Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear RNA binding domain

Species:

Leishmania major

UniProt:

Q4Q5K7_LEIMA

TriTrypDb:

LmjF.32.0750 , LMJLV39_320013100 , LMJSD75_320013100

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q5K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5K7

PDB structure(s): 5osg_h

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.473
CLV_NRD_NRD_1	86	88	PF00675	0.304
CLV_PCSK_KEX2_1	86	88	PF00082	0.300
CLV_PCSK_SKI1_1	111	115	PF00082	0.342
CLV_PCSK_SKI1_1	116	120	PF00082	0.342
CLV_PCSK_SKI1_1	201	205	PF00082	0.480
CLV_PCSK_SKI1_1	79	83	PF00082	0.425
CLV_PCSK_SKI1_1	8	12	PF00082	0.763
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.509
DOC_MAPK_gen_1	86	95	PF00069	0.501
DOC_MAPK_MEF2A_6	196	204	PF00069	0.483
DOC_PP2B_LxvP_1	119	122	PF13499	0.618
DOC_PP4_FxxP_1	139	142	PF00568	0.429
DOC_USP7_MATH_1	50	54	PF00917	0.713
DOC_USP7_UBL2_3	11	15	PF12436	0.570
DOC_USP7_UBL2_3	124	128	PF12436	0.535
DOC_USP7_UBL2_3	19	23	PF12436	0.659
DOC_USP7_UBL2_3	33	37	PF12436	0.571
DOC_USP7_UBL2_3	4	8	PF12436	0.674
DOC_WW_Pin1_4	123	128	PF00397	0.559
DOC_WW_Pin1_4	138	143	PF00397	0.496
DOC_WW_Pin1_4	176	181	PF00397	0.504
LIG_14-3-3_CanoR_1	145	154	PF00244	0.481
LIG_14-3-3_CanoR_1	196	201	PF00244	0.525
LIG_APCC_ABBA_1	105	110	PF00400	0.511
LIG_BRCT_BRCA1_1	135	139	PF00533	0.439
LIG_BRCT_BRCA1_1	140	144	PF00533	0.431
LIG_FHA_1	115	121	PF00498	0.568
LIG_FHA_1	197	203	PF00498	0.517
LIG_FHA_1	62	68	PF00498	0.607
LIG_LIR_Apic_2	136	142	PF02991	0.425
LIG_LIR_LC3C_4	117	121	PF02991	0.693
LIG_LIR_Nem_3	155	160	PF02991	0.591
LIG_SH2_CRK	90	94	PF00017	0.500
LIG_SH2_NCK_1	90	94	PF00017	0.500
LIG_SH2_SRC	176	179	PF00017	0.430
LIG_SH2_SRC	90	93	PF00017	0.465
LIG_SH2_STAP1	90	94	PF00017	0.500
LIG_SH2_STAT5	176	179	PF00017	0.423
LIG_SH2_STAT5	58	61	PF00017	0.525
LIG_SH3_3	6	12	PF00018	0.685
LIG_SH3_4	11	18	PF00018	0.780
LIG_SH3_4	19	26	PF00018	0.777
LIG_SH3_4	33	40	PF00018	0.756
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.663
LIG_TRAF2_1	214	217	PF00917	0.543
MOD_CDK_SPK_2	123	128	PF00069	0.536
MOD_CDK_SPxxK_3	138	145	PF00069	0.450
MOD_CK1_1	205	211	PF00069	0.484
MOD_CK1_1	51	57	PF00069	0.658
MOD_GlcNHglycan	204	207	PF01048	0.595
MOD_GlcNHglycan	50	53	PF01048	0.725
MOD_GlcNHglycan	74	77	PF01048	0.301
MOD_GlcNHglycan	96	100	PF01048	0.348
MOD_N-GLC_1	133	138	PF02516	0.564
MOD_N-GLC_1	190	195	PF02516	0.497
MOD_NEK2_1	114	119	PF00069	0.603
MOD_NEK2_1	95	100	PF00069	0.578
MOD_PKA_2	144	150	PF00069	0.501
MOD_Plk_1	133	139	PF00069	0.508
MOD_Plk_4	114	120	PF00069	0.525
MOD_ProDKin_1	123	129	PF00069	0.564
MOD_ProDKin_1	138	144	PF00069	0.500
MOD_ProDKin_1	176	182	PF00069	0.505
TRG_ENDOCYTIC_2	174	177	PF00928	0.438
TRG_ENDOCYTIC_2	90	93	PF00928	0.500
TRG_ER_diArg_1	164	167	PF00400	0.466
TRG_ER_diArg_1	212	215	PF00400	0.536
TRG_ER_diArg_1	85	87	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM50	Leptomonas seymouri	86%	100%
A0A0S4JT34	Bodo saltans	60%	100%
A0A1X0NUY5	Trypanosomatidae	70%	100%
A0A3Q8IT45	Leishmania donovani	96%	100%
A0A3R7KPL2	Trypanosoma rangeli	72%	100%
A4HK56	Leishmania braziliensis	89%	100%
A4I7P2	Leishmania infantum	96%	100%
D0A9U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	90%
D0A9U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	84%
E9B2J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%