RRM_8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5J8_LEIMA

TriTrypDb:

LmjF.32.0840 , LMJLV39_320014100 , LMJSD75_320014100

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5J8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	25	31	PF00089	0.499
CLV_NRD_NRD_1	350	352	PF00675	0.457
CLV_NRD_NRD_1	42	44	PF00675	0.499
CLV_PCSK_KEX2_1	350	352	PF00082	0.457
CLV_PCSK_KEX2_1	42	44	PF00082	0.499
CLV_PCSK_SKI1_1	356	360	PF00082	0.515
CLV_PCSK_SKI1_1	42	46	PF00082	0.499
CLV_PCSK_SKI1_1	434	438	PF00082	0.568
CLV_PCSK_SKI1_1	483	487	PF00082	0.567
CLV_PCSK_SKI1_1	88	92	PF00082	0.417
DEG_Nend_UBRbox_1	1	4	PF02207	0.869
DEG_SCF_FBW7_1	110	115	PF00400	0.760
DOC_CKS1_1	56	61	PF01111	0.499
DOC_MAPK_gen_1	355	361	PF00069	0.514
DOC_MAPK_gen_1	42	50	PF00069	0.499
DOC_PP2B_LxvP_1	181	184	PF13499	0.601
DOC_PP4_FxxP_1	219	222	PF00568	0.811
DOC_PP4_FxxP_1	314	317	PF00568	0.716
DOC_PP4_MxPP_1	226	229	PF00568	0.733
DOC_USP7_MATH_1	112	116	PF00917	0.858
DOC_USP7_MATH_1	214	218	PF00917	0.766
DOC_USP7_MATH_1	430	434	PF00917	0.595
DOC_WW_Pin1_4	102	107	PF00397	0.704
DOC_WW_Pin1_4	108	113	PF00397	0.789
DOC_WW_Pin1_4	362	367	PF00397	0.587
DOC_WW_Pin1_4	420	425	PF00397	0.560
DOC_WW_Pin1_4	55	60	PF00397	0.499
LIG_14-3-3_CanoR_1	28	36	PF00244	0.417
LIG_14-3-3_CanoR_1	397	407	PF00244	0.552
LIG_14-3-3_CanoR_1	43	49	PF00244	0.417
LIG_14-3-3_CanoR_1	462	471	PF00244	0.610
LIG_14-3-3_CanoR_1	80	86	PF00244	0.499
LIG_AP2alpha_1	72	76	PF02296	0.499
LIG_AP2alpha_2	233	235	PF02296	0.748
LIG_EVH1_2	317	321	PF00568	0.637
LIG_FHA_1	20	26	PF00498	0.417
LIG_FHA_1	317	323	PF00498	0.502
LIG_FHA_1	328	334	PF00498	0.492
LIG_FHA_1	35	41	PF00498	0.417
LIG_FHA_1	64	70	PF00498	0.459
LIG_FHA_2	336	342	PF00498	0.445
LIG_FHA_2	441	447	PF00498	0.507
LIG_FHA_2	462	468	PF00498	0.615
LIG_LIR_Apic_2	217	222	PF02991	0.814
LIG_LIR_Gen_1	319	329	PF02991	0.484
LIG_LIR_Gen_1	335	343	PF02991	0.448
LIG_LIR_Nem_3	13	17	PF02991	0.848
LIG_LIR_Nem_3	319	324	PF02991	0.462
LIG_LIR_Nem_3	341	346	PF02991	0.466
LIG_Pex14_2	72	76	PF04695	0.499
LIG_SH2_GRB2like	101	104	PF00017	0.632
LIG_SH2_GRB2like	452	455	PF00017	0.599
LIG_SH2_SRC	452	455	PF00017	0.599
LIG_SH2_STAP1	414	418	PF00017	0.618
LIG_SH2_STAT5	101	104	PF00017	0.654
LIG_SH2_STAT5	308	311	PF00017	0.744
LIG_SH2_STAT5	381	384	PF00017	0.649
LIG_SH2_STAT5	394	397	PF00017	0.467
LIG_SH2_STAT5	452	455	PF00017	0.517
LIG_SH3_3	135	141	PF00018	0.807
LIG_SH3_3	144	150	PF00018	0.808
LIG_SH3_3	153	159	PF00018	0.523
LIG_SH3_3	162	168	PF00018	0.545
LIG_SH3_3	171	177	PF00018	0.790
LIG_SH3_3	194	200	PF00018	0.715
LIG_SH3_3	225	231	PF00018	0.651
LIG_SH3_3	246	252	PF00018	0.824
LIG_SH3_3	403	409	PF00018	0.626
LIG_SH3_3	500	506	PF00018	0.567
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.487
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.615
LIG_TRAF2_2	228	233	PF00917	0.741
LIG_WRC_WIRS_1	372	377	PF05994	0.542
MOD_CDK_SPxxK_3	420	427	PF00069	0.553
MOD_CK1_1	51	57	PF00069	0.468
MOD_CK1_1	510	516	PF00069	0.738
MOD_CK2_1	121	127	PF00069	0.711
MOD_CK2_1	335	341	PF00069	0.449
MOD_CK2_1	439	445	PF00069	0.550
MOD_CK2_1	461	467	PF00069	0.683
MOD_GlcNHglycan	106	109	PF01048	0.804
MOD_GlcNHglycan	123	126	PF01048	0.554
MOD_GlcNHglycan	386	389	PF01048	0.475
MOD_GSK3_1	104	111	PF00069	0.653
MOD_GSK3_1	15	22	PF00069	0.671
MOD_GSK3_1	23	30	PF00069	0.321
MOD_GSK3_1	316	323	PF00069	0.543
MOD_GSK3_1	416	423	PF00069	0.606
MOD_GSK3_1	436	443	PF00069	0.524
MOD_GSK3_1	44	51	PF00069	0.499
MOD_GSK3_1	444	451	PF00069	0.504
MOD_GSK3_1	463	470	PF00069	0.613
MOD_GSK3_1	95	102	PF00069	0.550
MOD_N-GLC_1	102	107	PF02516	0.619
MOD_NEK2_1	121	126	PF00069	0.853
MOD_NEK2_1	245	250	PF00069	0.834
MOD_NEK2_1	416	421	PF00069	0.632
MOD_NEK2_1	99	104	PF00069	0.451
MOD_NEK2_2	214	219	PF00069	0.769
MOD_NEK2_2	332	337	PF00069	0.462
MOD_PIKK_1	15	21	PF00454	0.737
MOD_PIKK_1	187	193	PF00454	0.847
MOD_PK_1	507	513	PF00069	0.711
MOD_PKA_2	27	33	PF00069	0.417
MOD_PKA_2	461	467	PF00069	0.627
MOD_Plk_1	507	513	PF00069	0.550
MOD_Plk_1	64	70	PF00069	0.420
MOD_Plk_2-3	467	473	PF00069	0.601
MOD_Plk_4	214	220	PF00069	0.811
MOD_Plk_4	316	322	PF00069	0.495
MOD_Plk_4	332	338	PF00069	0.456
MOD_Plk_4	371	377	PF00069	0.562
MOD_Plk_4	448	454	PF00069	0.510
MOD_Plk_4	64	70	PF00069	0.420
MOD_ProDKin_1	102	108	PF00069	0.714
MOD_ProDKin_1	362	368	PF00069	0.582
MOD_ProDKin_1	420	426	PF00069	0.560
MOD_ProDKin_1	55	61	PF00069	0.499
MOD_SUMO_rev_2	491	498	PF00179	0.600
MOD_SUMO_rev_2	508	518	PF00179	0.711
TRG_ENDOCYTIC_2	286	289	PF00928	0.695
TRG_ENDOCYTIC_2	311	314	PF00928	0.666
TRG_ER_diArg_1	1	4	PF00400	0.883
TRG_ER_diArg_1	349	351	PF00400	0.440
TRG_ER_diArg_1	41	43	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M5	Leptomonas seymouri	60%	100%
A0A3Q8IFS5	Leishmania donovani	92%	100%
A0A422N8U4	Trypanosoma rangeli	40%	100%
A4HK65	Leishmania braziliensis	79%	100%
A4I7Q0	Leishmania infantum	92%	100%
V5B118	Trypanosoma cruzi	42%	100%