RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q5I4_LEIMA

TriTrypDb:

LmjF.32.0980 , LMJLV39_320015600 , LMJSD75_320015600

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q5I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5I4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	539	541	PF00675	0.754
CLV_PCSK_KEX2_1	242	244	PF00082	0.432
CLV_PCSK_KEX2_1	539	541	PF00082	0.751
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.432
CLV_PCSK_SKI1_1	161	165	PF00082	0.466
CLV_PCSK_SKI1_1	213	217	PF00082	0.504
CLV_PCSK_SKI1_1	242	246	PF00082	0.436
CLV_PCSK_SKI1_1	279	283	PF00082	0.495
CLV_PCSK_SKI1_1	75	79	PF00082	0.540
DEG_APCC_DBOX_1	270	278	PF00400	0.534
DEG_SPOP_SBC_1	123	127	PF00917	0.736
DOC_CKS1_1	39	44	PF01111	0.706
DOC_CYCLIN_RxL_1	153	162	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.636
DOC_MAPK_gen_1	220	229	PF00069	0.493
DOC_PP4_FxxP_1	397	400	PF00568	0.636
DOC_USP7_MATH_1	122	126	PF00917	0.719
DOC_USP7_MATH_1	326	330	PF00917	0.676
DOC_USP7_MATH_1	433	437	PF00917	0.595
DOC_USP7_MATH_1	472	476	PF00917	0.683
DOC_USP7_MATH_1	523	527	PF00917	0.677
DOC_USP7_MATH_1	76	80	PF00917	0.760
DOC_USP7_MATH_1	81	85	PF00917	0.797
DOC_USP7_MATH_1	95	99	PF00917	0.796
DOC_WW_Pin1_4	124	129	PF00397	0.637
DOC_WW_Pin1_4	285	290	PF00397	0.559
DOC_WW_Pin1_4	302	307	PF00397	0.643
DOC_WW_Pin1_4	316	321	PF00397	0.650
DOC_WW_Pin1_4	342	347	PF00397	0.639
DOC_WW_Pin1_4	360	365	PF00397	0.673
DOC_WW_Pin1_4	38	43	PF00397	0.705
DOC_WW_Pin1_4	401	406	PF00397	0.637
DOC_WW_Pin1_4	448	453	PF00397	0.728
DOC_WW_Pin1_4	500	505	PF00397	0.549
DOC_WW_Pin1_4	97	102	PF00397	0.620
LIG_14-3-3_CanoR_1	75	81	PF00244	0.536
LIG_Actin_WH2_2	259	277	PF00022	0.513
LIG_APCC_ABBA_1	169	174	PF00400	0.588
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_BRCT_BRCA1_1	135	139	PF00533	0.649
LIG_BRCT_BRCA1_1	156	160	PF00533	0.559
LIG_BRCT_BRCA1_1	384	388	PF00533	0.653
LIG_FHA_1	112	118	PF00498	0.650
LIG_FHA_1	12	18	PF00498	0.747
LIG_FHA_1	239	245	PF00498	0.473
LIG_FHA_1	313	319	PF00498	0.759
LIG_FHA_1	349	355	PF00498	0.542
LIG_FHA_1	39	45	PF00498	0.710
LIG_FHA_1	410	416	PF00498	0.614
LIG_FHA_1	464	470	PF00498	0.704
LIG_FHA_2	451	457	PF00498	0.546
LIG_LIR_Apic_2	394	400	PF02991	0.782
LIG_LIR_Gen_1	136	146	PF02991	0.675
LIG_LIR_Gen_1	223	234	PF02991	0.394
LIG_LIR_Nem_3	157	163	PF02991	0.648
LIG_LIR_Nem_3	223	229	PF02991	0.406
LIG_LIR_Nem_3	439	443	PF02991	0.608
LIG_LIR_Nem_3	506	512	PF02991	0.623
LIG_SH2_CRK	145	149	PF00017	0.575
LIG_SH2_STAP1	411	415	PF00017	0.612
LIG_SH2_STAT3	411	414	PF00017	0.615
LIG_SH2_STAT3	489	492	PF00017	0.595
LIG_SH2_STAT5	118	121	PF00017	0.610
LIG_SH2_STAT5	370	373	PF00017	0.646
LIG_SH2_STAT5	411	414	PF00017	0.612
LIG_SH3_1	387	393	PF00018	0.699
LIG_SH3_3	387	393	PF00018	0.717
LIG_SH3_3	446	452	PF00018	0.722
LIG_SH3_3	458	464	PF00018	0.623
LIG_SH3_3	498	504	PF00018	0.704
LIG_SUMO_SIM_par_1	482	487	PF11976	0.665
LIG_TYR_ITIM	507	512	PF00017	0.630
MOD_CDK_SPxxK_3	285	292	PF00069	0.628
MOD_CDK_SPxxK_3	448	455	PF00069	0.706
MOD_CK1_1	100	106	PF00069	0.691
MOD_CK1_1	127	133	PF00069	0.649
MOD_CK1_1	138	144	PF00069	0.636
MOD_CK1_1	293	299	PF00069	0.706
MOD_CK1_1	305	311	PF00069	0.583
MOD_CK1_1	329	335	PF00069	0.668
MOD_CK1_1	409	415	PF00069	0.612
MOD_CK1_1	451	457	PF00069	0.617
MOD_CK2_1	186	192	PF00069	0.431
MOD_CK2_1	433	439	PF00069	0.652
MOD_CK2_1	450	456	PF00069	0.656
MOD_CK2_1	5	11	PF00069	0.669
MOD_Cter_Amidation	537	540	PF01082	0.689
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	231	234	PF01048	0.388
MOD_GlcNHglycan	310	313	PF01048	0.561
MOD_GlcNHglycan	35	38	PF01048	0.677
MOD_GlcNHglycan	355	359	PF01048	0.682
MOD_GlcNHglycan	417	420	PF01048	0.627
MOD_GlcNHglycan	456	460	PF01048	0.724
MOD_GlcNHglycan	512	515	PF01048	0.696
MOD_GlcNHglycan	58	61	PF01048	0.723
MOD_GSK3_1	123	130	PF00069	0.660
MOD_GSK3_1	133	140	PF00069	0.608
MOD_GSK3_1	293	300	PF00069	0.692
MOD_GSK3_1	301	308	PF00069	0.644
MOD_GSK3_1	312	319	PF00069	0.671
MOD_GSK3_1	409	416	PF00069	0.725
MOD_GSK3_1	447	454	PF00069	0.614
MOD_GSK3_1	472	479	PF00069	0.654
MOD_LATS_1	218	224	PF00433	0.538
MOD_N-GLC_1	133	138	PF02516	0.719
MOD_N-GLC_1	229	234	PF02516	0.376
MOD_N-GLC_1	55	60	PF02516	0.715
MOD_NEK2_1	238	243	PF00069	0.447
MOD_NEK2_1	321	326	PF00069	0.629
MOD_NEK2_1	354	359	PF00069	0.642
MOD_NEK2_1	365	370	PF00069	0.499
MOD_NEK2_1	382	387	PF00069	0.546
MOD_NEK2_1	413	418	PF00069	0.605
MOD_NEK2_1	431	436	PF00069	0.561
MOD_NEK2_1	484	489	PF00069	0.604
MOD_NEK2_2	393	398	PF00069	0.705
MOD_NEK2_2	406	411	PF00069	0.467
MOD_OFUCOSY	217	224	PF10250	0.567
MOD_PIKK_1	133	139	PF00454	0.711
MOD_PIKK_1	484	490	PF00454	0.621
MOD_PKA_2	293	299	PF00069	0.702
MOD_Plk_1	229	235	PF00069	0.360
MOD_Plk_1	354	360	PF00069	0.685
MOD_Plk_2-3	5	11	PF00069	0.654
MOD_Plk_4	326	332	PF00069	0.658
MOD_Plk_4	393	399	PF00069	0.696
MOD_Plk_4	406	412	PF00069	0.472
MOD_ProDKin_1	124	130	PF00069	0.639
MOD_ProDKin_1	285	291	PF00069	0.565
MOD_ProDKin_1	302	308	PF00069	0.644
MOD_ProDKin_1	316	322	PF00069	0.649
MOD_ProDKin_1	342	348	PF00069	0.639
MOD_ProDKin_1	360	366	PF00069	0.674
MOD_ProDKin_1	38	44	PF00069	0.707
MOD_ProDKin_1	401	407	PF00069	0.635
MOD_ProDKin_1	448	454	PF00069	0.730
MOD_ProDKin_1	500	506	PF00069	0.541
MOD_ProDKin_1	97	103	PF00069	0.623
TRG_ENDOCYTIC_2	145	148	PF00928	0.578
TRG_ENDOCYTIC_2	509	512	PF00928	0.637
TRG_ER_diArg_1	539	541	PF00400	0.746
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMP7	Leptomonas seymouri	53%	100%
A0A1X0NUL4	Trypanosomatidae	33%	87%
A0A3S7X5C4	Leishmania donovani	94%	100%
A4HK79	Leishmania braziliensis	74%	100%
A4I7R4	Leishmania infantum	94%	100%
E9B2M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%