Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5J6_LEIMA

TriTrypDb:

LmjF.32.0860 , LMJLV39_320014300 , LMJSD75_320014300

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q5J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5J6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.451
CLV_C14_Caspase3-7	407	411	PF00656	0.539
CLV_NRD_NRD_1	153	155	PF00675	0.619
CLV_NRD_NRD_1	260	262	PF00675	0.386
CLV_NRD_NRD_1	561	563	PF00675	0.643
CLV_PCSK_FUR_1	151	155	PF00082	0.578
CLV_PCSK_KEX2_1	153	155	PF00082	0.580
CLV_PCSK_KEX2_1	172	174	PF00082	0.266
CLV_PCSK_KEX2_1	259	261	PF00082	0.372
CLV_PCSK_KEX2_1	329	331	PF00082	0.546
CLV_PCSK_KEX2_1	474	476	PF00082	0.479
CLV_PCSK_KEX2_1	559	561	PF00082	0.609
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.436
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.546
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.424
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.609
CLV_PCSK_PC7_1	325	331	PF00082	0.467
CLV_PCSK_SKI1_1	172	176	PF00082	0.524
CLV_PCSK_SKI1_1	184	188	PF00082	0.525
CLV_PCSK_SKI1_1	265	269	PF00082	0.313
CLV_PCSK_SKI1_1	293	297	PF00082	0.480
CLV_PCSK_SKI1_1	471	475	PF00082	0.446
CLV_PCSK_SKI1_1	561	565	PF00082	0.718
DEG_APCC_DBOX_1	111	119	PF00400	0.358
DEG_APCC_DBOX_1	376	384	PF00400	0.403
DEG_SCF_FBW7_1	13	20	PF00400	0.411
DEG_SCF_FBW7_1	400	407	PF00400	0.337
DEG_SPOP_SBC_1	346	350	PF00917	0.631
DOC_CKS1_1	14	19	PF01111	0.411
DOC_CKS1_1	401	406	PF01111	0.338
DOC_CYCLIN_yCln2_LP_2	320	323	PF00134	0.478
DOC_MAPK_gen_1	290	300	PF00069	0.449
DOC_MAPK_gen_1	312	320	PF00069	0.559
DOC_MAPK_MEF2A_6	293	302	PF00069	0.436
DOC_MAPK_MEF2A_6	445	454	PF00069	0.518
DOC_MAPK_NFAT4_5	293	301	PF00069	0.439
DOC_PP1_RVXF_1	108	114	PF00149	0.460
DOC_PP2B_LxvP_1	320	323	PF13499	0.478
DOC_PP4_MxPP_1	477	480	PF00568	0.535
DOC_USP7_MATH_1	214	218	PF00917	0.686
DOC_USP7_MATH_1	344	348	PF00917	0.651
DOC_USP7_MATH_1	367	371	PF00917	0.577
DOC_USP7_MATH_1	404	408	PF00917	0.395
DOC_USP7_MATH_1	42	46	PF00917	0.433
DOC_USP7_MATH_1	542	546	PF00917	0.578
DOC_WW_Pin1_4	13	18	PF00397	0.410
DOC_WW_Pin1_4	400	405	PF00397	0.336
LIG_14-3-3_CanoR_1	123	129	PF00244	0.452
LIG_14-3-3_CanoR_1	184	194	PF00244	0.439
LIG_14-3-3_CanoR_1	431	437	PF00244	0.471
LIG_14-3-3_CanoR_1	453	460	PF00244	0.637
LIG_14-3-3_CanoR_1	483	491	PF00244	0.505
LIG_14-3-3_CanoR_1	549	557	PF00244	0.557
LIG_14-3-3_CanoR_1	575	580	PF00244	0.534
LIG_14-3-3_CanoR_1	61	69	PF00244	0.380
LIG_14-3-3_CanoR_1	71	80	PF00244	0.400
LIG_Actin_WH2_2	470	485	PF00022	0.552
LIG_AP_GAE_1	586	592	PF02883	0.500
LIG_AP2alpha_2	387	389	PF02296	0.324
LIG_BRCT_BRCA1_1	272	276	PF00533	0.387
LIG_BRCT_BRCA1_1	401	405	PF00533	0.390
LIG_deltaCOP1_diTrp_1	517	526	PF00928	0.577
LIG_FHA_1	181	187	PF00498	0.436
LIG_FHA_1	24	30	PF00498	0.437
LIG_FHA_1	33	39	PF00498	0.419
LIG_FHA_1	483	489	PF00498	0.578
LIG_FHA_1	505	511	PF00498	0.536
LIG_FHA_1	595	601	PF00498	0.558
LIG_FHA_1	77	83	PF00498	0.338
LIG_FHA_2	140	146	PF00498	0.553
LIG_FHA_2	420	426	PF00498	0.367
LIG_FHA_2	484	490	PF00498	0.673
LIG_FHA_2	94	100	PF00498	0.297
LIG_LIR_Apic_2	12	17	PF02991	0.405
LIG_LIR_Apic_2	399	404	PF02991	0.351
LIG_LIR_Gen_1	402	412	PF02991	0.401
LIG_LIR_Gen_1	586	595	PF02991	0.504
LIG_LIR_LC3C_4	79	83	PF02991	0.419
LIG_LIR_Nem_3	273	278	PF02991	0.420
LIG_LIR_Nem_3	402	408	PF02991	0.379
LIG_LIR_Nem_3	438	443	PF02991	0.533
LIG_LIR_Nem_3	5	9	PF02991	0.390
LIG_LIR_Nem_3	586	592	PF02991	0.494
LIG_MLH1_MIPbox_1	272	276	PF16413	0.387
LIG_PCNA_yPIPBox_3	304	314	PF02747	0.364
LIG_PTAP_UEV_1	51	56	PF05743	0.410
LIG_SH2_CRK	14	18	PF00017	0.411
LIG_SH2_CRK	401	405	PF00017	0.356
LIG_SH2_GRB2like	168	171	PF00017	0.323
LIG_SH2_NCK_1	401	405	PF00017	0.462
LIG_SH2_NCK_1	497	501	PF00017	0.514
LIG_SH2_SRC	179	182	PF00017	0.391
LIG_SH2_SRC	199	202	PF00017	0.240
LIG_SH2_STAP1	585	589	PF00017	0.546
LIG_SH2_STAT5	103	106	PF00017	0.340
LIG_SH2_STAT5	168	171	PF00017	0.323
LIG_SH2_STAT5	199	202	PF00017	0.530
LIG_SH2_STAT5	275	278	PF00017	0.443
LIG_SH2_STAT5	69	72	PF00017	0.440
LIG_SH2_STAT5	9	12	PF00017	0.388
LIG_SH3_3	27	33	PF00018	0.433
LIG_SH3_3	49	55	PF00018	0.436
LIG_SH3_3	589	595	PF00018	0.594
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.466
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.296
LIG_SUMO_SIM_par_1	413	419	PF11976	0.472
LIG_SUMO_SIM_par_1	78	84	PF11976	0.329
LIG_TRAF2_1	487	490	PF00917	0.426
LIG_TRAF2_1	506	509	PF00917	0.514
LIG_TRAF2_1	96	99	PF00917	0.439
LIG_TYR_ITIM	101	106	PF00017	0.470
MOD_CK1_1	131	137	PF00069	0.638
MOD_CK1_1	34	40	PF00069	0.421
MOD_CK1_1	347	353	PF00069	0.580
MOD_CK1_1	399	405	PF00069	0.351
MOD_CK1_1	545	551	PF00069	0.733
MOD_CK2_1	346	352	PF00069	0.526
MOD_CK2_1	419	425	PF00069	0.371
MOD_CK2_1	453	459	PF00069	0.495
MOD_CK2_1	483	489	PF00069	0.466
MOD_CK2_1	93	99	PF00069	0.311
MOD_Cter_Amidation	151	154	PF01082	0.648
MOD_GlcNHglycan	187	190	PF01048	0.516
MOD_GlcNHglycan	224	227	PF01048	0.646
MOD_GlcNHglycan	237	240	PF01048	0.691
MOD_GlcNHglycan	340	343	PF01048	0.538
MOD_GlcNHglycan	369	372	PF01048	0.635
MOD_GlcNHglycan	498	501	PF01048	0.621
MOD_GlcNHglycan	51	55	PF01048	0.414
MOD_GSK3_1	17	24	PF00069	0.421
MOD_GSK3_1	185	192	PF00069	0.477
MOD_GSK3_1	334	341	PF00069	0.493
MOD_GSK3_1	358	365	PF00069	0.570
MOD_GSK3_1	396	403	PF00069	0.463
MOD_GSK3_1	406	413	PF00069	0.528
MOD_GSK3_1	543	550	PF00069	0.569
MOD_GSK3_1	571	578	PF00069	0.538
MOD_GSK3_1	9	16	PF00069	0.397
MOD_LATS_1	451	457	PF00433	0.593
MOD_N-GLC_1	359	364	PF02516	0.612
MOD_N-GLC_1	483	488	PF02516	0.536
MOD_NEK2_1	185	190	PF00069	0.377
MOD_NEK2_1	222	227	PF00069	0.535
MOD_NEK2_1	270	275	PF00069	0.353
MOD_NEK2_1	281	286	PF00069	0.310
MOD_NEK2_1	482	487	PF00069	0.531
MOD_NEK2_1	491	496	PF00069	0.562
MOD_NEK2_1	526	531	PF00069	0.555
MOD_NEK2_1	579	584	PF00069	0.617
MOD_NEK2_1	60	65	PF00069	0.454
MOD_NEK2_1	70	75	PF00069	0.377
MOD_NEK2_2	396	401	PF00069	0.321
MOD_NEK2_2	9	14	PF00069	0.393
MOD_OFUCOSY	269	274	PF10250	0.430
MOD_PIKK_1	17	23	PF00454	0.423
MOD_PIKK_1	334	340	PF00454	0.642
MOD_PIKK_1	453	459	PF00454	0.590
MOD_PIKK_1	504	510	PF00454	0.714
MOD_PKA_1	561	567	PF00069	0.532
MOD_PKA_2	122	128	PF00069	0.483
MOD_PKA_2	432	438	PF00069	0.501
MOD_PKA_2	482	488	PF00069	0.619
MOD_PKA_2	526	532	PF00069	0.554
MOD_PKA_2	548	554	PF00069	0.690
MOD_PKA_2	561	567	PF00069	0.483
MOD_PKA_2	60	66	PF00069	0.390
MOD_PKA_2	70	76	PF00069	0.402
MOD_PKB_1	525	533	PF00069	0.523
MOD_PKB_1	560	568	PF00069	0.675
MOD_Plk_1	214	220	PF00069	0.563
MOD_Plk_1	483	489	PF00069	0.693
MOD_Plk_2-3	410	416	PF00069	0.536
MOD_Plk_2-3	419	425	PF00069	0.511
MOD_Plk_2-3	93	99	PF00069	0.351
MOD_Plk_4	131	137	PF00069	0.512
MOD_Plk_4	2	8	PF00069	0.408
MOD_Plk_4	313	319	PF00069	0.490
MOD_Plk_4	396	402	PF00069	0.476
MOD_Plk_4	410	416	PF00069	0.420
MOD_Plk_4	575	581	PF00069	0.578
MOD_Plk_4	76	82	PF00069	0.317
MOD_Plk_4	9	15	PF00069	0.416
MOD_ProDKin_1	13	19	PF00069	0.410
MOD_ProDKin_1	400	406	PF00069	0.335
MOD_SUMO_rev_2	565	571	PF00179	0.614
TRG_DiLeu_BaEn_1	313	318	PF01217	0.452
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.494
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.459
TRG_ENDOCYTIC_2	103	106	PF00928	0.340
TRG_ENDOCYTIC_2	171	174	PF00928	0.328
TRG_ENDOCYTIC_2	275	278	PF00928	0.412
TRG_ENDOCYTIC_2	69	72	PF00928	0.307
TRG_ER_diArg_1	110	113	PF00400	0.462
TRG_ER_diArg_1	151	154	PF00400	0.550
TRG_ER_diArg_1	258	261	PF00400	0.370
TRG_ER_diArg_1	430	433	PF00400	0.557
TRG_ER_diArg_1	560	562	PF00400	0.605
TRG_ER_diArg_1	600	603	PF00400	0.654
TRG_NLS_MonoCore_2	558	563	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I873	Leptomonas seymouri	56%	100%
A0A1X0NWB4	Trypanosomatidae	35%	100%
A0A3S7X5C7	Leishmania donovani	93%	100%
A0A422N8X2	Trypanosoma rangeli	34%	100%
A4HK67	Leishmania braziliensis	77%	91%
A4I7Q2	Leishmania infantum	93%	100%
D0A9V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQN4	Trypanosoma cruzi	34%	100%