CLASP_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLASP N terminal, putative

Species:

Leishmania major

UniProt:

Q4Q5I8_LEIMA

TriTrypDb:

LmjF.32.0940 , LMJLV39_320015200 , LMJSD75_320015200

Length:

1064

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	2
GO:0005881	cytoplasmic microtubule	7	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5I8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.521
CLV_NRD_NRD_1	1024	1026	PF00675	0.578
CLV_NRD_NRD_1	16	18	PF00675	0.478
CLV_NRD_NRD_1	175	177	PF00675	0.277
CLV_NRD_NRD_1	220	222	PF00675	0.273
CLV_NRD_NRD_1	224	226	PF00675	0.253
CLV_NRD_NRD_1	283	285	PF00675	0.584
CLV_NRD_NRD_1	316	318	PF00675	0.580
CLV_NRD_NRD_1	332	334	PF00675	0.592
CLV_NRD_NRD_1	379	381	PF00675	0.603
CLV_NRD_NRD_1	399	401	PF00675	0.348
CLV_NRD_NRD_1	66	68	PF00675	0.452
CLV_NRD_NRD_1	769	771	PF00675	0.617
CLV_NRD_NRD_1	88	90	PF00675	0.292
CLV_NRD_NRD_1	913	915	PF00675	0.383
CLV_PCSK_KEX2_1	1024	1026	PF00082	0.578
CLV_PCSK_KEX2_1	151	153	PF00082	0.226
CLV_PCSK_KEX2_1	16	18	PF00082	0.402
CLV_PCSK_KEX2_1	174	176	PF00082	0.291
CLV_PCSK_KEX2_1	220	222	PF00082	0.273
CLV_PCSK_KEX2_1	224	226	PF00082	0.253
CLV_PCSK_KEX2_1	283	285	PF00082	0.651
CLV_PCSK_KEX2_1	316	318	PF00082	0.632
CLV_PCSK_KEX2_1	332	334	PF00082	0.541
CLV_PCSK_KEX2_1	379	381	PF00082	0.603
CLV_PCSK_KEX2_1	399	401	PF00082	0.348
CLV_PCSK_KEX2_1	66	68	PF00082	0.452
CLV_PCSK_KEX2_1	769	771	PF00082	0.618
CLV_PCSK_KEX2_1	88	90	PF00082	0.292
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.226
CLV_PCSK_PC7_1	220	226	PF00082	0.275
CLV_PCSK_SKI1_1	1024	1028	PF00082	0.460
CLV_PCSK_SKI1_1	143	147	PF00082	0.295
CLV_PCSK_SKI1_1	151	155	PF00082	0.305
CLV_PCSK_SKI1_1	302	306	PF00082	0.569
CLV_PCSK_SKI1_1	319	323	PF00082	0.662
CLV_PCSK_SKI1_1	333	337	PF00082	0.536
CLV_PCSK_SKI1_1	552	556	PF00082	0.451
CLV_PCSK_SKI1_1	612	616	PF00082	0.524
CLV_PCSK_SKI1_1	642	646	PF00082	0.399
CLV_PCSK_SKI1_1	66	70	PF00082	0.490
CLV_PCSK_SKI1_1	698	702	PF00082	0.537
CLV_PCSK_SKI1_1	799	803	PF00082	0.392
CLV_PCSK_SKI1_1	836	840	PF00082	0.333
CLV_PCSK_SKI1_1	954	958	PF00082	0.327
CLV_Separin_Metazoa	13	17	PF03568	0.456
CLV_Separin_Metazoa	179	183	PF03568	0.529
DEG_APCC_DBOX_1	551	559	PF00400	0.449
DEG_APCC_DBOX_1	798	806	PF00400	0.394
DEG_ODPH_VHL_1	1036	1049	PF01847	0.473
DEG_SPOP_SBC_1	128	132	PF00917	0.495
DEG_SPOP_SBC_1	273	277	PF00917	0.602
DEG_SPOP_SBC_1	542	546	PF00917	0.399
DOC_CDC14_PxL_1	731	739	PF14671	0.608
DOC_CYCLIN_RxL_1	140	149	PF00134	0.443
DOC_CYCLIN_RxL_1	330	338	PF00134	0.569
DOC_CYCLIN_RxL_1	638	648	PF00134	0.442
DOC_CYCLIN_RxL_1	833	842	PF00134	0.305
DOC_CYCLIN_yCln2_LP_2	737	743	PF00134	0.679
DOC_CYCLIN_yCln2_LP_2	989	995	PF00134	0.434
DOC_MAPK_gen_1	174	180	PF00069	0.529
DOC_MAPK_gen_1	224	232	PF00069	0.475
DOC_MAPK_gen_1	695	703	PF00069	0.402
DOC_MAPK_gen_1	88	94	PF00069	0.475
DOC_MAPK_gen_1	914	922	PF00069	0.327
DOC_MAPK_MEF2A_6	1013	1021	PF00069	0.517
DOC_MAPK_MEF2A_6	189	197	PF00069	0.478
DOC_MAPK_RevD_3	1010	1025	PF00069	0.438
DOC_PP2B_LxvP_1	989	992	PF13499	0.438
DOC_PP4_FxxP_1	1035	1038	PF00568	0.478
DOC_USP7_MATH_1	128	132	PF00917	0.501
DOC_USP7_MATH_1	2	6	PF00917	0.618
DOC_USP7_MATH_1	274	278	PF00917	0.712
DOC_USP7_MATH_1	298	302	PF00917	0.542
DOC_USP7_MATH_1	441	445	PF00917	0.277
DOC_USP7_MATH_1	542	546	PF00917	0.419
DOC_USP7_MATH_1	566	570	PF00917	0.516
DOC_USP7_MATH_1	577	581	PF00917	0.406
DOC_USP7_MATH_1	684	688	PF00917	0.541
DOC_USP7_MATH_1	708	712	PF00917	0.549
DOC_USP7_MATH_1	741	745	PF00917	0.602
DOC_USP7_MATH_1	84	88	PF00917	0.478
DOC_USP7_MATH_1	924	928	PF00917	0.520
DOC_WW_Pin1_4	267	272	PF00397	0.679
DOC_WW_Pin1_4	319	324	PF00397	0.641
DOC_WW_Pin1_4	725	730	PF00397	0.759
DOC_WW_Pin1_4	743	748	PF00397	0.614
LIG_14-3-3_CanoR_1	143	149	PF00244	0.428
LIG_14-3-3_CanoR_1	174	179	PF00244	0.568
LIG_14-3-3_CanoR_1	283	289	PF00244	0.587
LIG_14-3-3_CanoR_1	302	307	PF00244	0.536
LIG_14-3-3_CanoR_1	474	483	PF00244	0.411
LIG_14-3-3_CanoR_1	493	501	PF00244	0.413
LIG_14-3-3_CanoR_1	707	714	PF00244	0.666
LIG_14-3-3_CterR_2	1061	1064	PF00244	0.567
LIG_AP2alpha_2	894	896	PF02296	0.482
LIG_APCC_ABBA_1	1047	1052	PF00400	0.376
LIG_APCC_ABBA_1	837	842	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	836	842	PF00400	0.453
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_CaM_NSCaTE_8	581	588	PF13499	0.373
LIG_EH1_1	466	474	PF00400	0.444
LIG_FHA_1	132	138	PF00498	0.476
LIG_FHA_1	2	8	PF00498	0.664
LIG_FHA_1	236	242	PF00498	0.529
LIG_FHA_1	301	307	PF00498	0.581
LIG_FHA_1	383	389	PF00498	0.641
LIG_FHA_1	446	452	PF00498	0.442
LIG_FHA_1	477	483	PF00498	0.434
LIG_FHA_1	54	60	PF00498	0.426
LIG_FHA_1	661	667	PF00498	0.606
LIG_FHA_1	726	732	PF00498	0.613
LIG_FHA_1	967	973	PF00498	0.643
LIG_FHA_1	988	994	PF00498	0.426
LIG_FHA_2	303	309	PF00498	0.574
LIG_FHA_2	387	393	PF00498	0.588
LIG_FHA_2	455	461	PF00498	0.555
LIG_FHA_2	622	628	PF00498	0.417
LIG_FHA_2	651	657	PF00498	0.497
LIG_FHA_2	711	717	PF00498	0.691
LIG_GBD_Chelix_1	420	428	PF00786	0.459
LIG_GBD_Chelix_1	997	1005	PF00786	0.429
LIG_KLC1_Yacidic_2	1048	1052	PF13176	0.434
LIG_LIR_Apic_2	1032	1038	PF02991	0.480
LIG_LIR_Gen_1	460	469	PF02991	0.418
LIG_LIR_Gen_1	580	590	PF02991	0.505
LIG_LIR_Gen_1	699	708	PF02991	0.506
LIG_LIR_Gen_1	942	953	PF02991	0.369
LIG_LIR_Nem_3	1057	1063	PF02991	0.596
LIG_LIR_Nem_3	433	439	PF02991	0.406
LIG_LIR_Nem_3	460	464	PF02991	0.486
LIG_LIR_Nem_3	580	585	PF02991	0.518
LIG_LIR_Nem_3	594	599	PF02991	0.407
LIG_LIR_Nem_3	699	703	PF02991	0.443
LIG_LIR_Nem_3	942	948	PF02991	0.383
LIG_MAD2	265	273	PF02301	0.497
LIG_MYND_1	1034	1038	PF01753	0.484
LIG_MYND_1	729	733	PF01753	0.532
LIG_NRBOX	423	429	PF00104	0.376
LIG_NRBOX	863	869	PF00104	0.433
LIG_NRBOX	906	912	PF00104	0.425
LIG_PALB2_WD40_1	577	585	PF16756	0.385
LIG_PCNA_yPIPBox_3	496	509	PF02747	0.411
LIG_RPA_C_Fungi	170	182	PF08784	0.315
LIG_SH2_PTP2	532	535	PF00017	0.375
LIG_SH2_SRC	184	187	PF00017	0.315
LIG_SH2_SRC	200	203	PF00017	0.202
LIG_SH2_SRC	532	535	PF00017	0.375
LIG_SH2_STAP1	200	204	PF00017	0.388
LIG_SH2_STAT5	1050	1053	PF00017	0.414
LIG_SH2_STAT5	184	187	PF00017	0.388
LIG_SH2_STAT5	532	535	PF00017	0.347
LIG_SH2_STAT5	825	828	PF00017	0.524
LIG_SH3_1	715	721	PF00018	0.552
LIG_SH3_2	325	330	PF14604	0.684
LIG_SH3_3	1028	1034	PF00018	0.499
LIG_SH3_3	229	235	PF00018	0.340
LIG_SH3_3	268	274	PF00018	0.611
LIG_SH3_3	322	328	PF00018	0.705
LIG_SH3_3	448	454	PF00018	0.361
LIG_SH3_3	532	538	PF00018	0.388
LIG_SH3_3	715	721	PF00018	0.583
LIG_SH3_3	727	733	PF00018	0.539
LIG_SH3_3	821	827	PF00018	0.573
LIG_SH3_3	910	916	PF00018	0.419
LIG_SH3_3	972	978	PF00018	0.675
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.388
LIG_SUMO_SIM_par_1	152	157	PF11976	0.304
LIG_SUMO_SIM_par_1	265	270	PF11976	0.488
LIG_SUMO_SIM_par_1	301	309	PF11976	0.650
LIG_SUMO_SIM_par_1	801	807	PF11976	0.472
LIG_TRAF2_1	260	263	PF00917	0.520
LIG_TRAF2_1	344	347	PF00917	0.548
LIG_TRAF2_1	606	609	PF00917	0.585
LIG_TYR_ITIM	530	535	PF00017	0.370
LIG_UBA3_1	145	151	PF00899	0.340
MOD_CDC14_SPxK_1	327	330	PF00782	0.549
MOD_CDK_SPK_2	319	324	PF00069	0.661
MOD_CDK_SPxK_1	324	330	PF00069	0.588
MOD_CK1_1	131	137	PF00069	0.466
MOD_CK1_1	276	282	PF00069	0.675
MOD_CK1_1	368	374	PF00069	0.540
MOD_CK1_1	386	392	PF00069	0.461
MOD_CK1_1	414	420	PF00069	0.448
MOD_CK1_1	580	586	PF00069	0.407
MOD_CK1_1	710	716	PF00069	0.635
MOD_CK1_1	875	881	PF00069	0.406
MOD_CK2_1	180	186	PF00069	0.315
MOD_CK2_1	335	341	PF00069	0.614
MOD_CK2_1	386	392	PF00069	0.484
MOD_CK2_1	454	460	PF00069	0.458
MOD_CK2_1	603	609	PF00069	0.509
MOD_CK2_1	621	627	PF00069	0.363
MOD_CK2_1	650	656	PF00069	0.435
MOD_CK2_1	699	705	PF00069	0.557
MOD_CK2_1	710	716	PF00069	0.673
MOD_CK2_1	801	807	PF00069	0.514
MOD_CK2_1	843	849	PF00069	0.469
MOD_Cter_Amidation	64	67	PF01082	0.415
MOD_DYRK1A_RPxSP_1	319	323	PF00069	0.637
MOD_DYRK1A_RPxSP_1	324	328	PF00069	0.590
MOD_GlcNHglycan	1039	1042	PF01048	0.452
MOD_GlcNHglycan	131	134	PF01048	0.316
MOD_GlcNHglycan	137	140	PF01048	0.306
MOD_GlcNHglycan	169	172	PF01048	0.361
MOD_GlcNHglycan	311	314	PF01048	0.628
MOD_GlcNHglycan	337	340	PF01048	0.646
MOD_GlcNHglycan	34	37	PF01048	0.550
MOD_GlcNHglycan	359	362	PF01048	0.636
MOD_GlcNHglycan	370	373	PF01048	0.454
MOD_GlcNHglycan	469	472	PF01048	0.391
MOD_GlcNHglycan	518	521	PF01048	0.470
MOD_GlcNHglycan	61	66	PF01048	0.359
MOD_GlcNHglycan	666	669	PF01048	0.657
MOD_GlcNHglycan	679	682	PF01048	0.598
MOD_GlcNHglycan	710	713	PF01048	0.666
MOD_GlcNHglycan	814	817	PF01048	0.493
MOD_GlcNHglycan	844	848	PF01048	0.506
MOD_GlcNHglycan	874	877	PF01048	0.396
MOD_GlcNHglycan	922	925	PF01048	0.327
MOD_GlcNHglycan	942	945	PF01048	0.310
MOD_GSK3_1	127	134	PF00069	0.298
MOD_GSK3_1	189	196	PF00069	0.509
MOD_GSK3_1	272	279	PF00069	0.688
MOD_GSK3_1	298	305	PF00069	0.594
MOD_GSK3_1	319	326	PF00069	0.612
MOD_GSK3_1	364	371	PF00069	0.690
MOD_GSK3_1	382	389	PF00069	0.630
MOD_GSK3_1	390	397	PF00069	0.520
MOD_GSK3_1	441	448	PF00069	0.461
MOD_GSK3_1	660	667	PF00069	0.623
MOD_GSK3_1	720	727	PF00069	0.628
MOD_GSK3_1	739	746	PF00069	0.684
MOD_GSK3_1	920	927	PF00069	0.368
MOD_N-GLC_1	474	479	PF02516	0.480
MOD_N-GLC_2	1002	1004	PF02516	0.391
MOD_N-GLC_2	1006	1008	PF02516	0.385
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	127	132	PF00069	0.340
MOD_NEK2_1	146	151	PF00069	0.247
MOD_NEK2_1	335	340	PF00069	0.730
MOD_NEK2_1	365	370	PF00069	0.692
MOD_NEK2_1	445	450	PF00069	0.544
MOD_NEK2_1	467	472	PF00069	0.382
MOD_NEK2_1	541	546	PF00069	0.390
MOD_NEK2_1	615	620	PF00069	0.446
MOD_NEK2_1	920	925	PF00069	0.393
MOD_NEK2_1	948	953	PF00069	0.381
MOD_NEK2_2	1008	1013	PF00069	0.467
MOD_NEK2_2	71	76	PF00069	0.391
MOD_OFUCOSY	921	928	PF10250	0.349
MOD_PIKK_1	146	152	PF00454	0.243
MOD_PIKK_1	454	460	PF00454	0.418
MOD_PK_1	174	180	PF00069	0.315
MOD_PK_1	189	195	PF00069	0.189
MOD_PK_1	883	889	PF00069	0.382
MOD_PKA_1	174	180	PF00069	0.388
MOD_PKA_1	283	289	PF00069	0.587
MOD_PKA_2	174	180	PF00069	0.388
MOD_PKA_2	2	8	PF00069	0.537
MOD_PKA_2	283	289	PF00069	0.614
MOD_PKA_2	29	35	PF00069	0.571
MOD_PKA_2	323	329	PF00069	0.711
MOD_PKA_2	347	353	PF00069	0.623
MOD_PKA_2	473	479	PF00069	0.503
MOD_PKA_2	492	498	PF00069	0.406
MOD_PKA_2	615	621	PF00069	0.444
MOD_PKA_2	671	677	PF00069	0.731
MOD_PKA_2	792	798	PF00069	0.458
MOD_Plk_1	394	400	PF00069	0.445
MOD_Plk_1	53	59	PF00069	0.369
MOD_Plk_1	542	548	PF00069	0.523
MOD_Plk_2-3	699	705	PF00069	0.515
MOD_Plk_4	115	121	PF00069	0.478
MOD_Plk_4	158	164	PF00069	0.392
MOD_Plk_4	347	353	PF00069	0.574
MOD_Plk_4	383	389	PF00069	0.547
MOD_Plk_4	441	447	PF00069	0.382
MOD_Plk_4	460	466	PF00069	0.486
MOD_Plk_4	536	542	PF00069	0.397
MOD_Plk_4	577	583	PF00069	0.392
MOD_Plk_4	906	912	PF00069	0.449
MOD_Plk_4	948	954	PF00069	0.286
MOD_ProDKin_1	267	273	PF00069	0.679
MOD_ProDKin_1	319	325	PF00069	0.640
MOD_ProDKin_1	725	731	PF00069	0.760
MOD_ProDKin_1	743	749	PF00069	0.611
MOD_SUMO_for_1	9	12	PF00179	0.378
MOD_SUMO_rev_2	259	267	PF00179	0.503
MOD_SUMO_rev_2	623	631	PF00179	0.509
MOD_SUMO_rev_2	647	651	PF00179	0.449
TRG_DiLeu_BaEn_1	460	465	PF01217	0.477
TRG_DiLeu_BaEn_1	54	59	PF01217	0.435
TRG_DiLeu_BaEn_1	617	622	PF01217	0.458
TRG_DiLeu_BaEn_1	833	838	PF01217	0.336
TRG_DiLeu_BaLyEn_6	1058	1063	PF01217	0.562
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.450
TRG_DiLeu_LyEn_5	833	838	PF01217	0.373
TRG_ENDOCYTIC_2	532	535	PF00928	0.341
TRG_ER_diArg_1	1023	1025	PF00400	0.560
TRG_ER_diArg_1	15	17	PF00400	0.489
TRG_ER_diArg_1	173	176	PF00400	0.312
TRG_ER_diArg_1	219	221	PF00400	0.303
TRG_ER_diArg_1	282	284	PF00400	0.599
TRG_ER_diArg_1	316	319	PF00400	0.560
TRG_ER_diArg_1	398	400	PF00400	0.433
TRG_ER_diArg_1	768	770	PF00400	0.556
TRG_ER_diArg_1	786	789	PF00400	0.467
TRG_NES_CRM1_1	418	433	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	1025	1029	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.243
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	642	647	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	715	719	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICN1	Leptomonas seymouri	38%	100%
A0A3S7X5E0	Leishmania donovani	88%	100%
A4HK75	Leishmania braziliensis	69%	100%
A4I7R0	Leishmania infantum	89%	100%
E9B2L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%