GMC_OxRdtase_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania major

UniProt:

Q4Q5I9_LEIMA

TriTrypDb:

LmjF.32.0930 , LMJLV39_320015100 , LMJSD75_320015100

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5I9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	3
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0050660	flavin adenine dinucleotide binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.580
CLV_C14_Caspase3-7	685	689	PF00656	0.549
CLV_C14_Caspase3-7	700	704	PF00656	0.511
CLV_NRD_NRD_1	162	164	PF00675	0.499
CLV_NRD_NRD_1	282	284	PF00675	0.330
CLV_NRD_NRD_1	301	303	PF00675	0.367
CLV_NRD_NRD_1	379	381	PF00675	0.353
CLV_NRD_NRD_1	544	546	PF00675	0.333
CLV_NRD_NRD_1	607	609	PF00675	0.348
CLV_NRD_NRD_1	617	619	PF00675	0.323
CLV_NRD_NRD_1	64	66	PF00675	0.399
CLV_NRD_NRD_1	95	97	PF00675	0.436
CLV_PCSK_KEX2_1	266	268	PF00082	0.415
CLV_PCSK_KEX2_1	282	284	PF00082	0.330
CLV_PCSK_KEX2_1	301	303	PF00082	0.391
CLV_PCSK_KEX2_1	544	546	PF00082	0.340
CLV_PCSK_KEX2_1	607	609	PF00082	0.366
CLV_PCSK_KEX2_1	617	619	PF00082	0.312
CLV_PCSK_KEX2_1	64	66	PF00082	0.399
CLV_PCSK_KEX2_1	674	676	PF00082	0.382
CLV_PCSK_KEX2_1	95	97	PF00082	0.436
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.437
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.382
CLV_PCSK_PC7_1	603	609	PF00082	0.261
CLV_PCSK_SKI1_1	167	171	PF00082	0.327
CLV_PCSK_SKI1_1	249	253	PF00082	0.405
CLV_PCSK_SKI1_1	283	287	PF00082	0.412
CLV_PCSK_SKI1_1	370	374	PF00082	0.332
CLV_PCSK_SKI1_1	390	394	PF00082	0.317
CLV_PCSK_SKI1_1	452	456	PF00082	0.382
CLV_PCSK_SKI1_1	654	658	PF00082	0.358
CLV_PCSK_SKI1_1	692	696	PF00082	0.409
CLV_Separin_Metazoa	61	65	PF03568	0.535
DEG_Nend_Nbox_1	1	3	PF02207	0.342
DEG_ODPH_VHL_1	445	458	PF01847	0.609
DEG_SPOP_SBC_1	639	643	PF00917	0.623
DOC_CDC14_PxL_1	100	108	PF14671	0.658
DOC_CKS1_1	429	434	PF01111	0.557
DOC_CKS1_1	475	480	PF01111	0.606
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	475	481	PF00134	0.577
DOC_MAPK_gen_1	163	171	PF00069	0.529
DOC_MAPK_gen_1	327	336	PF00069	0.628
DOC_MAPK_gen_1	370	379	PF00069	0.566
DOC_MAPK_gen_1	95	102	PF00069	0.632
DOC_MAPK_HePTP_8	367	379	PF00069	0.552
DOC_MAPK_MEF2A_6	370	379	PF00069	0.566
DOC_MAPK_MEF2A_6	390	399	PF00069	0.413
DOC_MAPK_NFAT4_5	390	398	PF00069	0.508
DOC_MAPK_RevD_3	251	267	PF00069	0.531
DOC_MIT_MIM_1	297	306	PF04212	0.588
DOC_PP1_RVXF_1	265	272	PF00149	0.508
DOC_PP1_RVXF_1	450	457	PF00149	0.566
DOC_PP1_RVXF_1	96	103	PF00149	0.634
DOC_PP2B_LxvP_1	253	256	PF13499	0.580
DOC_PP2B_LxvP_1	284	287	PF13499	0.600
DOC_PP2B_LxvP_1	393	396	PF13499	0.505
DOC_PP2B_LxvP_1	438	441	PF13499	0.574
DOC_USP7_MATH_1	216	220	PF00917	0.651
DOC_USP7_MATH_1	285	289	PF00917	0.604
DOC_USP7_MATH_1	345	349	PF00917	0.537
DOC_USP7_MATH_1	403	407	PF00917	0.615
DOC_USP7_MATH_1	514	518	PF00917	0.716
DOC_USP7_MATH_1	630	634	PF00917	0.563
DOC_USP7_MATH_1	639	643	PF00917	0.623
DOC_USP7_MATH_1	644	648	PF00917	0.576
DOC_USP7_MATH_1	679	683	PF00917	0.599
DOC_USP7_MATH_1	83	87	PF00917	0.593
DOC_USP7_UBL2_3	596	600	PF12436	0.658
DOC_WW_Pin1_4	123	128	PF00397	0.749
DOC_WW_Pin1_4	361	366	PF00397	0.556
DOC_WW_Pin1_4	428	433	PF00397	0.561
DOC_WW_Pin1_4	474	479	PF00397	0.610
DOC_WW_Pin1_4	502	507	PF00397	0.697
DOC_WW_Pin1_4	546	551	PF00397	0.605
LIG_14-3-3_CanoR_1	21	30	PF00244	0.603
LIG_14-3-3_CanoR_1	214	224	PF00244	0.676
LIG_14-3-3_CanoR_1	237	243	PF00244	0.503
LIG_14-3-3_CanoR_1	301	306	PF00244	0.566
LIG_14-3-3_CanoR_1	413	423	PF00244	0.618
LIG_14-3-3_CanoR_1	513	523	PF00244	0.697
LIG_14-3-3_CanoR_1	544	552	PF00244	0.579
LIG_14-3-3_CanoR_1	608	616	PF00244	0.544
LIG_14-3-3_CanoR_1	64	73	PF00244	0.476
LIG_14-3-3_CanoR_1	683	688	PF00244	0.592
LIG_14-3-3_CanoR_1	98	103	PF00244	0.633
LIG_BRCT_BRCA1_1	240	244	PF00533	0.486
LIG_BRCT_BRCA1_1	562	566	PF00533	0.585
LIG_BRCT_BRCA1_1	633	637	PF00533	0.582
LIG_DLG_GKlike_1	683	691	PF00625	0.516
LIG_EH1_1	481	489	PF00400	0.542
LIG_FHA_1	183	189	PF00498	0.610
LIG_FHA_1	23	29	PF00498	0.644
LIG_FHA_1	258	264	PF00498	0.628
LIG_FHA_1	294	300	PF00498	0.604
LIG_FHA_1	36	42	PF00498	0.643
LIG_FHA_1	384	390	PF00498	0.575
LIG_FHA_1	481	487	PF00498	0.523
LIG_FHA_1	547	553	PF00498	0.659
LIG_FHA_1	565	571	PF00498	0.561
LIG_FHA_1	693	699	PF00498	0.624
LIG_FHA_2	124	130	PF00498	0.722
LIG_FHA_2	663	669	PF00498	0.451
LIG_FHA_2	683	689	PF00498	0.555
LIG_LIR_Gen_1	44	54	PF02991	0.481
LIG_LIR_Gen_1	563	571	PF02991	0.601
LIG_LIR_Gen_1	666	676	PF02991	0.635
LIG_LIR_Nem_3	44	49	PF02991	0.485
LIG_LIR_Nem_3	563	569	PF02991	0.593
LIG_LIR_Nem_3	666	672	PF02991	0.642
LIG_MYND_1	428	432	PF01753	0.564
LIG_Pex14_1	16	20	PF04695	0.410
LIG_RPA_C_Fungi	678	690	PF08784	0.361
LIG_SH2_GRB2like	17	20	PF00017	0.306
LIG_SH2_PTP2	46	49	PF00017	0.353
LIG_SH2_SRC	619	622	PF00017	0.468
LIG_SH2_STAT3	131	134	PF00017	0.641
LIG_SH2_STAT5	131	134	PF00017	0.513
LIG_SH2_STAT5	168	171	PF00017	0.518
LIG_SH2_STAT5	17	20	PF00017	0.306
LIG_SH2_STAT5	257	260	PF00017	0.547
LIG_SH2_STAT5	274	277	PF00017	0.243
LIG_SH2_STAT5	429	432	PF00017	0.543
LIG_SH2_STAT5	46	49	PF00017	0.362
LIG_SH3_3	104	110	PF00018	0.631
LIG_SH3_3	144	150	PF00018	0.534
LIG_SH3_3	228	234	PF00018	0.510
LIG_SH3_3	253	259	PF00018	0.470
LIG_SH3_3	266	272	PF00018	0.483
LIG_SH3_3	344	350	PF00018	0.574
LIG_SH3_3	376	382	PF00018	0.585
LIG_SH3_5	42	46	PF00018	0.474
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.410
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.417
LIG_SUMO_SIM_par_1	562	574	PF11976	0.511
LIG_SUMO_SIM_par_1	71	77	PF11976	0.391
LIG_UBA3_1	367	373	PF00899	0.399
LIG_WRC_WIRS_1	99	104	PF05994	0.525
MOD_CDK_SPK_2	361	366	PF00069	0.436
MOD_CK1_1	212	218	PF00069	0.691
MOD_CK1_1	304	310	PF00069	0.428
MOD_CK1_1	31	37	PF00069	0.564
MOD_CK1_1	406	412	PF00069	0.611
MOD_CK1_1	589	595	PF00069	0.509
MOD_CK1_1	631	637	PF00069	0.456
MOD_CK1_1	640	646	PF00069	0.587
MOD_CK1_1	648	654	PF00069	0.460
MOD_CK1_1	662	668	PF00069	0.402
MOD_CK1_1	682	688	PF00069	0.361
MOD_CK2_1	123	129	PF00069	0.686
MOD_CK2_1	215	221	PF00069	0.592
MOD_CK2_1	662	668	PF00069	0.289
MOD_Cter_Amidation	280	283	PF01082	0.409
MOD_Cter_Amidation	672	675	PF01082	0.482
MOD_Cter_Amidation	93	96	PF01082	0.542
MOD_GlcNHglycan	287	290	PF01048	0.505
MOD_GlcNHglycan	399	402	PF01048	0.469
MOD_GlcNHglycan	405	408	PF01048	0.477
MOD_GlcNHglycan	591	594	PF01048	0.507
MOD_GlcNHglycan	630	633	PF01048	0.365
MOD_GlcNHglycan	642	645	PF01048	0.540
MOD_GlcNHglycan	660	664	PF01048	0.286
MOD_GlcNHglycan	76	79	PF01048	0.485
MOD_GlcNHglycan	85	88	PF01048	0.548
MOD_GSK3_1	212	219	PF00069	0.586
MOD_GSK3_1	31	38	PF00069	0.545
MOD_GSK3_1	470	477	PF00069	0.486
MOD_GSK3_1	560	567	PF00069	0.447
MOD_GSK3_1	633	640	PF00069	0.405
MOD_GSK3_1	644	651	PF00069	0.472
MOD_GSK3_1	658	665	PF00069	0.381
MOD_GSK3_1	679	686	PF00069	0.370
MOD_N-GLC_1	209	214	PF02516	0.548
MOD_N-GLC_1	553	558	PF02516	0.471
MOD_NEK2_1	182	187	PF00069	0.577
MOD_NEK2_1	397	402	PF00069	0.527
MOD_NEK2_1	433	438	PF00069	0.367
MOD_NEK2_1	637	642	PF00069	0.551
MOD_NEK2_1	697	702	PF00069	0.431
MOD_NEK2_1	74	79	PF00069	0.570
MOD_NEK2_2	295	300	PF00069	0.385
MOD_PIKK_1	315	321	PF00454	0.500
MOD_PIKK_1	421	427	PF00454	0.538
MOD_PK_1	301	307	PF00069	0.477
MOD_PKA_1	301	307	PF00069	0.445
MOD_PKA_1	544	550	PF00069	0.432
MOD_PKA_1	64	70	PF00069	0.289
MOD_PKA_1	674	680	PF00069	0.453
MOD_PKA_2	22	28	PF00069	0.504
MOD_PKA_2	301	307	PF00069	0.400
MOD_PKA_2	329	335	PF00069	0.447
MOD_PKA_2	336	342	PF00069	0.449
MOD_PKA_2	415	421	PF00069	0.419
MOD_PKA_2	544	550	PF00069	0.522
MOD_PKA_2	63	69	PF00069	0.433
MOD_PKA_2	648	654	PF00069	0.407
MOD_PKA_2	674	680	PF00069	0.508
MOD_PKA_2	682	688	PF00069	0.490
MOD_PKB_1	96	104	PF00069	0.550
MOD_Plk_1	553	559	PF00069	0.423
MOD_Plk_1	564	570	PF00069	0.400
MOD_Plk_1	659	665	PF00069	0.403
MOD_Plk_4	118	124	PF00069	0.690
MOD_Plk_4	193	199	PF00069	0.472
MOD_Plk_4	301	307	PF00069	0.389
MOD_Plk_4	433	439	PF00069	0.439
MOD_Plk_4	470	476	PF00069	0.493
MOD_Plk_4	611	617	PF00069	0.483
MOD_Plk_4	633	639	PF00069	0.474
MOD_ProDKin_1	123	129	PF00069	0.705
MOD_ProDKin_1	361	367	PF00069	0.436
MOD_ProDKin_1	428	434	PF00069	0.442
MOD_ProDKin_1	474	480	PF00069	0.509
MOD_ProDKin_1	502	508	PF00069	0.638
MOD_ProDKin_1	546	552	PF00069	0.505
MOD_SUMO_rev_2	495	505	PF00179	0.479
MOD_SUMO_rev_2	572	578	PF00179	0.451
MOD_SUMO_rev_2	592	602	PF00179	0.485
TRG_DiLeu_BaEn_1	4	9	PF01217	0.300
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.483
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.322
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.544
TRG_ENDOCYTIC_2	15	18	PF00928	0.339
TRG_ENDOCYTIC_2	168	171	PF00928	0.592
TRG_ENDOCYTIC_2	274	277	PF00928	0.467
TRG_ENDOCYTIC_2	46	49	PF00928	0.365
TRG_ER_diArg_1	20	23	PF00400	0.501
TRG_ER_diArg_1	282	284	PF00400	0.403
TRG_ER_diArg_1	301	303	PF00400	0.491
TRG_ER_diArg_1	377	380	PF00400	0.413
TRG_ER_diArg_1	544	546	PF00400	0.417
TRG_ER_diArg_1	607	609	PF00400	0.445
TRG_ER_diArg_1	616	618	PF00400	0.376
TRG_ER_diArg_1	63	65	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY3	Leptomonas seymouri	60%	99%
A0A1X0NUW5	Trypanosomatidae	32%	100%
A0A3S5H7R6	Leishmania donovani	92%	100%
A0A422N8N4	Trypanosoma rangeli	31%	100%
A4HK74	Leishmania braziliensis	78%	100%
A4I7Q9	Leishmania infantum	92%	100%
D0A9W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B2L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BGK4	Trypanosoma cruzi	32%	100%