Ethanolamine-phosphate cytidylyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine-phosphate cytidylyltransferase

Species:

Leishmania major

UniProt:

Q4Q5J3_LEIMA

TriTrypDb:

LmjF.32.0890 , LMJLV39_320014600 , LMJSD75_320014600

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5J3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006646	phosphatidylethanolamine biosynthetic process	6	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046337	phosphatidylethanolamine metabolic process	6	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004306	ethanolamine-phosphate cytidylyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070567	cytidylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.451
CLV_C14_Caspase3-7	311	315	PF00656	0.552
CLV_NRD_NRD_1	215	217	PF00675	0.405
CLV_NRD_NRD_1	395	397	PF00675	0.528
CLV_NRD_NRD_1	71	73	PF00675	0.310
CLV_NRD_NRD_1	74	76	PF00675	0.312
CLV_PCSK_FUR_1	72	76	PF00082	0.178
CLV_PCSK_KEX2_1	167	169	PF00082	0.238
CLV_PCSK_KEX2_1	375	377	PF00082	0.455
CLV_PCSK_KEX2_1	380	382	PF00082	0.476
CLV_PCSK_KEX2_1	71	73	PF00082	0.310
CLV_PCSK_KEX2_1	74	76	PF00082	0.312
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.248
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.475
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.482
CLV_PCSK_PC7_1	376	382	PF00082	0.441
CLV_PCSK_SKI1_1	164	168	PF00082	0.251
CLV_PCSK_SKI1_1	180	184	PF00082	0.267
CLV_PCSK_SKI1_1	380	384	PF00082	0.512
CLV_Separin_Metazoa	89	93	PF03568	0.526
DEG_SCF_TRCP1_1	352	358	PF00400	0.413
DEG_SPOP_SBC_1	4	8	PF00917	0.690
DOC_ANK_TNKS_1	51	58	PF00023	0.324
DOC_CYCLIN_RxL_1	177	185	PF00134	0.514
DOC_CYCLIN_yClb1_LxF_4	368	373	PF00134	0.553
DOC_MAPK_gen_1	275	284	PF00069	0.501
DOC_MAPK_gen_1	71	82	PF00069	0.528
DOC_MAPK_MEF2A_6	46	55	PF00069	0.354
DOC_PP1_RVXF_1	215	222	PF00149	0.476
DOC_PP1_RVXF_1	368	374	PF00149	0.491
DOC_PP4_FxxP_1	93	96	PF00568	0.526
DOC_SPAK_OSR1_1	132	136	PF12202	0.456
DOC_USP7_MATH_1	2	6	PF00917	0.671
DOC_USP7_MATH_1	280	284	PF00917	0.395
DOC_WW_Pin1_4	11	16	PF00397	0.668
DOC_WW_Pin1_4	203	208	PF00397	0.624
DOC_WW_Pin1_4	223	228	PF00397	0.479
DOC_WW_Pin1_4	5	10	PF00397	0.696
LIG_14-3-3_CanoR_1	151	155	PF00244	0.435
LIG_Actin_WH2_2	175	193	PF00022	0.642
LIG_Actin_WH2_2	55	73	PF00022	0.451
LIG_APCC_ABBA_1	345	350	PF00400	0.462
LIG_FHA_1	12	18	PF00498	0.577
LIG_FHA_1	167	173	PF00498	0.440
LIG_FHA_1	357	363	PF00498	0.353
LIG_FHA_1	38	44	PF00498	0.480
LIG_FHA_1	48	54	PF00498	0.320
LIG_FHA_2	335	341	PF00498	0.484
LIG_Integrin_isoDGR_2	149	151	PF01839	0.249
LIG_LIR_Apic_2	336	342	PF02991	0.400
LIG_LIR_Gen_1	102	110	PF02991	0.465
LIG_LIR_Gen_1	153	160	PF02991	0.440
LIG_LIR_Gen_1	237	248	PF02991	0.430
LIG_LIR_Gen_1	324	331	PF02991	0.333
LIG_LIR_Gen_1	33	43	PF02991	0.596
LIG_LIR_Gen_1	56	67	PF02991	0.440
LIG_LIR_LC3C_4	327	331	PF02991	0.502
LIG_LIR_Nem_3	102	108	PF02991	0.440
LIG_LIR_Nem_3	153	157	PF02991	0.440
LIG_LIR_Nem_3	237	243	PF02991	0.430
LIG_LIR_Nem_3	324	329	PF02991	0.469
LIG_LIR_Nem_3	33	38	PF02991	0.452
LIG_LIR_Nem_3	393	398	PF02991	0.541
LIG_LIR_Nem_3	56	62	PF02991	0.430
LIG_LYPXL_yS_3	279	282	PF13949	0.501
LIG_OCRL_FandH_1	58	70	PF00620	0.440
LIG_PCNA_yPIPBox_3	285	295	PF02747	0.451
LIG_PTB_Apo_2	117	124	PF02174	0.481
LIG_PTB_Phospho_1	117	123	PF10480	0.481
LIG_Rb_LxCxE_1	33	50	PF01857	0.574
LIG_SH2_CRK	395	399	PF00017	0.477
LIG_SH2_SRC	154	157	PF00017	0.451
LIG_SH2_SRC	235	238	PF00017	0.440
LIG_SH2_SRC	260	263	PF00017	0.440
LIG_SH2_STAP1	266	270	PF00017	0.526
LIG_SH2_STAT3	266	269	PF00017	0.545
LIG_SH2_STAT5	123	126	PF00017	0.409
LIG_SH2_STAT5	137	140	PF00017	0.440
LIG_SH2_STAT5	235	238	PF00017	0.440
LIG_SH2_STAT5	260	263	PF00017	0.440
LIG_SH2_STAT5	296	299	PF00017	0.438
LIG_SH3_3	14	20	PF00018	0.581
LIG_SH3_3	204	210	PF00018	0.574
LIG_SH3_3	42	48	PF00018	0.484
LIG_TRAF2_1	153	156	PF00917	0.440
LIG_TRAF2_1	86	89	PF00917	0.465
LIG_WRC_WIRS_1	281	286	PF05994	0.378
MOD_CDK_SPK_2	223	228	PF00069	0.507
MOD_CK1_1	13	19	PF00069	0.664
MOD_CK1_1	222	228	PF00069	0.531
MOD_CK1_1	358	364	PF00069	0.421
MOD_CK1_1	5	11	PF00069	0.729
MOD_CK2_1	150	156	PF00069	0.451
MOD_CK2_1	189	195	PF00069	0.557
MOD_CK2_1	198	204	PF00069	0.574
MOD_CK2_1	280	286	PF00069	0.397
MOD_CK2_1	334	340	PF00069	0.499
MOD_CK2_1	83	89	PF00069	0.440
MOD_GlcNHglycan	352	355	PF01048	0.388
MOD_GSK3_1	166	173	PF00069	0.430
MOD_GSK3_1	219	226	PF00069	0.486
MOD_GSK3_1	3	10	PF00069	0.703
MOD_GSK3_1	33	40	PF00069	0.521
MOD_N-GLC_1	222	227	PF02516	0.476
MOD_NEK2_1	182	187	PF00069	0.529
MOD_NEK2_1	198	203	PF00069	0.584
MOD_NEK2_1	212	217	PF00069	0.331
MOD_NEK2_2	290	295	PF00069	0.451
MOD_PIKK_1	384	390	PF00454	0.619
MOD_PKA_2	150	156	PF00069	0.427
MOD_Plk_1	142	148	PF00069	0.440
MOD_Plk_1	198	204	PF00069	0.640
MOD_Plk_1	33	39	PF00069	0.470
MOD_Plk_2-3	142	148	PF00069	0.451
MOD_Plk_4	198	204	PF00069	0.574
MOD_Plk_4	33	39	PF00069	0.507
MOD_Plk_4	358	364	PF00069	0.480
MOD_ProDKin_1	203	209	PF00069	0.618
MOD_ProDKin_1	223	229	PF00069	0.483
MOD_ProDKin_1	5	11	PF00069	0.696
MOD_SUMO_rev_2	379	387	PF00179	0.523
TRG_ENDOCYTIC_2	105	108	PF00928	0.440
TRG_ENDOCYTIC_2	154	157	PF00928	0.440
TRG_ENDOCYTIC_2	279	282	PF00928	0.501
TRG_ENDOCYTIC_2	348	351	PF00928	0.450
TRG_ENDOCYTIC_2	35	38	PF00928	0.498
TRG_ENDOCYTIC_2	395	398	PF00928	0.486
TRG_ER_diArg_1	70	72	PF00400	0.528
TRG_ER_diArg_1	74	76	PF00400	0.524
TRG_NES_CRM1_1	311	324	PF08389	0.378
TRG_NLS_MonoExtN_4	164	171	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	396	400	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A3	Leptomonas seymouri	79%	100%
A0A0S4KIJ8	Bodo saltans	68%	96%
A0A1X0NUM2	Trypanosomatidae	70%	100%
A0A3S7X5B3	Leishmania donovani	94%	100%
A0A422N8Y0	Trypanosoma rangeli	67%	100%
A4HK70	Leishmania braziliensis	85%	100%
A4I7Q5	Leishmania infantum	94%	100%
D0A9W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B2L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O88637	Rattus norvegicus	43%	100%
P33412	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
Q55BZ4	Dictyostelium discoideum	52%	100%
Q5EA75	Bos taurus	45%	100%
Q8SQW6	Encephalitozoon cuniculi (strain GB-M1)	36%	100%
Q922E4	Mus musculus	42%	100%
Q99447	Homo sapiens	44%	100%
Q9UTI6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9ZVI9	Arabidopsis thaliana	43%	95%
V5DHH9	Trypanosoma cruzi	65%	100%