RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polypyrimidine tract-binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q5J7_LEIMA

TriTrypDb:

LmjF.32.0850 , LMJLV39_320014200 , LMJSD75_320014200

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5J7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5J7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	638	642	PF00656	0.516
CLV_C14_Caspase3-7	681	685	PF00656	0.675
CLV_C14_Caspase3-7	735	739	PF00656	0.647
CLV_NRD_NRD_1	200	202	PF00675	0.527
CLV_NRD_NRD_1	56	58	PF00675	0.542
CLV_NRD_NRD_1	623	625	PF00675	0.318
CLV_PCSK_FUR_1	538	542	PF00082	0.416
CLV_PCSK_KEX2_1	200	202	PF00082	0.527
CLV_PCSK_KEX2_1	501	503	PF00082	0.398
CLV_PCSK_KEX2_1	540	542	PF00082	0.440
CLV_PCSK_KEX2_1	56	58	PF00082	0.542
CLV_PCSK_KEX2_1	623	625	PF00082	0.318
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.398
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.440
CLV_PCSK_SKI1_1	20	24	PF00082	0.432
CLV_PCSK_SKI1_1	215	219	PF00082	0.418
CLV_PCSK_SKI1_1	272	276	PF00082	0.428
CLV_PCSK_SKI1_1	420	424	PF00082	0.636
CLV_PCSK_SKI1_1	555	559	PF00082	0.627
CLV_PCSK_SKI1_1	752	756	PF00082	0.658
CLV_PCSK_SKI1_1	759	763	PF00082	0.584
CLV_Separin_Metazoa	697	701	PF03568	0.585
DEG_APCC_DBOX_1	214	222	PF00400	0.419
DEG_COP1_1	741	749	PF00400	0.652
DOC_ANK_TNKS_1	407	414	PF00023	0.718
DOC_ANK_TNKS_1	733	740	PF00023	0.583
DOC_CYCLIN_RxL_1	17	27	PF00134	0.419
DOC_MAPK_gen_1	200	206	PF00069	0.511
DOC_MAPK_gen_1	649	658	PF00069	0.516
DOC_MAPK_MEF2A_6	652	660	PF00069	0.516
DOC_PP1_RVXF_1	270	276	PF00149	0.402
DOC_PP1_RVXF_1	655	661	PF00149	0.592
DOC_PP4_FxxP_1	246	249	PF00568	0.405
DOC_PP4_FxxP_1	274	277	PF00568	0.446
DOC_PP4_FxxP_1	514	517	PF00568	0.513
DOC_USP7_MATH_1	143	147	PF00917	0.618
DOC_USP7_MATH_1	153	157	PF00917	0.735
DOC_USP7_MATH_1	178	182	PF00917	0.790
DOC_USP7_MATH_1	196	200	PF00917	0.450
DOC_USP7_MATH_1	288	292	PF00917	0.654
DOC_USP7_MATH_1	330	334	PF00917	0.595
DOC_USP7_MATH_1	391	395	PF00917	0.582
DOC_USP7_MATH_1	667	671	PF00917	0.609
DOC_USP7_MATH_1	706	710	PF00917	0.702
DOC_USP7_MATH_1	716	720	PF00917	0.619
DOC_USP7_UBL2_3	608	612	PF12436	0.516
DOC_USP7_UBL2_3	755	759	PF12436	0.636
DOC_WW_Pin1_4	165	170	PF00397	0.674
DOC_WW_Pin1_4	440	445	PF00397	0.640
DOC_WW_Pin1_4	448	453	PF00397	0.674
DOC_WW_Pin1_4	722	727	PF00397	0.557
LIG_14-3-3_CanoR_1	56	60	PF00244	0.523
LIG_14-3-3_CanoR_1	657	661	PF00244	0.475
LIG_Actin_WH2_2	595	610	PF00022	0.516
LIG_AP2alpha_2	375	377	PF02296	0.620
LIG_APCC_ABBA_1	271	276	PF00400	0.464
LIG_APCC_ABBAyCdc20_2	584	590	PF00400	0.475
LIG_deltaCOP1_diTrp_1	486	494	PF00928	0.412
LIG_FHA_1	1	7	PF00498	0.409
LIG_FHA_1	212	218	PF00498	0.428
LIG_FHA_1	239	245	PF00498	0.453
LIG_FHA_1	405	411	PF00498	0.558
LIG_FHA_1	470	476	PF00498	0.407
LIG_FHA_1	506	512	PF00498	0.404
LIG_FHA_1	597	603	PF00498	0.469
LIG_FHA_2	44	50	PF00498	0.459
LIG_FHA_2	548	554	PF00498	0.540
LIG_FHA_2	636	642	PF00498	0.516
LIG_FHA_2	692	698	PF00498	0.651
LIG_FHA_2	743	749	PF00498	0.558
LIG_IBAR_NPY_1	321	323	PF08397	0.676
LIG_LIR_Apic_2	245	249	PF02991	0.402
LIG_LIR_Apic_2	302	307	PF02991	0.723
LIG_LIR_Gen_1	276	287	PF02991	0.616
LIG_LIR_Gen_1	486	494	PF02991	0.367
LIG_LIR_Gen_1	653	663	PF02991	0.568
LIG_LIR_Nem_3	276	282	PF02991	0.588
LIG_LIR_Nem_3	440	445	PF02991	0.628
LIG_LIR_Nem_3	486	491	PF02991	0.379
LIG_LIR_Nem_3	492	497	PF02991	0.382
LIG_LIR_Nem_3	653	658	PF02991	0.471
LIG_LIR_Nem_3	659	663	PF02991	0.443
LIG_MYND_1	363	367	PF01753	0.551
LIG_NRBOX	486	492	PF00104	0.346
LIG_NRP_CendR_1	762	763	PF00754	0.673
LIG_Pex14_2	275	279	PF04695	0.489
LIG_PTB_Apo_2	264	271	PF02174	0.485
LIG_PTB_Phospho_1	264	270	PF10480	0.494
LIG_REV1ctd_RIR_1	619	625	PF16727	0.484
LIG_SH2_CRK	150	154	PF00017	0.637
LIG_SH2_CRK	304	308	PF00017	0.669
LIG_SH2_NCK_1	150	154	PF00017	0.637
LIG_SH2_PTP2	270	273	PF00017	0.385
LIG_SH2_STAP1	126	130	PF00017	0.604
LIG_SH2_STAT3	157	160	PF00017	0.697
LIG_SH2_STAT3	306	309	PF00017	0.603
LIG_SH2_STAT5	270	273	PF00017	0.416
LIG_SH2_STAT5	526	529	PF00017	0.398
LIG_SH2_STAT5	594	597	PF00017	0.516
LIG_SH3_1	574	580	PF00018	0.529
LIG_SH3_2	195	200	PF14604	0.596
LIG_SH3_3	152	158	PF00018	0.688
LIG_SH3_3	190	196	PF00018	0.602
LIG_SH3_3	232	238	PF00018	0.500
LIG_SH3_3	281	287	PF00018	0.612
LIG_SH3_3	361	367	PF00018	0.620
LIG_SH3_3	441	447	PF00018	0.626
LIG_SH3_3	574	580	PF00018	0.529
LIG_SH3_3	661	667	PF00018	0.487
LIG_SH3_3	693	699	PF00018	0.616
LIG_SH3_3	702	708	PF00018	0.690
LIG_SH3_3	72	78	PF00018	0.597
LIG_SH3_3	720	726	PF00018	0.575
LIG_SH3_3	93	99	PF00018	0.636
LIG_SH3_CIN85_PxpxPR_1	747	752	PF14604	0.573
LIG_SUMO_SIM_par_1	2	7	PF11976	0.456
LIG_SUMO_SIM_par_1	227	232	PF11976	0.427
LIG_SUMO_SIM_par_1	471	476	PF11976	0.442
LIG_TRAF2_1	46	49	PF00917	0.475
LIG_TRAF2_1	715	718	PF00917	0.687
LIG_TRAF2_1	726	729	PF00917	0.568
LIG_TRAF2_1	733	736	PF00917	0.540
LIG_UBA3_1	643	649	PF00899	0.455
LIG_WW_3	697	701	PF00397	0.585
MOD_CDK_SPxK_1	448	454	PF00069	0.552
MOD_CK1_1	172	178	PF00069	0.706
MOD_CK1_1	181	187	PF00069	0.580
MOD_CK1_1	35	41	PF00069	0.540
MOD_CK1_1	352	358	PF00069	0.656
MOD_CK1_1	401	407	PF00069	0.631
MOD_CK1_1	448	454	PF00069	0.552
MOD_CK2_1	43	49	PF00069	0.462
MOD_CK2_1	440	446	PF00069	0.620
MOD_CK2_1	547	553	PF00069	0.532
MOD_CK2_1	600	606	PF00069	0.455
MOD_CK2_1	691	697	PF00069	0.654
MOD_CK2_1	742	748	PF00069	0.589
MOD_GlcNHglycan	114	117	PF01048	0.678
MOD_GlcNHglycan	183	186	PF01048	0.649
MOD_GlcNHglycan	301	304	PF01048	0.704
MOD_GlcNHglycan	351	354	PF01048	0.658
MOD_GlcNHglycan	355	358	PF01048	0.713
MOD_GlcNHglycan	431	434	PF01048	0.687
MOD_GlcNHglycan	446	450	PF01048	0.807
MOD_GlcNHglycan	542	545	PF01048	0.498
MOD_GlcNHglycan	555	558	PF01048	0.491
MOD_GlcNHglycan	718	721	PF01048	0.668
MOD_GlcNHglycan	759	762	PF01048	0.548
MOD_GSK3_1	165	172	PF00069	0.704
MOD_GSK3_1	177	184	PF00069	0.557
MOD_GSK3_1	293	300	PF00069	0.655
MOD_GSK3_1	349	356	PF00069	0.641
MOD_GSK3_1	465	472	PF00069	0.506
MOD_GSK3_1	547	554	PF00069	0.563
MOD_GSK3_1	555	562	PF00069	0.432
MOD_GSK3_1	596	603	PF00069	0.455
MOD_N-GLC_1	478	483	PF02516	0.444
MOD_N-GLC_1	596	601	PF02516	0.269
MOD_N-GLC_2	267	269	PF02516	0.492
MOD_N-GLC_2	469	471	PF02516	0.444
MOD_NEK2_1	24	29	PF00069	0.497
MOD_NEK2_1	532	537	PF00069	0.363
MOD_NEK2_1	566	571	PF00069	0.504
MOD_NEK2_1	593	598	PF00069	0.469
MOD_NEK2_1	656	661	PF00069	0.407
MOD_NEK2_2	40	45	PF00069	0.434
MOD_OFUCOSY	471	477	PF10250	0.402
MOD_PIKK_1	143	149	PF00454	0.584
MOD_PIKK_1	35	41	PF00454	0.477
MOD_PIKK_1	358	364	PF00454	0.684
MOD_PIKK_1	691	697	PF00454	0.658
MOD_PIKK_1	706	712	PF00454	0.571
MOD_PKA_1	540	546	PF00069	0.502
MOD_PKA_2	399	405	PF00069	0.613
MOD_PKA_2	429	435	PF00069	0.645
MOD_PKA_2	532	538	PF00069	0.382
MOD_PKA_2	540	546	PF00069	0.471
MOD_PKA_2	547	553	PF00069	0.491
MOD_PKA_2	55	61	PF00069	0.517
MOD_PKA_2	656	662	PF00069	0.486
MOD_PKA_2	667	673	PF00069	0.548
MOD_Plk_1	478	484	PF00069	0.472
MOD_Plk_1	742	748	PF00069	0.564
MOD_Plk_2-3	547	553	PF00069	0.532
MOD_Plk_2-3	600	606	PF00069	0.455
MOD_Plk_4	469	475	PF00069	0.437
MOD_Plk_4	532	538	PF00069	0.476
MOD_ProDKin_1	165	171	PF00069	0.678
MOD_ProDKin_1	440	446	PF00069	0.641
MOD_ProDKin_1	448	454	PF00069	0.677
MOD_ProDKin_1	722	728	PF00069	0.561
MOD_SUMO_rev_2	547	557	PF00179	0.568
MOD_SUMO_rev_2	600	610	PF00179	0.516
TRG_DiLeu_BaEn_1	49	54	PF01217	0.439
TRG_ENDOCYTIC_2	126	129	PF00928	0.676
TRG_ENDOCYTIC_2	270	273	PF00928	0.385
TRG_ER_diArg_1	200	203	PF00400	0.531
TRG_ER_diArg_1	583	586	PF00400	0.564
TRG_ER_diArg_1	622	624	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I1	Leptomonas seymouri	44%	100%
A0A3Q8IJ43	Leishmania donovani	92%	100%
A4HK66	Leishmania braziliensis	75%	100%
A4I7Q1	Leishmania infantum	91%	100%
E9B2K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%