1	145	151	PF00069	0.343
MOD_Plk_1	190	196	PF00069	0.543
MOD_Plk_2-3	286	292	PF00069	0.441
MOD_Plk_4	190	196	PF00069	0.488
MOD_Plk_4	226	232	PF00069	0.343
MOD_Plk_4	254	260	PF00069	0.440
MOD_Plk_4	474	480	PF00069	0.564
MOD_Plk_4	69	75	PF00069	0.276
MOD_ProDKin_1	444	450	PF00069	0.592
MOD_ProDKin_1	470	476	PF00069	0.601
MOD_SUMO_for_1	211	214	PF00179	0.436
MOD_SUMO_for_1	360	363	PF00179	0.351
MOD_SUMO_rev_2	286	296	PF00179	0.540
MOD_SUMO_rev_2	408	415	PF00179	0.682
MOD_SUMO_rev_2	42	50	PF00179	0.472
TRG_DiLeu_BaEn_4	133	139	PF01217	0.474
TRG_DiLeu_BaEn_4	310	316	PF01217	0.466
TRG_ENDOCYTIC_2	44	47	PF00928	0.361
TRG_ER_diArg_1	245	247	PF00400	0.376
TRG_ER_diArg_1	269	271	PF00400	0.458
TRG_ER_diArg_1	337	340	PF00400	0.480
TRG_ER_diArg_1	568	570	PF00400	0.664
TRG_NES_CRM1_1	484	498	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P804	Leptomonas seymouri	58%	99%
A0A0S4KIJ3	Bodo saltans	37%	100%
A0A3Q8IJ31	Leishmania donovani	89%	100%
A0A3R7KFT3	Trypanosoma rangeli	45%	100%
A4HK54	Leishmania braziliensis	74%	100%
A4I7P0	Leishmania infantum	89%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B2J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5D6Q2	Trypanosoma cruzi	44%	100%