Tyrosine-protein phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q5I1_LEIMA

TriTrypDb:

LmjF.32.1010 , LMJLV39_320016000 , LMJSD75_320016000

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q5I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5I1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.563
CLV_C14_Caspase3-7	380	384	PF00656	0.479
CLV_NRD_NRD_1	118	120	PF00675	0.348
CLV_NRD_NRD_1	142	144	PF00675	0.275
CLV_NRD_NRD_1	193	195	PF00675	0.549
CLV_NRD_NRD_1	208	210	PF00675	0.419
CLV_NRD_NRD_1	306	308	PF00675	0.500
CLV_PCSK_KEX2_1	118	120	PF00082	0.339
CLV_PCSK_KEX2_1	142	144	PF00082	0.275
CLV_PCSK_KEX2_1	208	210	PF00082	0.480
CLV_PCSK_KEX2_1	306	308	PF00082	0.500
CLV_PCSK_KEX2_1	60	62	PF00082	0.275
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.275
CLV_PCSK_SKI1_1	106	110	PF00082	0.243
CLV_PCSK_SKI1_1	195	199	PF00082	0.361
CLV_PCSK_SKI1_1	60	64	PF00082	0.329
CLV_PCSK_SKI1_1	70	74	PF00082	0.256
DEG_SPOP_SBC_1	275	279	PF00917	0.635
DOC_CYCLIN_RxL_1	106	117	PF00134	0.478
DOC_CYCLIN_RxL_1	57	66	PF00134	0.529
DOC_CYCLIN_yCln2_LP_2	12	15	PF00134	0.475
DOC_MAPK_gen_1	118	125	PF00069	0.529
DOC_MAPK_gen_1	164	174	PF00069	0.529
DOC_MAPK_MEF2A_6	167	174	PF00069	0.529
DOC_MAPK_NFAT4_5	167	175	PF00069	0.529
DOC_PP1_RVXF_1	108	115	PF00149	0.475
DOC_PP2B_LxvP_1	11	14	PF13499	0.315
DOC_PP2B_LxvP_1	390	393	PF13499	0.488
DOC_PP4_FxxP_1	125	128	PF00568	0.475
DOC_USP7_MATH_1	329	333	PF00917	0.546
DOC_USP7_MATH_1	375	379	PF00917	0.472
DOC_WW_Pin1_4	101	106	PF00397	0.496
DOC_WW_Pin1_4	371	376	PF00397	0.485
LIG_14-3-3_CanoR_1	223	230	PF00244	0.543
LIG_14-3-3_CanoR_1	276	281	PF00244	0.631
LIG_14-3-3_CanoR_1	409	413	PF00244	0.637
LIG_APCC_ABBA_1	170	175	PF00400	0.529
LIG_BRCT_BRCA1_1	149	153	PF00533	0.529
LIG_BRCT_BRCA1_1	226	230	PF00533	0.751
LIG_CaM_IQ_9	186	201	PF13499	0.399
LIG_Clathr_ClatBox_1	171	175	PF01394	0.529
LIG_Clathr_ClatBox_1	49	53	PF01394	0.475
LIG_deltaCOP1_diTrp_1	117	125	PF00928	0.475
LIG_EVH1_2	14	18	PF00568	0.475
LIG_FHA_1	107	113	PF00498	0.579
LIG_FHA_1	132	138	PF00498	0.485
LIG_FHA_1	43	49	PF00498	0.529
LIG_FHA_1	71	77	PF00498	0.553
LIG_FHA_2	267	273	PF00498	0.635
LIG_LIR_Apic_2	371	375	PF02991	0.513
LIG_LIR_Gen_1	157	166	PF02991	0.475
LIG_LIR_Gen_1	16	26	PF02991	0.529
LIG_LIR_Gen_1	269	275	PF02991	0.628
LIG_LIR_Nem_3	117	123	PF02991	0.475
LIG_LIR_Nem_3	157	162	PF02991	0.475
LIG_LIR_Nem_3	16	21	PF02991	0.529
LIG_LIR_Nem_3	269	273	PF02991	0.558
LIG_MYND_1	10	14	PF01753	0.312
LIG_Pex14_1	353	357	PF04695	0.368
LIG_Pex14_2	173	177	PF04695	0.529
LIG_SH2_CRK	159	163	PF00017	0.529
LIG_SH2_CRK	372	376	PF00017	0.551
LIG_SH2_CRK	397	401	PF00017	0.452
LIG_SH2_SRC	357	360	PF00017	0.449
LIG_SH2_STAT5	159	162	PF00017	0.529
LIG_SH2_STAT5	357	360	PF00017	0.449
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH3_3	281	287	PF00018	0.743
LIG_SH3_3	397	403	PF00018	0.621
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.529
LIG_SUMO_SIM_par_1	240	248	PF11976	0.563
LIG_SUMO_SIM_par_1	45	51	PF11976	0.478
LIG_TRAF2_1	31	34	PF00917	0.478
LIG_TRAF2_1	363	366	PF00917	0.409
LIG_TYR_ITIM	395	400	PF00017	0.430
MOD_CDK_SPK_2	101	106	PF00069	0.443
MOD_CK1_1	16	22	PF00069	0.488
MOD_CK1_1	244	250	PF00069	0.681
MOD_CK1_1	261	267	PF00069	0.595
MOD_CK1_1	271	277	PF00069	0.540
MOD_CK1_1	410	416	PF00069	0.569
MOD_CK1_1	65	71	PF00069	0.559
MOD_CK2_1	151	157	PF00069	0.475
MOD_CK2_1	16	22	PF00069	0.486
MOD_CK2_1	230	236	PF00069	0.651
MOD_CK2_1	266	272	PF00069	0.636
MOD_CK2_1	327	333	PF00069	0.693
MOD_CK2_1	413	419	PF00069	0.568
MOD_CMANNOS	353	356	PF00535	0.373
MOD_GlcNHglycan	149	152	PF01048	0.297
MOD_GlcNHglycan	184	187	PF01048	0.411
MOD_GlcNHglycan	231	235	PF01048	0.592
MOD_GlcNHglycan	253	256	PF01048	0.706
MOD_GlcNHglycan	27	30	PF01048	0.283
MOD_GlcNHglycan	296	299	PF01048	0.599
MOD_GlcNHglycan	329	332	PF01048	0.639
MOD_GlcNHglycan	379	382	PF01048	0.546
MOD_GlcNHglycan	98	101	PF01048	0.291
MOD_GSK3_1	147	154	PF00069	0.603
MOD_GSK3_1	158	165	PF00069	0.496
MOD_GSK3_1	222	229	PF00069	0.659
MOD_GSK3_1	25	32	PF00069	0.483
MOD_GSK3_1	257	264	PF00069	0.653
MOD_GSK3_1	271	278	PF00069	0.717
MOD_GSK3_1	371	378	PF00069	0.523
MOD_GSK3_1	70	77	PF00069	0.529
MOD_LATS_1	219	225	PF00433	0.476
MOD_N-GLC_1	16	21	PF02516	0.286
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	158	163	PF00069	0.522
MOD_NEK2_1	166	171	PF00069	0.461
MOD_NEK2_1	230	235	PF00069	0.725
MOD_NEK2_1	293	298	PF00069	0.653
MOD_NEK2_1	377	382	PF00069	0.540
MOD_PIKK_1	263	269	PF00454	0.570
MOD_PKA_1	327	333	PF00069	0.559
MOD_PKA_2	166	172	PF00069	0.496
MOD_PKA_2	222	228	PF00069	0.643
MOD_PKA_2	275	281	PF00069	0.630
MOD_PKA_2	408	414	PF00069	0.641
MOD_Plk_1	16	22	PF00069	0.460
MOD_Plk_1	271	277	PF00069	0.601
MOD_Plk_2-3	222	228	PF00069	0.522
MOD_Plk_4	166	172	PF00069	0.588
MOD_Plk_4	241	247	PF00069	0.705
MOD_Plk_4	336	342	PF00069	0.570
MOD_Plk_4	413	419	PF00069	0.587
MOD_ProDKin_1	101	107	PF00069	0.496
MOD_ProDKin_1	371	377	PF00069	0.488
MOD_SUMO_rev_2	339	349	PF00179	0.561
MOD_SUMO_rev_2	365	369	PF00179	0.465
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.529
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.522
TRG_ENDOCYTIC_2	159	162	PF00928	0.529
TRG_ENDOCYTIC_2	397	400	PF00928	0.439
TRG_ER_diArg_1	118	120	PF00400	0.529
TRG_ER_diArg_1	141	143	PF00400	0.475
TRG_ER_diArg_1	191	194	PF00400	0.427
TRG_ER_diArg_1	305	307	PF00400	0.502
TRG_NLS_Bipartite_1	194	213	PF00514	0.466
TRG_NLS_MonoExtN_4	208	213	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE45	Leptomonas seymouri	59%	99%
A0A3Q8IT66	Leishmania donovani	92%	100%
A4HK83	Leishmania braziliensis	76%	100%
A4I7R8	Leishmania infantum	93%	100%
E9B2M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%